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Objective:This study was performed to examine the effect of mixed medicinal herbal extract including Lespedeza bicolor Turcz. and 18 others (CS-10-H) on hair growth in an alopecia model of C57BL/6 mice. Methods:Male mice were divided into 3 experimental groups for treatment of CS-10-H or 5% minoxidil or vehicle solution, respectively. Dorsal skin of animals were shaved and topically applied with an amount of 200 μL of test materials once a day for 3 weeks. The apparent hair growth was monitored at 5, 10, 15 and 21 days after topical application. The changes of hair density and hair thickness were evaluated by phototrichogram using folliscope. Protein expression levels of hair growth-related factors were measured by western blotting. Results:Application of minoxidil or CS-10-H stimulated the hair growth compared to vehicle treatment. Hair density of minoxidil and CS-10-H group was increased about 206% and 208% on 14 day compared to that of vehicle group, respectively. Hair thickness of minoxidil and CS-10-H group was also increased about 220 % and 200% on 14 day compared to that of vehicle group. The protein expression of hair growth factors, IGF-1 and VEGF was significantly up-regulated in CS-10-H and minoxidil group than in vehicle treated group. Conclusion:These data suggest that CS-10-H shows potential usefulness as ingredients of hair tonic and hair-restorer for development of cosmetics and quasi-drugs, as result of its potent stimulating activity on hair growth in C57BL/6 alopecia model.