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Estrogen이 Tetracycline의 肝毒性에 미치는 影響에 關한 實驗的 硏究
朴文香,白承龍 고려대학교 의과대학 1977 고려대 의대 잡지 Vol.14 No.1
There have been many reports that large doses of teracycline induce fatty infiltration of the liver in rats, and when it is given intravenously to pregnant women who have pyelonephritis, it may give rise to severe hepatic injuries. Although the mechanism is uncertain, tetracycline in high concentration seems to impair metabolism of fat and removal of triglycerides from the liver. While the toxic effect of tetracycline in obstetric patients is known, the effect of sex hormones on liver tissue damaged by tetracycline is not understood. The author performed biochemical and histopathologic studies to clarify the effect of estrogen on tetracycline-induced hepatic damage in male albino rats weighing about 200 grams. The experimental animal were grouped into four categories: Group Ⅰ, normal control group, was intraperitoneally injected with 1㎖/day of normal saline for 4 weeks. Group Ⅱ, tetracycline administered group, was intraperitoneally injected with 75.5㎎/㎏/day of tetracycline for 4 weeks. Group Ⅲ, estrogen administered group, was intramuscularly injected with 6.25㎎/㎏/day of estradiol for 4 weeks. Group Ⅳ, tetracycline and estrogen combined administered group, was injected in the same manner as group Ⅱ and Ⅲ in combination. For 4 weeks. The results obtained were as follows: 1. In group Ⅱ, the values of globulin (at 3rd & 4th week), T.T.T., ammonia, total cholesterol, G.P.Y., G.P.T and alkaline phosphatase were significantly increased more than those of the normal control group. 2. In group Ⅱ, the values of globulin (at 4th week), ammonia, total cholesterol, alkaline phosphatase, G.O.T. and G.P.T. were slightly increased more than those of the normal control group, but less than the values shown by group Ⅱ. 3. In group Ⅳ, the values of ammonia, total cholesterol, alkaline phosphatase, G.O.T and G.P.T. were slightly increased more than those of the normal control group, and revealed results similar to those of group Ⅱ, but the values were significantly lower than those shown by group Ⅲ. 4. The values of protoporphyrin were especially decreased in group Ⅱ, while those in group Ⅲ and Ⅳ were observed to be similar to those of the normal control group. 5. In the histopathologe findings of the liver, hepatocytic injuries and vacuolar degeneration, which were most severe during the 1st and 2nd week, were observed in the test groups. There was no evidence of either cholestasis of change in bile duct epithelium. In summary the biochemical changes of the blood (liver function test) have yieled more significant data than the histopathologic changes of the liver. Comparison of the data shows that in group Ⅱ the biochemical alterations were much more significant than in group Ⅳ. The results we obtained in the experiment have indicated that estrogen exerted a protective effect against tetracycline-induced hepatic dysfunction.
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박문향,진소영,정현주,성순희,임범진,한지영,홍순원,임현이,최영진,조영미,강명재,문경철,차희정,하승연,강미선,설미영,서광선,주종은,김용진,원남희 대한병리학회 2010 Journal of Pathology and Translational Medicine Vol.44 No.6
Background : To standardize renal biopsy reporting and diagnosis, The Renal Pathology Study Group of the Korean Society of Pathologists (RPSKSP) has developed a renal pathology reporting format for the native and allograft kidney. Methods : A consensus checklist of a provisional renal biopsy format was sent to all members of the RPSKSP. Feed back opinions regarding the practical application of the checklist to the diagnostic work were received. Results : Kidney biopsies require three essential examinations: by light microscopy, immunofluorescence (IF), and electron microscopy (EM). A final report of a renal biopsy should include information on specimen adequacy and a description of the morphologic change using a systematic semiquantitative method for each of the compartments, with optional separate IF and EM reports. Conclusions : A standard renal biopsy report format is important in establishing clinicopathologic correlations, making reliable prognostic considerations, comparing the findings in sequential biopsies and evaluating the effects of therapy. This renal report system could encourage nationwide multi-institutional collaborative studies.
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