정신분열증의 음성증상 및 양성증상의 연관성

유재학,박광식 국립서울정신병원 1993 臨床硏究論文集 Vol.1993 No.-

기술교과 교육 제도 및 연구의 국제적 동향 : ICTES '95 발표 논문을 중심으로 through Analyzing of Papers Presented at the ICTES '95

이재원,김진순,류창렬,노태천,최완식,최유현,송일민 충남대학교 공업교육연구소 1995 論文集 Vol.18 No.1

The purposes of this study were: (a) to analyze the papers presented at the ICTES according to the papers' representing countries and their main subjects, (b) to analyze the educational systems of the countries in technology education, and (c) to review the international trends of technology education through the papers presented at the conference. The papers(64 total) presented at the ICTES could be classified into eight countries of papers representing Japan(37), Taiwan(8), Korea(6), U. S. A.(3), India(3), Philippines(3), China(2), Singapore(2). The main subjects the papers dealt with could also be classified into educational system/history(9). curriculum/objectives and contents(9), international activities(9), methods/teaching-learning process and teaching materials and new media(40). Followings were the major and new issues presented at the ICTES: (a) Introduction of each country's technology education system. (b) Proposition of a new framework for technology education and a world core curriculum in technology education. (c) Creativity and problem-solving for the instructional method of technology education. (d) Methods and utilization of high technology media in technology education. (e) Necessity of engineering concept in technology education in technology oriented society. (f) Proposition of philosophical direction of technology education based on famous Asian philosophers.

진균성 부비동염 환자의 상악동내 농성 분비물에 대한 세균 배양 및 항생제 감수성 결과

이윤식,김용재,김재호,정유삼,이봉재 대한이비인후과학회 2000 대한이비인후과학회지 두경부외과학 Vol.43 No.10

초음파 시험법에 의한 실존 콘크리트 구조체의 압축강도 추정식에 관한 연구

권영웅,유재은,신정식 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2

This study concerns the new strength equation of concrete by ultrasonic pulse velocity test. There are not only few estimate strength equations of concrete by nondestructive test, but also many problems to apply them because of time, cost, easiness, structural damage, reliability and so on. For this study, there performed a series of test and proposed a equation as follows ; Linear : fck = 70.57Vp - 222.9, r²=91.3% Quadratic : fck = 19.868Vp² - 76.6Vp + 48.1, r²=91.7% here, fc estimated compressive strength of concrete by MPa Vp : Ultrasonic Pulse Velocity of concrete by km/sec.

소아과 입원 환자에 대한 통계적 고찰

정용현,서우식,유재홍,변상현 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.2

For the purpose of assessing the disease patterns by the body organ system in patients of the pediatric age, we performed a statistical analysis of diseases of patients admitted to the department of pediatrics at Chungnam National University Hospital from January 1990 to December 1994. The results obtained were as follows : 1. Total numbers of in-patients were 8,007, of which 4,923 were male and 3,084 were female. The ratio male to female was 1.60 : 1. 2. Prevalence of the diseases classified by body organ system was in the following order : neonatal diseases (34.6%), respiratory diseases (17.4%), infectious diseases (11.5%), congenital anomalies (5.5%), digestive diseases (5.1%), genitourinary diseases (4.9%), neoplasm (4.7%), blood diseases (3.3%), nervous system diseases (2.8%), metabolic and endocrine diseases (2.4%), circulatory system diseases (2.3%), skin and subcutaneous diseases (1.3%), musculoskeletal and connective tissue diseases (1.2%), mental and behavior disorders (0.4%). 3. Major diseases in each body organ system were as follows : 1) infectious diseases : unspecified acute gastroenteritis (35.9%), viral meningitis (10.4%), Rotaviral enteritis (6.8%), sepsis (6.7%), measles (5.8%). 2) neoplasm ; ALL (34.1%), AML (15.8%), Wilms tumor (12.8%), NHL (8.2%), neuroblastoma (5.6%) 3) blood diseases : allergic purpura (24.2%), aplastic anemia (17.1%), ITP (16.4%), iron deficiency anemia (15.8%). 4) metabolic and endocrine diseases : short stature (22.0%), hypocalcemia (13.8%), metabolic acidosis (9.6%), IDDM (6.4%). 5) mental and behavior diseases : neurosis (47.7%), mental retardation (18.2%). 6) Nervous and sensory system diseases : epilepsy (43.2%), cerebral palsy (12.1%), otitis media (9.3%), encephalopathy (6.2%). 7) circulatory system diseases: congestive heart failure (29.2%), dilated cardiomyopathy (8.0%), rheumatic fever (8.0%), mitral insufficiency (6.8%), hypertension (6.4%). 8) respiratory diseases : pneumonia (40.1%), URI (9.6%), acute tonsillitis (9.4%), asthma (8.5%), acute bronchiolitis (8.3%), croup (7.1%), acute bronchitis (4.1%). 9) digestive system diseases : unspecified hepatitis (22.8%), acute gastritis (13.8%). CAH (12.6%), intussusception (7.8%), constipation (7.1%). 10) skin and subcutaneous diseases : cellulitis (23.1%), lymphadenitis (19.7%), urticaria (15.6%), atopic dermatitis (8.8%), furuncle (8.2%). 11) musculoskeletal and connective tissue diseases : Kawasaki disease (76.8%), JRA (8.5%), SLE (7.0%). 12) genitourinary system diseases : UTI (29.0%), minimal change nephrotic syndrome (27.3%), APSGN (7.6%), APN (4.9%). 13) congenital or chromosomal abnormalities : VSD (38.7%), ASD (10.5%), TOF (8.4%), PDA (5.2%), CHPS (4.5%), Down syndrome (4.1%). 14) neonatal diseases : jaundice (32.0%), prematurity (12.7%), RDS (5.7%), sepsis (4.5%), birth asphyxia (3.0%), SGA (3.0%). 15) Others : febrile convulsion (45.6%), failure to thrive (9.2%), FUO (8.9%), drug intoxication (8.2%). 4. Common diseases for admission in pediatrics were in the following order : jaundice, pneumonia, unspecified acute gastroenteritis, VSD, RDS, URI, acute tonsillitis, acute lymphadenitis, ALL, sepsis, asthma, acute bronchiolitis, UTI.

데스크탑 마이크로 성형시스템의 가진성형에 따른 동특성 연구

홍동표,고유곤,홍용,김현식,이재완 한국공작기계학회 2009 한국공작기계학회 춘계학술대회논문집 Vol.2009 No.-

In this study, a desktop forming system which enables hydro dynamic bearing forming was developed. It consists of power train system, frequency forming system, manufactured Die-set, and controller of desktop forming system. The desktop micro forming system is focused on a higher load capacity and a shorter forming time than conventional system. Therefore it was designed for power train capability and load condition of Ball Screw. Moreover, a Piezo actuator was installed to make accurate machining possible, however, the Piezo actuator generate noise and vibration. Thus we performed the analysis of dynamic characteristics through the experiment about developed system in order to reduce such problems and discuss the alternative methods.

Src/Syk-Targeted Anti-Inflammatory Actions of Triterpenoidal Saponins from Gac ( <i>Momordica cochinchinensis</i> ) Seeds

Yu, Jae Sik,Kim, Jun Ho,Lee, Seulah,Jung, Kiwon,Kim, Ki Hyun,Cho, Jae Youl World Scientific Publishing Company 2017 The American journal of Chinese medicine Vol.45 No.3

<P><I>Momordica cochinchinensis</I> Spreng (family Cucurbitaceae), also known as gac, or red melon, is an edible Southeast Asian fruit valued for its nutritional and medicinal properties. Specifically, Momordicae Semen, the seeds of the gac fruit, is used in traditional Chinese medicine to treat boils, rheumatic pain, muscle spasm, hemorrhoids, and hemangiomas. In this study, a chemical investigation into a gac seed ethanol (EtOH) extract resulted in the identification of three triterpenoidal saponins (<B>1</B>-<B>3</B>), which were investigated for their anti-inflammatory effects. Among the saponins, momordica saponin I (compound <B>3</B>) reduced the production of nitric oxide (NO) in LPS-activated RAW264.7 cells without inducing cytotoxicity. The mRNA levels of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 were decreased by momordica saponin I. Additionally, the translocation of p65 and p50 (subunits of the transcription factor NF-<TEX>$ \kappa $</TEX>B) into the nucleus was remarkably inhibited. Furthermore, the phosphorylation levels of inflammatory signaling proteins (I<TEX>$ \kappa $</TEX>B<TEX>$ \alpha $</TEX>, Src, and Syk) known to be upstream regulatory molecules of p65 were decreased under momordica saponin I-treated conditions. The molecular targets of momordica saponin I were confirmed in overexpression experiments and through immunoblot analyses with Src and Syk. This study provides evidence that momordica saponin I could be beneficial in treating inflammatory diseases, and should be considered a bioactive immunomodulatory agent with anti-inflammatory properties.</P>

Bioactivity-guided isolation of ginsenosides from Korean Red Ginseng with cytotoxic activity against human lung adenocarcinoma cells

Jae Sik Yu,노현수,Kwan-Hyuck Baek,Seul Lee,Sil Kim,Hae Min So,Eunjung Moon,Changhyun Pang,Tae-Su Jang,Ki Hyun Kim 고려인삼학회 2018 Journal of Ginseng Research Vol.42 No.4

Background: Lung cancer is the leading cause of cancer-related death worldwide. In this study, we used a bioactivity-guided isolation technique to identify constituents of Korean Red Ginseng (KRG) with antiproliferative activity against human lung adenocarcinoma cells. Methods: Bioactivity-guided fractionation and preparative/semipreparative HPLC purification were used with LC/MS analysis to separate the bioactive constituents. Cell viability and apoptosis in human lung cancer cell lines (A549, H1264, H1299, and Calu-6) after treatment with KRG extract fractions and constituents thereof were assessed using the water-soluble tetrazolium salt (WST-1) assay and terminal deoxyribonucleotidyl transferaseemediated dUTP nick end labeling (TUNEL) staining, respectively. Caspase activation was assessed by detecting its surrogate marker, cleaved poly adenosine diphosphate (ADP-ribose) polymerase, using an immunoblot assay. The expression and subcellular localization of apoptosis-inducing factor were assessed using immunoblotting and immunofluorescence, respectively. Results and conclusion: Bioactivity-guided fractionation of the KRG extract revealed that its ethyl acetatee soluble fraction exerts significant cytotoxic activity against all human lung cancer cell lines tested by inducing apoptosis. Chemical investigation of the ethyl acetatesoluble fraction led to the isolation of six ginsenosides, including ginsenoside Rb1 (1), ginsenoside Rb2 (2), ginsenoside Rc (3), ginsenoside Rd (4), ginsenoside Rg1 (5), and ginsenoside Rg3 (6). Among the isolated ginsenosides, ginsenoside Rg3 exhibited the most cytotoxic activityagainst all human lung cancer cell lines examined,withIC50 values ranging from161.1 mMto 264.6 mM. The cytotoxicity of ginsenoside Rg3 was found to be mediated by induction of apoptosis in a caspaseindependent manner. These findings provide experimental evidence for a novel biological activity of ginsenoside Rg3 against human lung cancer cells. 2018 The Korean Society of Ginseng, Pu

A new rearranged eudesmane sesquiterpene and bioactive sesquiterpenes from the twigs of Lindera glauca (Sieb. et Zucc.) Blume

Jae Sik Yu,Jiwon Baek,Hyun Bong Park,Eunjung Moon,Sun Yeou Kim,Sang Un Choi,Ki Hyun Kim 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.12

A new rearranged eudesmane sesquiterpene,named eudeglaucone (1), and five known sesquiterpenesincluding (?)-faurinone (2) and four eudesmane-typesesquiterpenes (3–6), were isolated from the twigs of Linderaglauca (Sieb. et Zucc.) Blume. The structure of 1 waselucidated by a combination of extensive spectroscopicanalyses, including extensive 2D NMR (1H-1H COSY,HMQC, HMBC, and NOESY) and HR-MS. Compound 1was a relatively rare rearranged eudesmane sesquiterpenein terpenoids. All isolates were evaluated for theirantiproliferative activities against four human tumor celllines (A549, SK-OV-3, SK-MEL-2, and HCT-15). Compounds3 and 6 showed significant cytotoxicity against SKMEL-2 and HCT-15 cell lines with IC50 values rangingfrom 9.98 to 12.20 lM. We also investigated the antineuroinflammatoryactivities of the isolates (1–6) in thelipopolysaccharide (LPS)-stimulated murine microglia BV-2 cell line by measuring nitric oxide (NO) levels. All isolatessignificantly inhibited NO production with IC50 valuesof 3.67–26.48 lM without inducing cell toxicity.

HCV, Acute, LT : Significance of Homeostasis Model Assessment-Insulin Resistance Level to Assess Insulin Resistance in Chronic Hepatitis C Patients

( Jae Hyuk Choi ),( Woo Jin Chung ),( Yu Jin Lee ),( Yu Jin Kang ),( Jung Min Lee ),( Eun Sung Choi ),( Sang Min Lee ),( Byoung Kuk Jang ),( Jae Seok Hwang ),( Eun Soo Kim ),( Kyung Sik Park ),( Kwang 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1

Background/Aim: Homeostasis model assessment-insulin resistance (HOMA-IR) is commonly used for assessment of insulin resistance (IR) and IR is associated with chronic hepatitis C (CHC) virus infection. Recently, several study presented data about irrelevance between HOMA-IR and IR. This study aimed to examine the significance of HOMA-IR as representative of IR. Methods: We retrospectively reviewed data from CHC patients who receive standard of care (SOC) from September 2009 to March 2013 at Keimyung University Dongsan Hospital. We analyzed the changes of HOMA-IR score before treatment, at the time of end of treatment and at 6 months after treatment. Results: 53 patients were included (26 men; mean age, 51 ± 10.10 years) for this study. The prevalence of genotype 1a, 1b, 2a, 2b, and 3a were 1.9%, 35.8%, 54.7%, 3.8%, and 3.8%. Before treatment, initially high HOMA-IR group (>2) was 25 patients (47.2%). 1. There were no significant difference of ETR (83% vs. 92.9%, P=0.404) and SVR rate (87.5% vs. 96.0%, P=0.505) in initially high (>2) vs low (≤2) HOMA-IR groups. 2. There were no significant differences of ETR and SVR according to changes of HOMA-IR level between before and after treatment (high to high vs. high to low vs. low to high vs. low to low HOMA-IR; 23.4%, 21.3%, 6.4%, 48.9%, P=0.750 at ETR, and 13.2%, 23.7%, 7.9%, 55.3%, P=0.424 at SVR). 3. Initial HOMAIR levels had no significant differences between ETR group and non-ETR group (3.30 ± 6.29 and 2.99 ± 1.90; P=0.795), and between SVR group and non-SVR group (2.33 ± 2.90 and 3.34 ± 2.77; P=0.795). Conclusion: HOMA-IR levels were not inversely correlated or predicted of SVR after SOC for CHC patients. So, another assessing modalities such as hyperinsulinaemic euglycaemic clamp may be needed to assess IR in CHC patients.