뇌혈관질환을 동반한 당뇨병 환자에서 지속적 혈당측정의 유용성 평가

정성훈,강인구,박철영,류미숙,우정택,김성운,김진우,김영설 대한당뇨병학회 2002 임상당뇨병 Vol.3 No.2

연구배경: 뇌혈관질환을 동반한 고령의 당뇨병환자는 이들의 신경학적 결손으로 경고 증상없이 심한 저혈당에 노출될 가능성이 크다. 실제로 하루 4번 정도의 자가 혈당 측정으로는 이를 감지하기 어려울 뿐 아니라 검사에 따른 고통으로 적극적인 혈당 조절에 제한이 따르게 된다. 이에 저자들은 Mini Med사의 지속적 혈당측정기(CGMS, continuous glucose monitoring system)를 이용하여 뇌혈관질환을 동반한 당뇨병 환자에서 24시간 혈당의 변동양상을 알아보고 각기 다른 인슐린 치료방침에 따른 혈당조절의 효율성을 비교하고자 하였다. 방법: 2001년 1월부터 6월까지 경희대학교 부속병원에 입원해 있는 10명의 뇌혈관질환을 동반한 제 2형 당뇨병환자를 대상으로 하였다. 이 들은 모두 튜브식이를 받고 있엇고 최소 1개월 이상 인슐린 치료를 시행 받았다. 지속적 혈당측정기를 착용하고 3일간의 연속적인 혈당을 측정하였고, 치료 첫 날은 NPH, 둘째 날은 속효성 인슐린과 NPH, 마지막 날은 혼합형 인슐린제제로 치료하여 그 효과를 비교하였다. 이들 각기 다른 인슐린 제재의 하루 총량에 차이는 없었다. 혈당치가 3.3mmol/L 미만이거나 7.8mmol/L를 초과하는 경우 그 차이값의 총합을 시간으로 나누어 이 값(△Glu)이 적을수록 치료효과가 우수한 것으로 판정하였다. 또한 당 수치가 3.3mmol/L 미만인 경우를 저혈당 event, 16.7mmol/L 초과한 경우를 고혈당 event로 임의로 정의하였고, 이를 통해 지속적 혈당측정의 유용성을 간접적으로 평가하고자 하였다. 결과: 평균 △Glu값은 첫째 날이 0.93 ± 0.43mmol/Lㆍmin?¹, 둘째날이 0.71 ± 0.29mmol/Lㆍmin?¹ 마지막 날이 0.58 ± 0.29mmol/Lㆍmin?¹로서 서로 다른 3가지 치료방침사이에 통계학적으로 유의한 차이는 없었다(p=0.115). 10명의 환자들 중 자가 혈당측정기로는 1명에서 저혈당 event, 2명에서 고혈당 event를 인지하였으나 지속적 혈당측정기로는 각각 9명에서 event를 확인하였다. 결론: 지속적 혈당측정기를 이용한 각각의 인슐린 치료방침에 따른 혈당조절 효율성의 차이는 없었으나, 자가혈당 측정기로는 알 수 없었던 일 중 혈당 변동사항을 정확하게 알 수 있어, 뇌혈관질환을 동반한 당뇨병 환자에서 보다 적극적인 인슐린 치료 및 관리를 할 수 있을 것으로 생각된다. Background: Diabetic stroke patients are susceptible to hypoglycemia. However, there are many limitations in detecting hypoglycemic events, even though glucoses levels are checked 3 to 4 times per day using the fingerstick method. Therefore, we investigated the glycemic excursions and pattern in diabetic stroke patients using the continuous glucose monitoring system (CGMS, MiniMed) and its clinical utility. The other objective was to compare the treatment dfficacy between insulin regimens. Methods: From jan 2001 to jun 2001, 10 adult type 2 diabetic stroke patients wore CGMS for consecutive 3 days, which continuously checked the glucose level. NPH insulin, multiple daily injection of regular insulin ± NPH and the mixed type(Novolet 30/70, Novo Nordisk) were used on the first, second and third days of the study, respectively. If the mean delta glucose(△Glu = A+B/time, A=∑(hlucose-7.8), glucose > 7.8 mmol/l, B=∑(3.3-glucose) if, glucose < 3.3 mmol/l) was calculated in order to recognize the degree of individual glycemic changes and to compare the efficacy of each treatment diverse insulin regimen. We arbitrarily defined a glucose level less than 3.3mmol/l, as a hypoglycemic event, and more than 16.7mmol/l as a hyperglycemic event. Results: Variable patterns of glycemic changes were observed among patients with the same dosage, but a different insulin regimen. The mean △Glu was 0.93±0.43 on the first day, 0.71±0.29 on the second day and 0.58±0.29 on the third. There was no significant difference in treatment efficacy between the 3 different insulin modalities(p=0.115). Of the 10 patients, a hypoglycemic event was detected in 1 with the fingerstick method, in contrast to 9 with CGMS, with hyperglycemic events being detedted in 2 and 9, respectively. Conclusion: Continuous glucose monitoring maybe useful in providing the information necessary for optimal glycemic control in the diabetic stroke patients.

韓國 看護大學 敎育課程에 對한 硏究

文姬子,金潤喜,趙潔子,趙美映,姜賢淑 慶熙大學校 1982 論文集 Vol.11 No.-

The changes of social issues and nursing concepts require the expansion of nursing needs and nursing role, therefore it is keenly demanded the necessity of the research for new curriculum development in nursing. So to make a contribution to the development of nursing education in Korea, we made a comparative study of nursing curriculum of each universities which have baccalaureate program and put them into operation at present; they are 10 Korean universities, 5 American universities and 4 Japanese Universities. Thus by researching the differences among them. We acquired the conclusions as followings. The purpose of Nursing education In case of Korean parts, the contents of those aims must be explained more clearly and more in detail than another results of research. There also has to be made the statements upon the scientific researching methodology in scholarly respect, or the self-development in individual respect, or the lasting endeavour for studies in professional respect. We must put an emphasis upon the statement and education of the direct nursing provider, or the primary health care manager at hospital and community, who is one of the important aims of modern nursing education. The substance of nursing curriculum. 1) Total credits for completion and the comparison of curriculums, classified by the field. The scope of total credits of each nation, according to Colleges ranges; Korea: 140-163, U.S.A.: 121-187, Japan: 13-158 Compared with those of U.S.A. and Japan, the average credits of Korea is higher. Classified by the field, the credits alloted to major courses are 73.3% and liberal courses, only 26%, which shows that it does not satisfy the current educational trend that emphasizes the liberal course. 2) The comparison of curriculums, classified by a school year. In case of Korea, the total credits are evenly assigned to all grades, but the freshman taken the concentration of liberal courses (81.2%). Among the major courses are preponderant the Nursing Supportive subjects in the sophomore and the nursing major ones in the junior and senior. 3) Curriculums classified by the subject. (1) As compared with those of Japan and U.S.A. Korean students are less free in chosing subjects their own way all over the curriculums. It is, therefore, required that the range of the optionals be widened for the open and flexible education. (2) We can find all of three nations (Korea, Japan, U.S.A.) neglect the sphere of the behavioral sciences among the fundamental nursing subjects. In the field of social sciences, among Korea, Japan, and U.S.A., top ranks Japan that tends of the interested in social well-being. In Korea only two universities have this subjects. (3) Nursing major subjects. Defficulties in comparing them lie in the gulfs of the title of subjects, and the structural differences of the formation of curriculums among nations. In case of Korea, although there are a few differences of the number of credit of subjects among colleges, she has uniform aspects for U.S.A., which says that there are no characteristics and self-control each colleges has in Korea. We can notice that the subjects each Korean university shares are also doubled with those of the national examination for nursing qualification. Japan differs from Korea in that subjects are more differentiated and students are provided with more chances to make a choice through the system of subjects and the texture of a curriculum are similar to those of Korea. In case of Korea, therefore, the unification of fundamental subjects (especially in the medical field) and clinical practices is required. (4) The course for teaching profession is taken as either the required or optional just in Korea (80%) and Japan (75%). The number of subjects and total credits of teaching courses is different according to the colleges of Korea and Japan. As for the contents of subjects Korea deals with theory and Japan, the practical thing with which students can adjust themselves to the spot of society. As a result of that, in case of Korea, demanded are the entire review and research upon the purpose of establishing a curriculum, its relation to the total credits and the choice of substance of subjects etc. 4) The patterns of organization in curriculum development. Most of the patterns of organization, classified by clinic subject pivot upon disease and subjests are not mutually unified in case of Korea and Japan. Though the patterns of organization of subjects if formally unified, that of curriculums is not substantially or wholy synthesized, while in case of U.S.A. the unification of the patterns of organization entire curriculum as well as the mutual unification of subjects is attained and each college runs a characteristic curriculum, since the application of nursing theory and the model of a curriculum are different according to college. The prevention of disease, the promoting health and the disease system is patterned, centering around the healthy and their families. Therefore, in case of Korea, it is urgent to unify the curriculum of nursing education for the efficiency of the future oriented nursing education, and it is also imminent to develop the new pattern of a nursing curriculum suited for our own social demand and situation. And we need the continuous studies and search for the method of application in order to development the new curriculum. The comparison of a curriculum with the purpose of nursing education. The substances of subjects are not consistently in accord with the aims of nursing education each college states in Korea, Japan and U.S.A. Especially in case of Korea, the most statements upon the purpose of education are in the social dimension, but the most subjects have the academic dimension. In Korea it is stringent to examine and study the choice of the contents of education in terms of learning, profession, individual and society.

Current Trends in the Epidemiological and Pathological Characteristics of Gastrointestinal Stromal Tumors in Korea, 2003-2004

Cho, Mee-Yon,Sohn, Jin Hee,Kim, Joon Mee,Kim, Kyoung-Mee,Park, Young Su,Kim, Woo Ho,Jung, Jin Sook,Jung, Eun Sun,Jin, So-Young,Kang, Dae Young,Park, Jae Bok,Park, Ho Sung,Choi, You Duck,Sung, Sun Hee The Korean Academy of Medical Sciences 2010 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.25 No.6

<P>Despite remarkable progress in understanding and treating gastrointestinal stromal tumors (GISTs) during the past two decades, the pathological characteristics of GISTs have not been made clear yet. Furthermore, concrete diagnostic criteria of malignant GISTs are still uncertain. We collected pathology reports of 1,227 GISTs from 38 hospitals in Korea between 2003 and 2004 and evaluated the efficacy of the NIH and AFIP classification schemes as well as the prognostic factors among pathologic findings. The incidence of GISTs in Korea is about 1.6 to 2.2 patients per 100,000. Extra-gastrointestinal GISTs (10.1%) are more common in Korea than in Western countries. In univariate analysis, gender, age, tumor location, size, mitosis, tumor necrosis, vascular and mucosal invasions, histologic type, CD34 and s-100 protein expression, and classifications by the NIH and AFIP criteria were found to be significantly correlated with patient's survival. However, the primary tumor location, stage and classification of the AFIP criteria were prognostically significant in predicting patient's survival in multivariate analysis. The GIST classification based on original tumor location, size, and mitosis is more efficient than the NIH criteria in predicting patient's survival, but the mechanism still needs to be clarified through future studies.</P>

대학생 장애인에 대한 태도에 영향을 미치는 요인

강현숙(Kang Hyun-Sook),조결자(Cho Kyoul-Ja),지은선(Ji Eun-Sun),장미희(Jang Mee-Hee),이경혜(Lee Kyung-Hye),최은영(Choi Eun-Young),송영아(Song Young-A),장정미(Chang Jung-Mee),이경재(Lee Kyoung-Jae),김소영(Kim So-Young),유경희(Yu Kyung- 한국재활간호학회 2003 재활간호학회지 Vol.6 No.2

Purpose: The purpose of this study is to analyze college sudents' attitudes toward people with disabilities, and factors affecting the attitudes, and further to examine possible ways to improve the attitudes. and to furnish guideline of curriculum and practice in rehabilitation nursing on the basis of this analysis. Method: A descriptive. relational study design was used. The subjects of this study were 448 college students. A convenient sampling is used. Data were collected through 4 types of previous questionnaires used to examine attitude from May 1 to May 30, 2003. Result: 1. The attitude toward people with disabilities whose mean is 3.762 was responded somewhat negatively. Especially, a contact tension whose mean was 4.00 is high. 2. As a result of analyzing the attitudes of college students toward people with disabilities. some factors were statistically significant. They were experience of contact with the disabled. concern toward the disabled, voluntary work related to the disabled, and disability experience education. 3. The more negative experience of people with disabilities and the lower stereotype of disability and the higher effects of parents, teachers, and mass media, then the more positive response of peoples attitude with disabilities. 4. The main factors of determining the attitude of people with disabilities were the stereotype of disability. contact experience concern about disability, voluntary work experience. Conclusion: These results suggested that an appropriate educational intervention and strategy is needed in order to change the attitudes of college students toward people with disabilities. Also experimental researches are needed to do it.<br/> <br/> <br/> <br/> <br/> <br/> <br/> <br/> <br/>

중소병원 간호사의 직업 존중감과 직무만족 및 현장적응에 관한 연구

강미 ( Kang Mee ),강경숙 ( Kang Kyung Sook ) 아시아문화학술원 2017 인문사회 21 Vol.8 No.2

본 연구는 중소병원에서의 간호 인력관리방안을 개선하는 기초자료를 제공하려는 목적으로 G광역시에 소재한 중소병원에서 근무하고 있는 간호사 213명을 대상으로 설문지를 이용하여 2014년 9월 20일부터 10월 15일까지 자료수집 하였다. 자료 분석은 SPSS/WIN 19.0 프로그램을 이용한 t-test, ANOVA, Scheffe`s test, Pearson`s Correlation Coefficient를 사용하였다. 연구결과 중소병원 간호사의 직무만족은 종교, 결혼여부, 총 임상근무 경력, 급여수준에 따라 차이가 있었으며, 현장적응은 연령, 종교, 결혼여부, 총 임상근무 경력, 간호직 선택 동기, 부서이동 경험, 급여수준, 직위에 따라 통계적으로 차이가 있었다. 직업 존중감은 직무만족과 현장적응 간에 유의한 상관관계가 있었으며, 직무만족과 현장적응 간에도 유의한 상관관계가 있었다. 결론적으로 중소병원 간호사의 직업 존중감과 직무만족이 현장적응에 영향을 주는 주요한 요인임이 확인되었다. This study aims to provide relevant information for the nursing human resources management in small and medium sized hospitals. The data were collected by using a self-administered questionnaire whose participants were 213 nurses working for small and medium sized hospitals in G city, between September 20th and October 15th in the year of 2014. The data analysis methods are t-test, ANOVA, Scheffe`s test, Pearson`s correlation coefficient with the SPSS/WIN 19.0 program. Through the analysis, the nurses` job satisfaction showed statistically significant differences according to religion, marital status, total clinical experiences, and salary level. Also, the field adaptation did so according to age, religion, marital status, total clinical working career, motivation of becoming a nurse, experience of transfer to different departments, salary level, and position in a working place. Moreover, there were significantly positive correlations between the job esteem, their job satisfaction, and field adaption. In conclusion, the job esteem and job satisfaction of the nurses in small and medium sized hospitals were identified as major determinants that influence their field adaptation.

Poster Session 5 : Tumor Biology Developmental Biology Plant Biology Molecular Medicine and Gene Therapy Procaryotic Genetics Biotechnology ; The primary culture and three-dimensional culture of human and rabbit Limbus epithelial cells

( Ki Sook Park ),( Hyun Ju Kang ),( Gung Sun Lee ),( Mee Kum Kim ),( Jae Lim Lee ),( Hyun Sook Park ),( Chun Ho Kim ),( Young Sook Son ) 생화학분자생물학회 2003 생화학분자생물학회 춘계학술발표논문집 Vol.2003 No.-

노인 건강지도자 양성 전략을 적용한 경로당 노인 건강증진 프로그램 효과검증

구미옥(Gu, Mee Ock),은영(Eun, Young),김은심(Kim, Eun Sim),안황란(Ahn, Hwang Ran),권인수(Kwon, In Soo),오현숙(Oh, Hyun Sook),강영실(Kang, Young-Sil),정면숙(Jung, Myun Sook),최소영(Choi, So Young),성경미(Sung, Kyung Mi),강혜연(Kang, H 한국간호과학회 2012 Journal of Korean Academy of Nursing Vol.42 No.1

노인성치매에 대한 생화학적 연구(Ⅱ) : DHA와 DHEA가 흰쥐에서 Ibotenic acid로 유발된 능동적조건회피반응감소에 미치는 영향에 관한 연구 Effects of DHA and DHEA on active avoidance impaired rats induced by ibotenic acid

강석연,한형미,정기경,김태균,안향숙,허인회,김승희 식품의약품안전청 1997 식품의약품안전청 연보 Vol.1 No.-

Alzheimer's disease(AD) is ass☞ciated wit31 feature of extracellutar deposition of firoos protein aggregation in the form of amyloid plaque and a loss of choliBergic neurons. This study'as designed to evaluate the effects of docosahexaenoir acid(DHA ) and dehydroepiandrosteroneDHEA) in animal models of dementia which wa:T induced by neurotoxin(iboteni acid ) and of alcohot(16) ethanol). Ibotenic acid was injected into the nucleus basalis meynert region of the rat brain byfreotarically. The oral doses of DHA (675mg/kg) and DHEA (130rng/kg) were given respectively dur-lg 24 days daily, and ibotenic acid was injected at 33th day and of alcohol was given during 48 weeks.he effects of DHA and OHEA were tested the active avoidance and activity of acetylcholinesterasetchs), AChB distrib'ution, amyloid protein distribution, synaptophysin distribution and lipidfroxidatfDn in the brfin. There were Bo differences in active avoidance, amyloid distribution,rnaptofsj,sin dist,ibution and lipid pe,oxidation by DHA, DHEA in the rat b.sin. The rats we.e3ministered DHEA only showed decrease body weight significantly. Alcohol had no e(fect on activeroidance. These findinB proposed that DHA and DHEA Irvels may not be related to the memory im-tirment induced by ibotenic acid.

Testosterone Protects Pancreatic β-cells from Apoptosis and Stress-Induced Accelerated Senescence

Kang Seon Mee,Jung Hye Sook,Kwon Min Jeong,Lee Soon Hee,Park Jeong Hyun 대한남성과학회 2021 The World Journal of Men's Health Vol.39 No.4

Purpose: Androgens are steroid hormones that are very important in the sexual development and the maintenance of male reproductive system, and also have diverse actions in non-reproductive tissues, including potent antioxidant capacity. Type 2 diabetes mellitus is caused by tissue insulin resistance and insufficient insulin secretion from the pancreatic β-cells. The progressive decline of pancreatic β-cells in diabetes is closely related with the severity of disease. We wanted to know whether dihydrotestosterone (DHT) can protect insulin secreting pancreatic β-cells from apoptosis and accelerated senescence induced by oxidative stress. Materials and Methods: Cultured INS-1 cells were used. Various concentrations of H2O2 were applied to exert oxidative stresses. The degrees of apoptosis, accelerated senescence, and the changes of the expressions of related signaling molecules after the application of DHT were analyzed by CCK-8, p16 expression, SA-β-Gal staining, reverse transcription polymerase chain reactions and Western blots. Results: The application of H2O2 significantly increased (p<0.05) the degree of senescence and apoptosis of cultured INS-1 β-cells. DHT not only showed anti-oxidant protective capacity, but also significantly reduced (p<0.05) the degree of accelerated senescence. Conclusions: DHT effectively protects pancreatic islet INS-1 β-cells from H2O2 induced oxidative stress.

Characterizations of Shell and Mantle Edge Pigmentation of a Pacific Oyster, Crassostrea gigas, in Korean Peninsula

Kang, Jung-Ha,Kang, Hyun-Sook,Lee, Jung-Mee,An, Chel-Min,Kim, Sung-Youn,Lee, Yun-Mi,Kim, Jong-Joo Asian Australasian Association of Animal Productio 2013 Animal Bioscience Vol.26 No.12

The objectives of this study were to investigate color patterns of shell and mantle edge pigmentation of a Pacific oyster, C. gigas, and to estimate variance components of the two colors. A sample of 240 F0 oysters was collected from six aquaculture farms in Tongyeong, Korea to measure shell color and mantle edge pigmentation. Among the F0s, male and female individuals with black (white) shell and black (white) mantle edge were selected and mated to generate three F1 full-sib black (white) cross families (N = 265). Two and four F2 cross families (N = 286) were also produced from black and white F1 selected individuals, respectively. Variance component estimates due to residuals and families within color were obtained using SAS PROC VARCOMP procedures to estimate heritability of shell and mantle edge pigmentation. In the F0 generation, about 29% (11%) had black (white) color for both shell and mantle edge. However, in the F1 and F2 black (white) cross families, 75% (67%) and 100% (100%) of oysters had black (white) shell colors, and 59% (23%) and 79% (55%) had black (white) mantle edge, respectively. Spearman correlation coefficients between shell and mantle edge color were 0.25, 0.74, and 0.92 in F0, F1, and F2 generations, respectively, indicating that, with generations of selection process, an individual with black (white) shell color is more likely to have black (white) mantle edge pigmentation. This suggests that shell color could be a good indicator trait for mantle edge pigmentation if selection of both the colors is implemented for a couple of generations. Estimates of heritability were 0.41 and 0.77 for shell color and 0.27 and 0.08 for mantle edge pigmentation in the F1 and F2 generations, respectively, indicating that, in general, significant proportions of phenotypic variations for the shell and mantle edge colors are explained by genetic variations between individuals. These results suggest that the two color traits are inheritable and correlated, enabling effective selection on shell and mantle edge color.