질확대경진의 새 용어와 분류법

김승조 대한부인종양 콜포스코피학회 1990 Journal of Gynecologic Oncology Vol.1 No.1

음주운전의 법적 처리 - 행정처분 및 행정구제와 관련하여 -

김승조 한국보호관찰학회 2002 보호관찰 Vol.2 No.-

Cyclic Adenosine Monophosphate와 Insulin이 BeWo 세포주의 성장 및 호르몬 분비에 미치는 영향

김승조,송승규,유영옥,정재근,이준모,남궁성은 대한부인종양 콜포스코피학회 1992 Journal of Gynecologic Oncology Vol.2 No.1

In order to find out the regulatory function of hormone release of malignant choriocarcinoma, we cultured BeWo cell lines in vitro. The control was cultured in cAMP and insulin free medium and for the experimental group, we add O. l, 0. 5 and l. 0 mM of cAMP $lt;Group 1$gt;, 1, 10 and. 20 uM of insulin $lt;Group II$gt; and, 0. 1 mM and l uM, 0.5 mM and 10uM, and l.0 mM and 20 uM of cAMP and insulin (Group III), respectively to the medium, then cultured for 3 days in vitro. Release of �-hCG, estradiol and progesterone was measured by radioimmunoassay. In order to find out the effect of cAMP and insulin on cell proliferation, we measured the number of ceils by using hemocytometer after 3-day culture. The results were as follows. 1. �-hCG release was increased in control and all experimental groups as prog~ressing the days of culture. Release of �-hCG was significantly increased in proportion to the amount of cAMP and decreased in proportion to the amount of insulin as compared with those of control in all groups. In Group II1, inhibitory effects of insulin was more predominant than cAWP of low concentration, and no inhibitory effect of insulin was found in the cases of stirnulatory effect, af high cancentration of cAMF in spite of high concentration of insulin. 2. Estradiol release was relatively increased in control and Group II and Group III, but decreased in Group I with low concentration of eAMP as progressing the days of culture. In Group I and 11, release of estradiol was decreased as compared with that of control, In Group III, there was no statistical significance as compared, with control. 3. Progestterone release was rellatively increased in control and experimental groups as Progressing the days of culture. In Group I(except low concentration group), release of progesterone was increased on the 1st day of culture as compared with that of control. However, in high cAMP concentration group, releee was decreased on the 2nd day of culture as compared with control. In Group III, there was a tendeney teward reduction of progesterone reiease as compared with control. 4. Number of cells was signifieantly inereased after 3-day culture. In Group l with high concentration of cAMP, number of cells was decrease, which suggested inhibition of cell proliferation. In Group II with high concetration of insulin, number of cells was increased, which suggested stimulatory effect of insulin on cell proliferation. In Group III, neither stimulatory nor inhibitory effect was found. From the above results, it is thought that cAMF and insulin are related to synthesis and release of hCG and estrdiol in BeWo cell line whieh is one of malignant trophoblastic cell and are inaignificantly related to role of progesterone as compared with �-hCG or estradiol. It was also found that cAMP inhibited and insulin stimulated BeWo cell proliferaition.

자궁경부암에서 cis-Platin을 포함한 복합항암요법에 의한 오심 및 구토의 조절에 있어 Ondansetron-Dexamethasone의 효과에 대한 비교분석

김승조,송승규,권용일,김미란,이유미,한상균,남궁성은 대한부인종양 콜포스코피학회 1993 Journal of Gynecologic Oncology Vol.4 No.2

Chemotherapy induced nausea and vomitting remain important concerns for patients. In recent years, many antiemetics based on diphenhydramine, dexamethasone, metoclopramide or lorazepam have eiinically demonstrable antiemetie effects. Cis-Platin, which is one of the most effective chemotherapeutic agents, produces severe emesis after its administration and delayed emesis also. Metoclopramide, which is a potent dopamine receptor antagonist, have been shown to be safe and effective single agent for the control of nausea and vomitting. But the antiemetic effects of metoclopramide was thought to be mediated by dopamine receptor blockade and so produced adverse events like as extrapyramidal reactions. Recently, Ondansetron is a highly selective 5-HT, (5-Hydroxytryptamine,) receptor antagonist that dose not have any activity at dopamine receptors. It has been shown to be an effective antiemetic activity especially when combined with dexamethasoe and also be safe and less side effects. All patients suffering from a diaease with cervical cancer were receiving cis-Platin (80 to 120 mg/ m) containing combination chemotherapy. OD( Ondan,setron (Hmg)-Dexamethasone (20mg) $gt;was given to 30 patiente. Their mean ages were 43 and 47 years old, respectively. In the OD group, Ondansetron 8mg and Dexamethasone 20mg were given by intravein 30 minutes prior to chemotherapy and administered intravenously by 8 hour intervals after chemotherapy on day 1 on days 2~3, the patients reveived Ondansetron at a dose of 8mg tid Fro the 3 days following, Ondansetron was administered as an oral dosage of 8 mg every 8 hours. In the MD group, Metoclopradmide 30 mg in normal saline 100ml and Dexamethasone 20mg were of given by intravein 30 minutes prior to cis-Platin administration for 30 minutes and administered intravenously by 8 hour intervals on days 1~3. For the 3 days following, the drugs were administered as an oral dosage of 30mg every 8 hours. In the MDL group, Metoclopramide 2mg/kg in normal saline 100ml, Dexamethasone 20mg and Lorazepam 1mg were fiven by intravein 30 minutes prior to chemotherapy and administered intravenously by 8 hour intervals on day 1. On days 2~3, the patients received Metoclopramide and Dexamethasone at a dosage of 2mg/kg and 20mg tid. For the 3 day following, Metoclopramide was administered by oral dosage of 100mg every 8 hours. In the OD group, MD group and MDL gorup, mausea was controlled in 100% of the patients(none:48.4%, mild $quot; 51.6%), 55% (5%, 50%(, 46%(13%, 33%) and vomitting was controlled in 100% of patients (complete: 87.1%, major: 12.9%), 60%(25%, 35%), 83%(43%, 40%) on day 1. On days 2 to 3, nausea was controlled in 71% of the patients(none: 12.9%, mild: 58.1%), 57.5(2.5%, 55%), 66.6%(13.3%, 53.3%) and vomitting was controlled in 80.7%(complete: 48.4%, major:32.3%), 67.5%(7.5%, 60%), 80%(23.3%, 56.7%). On days 4 to 6, mausea was controlled in 77.5% (none: 45.2%, mild: 32.3%), 77.5%(2.5%, 75%), 93.3%(33.3%, 60%), and vomitting was controlled in 87.1%(complete: 67.7%, major: 19.4%), 77.5%(20%, 57.5%), 96.7%(56.7%, 40%). The side effects of the OD group were mild with dystonic reaction(4 patients), headache(5 patients), constipation(5 patients), xerostomia(7 patients), nonspecific abdominal pain(6 patients) and cutaneous flushing(4 patients). In the MD group, expyramidal, side reaactions were seen with exrostomia(25 patinets), cutaneous flushing(26 patients), headache(10 patients), acute dystonic reaction(9 patients), restlessness(8 patients) and abdominal pain(8 patients), In the MDL group, the side effects were mild with sedation(6 patients), restlessness(1 patient) and no expyramidal reaction was seen, There is no patients who had treatment failure in 101 patients. the results showed that OD group was more effective than MD or MDL groups in a controlled envrionment of acute emesis induced by cis-Platin based combination chemotherapy. But in delayed emesis, the MDL group was the most effective regimen among the three groups. Lorazepam was an effective regimen in controlling the expyramidal side reactions

부인과영역의 오진

김승조 中央醫學社 1992 中央醫學 Vol.57 No.8

The type of misdiagnosis in gynecological disease can characteristically derived from various sorts of technical and analogic errors dealing withh various informations from menstrual disorders, infertility, abnormal vaginal bleeding, infections, neoplasms, pregnancy related' disorders, congenital anomalies, pelvic pains, and psychosomatic diseases, it is important that misdiagnoses are not less often be fatal in gynecological than in other patients. It's because the diseases themselves are mostly related with hemorrhage, septic infection and pregnancy related immune deficiency. Recently, there have appeared so many mordern ultrafashionable medical instruments which can dramatically reduce the misdiagnoses such as ultrasonography, and MRI etc. and otherwise physicochemical methods. In our neighborhood, however, we can see so many occasions with negative aspects of medical environment including misdiagnoses, medical accidents and medicolegal conflicts. As a fundamental reason, negligence to develop abilities that human can achieve in the power of attention and concentration to reduce errors can easily be considered. Another important thing for medical doctors to make misdiagnosis is failure in maintaining a good para-medical human relationship, the rapport and the cooreariton with the patients. Furthermore, indirect influences deriver from so many unreasonable political and medicosocial environments such as restricting medical insurance systems which can cause down regulation of the quality of medical treatment must be corrected or abolished, and, on the other hand, establishment of national political and socioenvironmental atmosphere to secure the adequate treatment will also be important to reduce misdiagnosis.

다중 프런트 기법을 이용한 PC 수퍼 컴퓨팅

김승조,이창성,여혜진,김정호 한국항공우주학회 1999 한국항공우주학회 학술발표회 논문집 Vol.- No.-

인터넷으로 연결된 64대의 PC를 이용한 수퍼컴퓨팅

김승조,이창성,손정우,하병언,최지덕 한국항공우주학회 2000 한국항공우주학회 학술발표회 논문집 Vol.- No.-

지반 조건에 따른 2-아치 대단면 터널의 굴착방법

김승조,이천한,이병식 대한토목학회 1999 대한토목학회 학술발표회 논문집 Vol.1999 No.2

구조물 진동에 의해 발생하는 소리의 가상구현에 대한 연구

김승조,송준영 한국항공우주학회 2000 한국항공우주학회 학술발표회 논문집 Vol.- No.-

자궁경부암의 다원복합요법(多元復合療法)

金丞兆 대한의학협회 1992 대한의학협회지 Vol.35 No.3