식이 단백질의 종류가 화학적발암원으로 유도된 쥐 간의 조직학적 변화에 미치는 영향

김현덕 기전여자대학 1995 論文集 Vol.15 No.-

The purpose of this study is to determine the effects of different dietary proteins on the hepatic histological changes in the chemically induced hepatocellular carcinogenesis. Weanling Sprague Dawley rats fed the diets containing casein(source of animal protein) and soy protein(source of plant protein) at the level of 20%(W/W) were treated with DEN as control group and treated with DEN followed by AAF and PB as treatment group, and then sacrificed at 6th and 10th wk after feeding diet. Diet intake, body weight, relativ liver weight, and hepatic histological changes were determined. Diet intake and body weight were higher in casein groups. Relative liver weight was increased in treatment group. The degree of hepatic histological changes, esfecailly, fatty changes and hyperplastic nodule formation, was higher in casein groups than in soy protein groups. This results suggest that casin diets are associated with a greater susceptibility of the animals to the acute effects of the carcinogen than soy protein diets.

2-AAF투여량과 BHT가 다른 식이지방을 먹인 쥐 간의 Cytochrome b5 및 지질 과산화물 함량에 미치는 영향

김현덕 기전여자대학 1992 論文集 Vol.12 No.-

Weanling male Sprague Dawley rats were fed the diet of beef tallow(P/S 0.08) and soybean oil(P/S 4.0) at the level of 15% fat with and without 0.3% BHT. After 8 weeks of feeding, 25mg and 100mg/kg/day of 2-AAF was injected for 3 days and sacrificed the next day. Cytochrome b5 and lipid peroxide values were determined from isolated microsomes. Cytochrome b5 was not infloenced by dietary fats and 2-AAF levels but increased by BHT. Lipid peroxide values were not influenced greatly by dietary fats, 2-AAF levels and BHT. However, AAF 100-BHT groups were higher than anyother group, and soybean oil group was higher than beef tallow group only in AAF 25 group. This results suggest that BHT induced cytochrome b5 to protect the cell from toxic effects of carcicogen.

전주지역 노인의 신체계측에 관한 연구

김인숙,김덕희,유현희 원광대학교 2001 論文集 Vol.27 No.-

The purpose of the survey was to study of anthropomeric measurements of elderly in Jeon-Ju area. One hundred seventeen (males 36, females 81) subjects aged from 65 years to 74 years. The average height and weight of the subjects were 164.1cm and 61.1kg in males and 151.6cm and 54.1kg in females. Height and weight in males were significantly higher than in females(p<0.001). W/H is also significantly higher in males than that of females(p<0.01). This indicates that fat distribution of males tend to be centralized toward the trunk of the body than females. But, ST, BFW and BF(%) in females were significantly higher than in males. The subjects were classified as 16.2%, 26.5% and 26.5% obesity by BMI, OR and PIBW, respectively. The subjects were classified as 16.2%, 26.5% and 57.3% overweight by BMI, OR and PIBW, respectively. The subjects were classified as 7.7%, 0% and 0% underweight by BMI, OR and PIBW, respectively. In males, obesity index(BMI, OR, PIBW) were strong positively correlated with waist(p<0.001). In female, obesity index(BMI, OR, PIBW) were strong positively correlated with BFW, hip(p<0.001).

화학적발암원으로 유도한 간세포 암화과정에서 단백질 수준이 간손상지표들에 미치는 영향

김현덕 기전여자대학 2000 論文集 Vol.20 No.-

Six -week-old Sprague dawley rats were fed a diet of 5, 10, 20% protein diet. Two weeks after diet feeding, hepatocellular chemical carcinogenesis were initiated by diethyl nitrosamine(DEN), and promoted by the diet containing 0.01% 2-acetylaminofluorene (AAF) and two-thirds partial hepatectomy (PH). The animalals were sacrificed 4 days and 8weeks after the DEN injection. The serum glutamic oxaloacetic transaminase(GOT), serum glutamic pyruvic transaminase(GPT) and glucos 6-phosphatase(G6pase) were determined to investigate the anticarcinogenic effect of dietary proteins on rat hepatocellular carcinogenesis. Relative liver weight was significantly increased in the rats fed 5% casein at promotional period. The serum GOT activities were significantly higher in rats fed casein 5% than rats fed 10% or 20%casein at initiation period, however at promotional period, both serum GOT and en activities were significantly higher in rats fed casein 5% than rats fed 10% or 20%casein. Glucos 6-phosphatase whose activity decrease as cancerous cells develops and is used as an indicative measure for the membrane stability, was decreased by the DEN initiation and was the lowest in the rats fed 5% casein. Thease results suggest that the the diet containing lower level protein than 5% may increase the initiation and promotion of chemical hepatocellular carcinogenesis.

男子大學生의 營養知識과 食習慣에 관한 調査硏究

地宣京,金賢德 기전여자대학 1991 論文集 Vol.11 No.-

The objective of this study is to investigate male college student's nutrition knowledge level and food habits and their correlation. The questionnaires answered by 378 male college students were analyzed for nutrition knowledge, food habits and their correlation. The subjects had a high level of perceived knowledge(85% ), that is the knowledge that each subject believed he had, but the accuracy of that knowledge was 71%. The mean nutrition knowledge score was 12 out of a possible 20 points, and habit score was 4.4 out of 10 points. Therefore most of the subjects had a high level of nutrition knowledge but belonged to the "Fair" food habit group, which is considered to be relatively poor. There was a Positive correlation between nutrition knowledge score and food habit score of the subjects. Furthermore with increasing monthly income and level of education of their parents, the food habit scores also increased. There was a positive correlation between nutrition knowledge score ad their mother's employment status. Meanwhile, the food habits of male college students show that the consumption level of fruits, milk and sea weed is relatively low, but vegetables consumption was normal and they ate breakfast everyday. Meals were never missed for reducing weigth. Seventy-nine percentage of the subjects have not been educated in nutrition. Most of the male students have mainly obtained nutritional information( knowledge) from mass media.

채용시 건강진단에서 요ㆍ천추부 단순 방사선 검사의 평가

임현술,김수군,김덕수,이현경,최대섭 대한산업의학회 2000 대한직업환경의학회지 Vol.12 No.2

Objectives : A study was conducted for investigating the status of simple X-rays on lumbo-sacral regions at pre-employment health examination and analysing the effectiveness of simple X-rays on lumbo-sacral regions. Methods : The study data were pre-employment health examination data in a university hospital from Jan 3, 1993 through October of 1997. And, 97 newly employed workers who claimed no low back pawn at pre-employment health examination of a certain company were follow-up survey about low back pain and related factors in April, 1995 and October of 1997. The data were collected by a self-reported questionnaire and a medical examination with a rehabilitation specialist. Results : 1. Taking the simple X-rays on lumbo-sacral regions was 1,591 workers (10.5%) among 15,166 pre-employment health examination from Jan 3, 1993 through October of 1997. And yearly application rates of these X-ray tests have been significantly statistical increasing (p〈0.01). 2. The abnormal findings of simple X-rays on lumbo-sacral regions at pre-employment health examination were 40 workers. But, there was not significantly statistical difference between normal and abnormal group for the complaint rate of low back pain. 3. The number of case with symptoms of low back pain at the follow-up survey were 46, so The incidence density was 37.1 persons/ 100 person-years. And the incidence density was not significantly statistical difference between normal and abnormal group of simple X-rays on lumbo-sacral regions. 4. Through the multivariate logistic regression, significantly associated factors with low back Pain were found to be tenure(OR=0.36, 95%CI : 0.17-0.79), lifting of heavy materials (OR=5.86, 95%CI : 1.58-21.74) . Conclusion : The simple X-rays on lumbo-sacral regions at pre-employment health examination is required further research for utilizing pre-employment health examination according to above results.

정신장애인의 재활의 위한 사회기술훈련의 효과성에 관한 연구

황태연,손덕순,백형의,박종원,김지현,이경화 용인정신의학연구소 1999 용인정신의학보 Vol.6 No.2

폐경후 여성에서 생화학적 골대사지표 검사의 비교

정윤석,송민경,박덕배,김현만,임영애,곽연식,이득주 대한골대사학회 1995 대한골대사학회지 Vol.2 No.2

Improved Gastrointestinal Symptoms and Quality of Life after Conversion from Mycophenolate Mofetil to Enteric-Coated Mycophenolate Sodium in Renal Transplant Patients Receiving Tacrolimus

Hwang, Hyeon Seok,Hyoung, Bok Jin,Kim, Sol,Oh, Ha Young,Kim, Yon Su,Kim, Jung Kyung,Kim, Yeong Hoon,Kim, Yong Lim,Kim, Chan Duck,Shin, Gyu Tae,Yang, Chul Woo The Korean Academy of Medical Sciences 2010 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.25 No.12

<P>It is reported that a conversion from mycophenolate mofetil (MMF) to enteric-coated mycophenolate sodium (EC-MPS) relieves gastrointestinal (GI) symptom burden and improves health-related quality of life (HRQoL). However, it is unclear whether renal transplant recipients using tacrolimus receive the same benefit from the conversion. In this prospective, multi-center, open-label trial, patients were categorized into two groups by their GI symptom screening. Equimolar EC-MPS (n=175) was prescribed for patients with GI burdens; those with no complaints remained on MMF (n=83). Gastrointestinal Symptom Rating Scale (GSRS) and Gastrointestinal Quality of Life Index (GIQLI) were evaluated at baseline and after one month. Patients and physicians completed Overall Treatment Effect (OTE) at one month. EC-MPS-converted patients had worse GSRS and GIQLI scores at baseline than MMF-continued patients (all <I>P</I><0.001). Significant improvements in GSRS and GIQLI scores were observed for EC-MPS-converted patients at one month, but MMF-continued patients showed worsened GSRS scores (all <I>P</I><0.05). OTE scale indicated that EC-MPS patients improved in overall GI symptoms and HRQoL more than MMF patients did (<I>P</I><0.001). In tacrolimus-treated renal transplant recipients with GI burdens, a conversion from MMF to EC-MPS improves GI-related symptoms and HRQoL.</P>

Mycobacterium abscessus Lung Disease in a Patient with Kartagener Syndrome

Kim, Jung Hoon,Song, Won Jun,Jun, Ji Eun,Ryu, Duck Hyun,Lee, Ji Eun,Jeong, Ho Jung,Jeong, Suk Hyeon,Kang, Hyung Koo,Kim, Jung Soo,Lee, Hyun,Chon, Hae Ri,Jeon, Kyeongman,Kim, Dohun,Kim, Jhingook,Koh, W The Korean Academy of Tuberculosis and Respiratory 2014 Tuberculosis and Respiratory Diseases Vol.77 No.3

Primary ciliary dyskinesia (PCD) is characterized by the congenital impairment of mucociliary clearance. When accompanied by situs inversus, chronic sinusitis and bronchiectasis, PCD is known as Kartagener syndrome. The main consequence of impaired ciliary function is a reduced mucus clearance from the lungs, and susceptibility to chronic respiratory infections due to opportunistic pathogens, including nontuberculous mycobacteria (NTM). There has been no report of NTM lung disease combined with Kartagener syndrome in Korea. Here, we report an adult patient with Kartagener syndrome complicated with Mycobacterium abscessus lung disease. A 37-year-old female presented to our hospital with chronic cough and sputum. She was ultimately diagnosed with M. abscessus lung disease and Kartagener syndrome. M. abscessus was repeatedly isolated from sputum specimens collected from the patient, despite prolonged antibiotic treatment. The patient's condition improved and negative sputum culture conversion was achieved after sequential bilateral pulmonary resection.