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기관지천식 환자에서 말초 혈액 단핵구와 기관지폐포 세척액 세포의 IL - 4 유전자 표현
이상무(Sang Moo Lee),문승혁(Seung Hyuk Moon),김경호(Kyung Ho Kim),임건일(Gune Il Lim),정성환(Seong Whan Jeong),김현태(Hyeon Tae Kim),어수택(Soo Taek Uh),김용훈(Yong Hoon Kim),박춘식(Choon Sik Park) 대한내과학회 1996 대한내과학회지 Vol.50 No.1
N/A Objectives: Type 2 CD4+ lymphocytes are presumed to have an important role in develompent of allergic inflammation. We measured m-RNA expressions of interleukin 4 in peripheral blood mononuclear cells and bronchoalveolar lavage cells to investigate the difference of interleukin 4 gene expression in the patients with atopic and nonatopic bronchial asthma, normal subjects and patients with other lung disease. Methods: Total RNA was obtained from peripheral blood mononuclear cells and bronchoalveolar lavage cells by acid-guanidium thiocyanate-phenol-chloroform method. The presence of interleukin 4 m-RNA was identified by RNA reverse transcription/polymerase chain reaction. Southern blot or DNA dot blot was applied to confirm the interleukin 4 gene products. Results: Interleukin 4 Gene products in peripheral blood mononuclear cells were detected in 90.9% (10/11) of the patients with bronchial asthrna and in 75%(9/12) of non-asthmatic control subjects. Interleukin 4 gene product in bronchoalveolar lavage cells was positive in one case of bronchial asthma. Conclusion: Interleukin 4 m-RNAs were constitutionally expressed in peripheral blood mononuclear cells of normal controls as well as in those of the patients with bronchial asthma
Interleukin-2가 호산구 생존에 미치는 영향과 기전에 관한 연구
김효석 ( Hyo Seok Kim ),이영목 ( Young Mok Lee ),최영수 ( Young Soo Choi ),김경호 ( Kyung Ho Kim ),임건일 ( Geon Il Im ),문승혁 ( Jeong Sung Whan ),정성환 ( Moon Seung Hyug ),김현태 ( Hyeon Tae Kim ),어수택 ( Uh Soo Taek ),김용훈 대한결핵 및 호흡기학회 1996 Tuberculosis and Respiratory Diseases Vol.43 No.3