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http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
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이지애,안보미,Lee, Jihae,An, Bomi Korea Convergence Society 2021 한국융합학회논문지 Vol.12 No.8
본 연구의 목적은 만성질환자를 대상으로 한국어판 자율성 선호도 측정 도구(K-API)의 타당도와 신뢰도를 검증하는 것이다. 총 569명의 만성질환자가 참여하였다. 구성타당도를 검증하기 위하여 탐색적, 확인적 요인분석을 시행하고, 신뢰도는 Cronbach's α 값으로 확인하였다. 원도구를 한국어로 번역한 후 내용 타당도 검증, 예비 조사를 시행하였다. 연구결과, K-API는 두 총 10개의 문항으로 구성되며 (i) 의사결정 선호도, (ii) 정보추구 선호도의 두 영역으로 구성되었다. K-API는 자율성 선호도의 53.4%를 설명하며, 2개 요인으로 구성된 도구의 적합도 지수가 충족되었다. Cronbach's α는 의사결정 선호도는 .77, 정보추구 선호도는 .75로 나타났다. 본 연구를 통하여 K-API의 타당도가 신뢰도가 확인되었으며, 이는 아시아 지역에서의 API 도구의 적용 가능성에 대한 추가적인 근거를 제공한다. The purpose of this study was to validate the Korean version of autonomy preference index (K-API) for chronic patients. Participants were 569 chronic patients. Construct validity and reliability of K-API were examined using exploratory and confirmatory factor analysis, and Cronbach's α test. Original API was translated to Korean, and we conducted contents validity test, and pilot test. The K-API consisted of 10 items divided into two domains: (i) Decision making preference (DMP); (ii) Information seeking preference (ISP). K-API explained 53.4% of autonomy preference; the two-factor structure showed an acceptance fit. Cronbach's α was. 77 for DMP, and. 75 for ISP. Validity and reliability of the K-API were established, and this study provides additional evidence for the usage of the API in Asian region.
과학 영재 학급 학생들의 소집단 STEM 프로젝트 학습을위한 안내된 프로젝트 학습 모형의 개발
이지애,김영민 韓國英才學會 2017 영재교육연구 Vol.27 No.4
The purposes of this study are to develop a teaching-learning model to support scientifically gifted secondary students in project-based learning through STEM task and provide practical considerations for its implementation in STEM classroom. For those purposes, at first, the problems with project-based learning for gifted students in STEM education were analyzed through theoretical review, and then existing general project-base learning model was applied for STEM project learning, checking and finding addictive problems and solutions. Two small groups of science gifted students participated in this study. In the teaching-learning model developed for the project-based learning of STEM, teacher’s important scaffolding elements are included in steps of the general model, such as process continuing, method for finding appropriate information, providing necessary concepts, etc. 본 연구의 목적은 중등 과학영재들이 STEM 수업에서 효과적으로 프로젝트 학습을 수행할 수있도록 하는 수업 모형을 개발하고, STEM 프로젝트 학습을 교실 수업에 적용하는 데 있어서의시사점을 도출하는 데 있다. 이를 위해 선행연구 분석을 통해 프로젝트 학습과 관련된 문제점을추출한 다음, 일반적인 프로젝트 학습 모형을 소집단 STEM 프로젝트 학습에 투입하여 개선점을찾아 모형을 구체화하였다. STEM 프로젝트 학습에 참여한 집단은 2개 집단이며, 모두 과학중점학교의 과학 영재학급 학생들이다. 본 연구에서 프로젝트 학습의 일반적인 모형을 실제STEM 프로젝트 학습에 적용해 본 결과, STEM 프로젝트 학습에서는 그 과정을 잘 유지하도록교사가 개입해야 하며, 학생들이 관련 정보를 찾고 잘 이해하도록 도와주어야 하며 때때로 스캐폴딩도 필요하다. 이외에도 여러 가지 교사가 안내해야 할 문제점들이 나타났으며 이러한 문제점들이 프로젝트 학습의 어떤 단계에서 필요한지를 파악하여 각 단계에서 교사의 역할을 정교화한 안내된 프로젝트 학습 모형을 제시하였다.
이지애,정순신,김영민 한국영재학회 2018 영재교육연구 Vol.28 No.3
The problem finding patterns of the well-known scientists are finding from insufficiencies and/or errors in conceptual or theoretical explanation of scientific phenomena at the time, finding by discovering of strange phenomena, which can not be explained by contemporary knowledges at the time, finding by analogy from known concepts or theories to newly assuming concepts or theories, finding while they utilize a newly invented experimental instrument, and finding while they conduct research projects. And their hypotheses were formulated mainly using abductive reasoning, and patterns of abductive reasoning were from similar geometric feature between target domain and source domain, from similar function between them, and from similar properties between them. However, today scientists show a little different pattern from them. And in the process of problem solving, they show different features from the well known scientists. This features of today scientists’ problem finding and solving gives various implications for today science gifted education.
이지애,김혜리,김지영,박기덕,김동진,황온유 한국뇌신경과학회 2018 Experimental Neurobiology Vol.27 No.5
We have previously reported a novel synthetic compound KMS99220 that prevented degeneration of the nigral dopaminergic neurons and the associated motor deficits, suggesting a neuroprotective therapeutic utility for Parkinson’s disease. Microglia are closely associated with neuroinflammation, which plays a key role in the pathogenesis of neurodegenerative diseases. In this study, we investigated the effects of KMS99220 on the signaling involving AMP-activated protein kinase (AMPK) and heme oxygenase-1 (HO-1), the enzymes thought to regulate inflammation. KMS99220 was shown to elevate the enzyme activity of purified AMPK, and phosphorylation of cellular AMPK in BV2 microglia. It increased the level of HO-1, and this was attenuated by AMPK inhibitors. KMS99220 lowered phosphorylation of IκB, nuclear translocation of NFκB, induction of inducible nitric oxide synthase, and generation of nitric oxide in BV2 cells that had been challenged with lipopolysaccharide. This anti-inflammatory response involved HO-1, because both its pharmacological inhibition and knockdown of its expression abolished the response. The AMPK inhibitors also reversed the anti-inflammatory effects of KMS99220. The induction of HO-1 by KMS99220 occurred within 1 h, and this appeared not to involve the transcription factor Nrf2, because Nrf2 knockdown did not affect the compound’s HO-1 inducing- and anti-inflammatory effects in this time window. These findings indicated that KMS99220 leads to AMPK-induced HO-1 expression in microglia, which in turn plays an important role in early anti-inflammatory signaling. Together with its neuroprotective property, KMS99220 may serve as a feasible therapeutic agent against neuroinflammation and neurodegeneration.