단순 캘리브레이션 모형에서 경험적 베이스 추정

이상호,박래현 충남대학교 기초과학연구소 1995 忠南科學硏究誌 Vol.22 No.2

In the simple calibration model, Maritz(1970) gave an empirical Bayes estimator of x_0 when y_01, …, y_0k on x_0 are observed. However, his estimator can not be applied in case k 1 which is occurred more often than not. We propose a new empirical Bayes estimator of x_0 which enables us to predict x_0 for all k and is a compromise between the classical estimator and the inverse estimator.

공동 수,배송 모델을 위한 프레임웍 구축

이명호,이계주,김내헌 대한설비관리학회 2003 대한설비관리학회지 Vol.8 No.2

With approaching a digital information society, the business environment of B2B and B2C is getting a portal service using mobile since the wire/wireless internet and web utilization is populated to customers. The development of digital information and internet technologies changed the environment of enterprises and the technology. And the achieving customer satisfaction and the various demand of customer made the integration of logistics information system on the consolidated transportation recognized as a core of the business. So in this study, we intend to provide the standard of product development that is valuable on the market through the implementing a framework of consolidated transportation model to the companies, designing a collaborated inventory and also suggest the standard of consolidated transportation model through the data modeling and case study.

다변량 역추정 모형에서 경험적 베이스 추정량에 관한 연구

이상호,박래현 충남대학교 기초과학연구소 1996 忠南科學硏究誌 Vol.23 No.2

In the multivariate calibration model, we propose a new Empirical Bayes estimator(EB estimator) which enables us to predict the panameter of interest. The EB estimator is a compromised type between the classical estimator and the inverse estimator, and attains better precision than any other estimator in Brown(1982).

미세혈관 협심증 환자의 임상상 및 지표에 관한 연구

박상호,온영근,김현정,이태훈,길효욱,김현건,박수진,송해정,한대희,방덕원,신원용,이내희,김성구,권영주 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.1

Background : Microvascular angina or syndrom X is heterogenous and encompasses different pathogenetic entities. Several studies suggest that microvascular angina have good prognosis and occurs predominantly in postmenopausal women. Lipoprotein (a), total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, homocystein, CRP and fibrinogen are the independent risk factor of acute coronary syndrome and are the chief underlying cause of atherosclerosis. We investigated clinical characteristics and markers in patients with microvascular angina. Methods : We studies 23 patients diagnosed with microvascular angina and 16 control group with negative treadmill exercise test and no significant coronary angiogram. We investigated clinical characteristics in patients group and evaluated symptom during a follow-up period of 4.2± 2.5 month. Exercise time in treadmill exercise test was compared between patients and control group. We assessed the level of markers, such as lipoprotein (a), total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, homocystein, CRP and ESR in two groups. Results : There is no difference in age between two groups. Patients group had a tendency to increase in female, hypertension, DM, and smoking history, but there was no statistical significance difference. Exercise duration time was significantly decreased in patients with microvascular angina (p<0,05). Serum lipoprotein (a), total cholesterol, LDL-cholesterol, HDL-cholestrol, Triglyceride, ESR, Fibrinogen and Homocystein value were no significant difference between microvascular angina and control group. Only CRP was significantly high in patients with microvascular angina (p<0.05). Conclusion : There was no statistical significance difference in age, sex, hypertension, DM and smoking history between two groups but patients group had a tendency to increase the prevalence in hypertension, DM and smoking history, female. Also, Symptom improvement and disappearance in follow-up was presented in 11 patients of 19(57.9%). Exercise tolerance was worse in patients group than control group. CRP value was significantly higher in patients group than control group. There was no statistical significance difference in lipoprotein (a), total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, homocystein, ESR and Fibrinogen between two groups.

전신성홍반성루푸스 환자에서 발생한 순수어농

김윤정,김해림,박시내,윤종현,이상헌,박성환,김호연 대한내과학회 2004 대한내과학회지 Vol.66 No.4

순수어농이란 발성언어에 대한 이해와 반복에 장애를 보이지만 읽기, 쓰기, 비발성언어에 대한 이해는 보존되는 경우를 일컫는다. 저자들은 45세 루푸스 환자에서 루푸스 혈관염으로 인해 일차 청각 피질을 포함한 왼쪽 관자이랑에 뇌경색이 발생하여 초래한 순수어농 1예를 경험하였기에 보고하는 바이다. Pure word deafness is characterized by an impairment of auditory comprehension and repetition of speech while a preservation of reading, writing, spontaneous speech and ability to comprehend non-verbal sounds. It is caused by trauma, infection in the temporal lobe of brain. In most cases, the lesions are bilateral, in the middle third of superior temporal gyri, but in a few cases unilateral lesions of dominant temporal lobe are localized. We experienced a case of 45 year-old right handed wonman with systemic lupus erythemato년 (SLE) who presented pure word deafness after left temporal lobe infarction including primary auditory center. Her comprehension was impaired, while reading and visual comprehension were normal. Audiometric tests and auditory evoked potentials disclosed no hearing defect. Brain MRI showed a left temporal lobe infarction without abnormal vascular finding in MRA. She wasdiagnosed as pure word deafness due to SLE vasculitis and managed with high dose steroid and cyclophosphamide therapies.

직장암 수술 후 국소재발과 예후

김태윤,백무준,김성용,신응진,박내경,이문수,김창호,송옥평 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

Locally recurrent rectal cancer is a difficult clinical problem. Local recurrence following treatment for rectal cancer is a major cause of morbidity and mortality. The reported range of local recurrence rates following surgical treatment for rectal cancer has varied from 4% to 50%. We retrospectively reviewed the charts of 142 rectal cancer patients from January 1991 to December 1999. Analysis of patients factors included age, gender, type of surgery, and adjuvant therapy. Tumors were assessed for level, stage, and grade. Local recurrence and distant metastases were also documented. Variables influencing local recurrence in this group were identified and disease-free survival is determined. Of the 142 patients(74 males, 68 females; mean age 62.6 years), 137 consecutive patients operated on for rectal cancer and followed up to December 2000 (range 23-118months) were analyzed. Local recurrence rate was 18.3%. Age and sex of patients, type of surgery, location of tumor in the rectum, size, morphology and grading of the tumor were all unrelated to the event under investigation. At Cox regression, the Dukes stage and the postoperative radiotherapy were the only independent prognostic factors for local recurrence, and Dukes stage (Hazard ratio=2.89, p<0.001) and local recurrence (Hazard ratio=3.31, p<0.01) were the only independent factors associated with improved survival.

Should the patients with small airway disease by spirometry have the preoperative consultations by pulmonologist? (초)

( Ho Seok Koo ),( Seung Heon Lee ),( Young Min Lee ),( Hyuk Pyo Lee ),( Ho Kee Yum ),( Soo Jeon Choi ),( I Nae Park ),( Hoon Jung ),( Sang Bong Choi ),( Jin Won Hur ),( Hyun Kook Kim ),( Hyun Kyung Le 대한내과학회 2008 대한내과학회지 Vol.75 No.1S

Single-Chain Atomic Crystals as Extracellular Matrix-Mimicking Material with Exceptional Biocompatibility and Bioactivity

Lee, Jin Woong,Chae, Sudong,Oh, Seoungbae,Kim, Si Hyun,Choi, Kyung Hwan,Meeseepong, Montri,Chang, Jongwha,Kim, Namsoo,Yong Ho Kim,,Lee, Nae-Eung,Lee, Jung Heon,Choi, Jae-Young American Chemical Society 2018 NANO LETTERS Vol.18 No.12

<P>In this study, Mo<SUB>3</SUB>Se<SUB>3</SUB><SUP>-</SUP> single-chain atomic crystals (SCACs) with atomically small chain diameters of ∼0.6 nm, large surface areas, and mechanical flexibility were synthesized and investigated as an extracellular matrix (ECM)-mimicking scaffold material for tissue engineering applications. The proliferation of L-929 and MC3T3-E1 cell lines increased up to 268.4 ± 24.4% and 396.2 ± 8.1%, respectively, after 48 h of culturing with Mo<SUB>3</SUB>Se<SUB>3</SUB><SUP>-</SUP> SCACs. More importantly, this extremely high proliferation was observed when the cells were treated with 200 μg mL<SUP>-1</SUP> of Mo<SUB>3</SUB>Se<SUB>3</SUB><SUP>-</SUP> SCACs, which is above the cytotoxic concentration of most nanomaterials reported earlier. An ECM-mimicking scaffold film prepared by coating Mo<SUB>3</SUB>Se<SUB>3</SUB><SUP>-</SUP> SCACs on a glass substrate enabled the cells to adhere to the surface in a highly stretched manner at the initial stage of cell adhesion. Most cells cultured on the ECM-mimicking scaffold film remained alive; in contrast, a substantial number of cells cultured on glass substrates without the Mo<SUB>3</SUB>Se<SUB>3</SUB><SUP>-</SUP> SCAC coating did not survive. This work not only proves the exceptional biocompatible and bioactive characteristics of the Mo<SUB>3</SUB>Se<SUB>3</SUB><SUP>-</SUP> SCACs but also suggests that, as an ECM-mimicking scaffold material, Mo<SUB>3</SUB>Se<SUB>3</SUB><SUP>-</SUP> SCACs can overcome several critical limitations of most other nanomaterials.</P> [FIG OMISSION]</BR>

Soft Tissue Reconstruction Using Perforator Flap in Patients with Infected Knee Prosthesis

Lee, Jin Won,Kim, Sung Hoon,Yoo, Jun Ho,Roh, Si Gyun,Lee, Nae Ho,Yang, Kyoung Moo The Korean Society for Microsurgery 2014 Archives of reconstructive microsurgery Vol.23 No.2

Purpose: Soft-tissue reconstruction in the knee area requires thin, pliable, and tough skin. The range of motion of the knee also acts as a limitation in using only local flaps for coverage. The author has successfully used various perforator flaps for soft tissue reconstruction around the knee while preserving its functional and cosmetic characteristics. Materials and Methods: Out of the twenty patients assessed from April 2009 to March 2011, seven received anterolateral thigh perforator flaps, four received medial sural perforator island flaps, four received lateral supragenicular perforaor perforator flaps, and five received medial genicular artery flaps. The age of the patients ranged from 44 to 79 and the size of the defects ranged from $4{\times}5cm$ to $17{\times}11cm$. Fifteen of the twenty patients had histories of total knee replacement (TKR) surgery. Results: There were no flap losses in any of the twenty patients assessed. Two patients showed partial losses in the distal area of the flap, but were treated through careful wound care. One patient presented with pedicle adhesion at the drainage site from a past TKR, but it did not hinder the flap survival. Primary closure at the donor site was possible in nine patients, while split skin graft was necessary for the other 13. Conclusion: In soft tissue reconstruction of the knee, various perforator flaps can be used depending on the condition of the preoperation scar, wound site, and size. It also proved to provide better functional and cosmetic results than in primary wound closure or skin grafts.

Exothermic Performance of a Mogul-Patterned Stretchable Micro-Heater with Various Geometrical Configurations

Lee, Yeon-Ho,Lee, Nae-Eung,Kim, Sung-Min,Kim, Youn-Jea American Scientific Publishers 2017 Journal of Nanoscience and Nanotechnology Vol.17 No.10

<P>Much effort has recently been devoted to stretchable heaters, which are widely used as microchannel chips, sensors and displays. A successful design of a flexible heater considering its performance requires a deeper understanding of the mechanics of micro-scale materials and heat generation by resistance. In this study, the relationships among stress, exothermic performance and heat distribution according to distance between the patterns on a mogul-patterned structure were numerically analyzed using the commercial software, COMSOL ver. 5.2. The results indicated that the pattern was correlated with exothermic performance.</P>