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박준숙,이관구,오세익,성갑규,우명룡 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.11
Twin pregnancies have a higher rate of premature delivery than singleton pregnancies and a substantially higher perinatal mortality. Twin gestation complicted by a single anomalous fetus diffculties in obstetric management. Options available to patients include continuing the entire pregnancy, selective termination of the anomalous fetus, or termination of the entire pregnancy. The incidence of one anomalous fetus in twin pregnancy is rare. Gastroschisis is intestinal herniation through a defect in the anterior abdominal wall usual ly to the right of umblicus. There is no sac and the intestines are covered with a thickened inflammatory exudate. Most case of gastroschisis occur sporadically and chromosomal anomaly are less common. A case of one gastroschisis in twin pregnancies diagnosed by ultrasonography is reported with a brief review of the literature.
Immunohistochemistry Diagnosis of an Ovarian Dysgerminoma in One Bitch
Park, JK,Goo, MJ,Hong, IH,Ki, MR,Han, JY,Jeong, KS Blackwell Publishing Ltd 2009 REPRODUCTION IN DOMESTIC ANIMALS Vol.44 No.5
<P>Contents</P><P>An ovarian enlargement (diameter, 8 cm) was identified and surgically excised from a 5-year-old female dog. Microscopic examination of the multinodular neoplasm revealed sheets of polygonal neoplastic cells with large nuclei, frequent mitosis, necrosis and haemorrhage. Immunohistochemically, the neoplastic cells were positive for vimentin and alkaline phosphatase but were negative for CD3, CD79a, cytokeratin, alpha-fetoprotein, inhibin-&agr; and S-100. The histopathological diagnosis of the mass was unilateral ovarian dysgerminoma.</P>
생쥐 초기 배아배양에 있어서 산소유리기 보집제인 Superoxide Dismutase (SOD) 가 미치는 영향
김미란,오기석,유희석,권혁찬,황경주,박지영,이영돈,홍순정,계명찬,최규환 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.7
It is well known that developmental delay or arrest occurs before implantation in mamals, which have undergone in vitro culture. Recently, these phenomena are being attributed to oxygen free radicals, and successful cell culture are being obtained by lowering the oxygen environment of in vitro culture. This is due to the fact that the oxygen concentration in the fallopian tube is around 5%, which is lower than the room air 20% concentraition for in vitro culture. Superoxide dismutase(SOD), which are free radical scavenger, were added to early embryo mice culture and compared the free radical level at each stage of development with that of culture in which free radical scavenging agent was not added. The highest free radical level in control group observed in the late 2-cell stage and was markedly decreased if SOD added to culture media. Blastulation rate, hatching rate, and blastomere count as the parameters of embryo development was significantly increased in the experimental group. This study suggests the possibility of improvement in in-vitro embryo culture with media including free radical scavengers.
수술 및 진단적 복강경수술 450 예에 대한 임상적 고찰
권용일,박태철,이진우,김수평,권동진,이근호,류진희,상미란 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.7
목 적: 산부인과 영역에서의 복강경술은 창상이 적고 유착이 적으며 수술후 통증 및 합병증이 적고 회복이 빨라 비용이 절감된다는 장점뿐 아니라 미용학적인 잇점이 있으므로 점차 개복술을 대체하여 치료영역이 확대되고 있는바 본 연구는 가톨릭대학교 의정부 성모병원 산부인과에서 1997년 1월부터 1998년 12월까지 시행한 복강경수술 450예를 분석하였다. 연구방법: 1997년 1월부터 1998년 12월까지 가톨릭대학교 의정부 성모병원 산부인과에서 복강경수술을 시행받은 환자 450명의 외래 및 입원기록을 검토하였다. 검토항목으로 환자의 연령, 출산력, 복강경수술의 적응증, 수술종류 및 시간, 입원기간, 합병증을 분석하였다. 결 과: 1997년 1월부터 1998년 12월까지 가톨릭대학교 의과대학 의정부 성모병원 산부인과에서 시행한 450예의 복강경술을 분석하여 다음과 같은 결과를 얻었다. 1. 환자들의 평균연령은 33.3세였다. 2. 환자들의 평균 출산력은 1.07회였고 초산부가 37.3%였다. 3. 복강경술의 적응증은 총 450예중에서 난소낭종이 156예[34.7%]로 가장 많았고 그외 자궁근종이 96예[21.2%],자궁외임신이 61예[13.6%], 자궁내막증 57예[12.7%]였다. 4. 복강경수술의 방법은 수술적 복강경술 총 376예 중 낭종절제술이 80예[27.0%], 복강경하 자궁 적출술 58예[19.5%], 복강경하 질식 자궁 적출술 50예[16.9%], 난관절제술이 42예[14.1%], 난소난관절제술 38예[12.8%]이었다. 5. 환자들의 평균입원기간은 3.06일이었다. 6. 수술시간은 복강경하 질식 자궁 적출술의 경우 평균 90분∼150분이 소요되었고 복강경하 자궁 적출술의 경우는 60분-120분, 그외 대부분의 경우에서는 60분미만이었다. 7. 복강경수술후의 합병증은 450예 중에서 8예가 있었고 이는 투과침에 의한 장손상, 자궁거상기에 의한 자궁손상, 상처부위 혈종, 감염, 단시간의 배뇨장애, 술후 장마비증, 재출혈등이었다. 8. 불임증으로 수술적 복강경술을 시행받은 환자들 28예중 10예에서 임신에 성공하였다. 결 론: 이상의 결과로 부인과 질환의 진단과 치료에 있어서 복강경술의 이용은 매우 유용하며 점차로 개복수술을 대치하는 상황으로 앞으로의 이용을 점차 극대화 해나가야 한다. Objective : Pelviscopic surgery has been reported to reduce inpatient hospital time and cost in addition to minimizing tissue damage and bleeding. To evaluate the efficacy of pelviscopic surgery in gynecologic patients, we reviewed and analyzed 450 cases of operative and diagnostic pelviscopy from January, 1997 to December, 1998. Methods : From January, 1997 to December, 1998, total 450 patients were received laparoscopic surgery on dept. OBGY of Uijungbu St. Mary`s Hosp. We reviewed the chart and analyzed these cases about age, parity, diagnostic name, operation title, duration of hospitalization, side effect, operation time. Results : The results of this study were summarized as follows : 1. The average age of patients was 33.3 years old and the great incidence occurred in 26∼30 years group [28.4%]. 2. The average parity of patients was 1.07 . 3. The common indication were ovarian cyst[34.7%], myoma uteri [21.2%], ectopic pregnancy[13.6%], pelvic endometriosis[12.7%]. In diagnostic pelviscopy, the most common indication was infertility[43.2%] and ovarian cyst [40.4%] was the most common indication in operative pelviscopy. 4. The major types of operative pelviscopy were cystectomy, total laparoscopic hysterectomy[TLH], laparoscopy assisted vaginal hysterectomy[LAVH], salpingectomy,adnexectomy, electrocauterization. 5. The mean duration of hospitalization was 3.06 days. 6. The major complication of surgery were intestinal injury, postoperative paralytic ileus, bleeding at resection site, but, they were controlled without difficulty. Conclusion : Now, the use of pelviscopic surgery are increased in gynecologic surgery. Pelviscopic surgery is useful and recommended for the treatment of gynecologic disease, because this is safe and has many advantages.
자궁경부암 세포주들에서 Transforming Growth Factor-β1의 세포성장 및 c-myc암유전자 발현 억제효과
김승조,이헌영,김진우,김미란,남궁성은,박태철,김태웅,김재훈 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.1
Transforming growth factor-β1(TGF-β1) is known to be a potent growth inhibitor for many cell types, including most epithelial cells. In skin keratinocytes, TGF-β1 has been shown to inhibit growth and to rapidly reduce c-myc expression. However, the molecular mechanism of TGF-β1 action on cell growth of cervical carcinoma has not yet been elucidated. We thus assessed the effect of TGF-β1 on the growth of cervical carcinoma cell lines. Two cervical squamous carcinoma cell lines were incubated with varying concentration of TGF-β 1, and growth inhibition was evaluated with tetrazolium-based colorimetric assay. After culturing in concentrations of 0.1~10 ng/ml in both cell lines. Northern blot analysis revealed c-myc mRNA expression was suppressed by 10 ng/ml of TGF-β 1 following 6-hour of treatment in both cell lines. These results suggest that TGF-β1 inhibits the growth of cervical carcinoma cells by suppressing c-myc oncogene expression.