Slide Session : OS-IFD-07 ; Infectious Disease : In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus

( Myung Jin Lee ),( Kye Hyung Kim ),( Jong Youn Yi ),( Su Jin Choi ),( Chung Jong Kim ),( Nak Hyun Kim ),( Kyoung Ho Song ),( Pyoeng Gyun Choi ),( Ji Hwan Bang ),( Wan Beom Park ),( Eu Suk Kim ),( San 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus Myung Jin LEE1, Kye-Hyung KIM1, Jongyoun YI2, SuJin CHOI1, Chung-Jong KIM1, Nak- Hyun KIM1, Kyoung-Ho SONG1, Pyoeng Gyun CHOI1, Ji-Hwan BANG1, Wan Beom PARK1, Eu Suk KIM1, Sang-Won PARK1, Hong Bin KIM1, Nam Joong KIM1, Myoung- Don OH1 Seoul National University College of Medicine, Korea1, Pusan National University School of Medicine, Korea2 Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel Bunyavirus, severe fever with thrombocytopenia syndrome virus (SFTSV). No effective antiviral therapy is proven yet, but clinical use of ribavirin (RBV) has been tried. We investigated the antiviral effect of RBV against SFTSV in vitro. Methods: To test for cytotoxicity of RBV, Vero cells were treated with different concentrations of RBV (3.90 to 500 μg/mL, two-fold dilution) and analyzed by cell viability MTS assay 48h post-infection. To determine antiviral activity of RBV against SFTSV, Vero cells were infected with SFTSV strain Gangwon/Korea/2012 at 100 TCID50 (50% tissue culture infective dose) per well in a 96-well plate, and RBV was added at the concentrations showing no or minimal cytotoxicity. Viral RNAs were extracted from the culture supernatants and quantifi ed using one-step real-time reverse transcription- PCR to amplify the partial large segment of SFTSV. Statistical analysis was done by one-way ANOVA with Tukey`s post hoc test. Results: Cytotoxicity due to RBV was not observed at RBV concentration =31.3 μg/ mL. Viral RNAs at 24h post-RBV treatment were reduced with increasing RBV concentrations (1-32 μg/mL), compared with those of mock-treated cells (P <0.01, Figure). Half maximal inhibitory concentration (IC50) of RBV was 3.69 μg/mL at 24h post-RBV treatment. Conclusions: Our study shows that RBV has antiviral effect against SFTSV in a dose-dependent manner. Further studies are required to evaluate the effi cacy of RBV in SFTS.

적외선 센서를 이용한 다종가스 계측기 구현

최낙진,류정호,강봉휘,이광우,이덕동 경북대학교 센서기술연구소 1997 센서技術學術大會論文集 Vol.8 No.1

The semiconductor gas sensors with a tin oxide as the raw material have been generally used to detect gases in the principle of electrical conductivity variation. However, it was difficult to design the gas detection system due to the non-selectivity, the non-stability and the influence of temperature, humidity etc. Therefore, it was proposed NDIR(non-dispersive infrared) method using pyroelectric infrared sensor to overcome the disadvantage of the semiconductor gas sensors. This method has been recently used to detect various gases in industrial parts. It has the advantages of selectivity, stability and responsibility. The gases used in this paper were CO_(2)(carbon dioxide) and HC(hydrocarbon) series. The system was designed with the Intel MCU i8097BH microprocessor. Main topics were to remove interference effect for other gases and to minimize influence for ambient circumstance by using the software and the hardware techniques.

소재의 정밀 Loading/unloading 기술 개발

최현석,탁태열,한창수,이낙규,최태훈,이혜진 한국공작기계학회 2005 한국공작기계학회 춘계학술대회논문집 Vol.2005 No.-

In micro factory, loading/unloading mechanism supply the row material to processing machines for manufacturing process such as pressing, cutting, plastic deformation. This mechanism for micro factory is designed as modularity robot. Micro factory system have to be flexible structure for variety product item. For system flexibility, applied mechanisms are developed as moduality. Robot moduality needs the specific charecteristics which are different from one of macro, typical robot system. In this paper, we discussed about the modularity robot. and proposed the loading/unloading mechanism for working in microfactory system.

農村 靑少年의 家庭生活에 관한 價値觀

崔敏浩,鄭址雄,金性洙,李洛薰,金鎭模 서울大學校 農科大學 1985 서울대농학연구지 Vol.10 No.2

The purposes of the study were to investigate the values of the rural youth in relation to family living, and to compare changes in the values with the similar study of the reseacher of 1970 in Korea. Data were collected by undergraduate and graduate students of the Seoul National University from randomly selected 993 rural youths of 13 to 24 years of age through questionnaire method. The data were analyzed by HP 3000 Computer in the College of Agriculture, Seoul National University. Major statistical techniques used for the study were frequency, percentile, chi square test. Statistical significance was tested at 0.05 level. The major findings of the study were as follows; 1. It was revealed that values on family living were changed into modern democratic ideals from traditional Confucian values 2. The view of respondents that the first son should take care of parents has decreased from 32.8% in 1970 to 23.8% in 1984. The Respondents who think that one of sons should take care of parents has increased from 45.8% in 1970 to 60.8% in 1984. 3. The rate of respondents claiming that the head of a family should govern the family with authority and dignity has increased from 61.1%in 1970 to 68.3% in 1984. 4. The respondents claiming that the head of a family should decide the important things of family living dogmatically has decreased from 16.9% in 1970 to 8.1% in 1984. 5. The rate of respondents claiming that father should respect mother's opinion in family has increased from 78.6% in 1970 to 90.5% in 1984. 6. The rate of respondents claiming that fathers should understand the things of children with maximum degree has increased from 86.8% in 1970 to 93.8% in 1984.

마이크로 정렬 시스템의 설계

최종필,이해진,이낙규,김성욱,주은덕,김병희 한국공작기계학회 2008 한국공작기계학회 추계학술대회논문집 Vol.2008 No.-

This paper presents the micro positioning/tilting system with flexure. The basic principle and the operation mechanism were introduced. The micro positioning system consists of a moving platform, three piezoelectric actuators, clamper and flexure hinges. The flexure hinges which are beam hinge, spherical notch joint, wide range hinge are designed and fabricated. The FEM simulation was used to design and optimize the flexure hinges mechanism. Form the result of FEM simulation we fabricated the micro position system by CNC machine and WEDM with the material of SUS 304. To evaluate the performance of the fabricated micro positioning system, the output displacement of the moving plate in vertical direction was measured and tested.

全北經濟의 停滯性 克服에 관한 硏究

崔洛弼,朴承基,安津,朴泰植,李海經,金宣坤 全北大學校 1991 論文集 Vol.33 No.-

This research is to give light upon the cause of stagnated economy of Chonbuk province by comparing the interreginal conditions of economy mainly since 1960s which is the period between Japanese Colony and the development of this province, and to propose its measures to overcome it. Chonbuk region, Since its opening of Kunsan port, through the term of Japanese colony, had been degenerated into a relative area of stagnation compared with other areas due to land seizure and exploitation of agricultural products by Japan. Thus since the opening of port the structure of economy in Chonbuk region was deformed into that is typical monoculture from colonial exploitation. Of course, althrough the structure of Korean economy under Japanese colony was generally maimed through exploitative structure of economy, it was demonstrated by substantiation data, that Chonbuk region with its opulent exploited as a primary object area of exploitation by Japan. Deprived of its autogenous vitality and alienated even from "the age of development" for decades, economical structure of Chonbuk province couldn't but be still aggravated rather than improved. Eventurally the gap between present growing regions is more over deepening through the compound geometrical functions of various factors that restrict regional development of economy as analyzed above.

열적 변화를 이용한 실내환경 가스의 분류

최낙진,심창현,송갑득,주병수,이윤수,이상문,이덕동,허증수 한국센서학회 2002 센서학회지 Vol.11 No.5

단일 기판위에 온도측정용 Pt 박막과 Pt 히터 그리고 가스 감지를 위하여 순수한 SnO_2 박막과 Pt가 첨가된 SnO_2박막을 설계하고 제작하였다. 제작된 소자는 실내환경가스인 이산화탄소, 프로판 그리고 부탄의 분류에 응용되었다. 동작 온도를 가변하기 위하여 히터의 입력 전압을 사다리꼴로 인가하면서 SnO_2 감지막의 반응특성과 실내환경가스들에 대한 분류여부를 조사하였다. 감지막 반응특성곡선에서 여러 변수들을 추출한 후 주성분분석(principal component analysis : PCA)을 통하여 가스 분류 특성을 검증하였다. Two SnO_2 based sensing films(pure SnO_2 and SnO_2/Pt) and a Pt thin film for temperature sensor on an alumina substrate were designed and fabricated for classifying the indoor environmental gases. By controlling the heating power in the shape of trapezoid, unique four sensing response curves created from both SnO_2 film and SnO_2/Pt film. Then, various parameters were extracted from sensing response curves and carried out principal component analysis(PCA). The results confirm that a sensor array with the proposed operating mode was extremely effective in classifying indoor environmental gases such as CO_2, C_3H_8, C_4H_10.

폐굴껍질 및 천연제올라이트 연속흡착탑을 이용한 피혁폐수 중의 유기물·질소제거 특성

정유진,하상안,최성문,성낙창,임영석 동아대학교 환경문제연구소 2001 硏究報告 Vol.24 No.1

The object of this study is to remove the nitrogen from tannery wastewater using waste oyster shells and natural zeolites. In many cases, components of industrial process wastewater are non-readily biodegradable, but can be effectively removed from wastewater by means of adsorption process. The technologies of removing nitrogen, considered as one of the most important control nutrients causing eutrophication in various water bodies, have been investigated by many researchers. Through the continuous adsorption experience, waste oyster shells have effects to control COD and pH rising. And natural zeolites are found to have the good ability to adsorb NH₄^(+) ion in the wastewater. As a result of this study, continuous adsorption column filled with oyster shells and natural zeolite, especially the ratio of 1 : 2 by volume, is found to be effective in nitrogen removal and economic aspect.

폴리에스테르 모르타르용 충전재로서 금속광산 폐광미의 활용 연구

윤성진,최낙운,문경주,소양섭 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2

The purpose of this study is to examine the basic properties of polyester mortars using fine tailing(FT) as a filler. The FT is obtained by centrifugal separation of tailing(TA), and checked for basic properties of shape, particle size distribution, chemical composition, resin absorption. Polyester mortars with FT and ground calcium carbonate(GC) are tested for working life, flexural and compressive strengths. The test results showed that FT has much the same properties as GC in the shape, size and resin absorption. The working life of the polyester mortars is lengthen with an increase in the filter/binder ratio. The polyester mortars with a filter/binder ratio of 1.0 have the maximum flexural and compressive strengths.

PWM을 이용한 화재 감지용 자외선 센서의 구동 방법

고낙용,최한수,김광진,임병현 조선대학교 에너지.자원신기술연구소 2004 에너지·자원신기술연구소 논문지 Vol.26 No.1

We propose driving method of Ultraviolet sensor for fire alarms using pulse width modulation that is used to fire detector. Ultraviolet sensor is UV Tron using gas multiplication effect to current discharge and photoelectric effect of metal. To have high sensibility and to gain proper output voltage. it should have highly responsive performance. This research designed a driving circuit with UV sensors and proposed a method for false alarm reduction. The result shows the prevention and extinction of fire technique degree, certificated operation of detector.