퍼지 추론을 이용한 분류 벡터 양자화기의 성능 개선

황병하,김혜숙,서재성,박민식,곽훈성 全北大學校 1994 論文集 Vol.37 No.-

In Classified Vector Quantization(CVQ) for image coding, the block classification pondering the block characteristics will be the most important procedure if we consider system performance. But it does not take effect because classification of conventional CVQ followed act on a heuristic and statistics method. In order to solve the problem of conventional methods, i.e, for block classification effectively we propose a fuzzy inferencing algorithm to improve its performance. To do this, fuzzy rules must be generated in the first. Our rules are based on energy distribution in transform domain with respect to spatial variation. Ultimately fuzzy inferencing of this paper apply these fuzzy rules for efficient block classification on a input image. As a result of efficient classification, our proposed method shows that blocking effect is decreased and PSNR(peak to peak signal to noise ratio) is increased by about 1 ∼ 2 dB for 0.2 ∼ 0.6 bpp range, when the performance is compared with Aizawa's scheme^[9].

Small Bowel Obstruction Caused by an Aberrant Congenital Band in a Child

Min Ha Kwak,김애숙,Ji Hae Kang,최성민,김두권,이동석,하동엽,김성우 대한소아소화기영양학회 2012 Pediatric gastroenterology, hepatology & nutrition Vol.15 No.3

Small bowel obstruction due to congenital band is not only rare in children, but also difficult to diagnose, because common symptoms such as vomiting and abdominal pain are observed in patients. In order to prevent a fatal result, an anomalous congenital band should be considered in the discriminative diagnosis of intestinal obstruction in children who have no previous experience of operation or intraperitoneal inflammation. This report presents a 4-year-old boy who was admitted with abdominal pain and nonbilious vomiting for a day. The initial suspicion was for acute gastroenteritis. However, after further investigation and performance of surgery, the intestinal obstruction associated with a congenital band was confirmed. No recurrence was observed during the 8-month follow-up period. Thus early confirmation based on radiologic study is a crucial factor for the diagnosis of small bowel obstruction caused by a congenital band.

Exogenous and Endogeneous Disialosyl Ganglioside GD1b Induces Apoptosis of MCF-7 Human Breast Cancer Cells

Ha, Sun-Hyung,Lee, Ji-Min,Kwon, Kyung-Min,Kwak, Choong-Hwan,Abekura, Fukushi,Park, Jun-Young,Cho, Seung-Hak,Lee, Kichoon,Chang, Young-Chae,Lee, Young-Choon,Choi, Hee-Jung,Chung, Tae-Wook,Ha, Ki-Tae,Ch MDPI 2016 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.17 No.5

<P>Gangliosides have been known to play a role in the regulation of apoptosis in cancer cells. This study has employed disialyl-ganglioside GD1b to apoptosis in human breast cancer MCF-7 cells using exogenous treatment of the cells with GD1b and endogenous expression of GD1b in MCF-7 cells. First, apoptosis in MCF-7 cells was observed after treatment of GD1b. Treatment of MCF-7 cells with GD1b reduced cell growth rates in a dose and time dependent manner during GD1b treatment, as determined by XTT assay. Among the various gangliosides, GD1b specifically induced apoptosis of the MCF-7 cells. Flow cytometry and immunofluorescence assays showed that GD1b specifically induces apoptosis in the MCF-7 cells with Annexin V binding for apoptotic actions in early stage and propidium iodide (PI) staining the nucleus of the MCF-7 cells. Treatment of MCF-7 cells with GD1b activated apoptotic molecules such as processed forms of caspase-8, -7 and PARP (Poly(ADP-ribose) polymerase), without any change in the expression of mitochondria-mediated apoptosis molecules such as Bax and Bcl-2. Second, to investigate the effect of endogenously produced GD1b on the regulation of cell function, UDP-gal: β1,3-galactosyltransferase-2 (GD1b synthase, Gal-T2) gene has been transfected into the MCF-7 cells. Using the GD1b synthase-transfectants, apoptosis-related signal proteins linked to phenotype changes were examined. Similar to the exogenous GD1b treatment, the cell growth of the GD1b synthase gene-transfectants was significantly suppressed compared with the vector-transfectant cell lines and transfection activated the apoptotic molecules such as processed forms of caspase-8, -7 and PARP, but not the levels of expression of Bax and Bcl-2. GD1b-induced apoptosis was blocked by caspase inhibitor, Z-VAD. Therefore, taken together, it was concluded that GD1b could play an important role in the regulation of breast cancer apoptosis.</P>

Comparison study between single enzyme and multienzyme complex in distiller’s dred grains with soluble supplemented diet in broiler chicken

Min-Jin Kwak,Dong-Jin Ha,Min Young Park,어주영,Kwang-Youn Whang,Young Hoon Kim 한국축산학회 2024 한국축산학회지 Vol.66 No.2

Upregulation of the nutritional value of feed is the major target of various studies in the livestock industry, and dietary enzyme supplementation could aid in digesting the nondegrading nutrients of grains in feed ingredients. Dried distillers’ grains with solubles (DDGS) is a byproduct of the fermentation process in the beverage industry and can be used as a large supply source of fiber in feed. Therefore, we conducted an experiment with male broiler chickens to investigate the effect of various types of enzymes on DDGS and compare the efficacy of single enzyme and multienzyme complexes on growth performance and gut environments in broiler chickens. We used 420 1-day-old broiler chickens (Ross 308), and they were allotted into 4 dietary treatments with seven replications (CON, corn-soybean meal [SBM] diet; NC, DDGS supplemented diet; SE, 0.05 % of mannanase supplemented DDGS-based diet; MC, 0.10% of multienzyme complex (mannanase and xylanase, glucanase) supplemented DDGS-based diet. The dietary exogenous enzyme in the DDGS-supplemented diet could improve growth performance as much as the growth of the control group, and digestibility of dry matter, crude protein, and gross energy were significantly increased by enzyme addition in groups of chicks fed DDGS-supplementation diet. Moreover, the populations of pathogenic bacteria, coliforms, and Bacteroidetes were significantly decreased by enzyme supplementation, which might lead to improved gut mucus-secreting cells and inflammatory cytokines in the jejunum. Collectively, dietary single enzyme and multienzyme complexes could improve gut environments, including intestinal immune responses and gut microbial population, and lead to improvement of growth performance in broiler chickens.

댕댕이나무에 대한 문헌고찰

곽민하 ( Min-ha Kwak ),이상남 ( Sang-nam Lee ),박지하 ( Ji-ha Park ) 한약응용학회 2020 한약응용학회지 Vol.20 No.2

Objectives : So far, there has been a lot of research on Lonicera caerulea var. edulis in korea. but, There has not been a systematic and comprehensive literature study. In order to use it as a basic data for future research on Lonicera caerulea var. edulis, a literature review was conducted. Methods : Lonicera caerulea var. edulis is called by various names, the English name is usually called blue honeysuckle, but it is also called honey berry, honeysuckle, edible honeysuckle, and sweetberry. After searching for related words mentioned above at RISS (http://www.riss.kr), DBpia (http://www.dbpia.co.kr), and kiss (http://kiss.kstudy.com), We have summarized the background, experimental method, and conclusion of the paper. Conclusion & Results : Among 12 selected papers, there were 1 paper on the plant, 2 papers for extraction & commercialization, and 1 paper for toxicity evaluation. The rest were all papers on efficacy evaluation.

GM-CSF가 골수줄기세포의 이동에 미치는 영향

한동하 ( Dong Ha Han ),곽민근 ( Min Geun Kwak ),최병현 ( Byung Hyune Choi ),하윤 ( Yoon Ha ),박현선 ( Hyun Seon Park ),민병현 ( Byoung Hyun Min ),우제홍 ( Ze Hong Woo ),박소라 ( So Ra Park ) 한국조직공학과 재생의학회 2005 조직공학과 재생의학 Vol.2 No.3

The granulocyte macrophage colony-stimulating factor (GM-CSF) is known to play an important role in the hematopoiesis of bone marrow-derived cells and the modulation of their functions as well as the maintenance of homeostasis and overall immune competence. In this study, we investigated the effects of GM-CSF on the activation of bone marrow stem cells in rats. GM-CSF was treated to SD rats via intraperitoneal injection everyday at 10 mg/ml for 5 consecutive days. After 6 days, the bone marrow (BM) and peripheral blood (PB) mononuclear cells (MNCs) were collected to analyze the colony forming units-fibroblasts (CFU-F), colony forming units-granulocyte macrophage (CFU-GM), and burst-forming units-erythroid (BFU-E). In result, the numbers of MNCs and the CFU-GM and BFU-E counts in BM were all decreased, while those of PB increased. These results suggest that GM-CSF induced the proliferation and mobilization of MNCs and hematopoietic stem cells (HSCs) to PB. The CFU-F counts showed no significant increase both in BM and PB suggesting that GM-CSF showed no significant effects on the proliferation of mesenchymal stem cells. In contrast, the increase in the alkaline phosphatase expression of CFU-F colonies in BM indicates that GM-CSF might induce the differentiation of MSCs at least to some extent. In conclusion, GM-CSF not only plays important roles in proliferation and differentiation of stem cells in BM but also promotes migration of HSCs into PB.

규칙적인 걷기운동이 비만 여중생들의 신체조성, 체력 및 혈압의 변화에 미치는 효과

성기동(Sung, Gi-dong),손원목(Son, Won-mok),하민성(Ha, Min-Seong),곽이섭(Kwak, Yi-Sub) 한국웰니스학회 2016 한국웰니스학회지 Vol.11 No.3

본 연구는 12주간의 걷기 운동프로그램이 비만여중생들의 신체조성, 체력 및 혈압에 어떠한 영향을 미치는지를 알아보는 것이다. 본 운동프로그램은 준비운동 5분, 본 운동 30분, 정리운동 5분으로 총 40분 주 5회 실시하였으며, 연구의 대상자는 체지방률 30%이상인 비만 여중생 운동군 10명, 대조군 10명 총 20명을 대상으로 실시하였다. 본 운동프로그램 실시 전, 12주 후의 결과를 관찰하여 다음과 같은 결론을 얻었다. 신체조성 중 체중은 운동군이 운동 실시 후 유의하게 감소하였고, 운동군이 대조군 보다 유의하게 감소하였다. BMI는 대조군이 운동 실시 후 유의하게 증가하였고, 대조군이 운동군보다 유의하게 증가하였다. 체지방률은 운동군이 운동 실시 후 유의하게 감소하였고, 운동군이 대조군 보다 유의하게 감소하였다. 체력에서 유연성, 심페지구력은 운동 실시 후 운동군이 유의하게 증가하였고, 순발력은 운동군이 대조군보다 운동 참여 후 유의하게 감소한 것으로 나타났다. 결론적으로 이 연구를 통하여 비만 여중생의 비만을 개선할 수 있다는 것을 알 수 있어, 추후 비만 여중생의 운동형태, 운동기간 및 식습관 등을 포함한 연구가 진행될 필요성을 가지고 있다. This study investigated the effect of 12 weeks" walking exercise program in female middle school students with obesity body composition, physical fitness, blood pressure. This exercise program of warm up 5 min, main exercise 30 min and cool down 5 min, 5 times a week for a total 12 weeks. As research subjects, 20 female middle school students were selected who were exercise group (n=10), control group (n=10), with over 30% of body fat percentage. This study came to the following conclusion by observing the subjects before the exercise program and 0 weeks and 12 weeks after the exercise program. Body composition in exercise group significantly decreased and exercise group was decreased than control group. Flexibility and Cardiorespiratory Endurance in exercise group significantly increased, React instantly in the exercise group significantly decreased than that of control group. Consequently, the results of this study showed that regular walking exercise iimproved obesity, is considered to suggest improving the female middle school students with obesity. For further studies, it seems necessary to carry out an accurate observation into obese female middle school exercise types, various periods of exercise, and even their eating habits, which is different from the research subjects for this study.

Gastrointestinal and Nongastrointestinal Complications of Esophagogastroduodenoscopy and Colonoscopy in the Real World: A Nationwide Standard Cohort Using the Common Data Model Database

( Ha Il Kim ),( Jin Young Yoon ),( Min Seob Kwak ),( Jae Myung Cha ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2021 Gut and Liver Vol.15 No.4

Background/Aims: The global trend of an expanding aged population has increased concerns about complications correlated with gastrointestinal (GI) endoscopy in elderly patients; however, there have been few reports published on this issue. Methods: In this retrospective, observational cohort study performed between 2012 and 2017, serious complications of esophagogastroduodenoscopy (EGD), colonoscopy, and colonoscopic polypectomy were compared between patients according to age (≥65 years vs 18-64 years). We used the Health Insurance Review and Assessment-National Patient Samples database, previously converted to the standardized Observational Medical Outcomes Partnership-Common Data Model. Serious complications within 30 days of the procedure included both GI complications (bleeding and perforation) and non-GI complications (cerebrovascular accident [CVA], acute myocardial infarction [AMI], congestive heart failure [CHF], and death). Results: A total of 387,647 patients who underwent EGD, 241,094 who underwent colonoscopy, and 89,059 who underwent colonoscopic polypectomy were assessed as part of this investigation. During the study period, endoscopic procedures in the older group steadily increased in number in all endoscopy groups (all p<0.001). Further, pooled complication rates of bleeding, CVA, AMI, CHF, and death were approximately three times higher among older patients who underwent EGD or colonoscopy. Moreover, pooled complication rates of CVA, AMI, CHF, and death were approximately 2.2 to 5.0 times higher among older patients who underwent colonoscopic polypectomy. Conclusions: Elderly patients experienced approximately three times more GI and non-GI complications after EGD or colonoscopy than young patients. Physicians should pay attention to the potential risks of GI endoscopy in elderly patients. (Gut Liver 2021;15:569-578)

Isolation and identification of α-glucosidase inhibitory constituents from the seeds of <i>Vigna nakashimae</i>: Enzyme kinetic study with active phytochemical

Ha, Tae Joung,Bo Song, Seok,Ko, Jeeyeon,Park, Chang-Hwan,Ko, Jong-Min,Choe, Myeong-Eun,Kwak, Do-Yeon,Lee, Jin Hwan Elsevier 2018 Food chemistry Vol.266 No.-

<P><B>Abstract</B></P> <P>The α-glucosidase inhibition effects of the 80% ethanol extracts in the seeds of five <I>Vigna</I> species (<I>V. nakashimae</I>, <I>V. nipponensis</I>, <I>V. umbellate</I>, <I>V. radiate</I>, and <I>V. angularis</I>) were evaluated and their half-maximal inhibitory concentration (IC<SUB>50</SUB>) values showed considerable differences (<I>p</I> < 0.05) ranging from 7.3 to >900 μg/ml. <I>V. nakashimae</I> exhibited the most potent inhibition with IC<SUB>50</SUB> value of 7.3 ± 1.1 μg/ml, followed by <I>V. nipponensis</I> (184.0 ± 9.5 μg/ml) and <I>V. umbellata</I> (520.0 ± 8.1 μg/ml). Bioactivity-guided fractionation of <I>V. nakashimae</I> seeds yielded three phenolics by silica gel chromatography and their structures were elucidated as gambiriin D (<B>1</B>), luteoliflavan-7-<I>O</I>-glucopyranoside (<B>2</B>), and catechin-7-<I>O</I>-glucopyranoside (<B>3</B>) using nuclear magnetic resonance (NMR) spectroscopy. In particular, gambiriin D (<B>1</B>) possessed strong inhibition activity with IC<SUB>50</SUB> of 36.8 ± 2.3 μM through simple reversible slow-binding inhibition (kinetic parameters: <I>k</I> <SUB>4</SUB> = 0.0048 μM<SUP>−1</SUP>s<SUP>−1</SUP>; <I>K</I> <SUB>i</SUB> <SUP>app</SUP> = 48 μM). Furthermore, this compound inhibited recombinant human aldose reductase with IC<SUB>50</SUB> value of 12.0 ± 0.7 μM. Results suggest that <I>V. nakashimae</I> may be a potent α-glucosidase inhibition for health products.</P> <P><B>Highlights</B></P> <P> <UL> <LI> <I>V. nakashimae</I> seeds showed potent α-glucosidase inhibition (IC<SUB>50</SUB> = 7.3 ± 1.1 μg/ml). </LI> <LI> Three phenolic compounds were identified from the seeds of <I>V. nakashimae</I>. </LI> <LI> Gambiriin D inhibited α-glucosidase with reversible slow-binding mode (IC<SUB>50</SUB> = 36.8 ± 2.3 μM). </LI> <LI> Gambiriin D inhibited human aldose reductase with IC<SUB>50</SUB> value of 12.0 ± 0.7 μM. </LI> </UL> </P>

Momordica charantia extract supplementation tend to affect improvements in body composition and metabolic parameters on tennis players: A pilot study

Kwak, Jae-Jun,Yook, Jang Soo,Ha, Min-Seong The Korean Society of Applied Science and Technolo 2019 한국응용과학기술학회지 Vol.36 No.4

Dietary supplements derived from natural sources are an essential factor in optimizing athletic performance. It has been proposed that the extract of Momordica charantia (M. charantia) that is known as a bitter melon can be potentially used as a novel supplement for health promotion. This pilot study aimed to examine the effects of the M. charantia extract when administered in the form of a sports drink, and we evaluated changes in body composition and metabolic factors in tennis players after 4-week consumption of the extract. Eight male college tennis players were instructed to consume an M. charantia extract 6 times per day (3 in the morning and 3 in the afternoon, and the total daily intake was 600 ml). Collected data were analyzed using paired t-tests to examine the changes over time after consumption of the M. charantia extract. The results revealed a significant increase in the trunk muscle mass, basal metabolic rate, and daily calorie intake (p < 0.05). Levels of protein, minerals, and total body water showed an increased tendency (not statistically significant), whereas intracellular water and extracellular water showed a decreased trend. Furthermore, fat-free mass, skeletal muscle mass, and muscle mass showed an increased tendency. In conclusion, consumption of the M. charantia extract caused an increase in parameters related to protein, muscle mass, and metabolism. It seems that follow-up studies related to fatigue, inflammation, and stress hormones related to the M. charantia extract consumption would be needed.