부산 경남지방에 발생한 쭈쭈가무시병 64예의 임상적 고찰

이상훈,전명호,신병철,박기찬,김영효,배성,전광수,김종성 동아대학교의과대학 1992 동아의대학술지 Vol.4 No.1

Apoptotic Effect of Co-treatment with Chios Gum Mastic and HS-1200 on G361 Human Melanoma Cell Line

Young-Joo Hur,Young-Ki Kim,Hyun-Ho Kwak,Gyoo-Cheon Kim,Seung-Eun Lee,In-Ryoung Kim,Chul-Hoon Kim1,Bong-Soo Park 대한해부학회 2009 Anatomy & Cell Biology Vol.42 No.2

Chios gum mastic (CGM) is a resinous exudate obtained from the stem and the main leaves of Pistacia lenticulus tree native to Mediterranean areas. Recently it reported that CGM induce apoptosis in a few cancer cells in vitro. Bile acids and their synthetic derivatives induced apoptosis in various kinds of cancer cells and anticancer effects. It has been reported that the synthetic chenodeoxycholic acid (CDCA) derivatives showed apoptosis-inducing activity on various cancer cells in vitro. This study was undertaken to investigate the synergistic apoptotic effect of cotreatment with a natural product, CGM and a CDCA derivative, HS-1200 on G361 human melanoma cells. To investigate whether the co-treatment of CGM and HS-1200 compared with each single treatment efficiently reduced the viability of G361 cells, MTT assay was conducted. To investigate augmentation of apoptosis in G631 cells co-treated with CGM and HS-1200, DNA electrophoresis, Hoechst staining, proteasome activity assay, flow cytometry, Westen blot analyses, immunofluorescent staining and confocal microscopy were performed. In this study, G361 cells co-treated with CGM and HS-1200 showed several lines of apoptotic manifestation such as nuclear condensations, DNA fragmentation, the reduction of MMP and proteasome activity, the decrease of DNA content, the release of cytochrome c into cytosol, the translocation of AIF and DFF40 (CAD) onto nuclei, activation of caspase-9, caspase-3, PARP and DFF45 (ICAD), and up-regulation of Bax whereas each single treated G361 cells did not. Although the single treatment of 40 μg/mL CGM or 25 μM HS-1200 for 24 hrs did not induce apoptosis, the co-treatment of them induced prominently apoptosis. Therefore, combination therapy of CGM and HS-1200 could be considered, in the future, as an alternative therapeutic strategy for human melanoma.

국산·수입산 동부를 이용한 모시잎송편의 영양성분비교

김영섭,김소민,오지연,황진봉,이기택,신정아,김상천,김세나,김행란,황영,최용민 忠北大學校 農業科學硏究所 2015 農業科學硏究 Vol.31 No.2

Flangeless Esser PET Phantom 영상 자동 분석 프로그램의 유용성 평가

남궁창경,남기표,김경식,김정선,임기천,신상기,조시만,동경래,NamGung, Chang-Kyeong,Nam, Ki-Pyo,Kim, Kyeong-Sik,Kim, Jeong-Seon,Lim, Ki-Cheon,Shin, Sang-Ki,Cho, Shee-Man,Dong, Kyung-Rae 대한핵의학기술학회 2009 핵의학 기술 Vol.13 No.1

Purpose: ACR (American College of Radiology) offers variable parameters to PET/CT quality control by using ACR Phantom. ACR Phantom was made to evaluate parameters which are uniformity, attenuation, scatter, contrast and resolution. Manual analysis method wasn't good for the use of QC because values of parameter were changed as it may user and it takes long time to analysis. Ki-Chun Lim, a nuclear scientist in AMC, developed program that automatically analysis values of parameter by using ACR Phantom to overcome above problems. In this study, we evaluated automatic analysis program's usability, through the comparing SUV of each method, reproducibility of SUV when repeated analysis and the time required. Materials and Methods: Using Flangeless Esser PET Phantom, the ideal ratio of 4 : 1 hot cylinder and BKG but it actually showed a ratio of 3.89 to 1 hot cylinder and BKG. SIEMENS Biograph True Point 40 was used in this study. We obtained images using ACR phantom at Fusion WB PET Scan condition (2 min/bed) and 120 kV, 100 mAs CT condition. Using True X method, 3 iterations, 14 subsets, Gaussian filter, FWHM 4 mm and Zoom Factor 1.0, $168{\times}168$ image size. We obtained Max. & Min. SUV and SUV Mean values at Cylinder (8, 12, 16, 25 mm, Air, Bone, Water, BKG) by automatic program and obtained SUV by manual method. After that, we compared manual and automatic method. we estimate the time required from opened the image data to final work sheet was completed. Results: Automatic program always showed same result and same the time required. At 8, 12, 16 and 25 m cylinder, manual method showed 6.69, 3.46, 2.59, 1.24 CV values. The larger cylinder size became, the smaller CV became. In manual method, bone, air, water's CV were over 9.9 except BKG (2.32). Obtained CV of Mean SUV showed BKG was low (0.85) and bone was high (7.52). The time required was 45 second, 882 second respectably. Conclusions: As a result of difference automatic method and manual method, automatic method showed always same result, manual method showed that the smaller hot cylinders became, the lager CV became. Hot cylinders mean region size, the smaller hot cylinder size becomes we had some trouble in doing ROI poison setting. And it means increase in variation of SUV. The Study showed the time required of automatic method was shorten then manual method.

수송기계용 복합재 원형튜브의 에너지흡수특성

김영남,황재중,차천석,심재기,양인영 朝鮮大學校 機械技術硏究所 2002 機械技術硏究 Vol.5 No.1

본 연구에서는 일 방향 CFRP 복합재 튜브에서 나타나는 상이한 압궤특성의 일관성을 보이고자 하며, 또한 계면수가 에너지 흡수능력의 함수인지 아닌지를 결정하고자 한다. 계면수는 최외층각도 0?를 갖는 4가지 형태(계면수는 2, 3, 6, 7 개)이며, 각 튜브에 압궤하중이 가해졌을 때 그 응답은 압궤과정을 제어하는 상이한 메카니즘 사이에서의 상호작용에 의존하고 그것을 매우 복잡하다. 따라서 본 연구에서는 정적 및 충격압궤실험을 행하고, 그 결과 계면함수, g(k)에 대해 정의하였다. 또한 일반적으로 [0/90〕_(2s) 적층된 CFRP 튜브가 더 높은 에너지를 흡수하였으며, 이론적 및 실험적 데이터는 서로 일치하였다. The objective of this paper is to present a consistent description of the different collapse characteristics exhibited by uni-directional CFRP(Carbon Fiber Reinforced Plastics) composite tubes and determine whether the energy-absorption capability of these tubes is a function interlaminar number. Tube interlaminar number was 4 types (2, 3, 6 and 7) included ply orientation angle of outer was 0. When such tubes are subjected to crushing loads, the response is complex and depends on the interaction between the different mechanisms that control the crushing process. In this study static and impact collapse test were performed and the results have been shown as a function interlaminar number(g(k)). In general, the stacking sequence [0/90〕_(2s) CFRP tubes absorbed more energy than other tubes, theoretical and experimental data were to be likely each other.

과민성 대장증후군에서 Fenoverine(Fexadin^(�))의 임상효과

김영건,성자원,김병호,이기천,허승식,정현용,이헌영 최신의학사 1992 最新醫學 Vol.35 No.4

籠球競技의 Position別 Shoot實態 分析 : 高等部와 大學部를 中心으로 Chiefly on the Basketball games of High School team and College team

金基學,李淳川 慶北大學校 師範大學 1978 敎育硏究誌 Vol.20 No.-

The investigation and analysis of ideal shooting angle, region and form in the basketball games of high school and college team, shows the following result. 1. The success of field throw in Angle and Region according to each position; The success of field throw in a angle according to each position made no difference in angle "A", "B" and "C" with High School team as well as with College team, except that, as for center position, it marked 45.9% at angle "A" and 21.3% angle "C". From the regional standpoint, as for the position of the high school team, it marked 70% in the inner field(restricted area), 30% in the outer field at angle "C", and 71.79% in the inner field, 28.21% in the outer field at angle "B". As for Guard position it made no. difference between inner and outer field in the high school team, but in the college team it marked 85.96% in the inner field, 14.04% in the outer field at angle "C". As for center position, the frequency of success in field throw was higher in the inner field than in the outer field except the case of field throw at angle "C" in the college team. As a result, the frequency of success in field throw makes no difference in angle, but from the regional standpoint, it is higher in the restricted area. 2. Field throw Form according to each position; Both in high school and in college team, Jumpshoot is the main form of making goals and the frequency of success marked 66.23% in Forward positions 69.68% in Guard position and 71.28% in Center position. But ifs particular that the player in Forward or Guard position made goals by means of Lay up shoot as his secondary form of shooting; the player in Center position by means of pivot or turn shoot. The frequency of success as a secondary form of shooting marked 14.29% in Forward position, 16.29% in Guard position and 20.21% in Center position. 3. The Frequency of Success in field throw according to each position; Both in high school and in college team, the success in field throw rates the highest in Forward position, the higher in Guard, and the lowest in Center. But in high school team, the success frequency in Guard position, which is similiar to that in Forward position, is higher and in college team it is lower as in the case of Center position. As a conclusion it is supposed that we should develop the technique of shooting, the last goal of basketball game, with reference to the result mentioned above.

백서 적혈구에서 glutathione이 paraquat 독성에 미치는 영향

김명철,박재윤,채기영,천영욱,박평심,차종희 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.16 No.2

The participation of superoxide in initiating tissue damage from administration of a xenobiotics is best illustrated by paraquat intoxication, in which it is known that one electron reduction of paraquat leads to the formation of radicals which react with molecular oxygen to give superoxide. In the present study, the effects of paraquat on the level of glutathione and activities of superoxide dismutase(SOD), catalase, glutathione peroxidase, glutathione reductase and glutathione stransferase were investigated in rat liver and erythrocytes. The contents of glutathione in liver and blood were sinificantly decreased by paraquat administration, but the activities of enzymes were unaltered. Incubation of the buffered aerobic mixture of erythrocyte in the presence of 5mM glucose, Paraquat and/or N-ethylmaleimide(NEM) resulted in the formation of lipid peroxide, the activities of various enzyme and the levels of glutathione were determined. The malondialdehyde(MDA) contents as a indicator of lipid peroxidation was decreased and the levels of total glutathione were not changed but the levels of oxidized glutathione(GSSG) were in creased in paraquat treated erythrocytes. The activites of ezyme were decreased in paraquat treated erythrocytes but in reduced glutathione(GSH) treated erythrocyte, the enzymes activities were less decreased by paraquat. These results suggest that paraquat toxicity was probably somewhat reduced by GSH, but paraquat-induced injury were not increased by GSH depletion in erythrocytes.

多衆 채널 DPSK Heterodyne/Coherent 光通信 시스템의 性能 評價

金玄起,李天熙 청주대학교 산업과학연구소 1992 産業科學硏究 Vol.10 No.-

In this paper, system modeling for multichannel DPSK communications system is presented and its receiver performance is evaluated. The receiver is deteriorated due to shot noise originating from the photo diode, phase noise stemming from transmisson and local source, and crosstalk between adjacent channels. Such noise exist in signal is estimated Bit Error Rate(BER) and sensitivity penalty by the transmisson power, when it is in consideration of laser linewidth. And it account for the impact of the laser linewidth. It is assumed that the IF bandwidth needed to avoid intersymbol interference is 2.2 bit rates for a modulation index m=1; it is larger for other modulation index values. For DPSK systems, desired channel spacing is rapidly increased from 2.08R_(b) to 3R_(b), when channel spacing increased from △?? T=0% to △?? T=0.5%, Such a criterion gives a 1dB penalty in the optical receiver sensitity at P_(e)=10^(-9)

급성 및 만성 간질환에서 C형 간염바이러스 항체(anti-HCV)양성률

김삼용,성자원,김병호,이기천,허승식,길준영,정현용,이헌영,김영건 충남대학교 의과대학 지역사회의학연구소 1992 충남의대잡지 Vol.19 No.2

The prevalence of antibody against hepatitis C virus (anti-HCV) was investigated in 331 patients with various liver diseases from April 1992 to September 1992. The presence of anti-HCV was detected by Lucky HCD EIA test in 331 cases and by (Ortho HCV Antibody ELISA test 148 patients) The results are summarized as follows: 1. Overall, antibody to HCV(anti-HCV) was positive in 37(11%) of 331 patients with various liver diseases. 2. 16(11%) of 144 patients with chronic hepatitis, 2(5%) of 37 patients with alcoholic liver disease, 17(22%) of 76 patients with liver cirrhosis and 2(5%) of 38 HBsAg carriers were positive for anti-HCV.None of 12 patients with acute hepatitis, 11 patients with drug induced hepatitis and 13 patients with hepatocellular carcinoma was anti-HCV positive. 3. HBsAg positivity in patients who had anti-HCV was 24%(9/37). 4. A positive correlation was found between Lucky HCD and Ortho HCV test. Of 128 Lucky HCD negative cases, 124 cases were negative for Ortho HCV ELISA and 4 cases were positive for Ortho HCV ELISA Of 20 Lucky HCD positive cases, 11 cases were positive for Ortho HCV ELISA and 9 cases were negative for Ortho HCV ELISA. These results suggest that hepatitis C virus has an important etiologic role in HBsAg negative chronic hepatitis and liver cirrhosis in Korea. The diagnostic value of Lucky HCD EIA test may be slightly better or equivalent to Ortho HCV ELISA test in the diagnosis of Hepatitis C virus infection.