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새로운 Acetylcholinesterase inhibitors의 합성
최순규,김형민,조승환,최학기,박유미,이용균,정대일,김인식,한정태 동아대학교 부설 기초과학연구소 2004 基礎科學硏究論文集 Vol.21 No.1
노인성 치매의 일종인 alzheimer's disease의 효과적인 억제제를 합성하기 위해 우리는 분자 모델링에 의한 가장 적합한 물질인 m-[(N,N,N-trimethylammonio)phenyl]boronic acid를 합성하였다. 출발물질인 3-aminophenylboronic acid monohydrate의 경우 boronic acid의 작용기인 hydroxyl group을 protecting시킴으로써 반응의 안정성을 기하였다. Quarternary ammonium salt는 과량의 methyliodide와 염기 촉매인 potassium hydrogen carbonate를 사용하여 용매인 methanol에서 반응시켜 상당히 높은 수율을 얻을 수 있었다. 또한 과량의 methyliodide와 염기촉매인 potassium hydrogen carbonate를 사용하여 용매인 methanol에서 반응시킨 결과 boronic acid의 protection없이도 안정하게 반응이 진행되어짐을 확인할 수 있었다. In order to syntheisize a effective inhibotor for alzheimer's disease, we synthesized m-[(N,N,N-trimethylammonio)phenyl]boronic acid 4 which is designed by molecular modeling form. We protected the hydroxyl group of 3-aminophenylboronic acid monohydrate 1 with ethlyne glycol to remove the reactivity if hydroxyl group. To synthesize m-[(N,N,N-trimethylammonio)phenyl]boronic acid 4, we reacted 3-aminophenylboronic acid monohydrate 1 with ezcess methyl iodide and potassium hydrogen carbonate as a base-catalyst in methanol. but On executed reaction without protection on hydroxyl group, we found out the result that the hydroxyl group of boronic acid group at 3-aminophenylboronic acid monohydrate 1 didn't react with excess methyliodide. Synthesized m-[(N,N,N-trimethylammonio)phenyl]boronic acid 4 is in progress about biological tests as a plausible acetylcholinesterase inhibitor.
국내 아파트 단위주호 평면의 공간 분석 : 1966년∼2002년의 서울지역 아파트를 대상으로
최재필,조형규,박인수,박영섭 대한건축학회 2004 대한건축학회논문집 Vol.20 No.6
This study intends to examine changes found in the unit floor plans of the apartments built in Seoul Metropolitan area from 1966 to 2002. The changes found in the unit floor plans are analyzed in the context of the Space Syntax Model and compared to the lifestyle and societal changes in Korea. The results of the study indicate the followings ; the unit floor plans have changed a lot from 3rd period to 4th period ; there is a tendency that design element in large unit such as numbers of bathrooms and bedrooms, etc. is imitated by small unit ; the unit floor plans of 3LDK apartments have been changing into the kitchen-dining-centered unit plans, but the unit floor plans of 4LDK apartments have hold down the living-centered unit plans ; there is a tendency that RRAs of master bedroom of 3LDK and 4LDK apartments have been decreasing.
최재필,조형규,최현철,황용하 대한건축학회 2003 대한건축학회논문집 Vol.19 No.11
The purpose of the ERAM model proposed in this paper is to analyze the spatial importance immanent in the intrinsic structure of spaces. Use of the adjacency matrix representing the connection of spaces makes it possible to analyze the spatial structure itself. On the assumption that a large number of people move continually at random in the system, the ratio of elements in any row of the n-th power of the adjacency matrix means the ratio of people of all nodes in equilibrium. Mathematically, it is the ratio of eigenvector corresponding to the dominant (maximum) eigenvalue, Therefore it is the attribute immanent in the structure of spaces itself. Moreover, it is possible to consider the relative level of attraction of spaces and the relative flow from spaces to spaces only by putting the gravity on the adjacency matrix. The ERAM model brings forth the flexible result reflecting the relativity of spaces and flows.
최재필,조형규,최현철,조영진 대한건축학회 2004 대한건축학회논문집 Vol.20 No.11
ERAM theory is an analytical tool for spatial configuration of architectural and urban spaces such as Space Syntax model. In this study, we tried (1) to reinterpret ERAM theory in terms of Markov process which is a kind of stochastic process and (2) to compare ERAM theory with Space Syntax model using pedestrian movement data. Besides, a new quantitative index ERAM and ERAM(r) for the spatial attribute is suggested. The results of the study include the followings. From the reinterpretation of ERAM theory, it can be said that ERAM theory is well compatible with stochastic process. From the comparison of integration and ERAM, it can be said that ERAM reflects the spatial configuration better than integration. Therefore, ERAM analysis can be used as a powerful tool for predicting accessibility of architectural and urban spaces.
( Hyun Young Woo ),( Jeong Won Jang ),( Sang Gyune Kim ),( Chang Hyeong Lee ),( Tae Yeob Kim ),( Won Young Tak ),( Sung Kyu Choi ),( Mong Cho1 ),( Jong Young Choi ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background: Cirrhosis-related complications are indications for transplantation. However, the mode of complication has not been evaluated so far. To better address this issue, we investigated the mode of cirrhosis related complication and impact of these complications on survival in prospective, multicenter, inception cohort study of subjects with liver cirrhosis presenting with the first onset of decompensated complication. Methods: In this observational study, 1515 patients with the confirmed onset time of the first decompensated complication were enrolled. The mortality risk of cirrhosis-related complications, including ascites, portal hypertensive gastrointestinal bleeding (PHGB), spontaneous bacterial peritonitis (SBP), hepatic encephalopathy (HE), hepatorenal syndrome (HRS), was analyzed in these cirrhotic patients. Result: As the first complication, ascites was the most frequent (53.8%), followed PHGB (36.2%), HE (7.6%), SBP (1.7%) and HRS (0.7%). During follow-up (mean 32±47 months), 484 (31.9%) experienced subsequent decompensations and the proportion of subsequent complication was consistently changed; the proportion of HE, SBP, HRS increased as time progressed. The interval between subsequent decompensative events was progressively shortened. The mortality rate according to the first complication was as follows; Ascites =PHGB> HE=SBP>HRS. The mortality rate of patients experienceing subsequent complication was significantly higher than those without subsequent complication. According to the kinds of subsequent complication, survival of HE was also higher than HRS but lower than ascites or PHGB and similar to that of SBP and this difference of survival disappeared after repeated complication. Conclusion: The mortality risk correlated with initial complication and the risk increases as the number of complication episodes is repeated. Patient`s mean age was 56±11.50 years and 72.1% was male. The cause of liver cirrhosis is hepatitis B virus (38.6%), alcohol (35.5%) and hepatitis C virus (8.9%).
Analog Front-end for EMG Acquisition System
Hyeong-Kyu Kim,Bum-Sik Chung,Kang-Il Cho,Ho-Jin Kim,Gil-Cho Ahn 대한전자공학회 2018 Journal of semiconductor technology and science Vol.18 No.6
This paper presents a four-channel analog front-end (AFE) for electromyogram (EMG) acquisition systems. Each input channel consists of a chopper-stabilized instrumentation amplifier (IA) and a low-pass filter (LPF). A 16-bit analog-to-digital converter (ADC) is shared between four-input channels through a 4-to-1 multiplexer and a buffer amplifier. To achieve a 16-bit resolution, a secondorder feed-forward incremental ADC (IADC) with a 1.5-bit quantizer is employed. The prototype AFE is fabricated in a 0.18 μm CMOS process with an active die area of 1.4 mm². It achieves a 1.12 μVRMS input referred noise with an input channel gain of 44 Db and an LPF cutoff frequency of 500 Hz, while consuming 615 μW/channel from a 1.8 V supply.