http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Association of DOCK8, IL17RA, and KLK12 Polymorphisms with Atopic Dermatitis in Koreans
( Won Il Heo ),( Kui Young Park ),( Mi-kyung Lee ),( Yu Jeong Bae ),( Nam Ju Moon ),( Seong Jun Seo ) 대한피부과학회 2020 Annals of Dermatology Vol.32 No.3
Background: Early-onset and severe atopic dermatitis (AD) in patients increase the probability of the development of allergic rhinitis or asthma. Treatment and prevention strategies in infants and young children with AD are targeted toward treating the symptoms, restoring skin barrier functions, and reducing the absorption of environmental allergens in an attempt to attenuate or block the onset of asthma and food allergy. Objective: Given that the initiating events in AD remain poorly understood, identifying those at risk and implementing strategies to prevent AD is necessary. Methods: Whole-exome sequencing (WES) was performed in a 43 control group and a disease group with 20 AD patients without atopic march (AM) and 20 with AM. Sanger sequencing was carried out to validate found variants in cohorts. Results: DOCK8, IL17RA, and KLK12 single-nucleotide polymorphisms were identified by WES as missense mutations: c.1289C>A, p.P97T (rs529208); c.1685C>A, p.P562G (rs12484684); and c.457+27>C, rs3745540, respectively. A case-control study show that total immunoglobulin E (IgE) level was significantly increased in the AA genotype of DOCK8 compared to the CA genotype in allergic patients. The rs12484684 of IL17RA increased risk of adult-onset AD (odds ratio: 1.63) compared to the control for (A) allele frequency. AD and AM Patients with the IL17RA CA genotype also had elevated IgE levels. rs3745540 of KLK12 was associated with AD in dominant model (odds ratio: 2.86). Conclusion: DOCK8 (rs529208), IL17RA (rs12484684), and KLK12 (rs3745540), were identified using a new WES filtering method. the result suggests that polymorphism of DOCK8 and IL17RA might be related to increase the total IgE level. (Ann Dermatol 32(3) 197∼205, 2020)
Interleukin-2가 호산구 생존에 미치는 영향과 기전에 관한 연구
김효석 ( Hyo Seok Kim ),이영목 ( Young Mok Lee ),최영수 ( Young Soo Choi ),김경호 ( Kyung Ho Kim ),임건일 ( Geon Il Im ),문승혁 ( Jeong Sung Whan ),정성환 ( Moon Seung Hyug ),김현태 ( Hyeon Tae Kim ),어수택 ( Uh Soo Taek ),김용훈 대한결핵 및 호흡기학회 1996 Tuberculosis and Respiratory Diseases Vol.43 No.3
The Lipopolysaccharide from Porphyromonas gingivalis Induces Vascular Permeability
Su-Ryun Kim,Seong-Kyoon Jeong,Woo-Sik Kim,Hwa-Jin Jeon,Hyun-Joo Park,Mi-Kyoung Kim,Hye-Ock Jang,Il Yun,Soo-Kyung Bae,Moon-Kyoung Bae KOREAN ACADAMY OF ORAL BIOLOGY 2011 International Journal of Oral Biology Vol.36 No.1
Porphyromonas gingivalis, one of the major periodontal pathogens, is implicated in the initiation and progression of periodontal disease. The initial stages of periodontal inflammation are accompanied by vascular hyperpermeability. In our present study, we report that the P. gingivalis lipopolysaccharide (LPS) increases the mRNA expression of interleukin-8 (IL-8), a major inducer of vascular permeability, in vascular endothelial cells. P. gingivalis LPS also stimulated the induction of IL-8 secretion in endothelial cells. The P. gingivalis LPS-induced expression of IL-8 was primarily modulated by nuclear factor-κB (NF-κB). P. gingivalis LPS significantly enhanced the vascular permeability both in vitro and in vivo, and a blockade of the IL-8 receptor decreased the P. gingivalis LPS-induced vascular permeability. Taken together, these results suggest that P. gingivalis LPS increases vascular permeability through the NF-κBdependent production of IL-8 in vascular endothelial cells.
임베디드 시스템용 키패드의 알파벳 모양에 의한 영문자 입력방법
문경일,이현엽 湖南大學校 情報通信硏究所 2003 정보통신연구 Vol.13 No.-
In this paper, a new method capable of directly inputting English characters using the characteristic shapes of alphabets for a small keypad used in the imbedded systems has been introduced. The new method selects keypad buttons for each character by its ending and crossed points of the character line in order to input a specific character. This method is capable of directly inputting characters to the system through keypad since it utilizes the characteristics of each character and also the user does not need to read small character arrays written in keypad buttons, thus the rapid input of alphabets are possible and the fatigue in user's eyes can greatly be reduced, which leads to the improvement in overall embedded system performance.
응급실에 내원한 환자에서 어지럼증의 원인과 임상양상의 분석
문원식,정경운,위준선,문정미,전병조,김용권,소정일,류진호,허탁,민용일 대한응급의학회 2001 대한응급의학회지 Vol.12 No.3
Background: Recently, The number of patients who have been complaining of the vertigo or dizziness has been increasing due to rapid growth of elderly population and senile disease. The differentiation of dizzy patients is not familiar to most emergency physicians. This study was designed to differentiate true vertigo and to investigate the clinical difference among central vertigo, peripheral vertigo, and other causes of dizziness. Methods: The authors analyzed the cases of 237 dizzy patients who visited the emergency department of Chonnam University Hospital during the recent 2 years. For the base of dizziness, associated past illnesses, severity, nystagmus type, and the causes of central and peripheral vertigo. Results: Female patients were 142(59.9%) and male patients were 95(40.1%). The most common age group was the 6th decade. The origin of dizziness was classified as peripheral cause(25.3%), central cause(32.9%), and others(41.8%). As to nature of the dizziness, the rotatory sense was dominant in peripheral vertigo and the floating sense and blurred vision in central vertigo. Peripheral vertigo was triggered by position change of head and body, and central vertigo by the eye movement. Audiograms I showed that most patients with central vertigo had normal hearing, but 46.7% of thoswith peripheral vertigo had an abnormal hearing disturbance. Nystagmus was more prevalent in peripheral vertigo Conclusion: History taking and physical examination played an important role in the diagnosis of dizzy patients. An important part of the diagnosis of a dizzy patient could be to evaluate the peripheral origin, the central origin and others causes. Because central vertigo may be associated with a significant neurological pathology, spectral radiological studies, including MRI and CT, are mandatory to rule out a devastating brain lesion.
문경일 호남대학교 1997 호남대학교 학술논문집 Vol.18 No.4
Several researchers have proved that multilayer neural networks, with an arbitrary transfer function in the hidden layer, can approximate any multivariate function to any degree of accuracy. However, standard backprogation networks may an inappropriate response by the network. To avoid these extremes, a kind of cascaded network can be used for multivariate function approximation, which represents the neural network topology motivated by Kolmogorov's theorem. In this paper, an alternative neural network architecture is proposed to approximate any multivariate functions, based on the cascaded backprogation networks representing the class of distinct univariate approximators. The cascaded backprogation networks rapidly converge to meaningful solutions which may be analyzed either analytically or numerically.
문경일 호남대학교 정보통신연구소 1998 정보통신연구 Vol.8 No.-
The purpose of this paper is to obtain a single number which can be considered a typical value of a given fuzzy set. Quantities such as the arithmetic mean, the fuzzy expected value and the clustering fuzzy expected value fail to represent a typical value since they are all derived by some process of numerical averaging and lead to compromise solutions. In addition, they always provide a unique typical value even when it does not exist. In this paper a new quantity for fuzzy sets is defined. A given fuzzy set is first clustered and replaced by a finite set of clusters, each represented by the cluster center and its size.
경희문,김일봉 대한치과교정학회 1991 대한치과교정학회지 Vol.21 No.2
The author treated 3 class I malocclusion patients with the lingual appliance followed by the extraction of the 4 bicuspids. One of them was finished with the labial appliance at the final stage. The treatment results were acceptable and the patients gad good tolerance to the lingual appliance without complaints in these cases. There were some problems in treatment on the lingual side both the patient and the practioner, but I think we can overcome them with the development of the orthodontic materials, the treatment technics & the increased clinical experience. Of course, we cannot treat all the patients with the lingual braces, but patients are carefully selected, lingual braces will be a valuable orthodontic appliance. In conclusion, the lingual braces have very good esthetic advantages, so the patients, especially in adults, who hesitate or refuse the orthodontic treatment due to the esthetic problem of the labial braces will get the motivation & the chance for the orthodontic treatment.
문영일,김종남,홍순관,이지애,정옥경,김문정 梨花女子大學校 醫科大學 醫科學硏究所 1997 EMJ (Ewha medical journal) Vol.20 No.3
Rhinocerebral mucormycosis is a well-described fulminant fungal infection that typically presents in a rapidly fulminant manner. This condition is more likely to occur among patient with diabetes mellitus, malignant tumors, who have long-term steroid treatment, or who suffer from some debilitating diseases. We report 3 cases of rhinoorbitocerebral mucormycosis, all suffered from diabetes mellitus. In all 3 cases, endoscopic sinus surgery was done and the antifungal agent(amphotericin B) was administered intravenously, and two patients died. One survivor who had focal extension of paranasal sinus and orbit, required one surgical intervention without orbital exenteration and he is alive without recurrence disease. The severity of the disease is probably dependent upon the gost resistance to the invasion of phycomycetes. Early diagnosis and immediate, effective treatment are the key for cure of the disease.