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구강점막 부착용 케토프로펜 고분자 필름의 제조 및 평가
박진석,이상은,강봉석,이경록,이은주,박정숙 충남대학교 약학대학 의약품개발연구소 2014 藥學論文集 Vol.29 No.-
Abstract – The objective of this study was to prepare ketoprofen-loaded buccal adhesive patch. The adhesive patch was formulated by casting method using aqueous soluble polymer povidone K17 (PVP 17PF) as film-forming agent and hydroxypropylmethylcellulose (HPMC) as adhesive agent. To compare the effect of HPMC type, different molecular weight of K4M and K15M HPMC was used. The physicochemical properties of patches such as appearance, thickness, in vitro release, and adhesiveness were investigated. The concentration of ketoprofen was determined spectrophotometrically at a wavelength of 233 nm. The appearance of prepared patches was semi-transparent, light-yellow or almost colorless, and odorless. Thickness of each patches (n=6) was 0.895 ± 0.033 mm for K4M patch and 0.727 ± 0.036 mm for K15M patch. In vitro release test, both K4M and K15M patches showed over 20% release within 30 min. At 120 min, K4M and K15M patches demonstrated 95% and 67.5% release of ketoprofen, respectively, and up to 240 min, both patches released drug completely. Maximum adhesive force of K4M and K15M patches was 6.571 ± 2.703 gf and 2.735 ± 1.151 gf, respectively. Moreover, it took 28.29 ± 0.38 sec and 28.30 ± 0.34 sec for K4M and K15M patch to peel off them after adhesion, showing no significant difference. In conclusion, thickness, in vitro release, and maximum adhesive force could be modulated by alteration of polymer types.
정봉식,이규한,김진길 東亞大學校 附設 情報通信硏究所 1999 情報通信硏究所論文誌 Vol.7 No.1
In this paper the band-stop filter that rejects the undesired 3th and 5th harmonics generated from high frequench generator is analyzed and optimized. The length of the band-stop filter is setup initially a quarter of a wavelength fo the harmonic, but initial filter structure is unable to cutoff the harmonics because of the fringing effect at the input of the choke. To reduce the mismatch between the cutoff frequency and the harmonics, the length of the choke is optimized by using iterative Levenberg-Marquardt Algorithm.
등방성 이종재료 내의 Ⅴ-노치 균열에 대한 응력강도계수 결정에 관한 연구
조상봉,정휘원,김진광 경남대학교 신소재연구소 1999 論文集 Vol.11 No.-
접합계면 V-노치 균열 문제는 고유치와 고유벡터 문제로 수식화할 수 있다. V-노치 균열첨단에서 응력특이성을 가지는 고유치가 존재한다. 상반일 등고선 적분법(RWCIM)은 고유치와 관련된 고유벡터의 계수를 구하는 한 가지의 방법이다. 상반일 등고선 적분법을 이용하여 접합계면 균열의 응력확대계수를 구하도록 시도하였다. 상반일 등고선 적분법으로 구한 응력확대계수와 경계요소법과 변위외삽법을 이용하여 구한 결과를 비교하였다. An inteiface 17-notched crack problem can be formulated as a eigenvalue problem. there are the eigenvalues which give stress singularities at the V-notched crack tip. The RWCIM is a method of calculating the eigenvector coefficients associated with eigenvalues. Obtaining the stress intensity factors for an interface crack in dissimilar materials was examined by the RWCIM. The results obtained for stress intensity factors using RWCIM were compared with those obtained by using the displacement extrapolation method and the BEM.
운동형태의 차이가 Alloxan유발 당뇨쥐의 혈당 및 인슐린 농도에 미치는 영향
윤진환,정일규,김종오,이희혁,지용석,오봉석,채정룡 대한스포츠의학회 2003 대한스포츠의학회지 Vol.21 No.1
The Purpose of this study was to investigate the effect of exercise intensity on blood glucose and insulin levels in diabetic rats with alloxan. Twenty sprague-dawley male rats were assigned to power training groups(n=10) and endurance training groups(n=10). Diabetes was induced by single injection of alloxan(50 mg/kg B.W) Blood glucose and insulin were determined every week for 4-weeks. The conclusion of this study follows as below: 1) There was significantly different on blood glucose levels in two groups. 2) There was significantly different on insulin levels in two groups These results suggest that proper exercise intensity in diabetic rats can significantly decrease blood glucose and insulin level and make good glycemic control. In conclusion, it has been found that regular prolonged endurance training with diabetic rats, improves insulin and blood glucose.
공간능력, 시지각 회상 능력, 학습양식에 따른 지구와 달의 운동 개념
김봉섭,정진우,양일호,정지숙 한국교원대학교 과학교육연구소 1998 청람과학교육연구논총 Vol.8 No.1
The purpose of this study was to investigate the relationship among spatial ability, learning styles, visual-perception-recall ability, and the conceptual construction of the earth and moon's motion. Four paper-and-pencil tests were used to measure students' cognitive variables. Spatial ability was measured by Spatial Visualization Test, visual-perception-recall ability was measured by Rey's Figure which also have used to test visual-perception-recall ability of right-temporal lobes, and VVT were used to investigate students' learning styles. Further, the test of concept construction was consisted of 15 items about the earth and moon's motion developed by researcher. One hundred and twenty-seven 6th-, one hundred and sixteen 7th-, eighty-seven 9th-grade, ninety-three college students were participated in the investigation of the effects of age and learning style on conceptual construction. In the analysis of students' performances, spatial ability, visual-perception-recall ability, and conceptual achievement showed an increasing pattern with grading. In addition, visual learner's conceptual achievement showed a significantly higher score on conceptual test than verbal learner's(p<0.05). The results of the present study supported the hypothesis that learning styles would differently influence to learning atmospheric concepts by students' learning styles. This study also indicated to be considered the students' spatial ability in learning atmospheric concepts.
최낙진,류정호,강봉휘,이광우,이덕동 경북대학교 센서기술연구소 1997 센서技術學術大會論文集 Vol.8 No.1
The semiconductor gas sensors with a tin oxide as the raw material have been generally used to detect gases in the principle of electrical conductivity variation. However, it was difficult to design the gas detection system due to the non-selectivity, the non-stability and the influence of temperature, humidity etc. Therefore, it was proposed NDIR(non-dispersive infrared) method using pyroelectric infrared sensor to overcome the disadvantage of the semiconductor gas sensors. This method has been recently used to detect various gases in industrial parts. It has the advantages of selectivity, stability and responsibility. The gases used in this paper were CO_(2)(carbon dioxide) and HC(hydrocarbon) series. The system was designed with the Intel MCU i8097BH microprocessor. Main topics were to remove interference effect for other gases and to minimize influence for ambient circumstance by using the software and the hardware techniques.