Phase I/II study of S-1 combined with weekly docetaxel in patients with metastatic gastric carcinoma

Park, S R,Kim, H K,Kim, C G,Choi, I J,Lee, J S,Lee, J H,Ryu, K W,Kim, Y-W,Bae, J-M,Kim, N K Cancer Research UK 2008 The British journal of cancer Vol.98 No.8

We designed a phase I/II trial of S-1 combined with weekly docetaxel to determine the maximum tolerated dose (MTD) and recommended dose (RD) and to evaluate the efficacy and toxicity in metastatic gastric carcinoma (MGC). Patients with measurable disease received S-1 orally b.i.d. on days 1–14 and docetaxel intravenously on days 1 and 8 every 3 weeks. In phase I (n=30), each cohort received escalating doses of S-1 (30–45 mg m<SUP>−2</SUP> b.i.d.) and docetaxel (25–40 mg m<SUP>−2</SUP>); MTD was 45 mg m<SUP>−2</SUP> b.i.d. S-1/35 mg m<SUP>−2</SUP> docetaxel and RD was 40 mg m<SUP>−2</SUP> b.i.d. S-1/35 mg m<SUP>−2</SUP> docetaxel. Dose-limiting toxicities included grade 3 elevated liver enzymes, gastric perforation, grade 3 diarrhoea/fatigue, febrile neutropenia with grade 3 anorexia/fatigue, and neutropenic infection with grade 3 stomatitis/anorexia. In phase II (n=52), the overall response rate was 66.7% (95% confidence interval (CI): 53.8–79.6%) and the median time to progression and overall survival were 6.5 months (95% CI: 4.9–8.1) and 13.7 months (95% CI: 9.9–17.5), respectively. The most common grade 3/4 toxicity was neutropenia (29.4%), and febrile neutropenia/neutropenic infection occurred in 19.6% of patients. Non-haematological toxicities were generally mild. There was one treatment-related death due to pneumonitis. S-1 combined with weekly docetaxel is active in MGC with moderate toxicities.British Journal of Cancer (2008) 98, 1305–1311. doi:10.1038/sj.bjc.6604312 www.bjcancer.com Published online 25 March 2008

Monte Carlo comparisons of the top quark mass measurement techniques using kinematic constraints

Ryu, G.,Kim, J. H.,Lee, J. S.,Park, I. 한국물리학회 2016 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol. No.

<P>A Monte Carlo study to compare the sensitivities of the top-quark mass-reconstruction methods using the b-quark decay as a kinematic constraint was performed. The top quark is reconstructed from its decay products, the W boson and the b-quark, and its mass can be obtained by using the 4-vector sum of their final states. However, missing neutrinos and the poor jet energy resolution makes the mass measurement biased and imprecise, always requiring further calibration, and dominates the systematic uncertainties. Several new ideas to increase the mass resolution by using the kinematic constraints of the b quark decays using a charm quark meson were suggested and performed to overcome such systematic limits. In this study, we compare three methods, one using J/psi, another using D (0), and the other using D* meson, by extracting their sensitivities to the top-quark mass, as well as their statistical advantages. This study is intended to set a priority in the real data analyses using a new data set from abundant production in the Large Hadron Collider (LHC) Run 2.</P>

Alcohol+iso-Octane 혼합계의 등온 기액평형과 공비점

류선아,오종혁,나재익,백승관,한규진,박소진 忠南大學校 産業技術硏究所 1997 산업기술연구논문집 Vol.12 No.1

Isothermal vapor-liquid equilibria(VLE) for binary systems of C₂∼C₄ alcohol+iso-octane were measured by headspace gas chromatography(HSGC) at 60℃. All the binary mixtures showed the positive deviation from the Raoult's law and homogeneous minimum azeotropes. VLE data were correlated by common ge models and compared with calculated values by modified UNFAC group contribution method. Their mean deviations of vapor phase composition were less than 1%. Precise azeotropic concentrations were also measured directly by spining band distillator for each binary systems.

OGLE-2016-BLG-1190Lb: The First<i>Spitzer</i>Bulge Planet Lies Near the Planet/Brown-dwarf Boundary

Ryu, Y.-H.,Yee, J. C.,Udalski, A.,Bond, I. A.,Shvartzvald, Y.,Zang, W.,Jaimes, R. Figuera,Jørgensen, U. G.,Zhu, W.,Huang, C. X.,Jung, Y. K.,Albrow, M. D.,Chung, S.-J.,Gould, A.,Han, C.,Hwang, K.-H.,Sh American Astronomical Society 2018 The Astronomical journal Vol.155 No.1

<P>We report the discovery of OGLE-2016-BLG-1190Lb, which is likely to be the first Spitzer microlensing planet in the Galactic bulge/ bar, an assignation that can be confirmed by two epochs of high-resolution imaging of the combined source-lens baseline object. The planet's mass, M-p = 13.4 +/- 0.9 M-J, places it right at the deuteriumburning limit, i. e., the conventional boundary between 'planets' and 'brown dwarfs.' Its existence raises the question of whether such objects are really ' planets' (formed within the disks of their hosts) or 'failed stars' (lowmass objects formed by gas fragmentation). This question may ultimately be addressed by comparing disk and bulge/bar planets, which is a goal of the Spitzer microlens program. The host is a G dwarf, M-host = 0.89. +/- 0.07 M-circle dot, and the planet has a semimajor axis a similar to 2.0 au. We use Kepler K2 Campaign 9 microlensing data to break the lens-mass degeneracy that generically impacts parallax solutions from Earth-Spitzer observations alone, which is the first successful application of this approach. The microlensing data, derived primarily from near-continuous, ultradense survey observations from OGLE, MOA, and three KMTNet telescopes, contain more orbital information than for any previous microlensing planet, but not quite enough to accurately specify the full orbit. However, these data do permit the first rigorous test of microlensing orbital-motion measurements, which are typically derived from data taken over < 1% of an orbital period.</P>

Protective effect of EC-18, a synthetic monoacetyldiglyceride on lung inflammation in a murine model induced by cigarette smoke and lipopolysaccharide

Shin, I.S.,Ahn, K.S.,Shin, N.R.,Lee, H.J.,Ryu, H.W.,Kim, J.W.,Sohn, K.Y.,Kim, H.J.,Han, Y.H.,Oh, S.R. Elsevier Science 2016 INTERNATIONAL IMMUNOPHARMACOLOGY Vol.30 No.-

The antler of Sika deer (Cervus nippon Temminck) has been used a natural medicine in Korea, China and Japan, and a monoacetyldiaglyceride (1-palmitoyl-2-linoleoyl-3-acetylglycerol, PLAG) was found in the antler of Sika deer as a constituent for immunomodulation. In this study, we investigated protective effects of EC-18 (a synthetic copy of PLAG) on inflammatory responses using a cigarette smoke with lipopolysaccharide (LPS)-induced airway inflammation model. Mice were exposed to cigarette smoke for 1h per day for 3days. Ten micrograms of LPS dissolved in 50μL of PBS was administered intra nasally 1h after the final cigarette smoke exposure. EC-18 was administered by oral gavage at doses of 30 and 60mg/kg for 3days. EC-18 significantly reduced the number of neutrophils, reactive oxygen species production, cytokines and elastase activity in bronchoalveolar lavage fluid (BALF) compared with the cigarette smoke and LPS induced mice. Histologically, EC-18 attenuated airway inflammation with a reduction in myeloperoxidase expression in lung tissue. Additionally, EC-18 inhibited the phosphorylation of NF-κB and IκB induced by cigarette smoke and LPS exposure. Our results show that EC-18 effectively suppresses neutrophilic inflammation induced by cigarette smoke and LPS exposure. In conclusion, this study suggests that EC-18 has therapeutic potential for the treatment of chronic obstructive pulmonary disease.

대학생의 정서적 데이트 폭력 인식과 이성관계 만족도의 상관관계

구은정,권민지,김소라,류연수,신지연,유현아,장민주,홍자인,Lanjingjing,배성희,도지영 이화여자대학교 간호과학대학 2019 이화간호학회지 Vol.- No.53

Purpose: This study aims to identify the correlation between perception of emotional dating violence and satisfaction of relationship of college students to provide objective data for college students to improve perception of emotional dating violence and satisfaction of relationship. Methods: Data was collect using questionaries between November 3rd to November 20th, 2018. Participants of this study were 110 male college students and 127 female college student who are currently attending universities aged 18 to 29 years old. Data were analyzed using average, standard deviation, t-test, ANOVA, and Pearson’s correlation using the SPSS 21.0 program. Result: The study has established the negative correlation between perception of emotional dating violence and satisfaction of relationship(R=-.587, p<.001). As the level of perception of emotion dating violence is lower, satisfaction of relationship is higher. The number of relationships recognized by oneself, experience of dating violence, and severity of dating violence also demonstrated significant difference in perception of emotional dating violence and satisfaction of relationship. Conclusion: The result of the study suggests that perception of emotional dating violence is negatively related to satisfaction of relationship. Furthermore, this study suggests that it is important to increasing perception of dating violence for healthier and better quality of relationships.

Efficacy and safety findings from DREAM: a phase III study of DHP107 (oral paclitaxel) versus i.v. paclitaxel in patients with advanced gastric cancer after failure of first-line chemotherapy

Kang, Y.-K.,Ryu, M.-H.,Park, S.H.,Kim, J.G.,Kim, J.W.,Cho, S.-H.,Park, Y.-I.,Park, S.R.,Rha, S.Y.,Kang, M.J.,Cho, J.Y.,Kang, S.Y.,Roh, S.Y.,Ryoo, B.-Y.,Nam, B.-H.,Jo, Y.-W.,Yoon, K.-E.,Oh, S.C. Elsevier 2018 ANNALS OF ONCOLOGY Vol.29 No.5

<P>Conclusions: DHP107 as a second-line treatment of AGC was non-inferior to paclitaxel for PFS; other efficacy and safety parameters were comparable. DHP107 is the first oral paclitaxel with proven efficacy/safety for the treatment of AGC.</P>

초기성인의 생활습관과 당뇨에 대한 지식

소선이,마지은,고지윤,김은혜,박현화,서유진,서형은,유은미,이하늬,이혜인,정지연,현혜리,이자형,정덕유,강지숙 이화여자대학교 간호과학대학 2009 이화간호학회지 Vol.- No.43

Purposes :The purposes of this study was to investigate the self-managing status according to the life styles and the diabetic knowledge of early adulthood. The subjects in this study were 240people, the early adult aged twenties to thirties living in the metropolitan area. Data were collected by using self-administered questionnaires that measure about the knowledge of diabetes; the dietetic behavior; the knowledge of diet; the exercise behavior; the knowledge of exercise. Descriptive statistics, t-test, ANOVA, and correlation were used for data analysis. Result :1. At the knowledge of diabetes degree based on the general character, the subjects who had experiences of diabetic education have higher degree of the diabetic knowledge. 2. At the knowledge of diabetes degree according to the life style, the subjects who have regular diet are appeared highly. Also the subjects who don't take much food of animal origin have higher degree. 3. At the knowledge of diet based on the life style, the subjects who don't keep three times meals a day are appeared highly. Also the subjects who have regular diet have higher degree. 4. At the knowledge of exercise according to the life style, the subjects who take extra nutritions 3-4 times a week are appeared highly. Although the subjects tend to know about dietary, exercise and health management, it showed that they actually don't perform what they know in their everyday of life. The reason for this could be the lack of perceived seriousness about diabetes mellitus. Thus as nursing professionals, we should provide them proper health education and support. Moreover, advanced research on the empowerment is warranted.

Toward a Galactic Distribution of Planets. I. Methodology and Planet Sensitivities of the 2015 High-cadence<i>Spitzer</i>Microlens Sample

Zhu, Wei,Udalski, A.,Novati, S. Calchi,Chung, S.-J.,Jung, Y. K.,Ryu, Y.-H.,Shin, I.-G.,Gould, A.,Lee, C.-U.,Albrow, M. D.,Yee, J. C.,Han, C.,Hwang, K.-H.,Cha, S.-M.,Kim, D.-J.,Kim, H.-W.,Kim, S.-L.,Ki American Institute of Physics 2017 The Astronomical journal Vol.154 No.5

<P>We analyze an ensemble of microlensing events from the 2015 Spitzer microlensing campaign, all of which were densely monitored by ground-based high-cadence survey teams. The simultaneous observations from Spitzer and the ground yield measurements of the microlensing parallax vector pi(E), from which compact constraints on the microlens properties are derived, including less than or similar to 25% uncertainties on the lens mass and distance. With the current sample, we demonstrate that the majority of microlenses are indeed in the mass range of M dwarfs. The planet sensitivities of all 41 events in the sample are calculated, from which we provide constraints on the planet distribution function. In particular, assuming a planet distribution function that is uniform in log q, where q is the planet-to-star mass ratio, we find a 95% upper limit on the fraction of stars that host typical microlensing planets of 49%, which is consistent with previous studies. Based on this planet-free sample, we develop the methodology to statistically study the Galactic distribution of planets using microlensing parallax measurements. Under the assumption that the planet distributions are the same in the bulge as in the disk, we predict that similar to 1/3 of all planet detections from the microlensing campaigns with Spitzer should be in the bulge. This prediction will be tested with a much larger sample, and deviations from it can be used to constrain the abundance of planets in the bulge relative to the disk.</P>

충청지역에서 발생한 쭈쭈가무시병의 임상상, 원인균의 혈청형 및 혈청역학적 연구

김선영,김윤성,박장규,윤태영,강재승,송인숙,최명식,최인학,차창룡,이우곤,박종우,이증훈,장우현,유영해,윤광혁,송계용 대한감염학회 1989 감염 Vol.21 No.2

From September to december 1987, eighty-six cases of tsutsugamushi disease were diagnosed by indirect immunofluorecent test or by isolating the causative agent in Chungcheung area. Their clinical features and patterns of antibody response to R. tsutsugamushi were analyzed. For the indenfication of prevalent antigenic types of R. tsutsugamushi in Chungcheung area, twenty-seven strains isolated were tested by indirect immunofluorescent test. To assess the extent of exposure to R.tsutsugamushi of a general population in Korea, the prevalence of antibody was investigated in 6,572 sera obtained from the residents of Chungcheung area by indirect immunofluorescent test. The female patients slightly outnumbered the male patients. More cases (68%) were older than 40 years of age. The epidemic peaked in October. The mean incubation period estimated was about 8 days. The major clinical features were fever and chill, headache, rash, eschar, and lymphadenopathy. Increased serm transaminase was the most singificant laboratory findings. Abnormalities in the chest roentgenography were often observed. The antibody titer rose rapidly 5 days after the onset, reached its peak at 20 days (1:640), and then declined agradually until 7 months(1:20). The seroype of 23 out of the 27 isolates wase found to be karp, one was Gilliam, and 3 isolates could not be classified by using polyclonal mouse hyperimmune sera. The prevalence of antibody to R.tsutsugamushi in the residents of Chungcheung area was 4.8%. The prevalence of antibody was higher in the female than in the male. The prevalence was higher in the residents of age above 40 years than below 40 years, and was the lowest in the children less than 10 years of age. Of the 318 positive sera from normal residents, only 2 sera showed the titers higher than 1:80.