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Sulfadimethoxine 투여에 의해 유발된 갑상선 증식성 병변에 나타난 피막 섬유화의 병리학적 특성
김혜성,손화영,조성환,최종윤,윤원기 충남대학교 수의과대학 동물의과학연구소 2001 動物醫科學硏究誌 Vol.9 No.-
Sulfadimethoxine (SM) is one of the anti-thyroid (goitrogenic) agents and has a thyroid tumor promoting effects. In this study, we analyzed the pathology of SM induced thyroid proliferative lesions to see if these lesions showed any distinctive features. Five-week-old male F344 rats were given a single subcutaneous injection of N-bis(2-hydroxypropyl)nitrosamine (DHPN: 2800㎎/㎏, body weight). Starting one week thereafter, SM (1000 ppm in drinking water) was administered for 12 weeks. All animals were autopsied and histopathological observation of the thyroids was perfomed. Thyroid follicular proliferative lesions were induced in all rats treated with SM. In addition, the formation of thick perithyroidal fibrous capsule and pleomorphic follicles within the capsule were observed. These pleomorphic follicles showed invasive figure in some area, especially around follicular adenomas and adenocarcinomas. This confuses adenoma with adenocarcinoma. However, pleomorphic follicles were also observed in the area without adenomas and adenocarcinomas. Therefore, we suggest that it should be careful to diagnose adenoma and adenocarcinoma in the presence of the invasive lesions in surrounding fibrous tissue, especially SM induced thyroid lesion.
Synthesis of ruthenium complex and its application in dye-sensitized solar cells
Hye-Kyung Song,박영호,한치환,Jong-Gi Jee 한국공업화학회 2009 Journal of Industrial and Engineering Chemistry Vol.15 No.1
An amphiphilic bipyridyl ligand, 4,40-dicarboxy-octyl-2,20-bipyridine, and its ruthenium(&) complex (termed as S8) were synthesized and characterized by UV/Vis, IR and NMR spectroscopy. The performance of this S8 complex as charge transfer photo-sensitizer in TiO2-based dye-sensitized solar cells was studied under standard AM 1.5 sunlight and by using an electrolyte consisting of 0.70 M 1,2-dimethyl-3-propyl-imidazolium iodide, 0.10 M LiI, 40 mM iodine and 0.125 M 4-tert-butylpyridine in acetonitrile. Aliphatic chains linking to carboxylate groups of S8 act as an effective electron donor and carboxylate groups act as an effective electron withdrawing between the TiO2 layer and the carboxylate linking TiO2 layer leading to increasing of electron density at this interface, which is attributed to increasing efficiency of electron injection to the TiO2 conduction band from the excited state of dye. The complex, S8, gave a photocurrent density of 13.02 mA/㎠ 0.60 V open circuit voltage and 0.69 fill factor yielding 5.36% efficiency. The S8 dye with aliphatic chain improved conversion efficiency of the resulting DSSCs compared with a cell fabricated using the N3 dye.
전국 12개 병원 환자에서 분리된 Extended-Spectrum β-Lactamase 생성 Escherichia coli와 Klebsiella pneumoniae
송원근,이경원,김선주,정석훈,장철훈,신혜정,조성란,안지영,어영,신종희,이혜수,홍성근,용동은,정윤섭 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.4
목적 : Extended-spectrum β-lactamase(ESBL) 생성 그람음성간균에 관한 연구가 우리나라에서도 있으나 전국 규모의 연구가 없었으므로 ESBL 생성 Escherichia coli와 Klebsiella pneumoniae의 비율을 검체별, 환자별로 규명하고 다른 항균제에 대한 감수성 양상을 조사하고자 하였다. 방법 : 1999년 9월부터 12월 사이에 전국 12개 병원의 임상검체에서 분리된 일련의 E. coli 1,171주와 K. pneumoniae 585주를 대상으로 하였다. ESBL 생성균주의 선별은 cefpodoxime, cefotaxime, ceftazidime, 및 aztreonam 디스크로 시험하여 National Committee for Clinical Laboratory Standards의 기준에 따라 해석하였고, double disk synergy 시험 양성인 경우를 ESBL 생성균주로 판정하였다. 결과 : 참여 병원 모두에서 ESBL 생성균주가 확인되었다. 균종별 ESBL 생성균주의 비율은 E. coli가 9.8% (3.5-19.6%)이었고, K. pneumoniae가 25.6% (10-41.3%)이었다. 검체 별로는 객담에서, 환자별로는 중환자실에서 분리된 ESBL 생성균주의 빈도가 각각 27.4%와 31.7%로 가장 높았다. ESBL 생성균주의 aminoglycoside제와 co-trimoxazole에 대한 내성율은 ESBL 비생성균주보다 현저히 높았다. 결론 : ESBL 생성 E. coli와 K. pneumoniae는 국내 병원에 널리 퍼져 있었으며, 요와 객담 검체에서 흔히 분리되었고, 중환자실 환자에서의 분리율이 높았고, 다른 항균제에 대한 내성율이 ESBL 비생성균주에 비해 높았다. Background : Presence of extended spectrum β-lactamase (ESBL) -producing gram-negative bacilli have been reported in Korea, but our understanding of the prevalence is limited. The aim of this study was to determine the nationwide prevalence and antimicrobial susceptibility of ESBL -producing Escherichia coli and Klebsiella pneumoniae, and to characterize the patients and sources. Methods: A total of 1.171 E. coli and 585 K. pneumoniae non-duplicate isolates were collected from 12 hospitals in September to December 1999. ESBL production was determined by National Committee for Clinical Laboratory Standards methods using cefpodoxime, cefotaxime, ceftazidime, and aztreonam disk. Positive double disk synergy tests were considered ESBL producers. Results : ESBL-producing E. coli and K. pneumoniae isolates were detected from all 12 hospitals. The proportion of ESBL-producers was 9.8% (3.5-19.6%) of the E. coli and 25.6% (10-41.3%) of the K.. pneumoniae isolates. The common source of ESBL-producers was sputum (27.4%) and patients in intensive care unit (31.7%). ESBL-producing isolates were more often resistant to aminoglycosides and cotrimoxazole. Conclusion : ESBL-producing E. coliand K.. pneumoniae are widespread to all levels of Korean hospitals. ESBL-producers are more prevalent among isolates from urine and sputum and from intensive care unit patients. These organisms are more often resistant than the non- ESBL -producers to amjnoglycosides and cotrimoxazole.
( Hye Sook Min ),( Jung Eun Kim ),( Mi Hwa Lee ),( Hye Kyoung Song ),( Mi Jin Lee ),( Ji Eun Lee ),( Hyun Wook Kim ),( Jin Joo Cha ),( Young Youl Hyun ),( Jee Young Han ),( Dae Ryong Cha ),( Young Sun 대한신장학회 2014 Kidney Research and Clinical Practice Vol.33 No.1
Background: Obesity-related metabolic disorders are closely associated with inflammation induced by innate immunity. Toll-like receptors (TLRs) play a pivotal role in the innate immune system by activating proinflammatory signaling pathways. GIT27 (4,5-dihydro-3-phenyl-5-isoxasole acetic acid) is an active immunomodulatory agent that primarily targets macrophages and inhibits secretion of tumor necrosis factor α [as well as interleukin (IL)-1β, IL-10, and interferon γ]. However, the effect of TLR antagonist on kidney diseases has rarely been reported. We investigated whether the TLR antagonist GIT27 has beneficial effects on the progression of kidney disease in obese mice on a high-fat diet (HFD). Methods: Six-week-old male C57BL/6 mice were divided into three groups: mice fed with normal chow diet (N=4); mice fed with a HFD (60% of total calories from fat, 5.5% from soybean oil, and 54.5% from lard, N=4); and GIT27-treated mice fed with a HFD (N=7). Results: Glucose intolerance, oxidative stress, and lipid abnormalities in HFD mice were improved by GIT27 treatment. In addition, GIT27 treatment decreased the urinary excretion of albumin and protein in obesity-related kidney disease, urinary oxidative stress markers, and inflammatory cytokine levels. This treatment inhibited the expression of proinflammatory cytokines in the kidneys and adipose tissue, and improved extracellular matrix expansion and tubulointerstitial fibrosis in obesity-related kidney disease. Conclusion: TLR inhibition by administering GIT27 improved metabolic parameters. GIT27 ameliorates abnormalities of lipid metabolism and may have renoprotective effects on obesity-related kidney disease through its anti-inflammatory properties.
Efficient MIMO Receiving Technique in IEEE 802.11n System for Enhanced Services
Jee-Hye Lee,Myung-Sun Baek,Hyoung-Kyu Song IEEE 2007 IEEE transactions on consumer electronics Vol.53 No.2
<P>A combining of MIMO signal processing with OFDM is regarded as a promising solution of enhancing the performance of next generation WLAN system. Therefore, in this paper, IEEE 802.1 In system employing layered space-time architecture is considered for a high-rate transmission service. However, the IEEE 802.1 In system with V-BLAST scheme has not reached the available capacities due to imperfect nulling and cancellation. In this paper, efficient detection is proposed for IEEE 802.11 n system. In this proposed scheme, T probable streams are detected according to the first detected sub-stream of DFE detector and most probable stream is selected by likelihood test, since the performance of V-BLAST system depends on the first sub-stream detection capability. It has been shown that the performance of IEEE 802.1 In system can be improved by adopting the proposed detection, and the decoding complexity and system performance can be controlled by adjusting the number of T<SUP>1</SUP>.</P>