Novel dentin phosphoprotein frameshift mutations in dentinogenesis imperfecta type II

Lee, K‐,E,Kang, H‐,Y,Lee, S‐,K,Yoo, S‐,H,Lee, J‐,C,Hwang, Y‐,H,Nam, KH,Kim, J‐,S,Park, J‐,C,Kim, J‐,W Blackwell Publishing Ltd 2011 Clinical genetics Vol.79 No.4

<P>Lee K‐E, Kang H‐Y, Lee S‐K, Yoo S‐H, Lee J‐C, Hwang Y‐H, Nam KH, Kim J‐S, Park J‐C, Kim J‐W. Novel dentin phosphoprotein frameshift mutations in dentinogenesis imperfecta type II.</P><P>The dentin sialophosphoprotein (<I>DSPP</I>) gene encodes the most abundant non‐collagenous protein in tooth dentin and DSPP protein is cleaved into several segments including the highly phosphorylated dentin phosphoprotein (DPP). Mutations in the <I>DSPP</I> gene have been solely related to non‐syndromic form of hereditary dentin defects. We recruited three Korean families with dentinogenesis imperfecta (DGI) type II and sequenced the exons and exon–intron boundaries of the <I>DSPP</I> gene based on the candidate gene approach. Direct sequencing of PCR products and allele‐specific cloning of the highly repetitive exon 5 revealed novel single base pair (bp) deletional mutations (c.2688delT and c.3560delG) introducing hydrophobic amino acids in the hydrophilic repeat domain of the DPP coding region. All affected members of the three families showed exceptionally rapid pulp chambers obliteration, even before tooth eruption. Individuals with the c.3560delG mutation showed only mild, yellowish tooth discoloration, in contrast to the affected individuals from two families with c.2688delT mutation. We believe that these results will help us to understand the molecular pathogenesis of DGI type II as well as the normal process of dentin biomineralization.</P>

조기진통 임신부의 경질초음파에 의한 자궁경부 평가

이권해,이임순,이해혁,이정재,신정옥,이명환,구도형,이항재,양회경,전섭,최경훈 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.4

목적: 경질초음파에 의해 평가된 자궁경부의 특징이 조기진통과 조기분만에 관련이 있다는 가설을 검증하는데 우리의 목적이 있었다. 방법: 조기진통이 있는 단태아 임신으로 입원한 51명의 임신부를 대상으로 치료를 시작하기 전 경질초음파를 시행하였다. 조기분만은 37주 이전에 분만된 경우로 정의하였다. 초음파 계수로 자궁경부 길이, 쇄기형[wedging]의 존재가 평가되었다. 자료분석은 student t test와 카이제곱검정법[chi-square test]을 이용하였다. P value가 0.05 미만일 때 유의성이 있는 것으로 하였다. 결과: 자궁경부에 쇄기형[wedging]이 존재하는 경우와 자궁경부 길이가 짧아져 있는 경우 조기분만과 상당히 관련이 있는 것으로 나타났다[p$lt;0.001]. 조기분만을 예측하는데 있어서 자궁경부 쇄기형[wedging]이 있는 경우 100%의 민감도, 81.6%의 특이도, 65%의 양성 예측도, 100%의 음성 예측도를 보였다. 조기분만을 예측하는데 있어서 자궁경부 길이가 29 mm 이하인 경우 100%의 민감도, 89.5%의 특이도, 76.2%의 양성 예측도, 100%의 음성 예측도를 보였다. 결론: 조기진통이 있는 산모에서 경질초음파에 의해 측정된 자궁경부의 쇄기형[wedging]의 존재와 짧아진 자궁경부 길이는 조기분만의 예측자로서 유용할 것으로 생각된다. Objective: Our purpose was to test the hypothesis that characteristics of the cervix evaluated by transvaginal ultrasonography are associated with preterm labor and preterm delivery. Methods: Fifty-one patients with preterm labor of singleton pregnancy admitted to the hospital were evaluated by transvaginal ultrasonography before institution of treatment. Preterm delivery was defined as any delivery before 37 weeks of gestation. The ultrasonographic parameters evaluated were cervical length and presence of wedging. Data analysis was performed by the student t test and chi-square test. The p value $lt; 0.05 was considered significant. Results: The presence of cervical wedging and shorter cervical length were significantly associated with preterm delivery[p$lt;0.001]. The presence of cervical wedging in the prediction of preterm delivery in this data set yielded a sensitivity of 100%, a specificity of 81.6%, a positive predictive value of 65%, and a negative predictive value of 100%. The cervical length ≤ 29mm in the prediction of preterm delivery in this data set yielded a sensitivity of 100%, a specificity of 89.5%, a positive predictive value of 76.2%, and a negative predictive value of 100%. Conclusion: The presence of cervical wedging and shorter cervical length in patients with preterm labor measured by transvaginal ultrasonography are useful as a predictor of preterm delivery.

산후 심근병증 2 례

이권해,이승호,이해혁,이정재,이은찬,노경원 대한산부인과학회 1995 Obstetrics & Gynecology Science Vol.38 No.11

최근 순천향대학교 의과대학 부속병원 산부인과에서 각각 정상 자연분만과 제왕절개술 후에 호흡곤란과 전신적 부종 및 혈압상승을 보였던 산후 심근 병증 환자 2례를 임상적으로 경험 하였기에 문헌적 고찰과 함께 보고하는 바이다. Postpartum cardiomyopathy is a relatively uncommon from of heart failure that affects the women in the puerperium. It is usually defined as a cardiomyopathy occruing in the puerperium . An additional criteria includes the absence of other identifialbe cause of heart failure and the absence of other prior heart disease. It is important to recognize that the prognosis for this disorders is poor and that the mortality rate is generally ranged from 25 to 50 precent. Thus postpartum cardiomyopathy should be treated promptly and aggressively. We have experienced two cases of postpartum cardiomypathy which are presented with a brief review of the literatures.

폐경기 전후 여성의 임상적 특징에 관한 연구

이권해,이해혁,문원실,김상엽,이석민,이명환,김진수,구도형,이효환 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.8

본 연구에서 다음과 같은 결과를 얻었다. 1. 평균 폐경 연령은 만 48.3±4.1세였다. 2. 갱년기 증상 빈도는 Ⅰ군에서는 열성 홍조, 요통, 관절통 순, Ⅱ군에서는 요통, 관절통, 열성 홍조, 빈뇨 순, Ⅲ군에서는 요통, 빈뇨, 관절통, 열성 홍조 순이었으며, Ⅳ군에서는 요통, 관절통, 빈뇨, 불면증, 열성 홍조 순으 로 나타났다. 연령에 관계없이 전체 환자의 증상 빈도 순으로 보면 요통, 관절통, 열성 홍조, 빈뇨 등의 순서로 증 상이 나타났다. 3. 골밀도 측정의 결과는 요추 전후, 요추 측면, 대퇴 경부, 대퇴 Ward`s 삼각의 골밀도는 연령이 증가함에 따라 모두 통계학적으로 유의하게 감소하는 결과를 보였다. 4. 골대사의 생화학적 지표는 혈청 오스테오칼신치와 요중 디옥시피리디놀린 배설량은 연령의 증가에 따른 일관된 변화를 보이지 않았으며, 통계학적 유의성은 없었지만, 혈청 총 알칼라인포스파타제치는 연령이 증가함 에 따라 오히려 계속 증가되어, 폐경이 경과된 후에도 여 전히 골교체율이 증가되어 있는 경우가 많았다. 5. 혈청 지질의 변화에서 통계학적 유의성은 없었지 만, 혈청 총콜레스테롤치, 저밀도지단백콜레스테롤치와 중성지방치는 연령이 증가함에 따라 증가하는 양상이었으며, 고밀도지단백콜레스테롤치는 연령이 증가함에 따라 감소하였다. 6. 혈청 총 칼슘치와 혈청 요산치는 연령에 따른 변화가 없었다. 이상의 결과로 상당히 많은 폐경기 전후 여성이 폐경 기 증상으로 고통받고 골밀도가 감소하므로 호르몬 대 치요법을 적절한 시기에 시작한다면 갱년기의 불편한 증상을 줄이게 되고, 골밀도 및 혈청 지질 변화를 호전시 켜 폐경기 이후의 삶의 질을 향상시킬 것으로 기대된다. Purpose: We have evaluated the characteristics of perimenopausal women in Korea, by the age of menopause, climacteric symptoms, bone mineral density, biochemical bone markers and lipid profiles. Methods: There is 233 perimenopausal women who are divided into four groups (Group Ⅰ, Group Ⅱ, Group Ⅲ, Group Ⅳ) by age. The age distributions of Group Ⅰare below 50 years old. Those of Group Ⅱ, Ⅲ, Ⅳ are 51∼55 years old, 56∼60 years old and above 61 years old. We asked them for their climacteric symptoms and we checked them for the bone mineral density, biochemical bone markers and lipid profiles. Results : 1) The mean age of menopause is 48.3±4.1 years old. 2) The common symptoms of the Korean perimenopausal women were backache, arthralgia, hot flashing and urinary frequency in order of frequency. 3) The bone mineral densities of climacteric women were significantly decreased by increasing age. 4) The serum alkaline phosphatase among biochemical markers of bone turnover was significantly increasing state by increasing age. 5) The levels of serum total cholesterol, LDL-cholesterol and triglycerides were increasing tendency, but HDL-cholesterol was decreasing tendency by increasing age. 6) There are no variation by increasing age in the serum total calcium and serum uric acid. Conclusions: Increasing age had a great effect on bone mineral loss and lipid profiles in the climacteric women.

임신 일삼분기의 임신 종결을 위한 경구 미소프로스톨 투여와 질내 미소프로스톨 투여 방법에 따른 자궁경관 개대와 부작용의 비교

남계현,이권해,이임순,최승도,이해혁,이정재,신정옥,정한우,이항재 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.4

목적: 임신 일삼분기중 임신 중절 소파 수술을 위한 자궁경관 개대 목적으로 미소프로스톨[misoprostol]을 사용하는 경우, 질내 투여와 경구 투여의 자궁경관 개대 정도와 부작용을 비교하고자 하였다. 연구 방법: 1996년 3월부터 1998년 2월까지 임신 5-12주 사이에 치료적 유산을 목적으로 순천향대학교 의과대학 부속병원 산부인과에 입원한 환자중 불완전 유산을 제외한 66명을 대상으로 무작위로 추출하여 35명은 미소프로스톨을 질내 투여하고 31명은 경구로 투여하여 비교하였다. 미소프로스톨 질내 투여 군은 미소프로스톨 분말 100μg 을 질의 후원개에 삽입한 후 12시간 뒤, 경구 투여 군은 미소프로스톨 200μg을 경구 투여한 후 12시간 뒤에 소파 수술을 시행하였으며. 이 때 헤가[Hegar] 개대기를 이용하여 자궁경관의 개대 정도와 오심, 구토, 설사, 빈맥, 저혈압, 복부 통증, 질 출혈 등의 부작용을 비교하였다. 결과: 자궁경관의 개대 정도는 헤가[Hegar] 개대기 9번이 저항없이 통과하는 정도의 개대가 미소프로스톨 질내 투여군 87%, 경구 투여군 89%로 양군간에 통계학적인 차이가 없었다[p$gt;0.05]. 구토, 설사, 빈맥, 저혈압은 양군에서 발생하지 않았으며, 오심은 경구 투여군에서 5명[16%]에서 발생하였으나 질내 투여군에서는 발생하지 않았다. 복부 통증은 질내 투여군에서 8명[22.9%], 경구 투여군에서 6명[19.3%]이 발생하였다. 질 점상출혈은 질내 투여군에서 16명[45.7%], 경구 투여군에서는 8명[25.8%]으로 질내 투여군에서 의미있게 많았으나[p$lt;0.05] 그 양이 양 군 모두 경미하였다. 결론: 임신초기 치료적 유산을 목적으로 질내 미소프로스톨을 투여하는 방법과 경구 투여하는 방법은 자궁경관 개대와 부작용의 발생에서 양군간에 의미가 있는 차이는 없었다. Objective: To compare the effect of misoprosotol on the cervical dilatation and the side effects according to the route of administration in the first trimester therapeutic abortion. Methods: This study was made on 66 patients for therapeutic abortion except incomplete abortion at department of Obstetrics and Gynecology, Soonchunhyang University Hospital from March 1996 to February 1998. Thirty one women received 200㎍ of misoprostol tablet and thirty five women received 100㎍ of misoprostol as powder in the posterior vaginal fornix before 12 hours of curettage in the first trimester pregnancy. The extent of cervical dilatation was measured with Hegar dilatator and the side effects such as nausea, vomitting, diarrhea, tachycardia, hypotention, abdominal pain and vaginal spotting were compared. Results: The effect of cervical dilatation was not statistically different between the groups[oral misoprostol : 87% versus vaginal misoprostol : 89%]. The occurrence of vomiting, diarrhea, tachycardia and hypotension were none in both groups. Nausea was occurred only in the women receiving oral misoprostol[16%]. Abdominal pain was less frequent in the women receiving oral misoprostol than in those vaginal insertion [19.3% versus 22.9%]. Vaginal spotting was less frequent in the women receiving oral misoprostol than in those vaginal insertion[25.8% versus 45.7%]. But the amount of vaginal bleeding was only minimal, it was not clinically significant. Conclusions: There were no significant difference the cervical dilatation and side effects between the oral and vaginal administration of misoprostol except for vaginal spotting and nausea.

초기 임신에서 혈청 Progesterone 측정의 의의

남계현,이권해,이해혁,이정재,이석민,이명환,강준모 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.7

임신 4∼5주 사이의 초기 임신시 정상 임신군과 비정상 임신군의 혈청 progesterone치는 통계학적 유의한 차이를 보였다(p<0.05). 반면에 임신 6∼7주 사이의 임신시 비정상 임신군에서는 정상 임신군에 비해 혈청 progesterone치가 감소되어 있었지만, 통계학적으로 유의성은 없었다. 초기 임신에서 비정상 임신을 감별하고 예후를 결정하는 데 있어서 혈청 progesterone의 일 회 측정이 도움을 주며 비정상 임신을 예측하기 위한 혈청 progesterone 농도의 가장 적절한 임계 농도치는 14 ng/mL이었다. Objectives: To assess the prognostic value of a single maternal serum progesterone measurement in the immediate diagnosis of early pregnancy and in the long term prognosis of pregnancy outcome. Methods: Women with early pregnancies of 4∼7 weeks who visit to the hospital for a pregnancy test were included to this study. Measurement of serum progesterone was peformed prospectively. The comparative study groups were divided into two groups according to their final diagnosis retrospectively at each gestational age. Seventy patients were evaluated in this study. Normal intrauterine pregnancy group consisted of 34 patients with continuing pregnant with fetal heart activity by ultrasonography, abnormal intrauterine pregnancy group consisted of 36 patients with missed abortion, incomplete abortion and anembryonic pregnancy. Results: Progesterone levels were significantly lower in the abnormal intrauterine pregnancy (5.6±3.8 ng/mL, 11.5±5.8 ng/mL) than in the normal intrauterine pregnancy group (21.0±6.5 ng/mL, 20.3±6.6 ng/mL) at 4∼5 weeks of gestation (p<0.001, p<0.05), but were not significantly differentiated between two groups at 6∼7 weeks of gestation. The level of progesterone below 15 ng/mL conceived by receiver-operator characteristic curve was found to be detecting a abnormal pregnancy from comparative groups at 4∼5 weeks (specificity 88.9%, 77.0%, sensitivity 100%, 88.9%). Conclusions: A single serum progesterone measurement taken in 4∼5 weeks of gestation is valuable in the immediate diagnosis of early pregnancy and in the long term prognosis of pregnancy outcome. The best progesterone cut off point that predicts abnormal early pregnancy is 14 ng/mL.

골반벽을 침윤한 재발성 자궁경부암 환자에 대한 시술 1 예보고

김병기,박상윤,김종훈,박기복,이경희,이강현,이의돈,김미숙,이경화,황대용,조철구 대한산부인과학회 1995 Obstetrics & Gynecology Science Vol.38 No.11

최근 본원에서는 골반벽에 침윤된 국소 재발성 자궁경부암 환자를 대상으로 CORT를 시행하여 시술 후 6개월 현재 건강하게 살아 있기에 보고한다. 추가로 환자에서 CORT 에 대하여 설명할 때 대, 소변을 복부로 보게된다고 하면 치료를 포기하는 경향이 많은데 자궁암 말기의 비참한 죽음을 맞이하기보다 건강한 삶에 대한 희망을 갖고 새로운 삶을 영위하도록 권장되어져야 할 것으로 생각되며, 치료후에도 계속적으로 의료진과 가족들과 따뜻한 배려가 있어야 할 것으로 사료된다. The search for new treatment modalities for patients with recurrent gynecologic tumors infiltrating the pelvic wall appears to be of high priority in gynecologic oncology since the prognosis of these patients treated by conventional methods is very poor, although a significant number of patients might be cured if local control could be achieved. Recently, a combined operative and radiotherapeutic treatment(CORT) was developed for the treatment of pelvic wall recurrence based on considerations of tumor and radiation biology. We have experienced one case of CORT with good result. This case is presented with a brief review of the literatures.

한국형 자궁경부 촬영진 ( New Cervicography ) , 세포검사 그리고 HPV-DNA 검사를 이용한 새로운 자궁경부암 검진 모델 ( Model ) 개발

김승조(SJ Kim),박찬규(CK Park),이효표(HP Lee),남궁성은(SE Namkoong),강순범(SB Kang),서호석(HS Saw),이재관(JK Lee),김수녕(SN Kim),김재원(JW Kim),배석년(SN Bae),김찬주(CJ Kim),이근호(KH Lee),이선영(SY Lee),김인호(IH Kim),이찬(C Lee),이정노(JN Lee) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.5

N/A Objective : The false negative rate of conventional cytology is reported to range from 18 to 45%. It is necessary to develop more effective screening strategies that would ideally be more accurate than conventional cytology. This study is designed to investigate the potential of conventional cytology, cervicography, HPV-DNA testing and their combinations as primary screening techniques for cervical neoplasia. The purpose of this project is to develop the models and guidelines for screening tools of cervical cancer of the uterus by evaluating sensitivity, specificity and cost-effectiveness of all the screening methods. Study design : We conducted a screening of random sample of women who visited the department of OB-Gyn. of five different major university hospitals such as Catholic University Hospital, Korea University Hospital, Seoul National University Hospital, Yeonsei University Hospital and Pochon CHA University Bundang CHA Hospital, from May 1, 1996 to April 30, 1999. In a cohort women with an age range of 20 to 70 who underwent routine cytologic screening at Catholic University, Hospital Bundang CHA General Hospital and local clinics from April 1, 1996 to Decomber 31, 2000. cervicography (n=417,125) and testing for HPV-DNA (n=1,347) by the hybrid capture assay were studied for the ability of the cervical cancer screeuing. A new cervicography system with Kim's classification which was developed by Prof. Kim Seung Jo as an adjunctive method for the cervical cancer screening was applied in this cohort study. And then, accuracy, effectivencess, cost-effectiveness of the single or combined screening method were analysed. Result : Sensitivity and specificity of Pap smear were ranged from 55.6% to 83.1% and 72.8% to 88.3% respectively. The combination of Pap smear and cervicography had sensitivity from 89.7% to 98.6%, specificity from 68.2% to 93.2%. With combination of Pap smear, HPV DNA test and cervicography, sensitivity became also highest accuracy among all screening methods from 92.8% to 98.8%. Considering medical charges for diagnosis and social cost occurred by false positive and false negative results, the most cost-effective diagnostic modality was thought to be the combination of Pap smear and cervicography(91,433 won). In patients who were diagnosed as LSIL, colposcopic examination confirmed progression to high grade intraepithelial lesion(HSIL) in 10.7% patients, persistence of LSIL in 55% patients during the 3 year follow-up period. Accuracy of the screening for cervical cancer and CIN can significantly be improved by cytology with new cervicography rather than cytology alone. We concluded that cervicography can be important adjunctive tests for cervical cytology, improving the effectiveness of cervical screening by allowing a more sensitive detection of cervical neoplasia.

상피성난소암에서 p53 및 HER-2/neu 유전자 관련 단백의 발현과 DNA 분포양상에 관한 연구

이규완,김혜선,이낙우,염범우,장기훈,이용호 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.11

Expression of mutant p53 and HER-2/neu oncoprotein is thought to be prognostic indicies in patients with epithelial ovarian cancer. DNA ploidy and SPF(S-phase fraction) are also tho-ught to be biologic or prognostic indicies in epithelial ovarian cancer. The present study was carried out to investigate the expression and prognostic role of mutant p53, HER-2/neu oncopr-otein, and DNA ploidy in epithelial ovarian cancer. Another purpose of this study was to evalu-ate the relationship between these molecular characteristics(HER-2/neu, p53 dncoprotein and DNA ploidy) and other prognostic factors(stage, grade, histologic type). We reviewed archival specimens from 41 patients with epithelial ovarian cancer diagnosed during the period 1988∼1994. Immunohistochemistry was used to detect p53 and HER-2/neu oncoprotein expression. We used flow cytometry to calculate DNA ploidy and S-phase fraction. Kaplan-Meier method and log-rank test were used to analyze clinical and molecular data with respect to survival. The obtained results are summarized as follows: 1. Expression of p53 oncoprotein was demonstrated in 48.8% of the tumors and was associated with a 36.3% probability of 5-year survival, compared to a 67.4% probability of 5-year survival for the p53 oncoprotein negative cohort(p=0.019). 2. There was no significant relationship between overall survival and HER-2/neu oncoprotein expression. 3. Coexpression of p53 and HER-2/neu oncoprotein was associated with a 16.7% probability of 5-year survival, compared to a 66.7% probability of 5-year survival for the p53 and ER-2/neu oncoprotein negative cohort(p=0.021). 4. The percentage of p53 and HER-2/neu expression was higher in advanced ovarian cancer(stage Ⅲ, Ⅳ), although statistical evaluation was not significant. p53, HER-2/neu oncoprotein expression had no correlation with tumor grade or histologic type. 5. About 58.5% of tumors were aneuploidy, which was associated with poor prognosis(p=0.042). S-phase fraction greater than 15% showed similar trends(p=0.018). It is suggested that molecular charcteristics provide objective data that may be useful in predicting prognosis in patients with epithelial ovarian cancer. But further investigation of molecular and genetic characteristiics are needed to refind our diagnositc and treatment modalities.

만삭임신부의 유도분만에서 Misoprostol 경구투여와 Dinoprostone 경구투여의 비교

이우영,이병익,임문환,김우성,원영석,이정례,방금화 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.9

1997년 1월부터 1997년 12월까지 인하대학교병원 산부인과에 유도분만을 목적으로 내원한 산모 120명을 대상으로 misoprostol 경구투여 및 dinoprostone 경구투여를 통해 그 효능과 안전성을 비교하여 다음과 같은 결론을 얻었다. 경구 misoprostol 사용군 60명과 경구 dinoprostone 60 명은 무작위로 선별되었으며, 양 군간의 연령, 분만력, 임신주수에는 차이가 없었다. 유도분만시작전 Bishop 점수는 양 군간에 유의한 차이는 없었다. 경구복용 후 질식 분만까지의 시간은 mi soprostol군에서 통계적으로 유의하게 짧았다(p<0.05). 유도분만중 oxytocin 정맥주입이 필요했던 경우는 miso prostol군에서 빈도가 높았고 12시간내 분만의 빈도는 misooprostol 경구투여군이 높았으며(p<0.05), 12시간에 서 24시간 사이의 분만의 빈도는 dinoprostone군에서 높았다(p<0.05). 양 군간에 태아곤란증, 빈맥 수축 및 과도긴장, 과자극 증후군의 빈도, 자궁수축억제제의 사용 빈도, 분만실패 빈도와 분만 방법을 비교할 때 유의한 차이가 없었으며 산모의 합병증도 양 군에서 통계적으로 차이가 없었다. 이와 같은 결과를 볼 때 만삭 임신의 유도 분만에 있어서 경구 misoprostol이 dinoprostone 경구투여보다 더 빨리 분만이 이루어졌고, 태아와 산모에 미치는 영향은 차이가 없었으며, 경구 misoprostol 또한 효과적이고 안전한 유도분만을 위한 방법으로 생각된다. 그러나 앞으로 misoprostol 경구 투여의 적절한 용량과 안전성에 대한 더 많은 연구가 필요할 것으로 사료된다. This study was to compare oral misoprostol with oral dinoprostone for induction of labor at term pregnancy. One hundred twenty patients at term were randomized to receive either 200μg of misoprostol orally or 0.5 mg dinoprostone 1 tablets orally every 1 hour for a maximum of six tablets. Labor was induced with intravenous oxytocin infusion 8 hours after the onset of oral medication if the patients did not go into labor. We compared the frequency of oxytocin augmentation, oral administration-to-delivery interval, vaginal delivery within 12 hours & 24 hours, intrapartum complications, induction failure, mode of delivery, neonatal outcomes, and maternal complications between two groups. There was a less frequency of oxytocin augmentation in the misoprostol group than in the dinoprostone group but there was no significant difference. The interval from oral administration to vaginal delivery was shorter in the misoprostol group (543.6 276.7 minutes) than in the dinoprostone group (864.4 272)(p<0.05). The frequency of vaginal delivery within 12 hours was higher in the misoprostol group (78.3%) than in the dinoprostone group (20.0%)(p<0.05) and the frequency of vaginal delivery within 12 hours to 24 hours was lower in the misoprostol group (6.7%) than in the dinoprostone group (53.3%)(p<0.05). There was no significant difference in intrapartum complications, the frequency of induction failure, mode of delivery, neonatal outcomes, maternal complications. Orally administered misoprostol is an effective than dinoprostone and safe agent for induction of labor at term pregnancy, however further studies are required to delineate an optimal dosing regimen for oral misoprostol.