Protective Effects of Hyperoside against Carbon Tetrachloride-Induced Liver Damage in Mice

Choi, Jun-Ho,Kim, Dong-Wook,Yun, Nari,Choi, Jae-Sue,Islam, Md. Nurul,Kim, Yeong-Shik,Lee, Sun-Mee American Chemical Society and American Society of 2011 Journal of natural products Vol.74 No.5

<P>In this study, the hepatoprotective effects of hyperoside (<B>1</B>), a flavonoid glycoside isolated from <I>Artemisia capillaris</I>, have been examined against carbon tetrachloride (CCl<SUB>4</SUB>)-induced liver injury. Mice were treated intraperitoneally with vehicle or <B>1</B> (50, 100, and 200 mg·kg<SUP>−1</SUP>) 30 min before and 2 h after CCl<SUB>4</SUB> (20 μL·kg<SUP>−1</SUP>) injection. Levels of serum aminotransferases were increased 24 h after CCl<SUB>4</SUB> injection, and these increases were attenuated by <B>1</B>. Histological analysis showed that <B>1</B> prevented portal inflammation, centrizonal necrosis, and Kupffer cell hyperplasia. Lipid peroxidation was increased and hepatic glutathione content was decreased significantly after CCl<SUB>4</SUB> treatment, and these changes were reduced by administration of <B>1</B>. Protein and mRNA expression of tumor necrosis factor-α (TNF-α), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and heme oxygenase-1 (HO-1) and nuclear protein expression of nuclear factor erythroid 2-related factor 2 (Nrf2) significantly increased after CCl<SUB>4</SUB> injection. Compound <B>1</B> suppressed TNF-α, iNOS, and COX-2 protein and mRNA expression and augmented HO-1 protein and mRNA expression and Nrf2 nuclear protein expression. These results suggest that <B>1</B> has protective effects against CCl<SUB>4</SUB>-induced acute liver injury, and this protection is likely due to enhancement of the antioxidative defense system and suppression of the inflammatory response.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2011/jnprdf.2011.74.issue-5/np200001x/production/images/medium/np-2011-00001x_0006.gif'></P>

척추주위근을 침범한 신경통양 근위축증(Neuralgic Amyotrophy) 2례

전포성,정상욱,김기찬,정호중 高神大學 醫學部 1998 高神大學醫學部 論文集 Vol.13 No.1-2

고객 보상 프로그램에서 중간 보상물의 위치가 소비자의 프로그램 참여의도에 미치는 영향 : 메시지 프레이밍과 메시지 표현 방법의 조절효과를 중심으로

전성률,주태욱,강호일 한국방송광고공사 2009 광고연구 Vol.0 No.83

오늘날 고객 보상 프로그램은 우리 일상에서 흔히 볼 수 있을 정도로 보편화된 판촉수단이 되었다. 하지만 지나치게 많아진 고객 보상 프로그램으로 인해 그 효과성에 대한 의문이 제기되고 있다. 따라서 본 연구에서는 효과적인 고객 보상 프로그램을 개발하기 위해 기존 연구에서 다루지 않은 다중 매개물(multimedium)이 제공되는 상황에서 소비자들을 보상 프로그램에 적극적으로 참여시키기 위한 방법을 살펴보았다. 즉, 고객 보상 프로그램에서 중간 보상물의 위치가 소비자의 참여의도에 미치는 차별적인 영향을 살펴보았으며, 노력에 대한 메시지 프레이밍 방법과 중간 보상물의 구제적인 제시 여부가 어떠한 조절효과를 발생시키는가를 살펴보았다. 연구 결과, 고객 보상 프로그램에서 중간 보상물이 전반부에 위치하는 경우, 후반부에 위치하는 경우에 비해 보상 프로그램에 대한 소비자들의 참여의도가 더 높게 나타났다. 또한 이러한 중간 보상물의 위치에 따른 효과의 차이는 중간 보상물까지 남아있는 노력에 대하여 메시지를 프레이밍 시키는 경우보다 이미 달성한 노력에 대하여 메시지를 프레이밍 시키는 경우에 줄어드는 것을 발견하였다. 그러나 중간 보상물의 제시 방법에 있어 중간 보물상을 구체적으로 제시하지 않는 경우에 비해 중간 보상물을 제시하는 경우 중간 보상물의 위치에 따른 효과의 차이는 줄어든다는 사실을 발견하였다. 따라서 본 연구는 다중 매개물이 제공되는 보상 프로그램에 있어 중간 보상물의 위치로 인해 발생되는 효과와 이를 조절할 수 있는 변수를 보여줌으로써 기존의 고객 보상 프로그램에 대한 연구를 더욱 확장시켜주었다. 마지막으로, 본 연구결과의 이론 및 실무적 시사점과 연구의 한계점 및 미래 연구방향에 대해서 논의하였다 Customer Reward Programs(CRP) have become so popular thesedays that they can be found easily in our daily fives. Accordingly, concerns have been raised about the effectiveness of CRPs because of its excessive popularity. This research investigates a CRP in which multiple interim rewards are offered to more actively motivate consumers to participate the promotion program. Especially, the present research looks into the effects of the placement - earlier or later - of an interim reward on consumer's intention to participate in the CRP. We also examine the moderating effects of how consumer's effort is framed and how concrete and vivid the interim reward is presented. The results are as follows: First, when the interim reward is offered, early in the program, people are more likely to participate in the program than when it is offered later. Second, there exists an interaction effect between the interim reward placement and the message framing of consumers' efforts, In detail, the differential effects of the interim reward placement decreases when the promotional message is framed to focus on what the consumer has obtained so far rather than what's remaining to acquire the interim reward. Third, the Level of concreteness in presenting the interim reward is also found to have a moderating effect. Specifically, the differential effects of the interim reward placement decreases when the interim reward is described in much detail compared to when the interim reward is presented in more abstract terms, Implications for researchers and practitioners are proposed and [imitations and future research issues are discussed in the conclusion.

척추주위근을 침범한 신경통양 근위축증 (Neuralgic Amyotrophy) 2례

전포성,정상욱,김기찬,정호중 고신대학교 의학부 1998 高神大學校 醫學部 論文集 Vol.13 No.1-2

Neuralgic amyotrophy is a clinical syndrome of unknown etiology characterized by the acute onset of severe shoulder girdle pain followed by motor weakness or paralysis, and variable sensory loss. Up to 90 percent of patients eventually recover within the third years and the treatment is symptomatic. Neurologic findings and electrodiagnostic studies are only useful diagnostic methods of neuralgic amyotrophy and other laboratory testing are frequently normal or nonspecific. We report two cases of neuralgic amyotrophy with paraspinal muscles involvement with review of literature.

신증후군, 단클론성 감마병증 및 다발성 골용해 병변으로 발현한 소형 림프구성 림프종 1예

유준호,안명주,김호중,이웅수,박용욱,박문향 한양대학교 의과대학 1999 한양의대 학술지 Vol.19 No.2

We reported here a 70-year-old woman with small lymphocytic lymphoma who was initially presented with recurrent nephrotic syndrome and later developed multiple bone lytic lesions and monoclonal gammopathy, mimicking plasma cell dyscrasia and only involving bone marrow without lymphadenopathy or hepatosplenomegaly. She responded to combination chemotherapy, including cyclophosphamide and prednisone with proteinuria disappearing. The unusual features of this case includes : (1) nephrotic syndrome of minimal change lesion as the initial manifestion in lymphocytic lymphoma, (2) only bone marrow involvement of lymphoma without organomegaly or lymphadenopathy, (3) the presence of multiple bone lytic lesions in conjunction with monoclonal gammopathy in a patient with lymphoma rather than multiple myeloma.

3관능성 BPA-3MA를 기질로한 광중합형 치면열구전색재의 물성 연구

박경준,김경남,안광덕,김광만,한동근,전호욱 대한치과기재학회 1998 대한치과재료학회지 Vol.25 No.2

The BPA-3MA(bisphenol-A trimethacrylate) in which one of two hydroxy group was substituted by methacrylate was synthesized by reaction of Bis-GMA with methacryloyl chloride. To investigate the possibility to apply BPA-3MA as matrix of composite resin or pit and fissure sealant, BPA-3MA(3MA) or Bis-GMA(GMA) as matrix, TEGDMA as diluent, CQ as photosensitizer, EDMAB as photoinitiator and 5㎛ pyrogenic silica as filler were used for making experimental sealants. In addition, these experimental sealants were compared to a commercial Concise L/C White sealant(CLW, 3M Co, U.S.A.) for flexural strength, diametral tensile strength, amount of abrasion, surface hardness, water sorption and solubility, and degree of conversion. The flexural strength of CLW was the highest value but there was not significant difference with 3MA. Diametral tensile strength of all 3 groups were similar(p>0.05) and the amounts of abrasion of 3MA and GMA were less than that of CLW(p<0.05). The surface hardness of 3MA was higher than that of GMA(p<0.05) but similar to that of CLW. The water sorption of 3MA was less than that of GMA and CLW(p<0.05) and the solubilities of 3MA and CLW were than that of GMA(p<0.05). GMA and CLW were relatively polymerized well as compared to 3MA. From these results, pit and fissure sealant using trifunctional BPA-3MA as matrix had superior physical and mechanical properties to existing Bis-GMA sealant. Furthermore, it will be possible to develop composite resin having superior properties to existing composite resin.

고출력 레이저를 이용한 인코넬 600 합금의 용접 특성 연구

송성욱,유영태,신호준 한국공작기계학회 2004 한국공작기계학회 춘계학술대회논문집 Vol.2004 No.-

The laser welding process is one of the most advanced manufacuring technologies owing to its high speed and deep penetration. Welding characteristics of Inconel 600 Alloy using a continuous wave Nd:YAG laser are experimentally investigated. The major process parameters studied in the present laser welding experiment were position of focus, laser power, travel speed. The gap and offset maintained as small as possible. Optical microscope were used to investigate the microstructures of the welded zone. The follow conclusions can be drawn the laser power and travel speed have a pronounced effect the fusion zone size and shape.

HPLC를 이용한 Alnus속 식물에서의 diarylheptanoids의 정량분석

정동욱,김준식,조수민,이연아,김광호,김세원,이민원 중앙대학교 약학연구소 1999 약학 논총 Vol.13 No.-

Quantitative determination of diarylheptanoids (oregonin and hirsutanonol), which were characteristic components of Alnus spp. has been conducted by High Performance Liquid Chromatography. The HPLC analysis was carried out using an YMC J'sphere ODS-H80 column [150×4.6mm, S-4μm. 80A(particle)] and a combination of acetonitrile and H2O was used as mobile phase in gradient solvent system. The results showed differnce in the species (Alnus japonica, A hirsuta and A. hirsuta var. sibirica)

고압전류 감전자에게서 나타난 말초신경병증 증례보고

손준석,김영욱,채창호,민경범,이철호 대한산업의학회 2006 대한직업환경의학회지 Vol.18 No.4

Background: With increasing industrial development, opportunities are growing to contact electricity in the workplace or home. Therefore, the risk of electrical accident has been increased gradually. In general, electrical injuries involve the extremities and result in amputation or severe disability of limbs. Delayed spinal cord injury and peripheral neuropathies following electrical accidents are extremely rare. Case report: A 32-year-old man with 10 years working experience at a CRT-monitor manufacturer with repetitive exposures to high voltage current visited our hosipital. He complained of left leg weakness and atrophy, and intermittent pain. The symptoms were progressive. Other symptoms occurred such as nocturia, hesitancy, and weak urinary stream. We examined the patient and conducted EMG, L-spine MRI, neurometer test, isokinetic strength test, and physical examination. The results showed neural injuries due to anterior horn lesions or compression of the left femoral nerve pathway, with a consequent diagnosis of neurogenic bladder.

정의적 특성이 수학적 문제 해결력에 미치는 영향

강호욱,노은환,박은진,송현준,이혜경,주채연 진주교육대학교 초등교육연구소 2005 科學敎育硏究 Vol.28 No.-

The purpose of this study is to provide some basic data which can be helpful for improving the methods of mathematics teaching-learning emphasizing the affective factors by investigating the effect on affective characteristics and mathematical problem solving ability of the students on the elementary school sixth grade. In order to achieve these purpose, the following research problems were set up for the present study: The results of this study are as follows: First, it was appeared that there was not any difference on attitude on mathematics, belief, self-confidence and the degree of mathematical problem solving ability by sex. Second, it was appeared that there was some statistical meaningful difference on attitude on mathematics, belief, self-confidence and the degree of mathematical problem solving ability according to high middle low ability on mathematics which the students think that they have. Based on the results of this study, I'd like to give some suggestions as followings to provide some help to teaching and learning mathematics. First, the succeeding studies are needed by selecting different population from the population of this study, classifying low-ranking factors consisting of affective characteristics differently from this study, compounding each low-ranking factors in various manners like using new items, etc. Second, the succeeding studies are needed in this part, because what mathematical belief teachers have mathematics can have an effect on students' mathematical belief and action as well as on teachers' thinking process and action in the class. Third, the succeeding studies are needed to develop concrete field study and program which can be helpful for improving actually students' affective behavior characteristics in school field.