Mo 화학기상증착에 있어서 불순물 농도에 미치는 증착조건의 영향

배상석,서성교,홍은식,김승모,조미정,한혜정,이두성,김세훈,민석홍 국립7개대학공동논문집간행위원회 2001 공업기술연구 Vol.1 No.-

The thermal decomposition process of Mo(CO)_6 on chemical vapor deposition was investigated by analyzing the effects of deposition temperature, pressure, and reaction gas on the phase change of deposited films. Mo_2C was deposited at or below 350℃ due to the incompleteness of thermal decomposition of Mo(CO)_6, but Mo films was successfully deposited at 400℃ or higher temperatures. The variation of deposition pressure did not change the dependence of decomposition process on deposition temperature. The activation energy of surface reaction was 5.8 ㎉/mole.

가토에서 일측 요관 부분 및 완전폐색시 신장과 요관의 조직학적 변화

김상현,김용웅,육승모,한동석,노안식,임재성,김홍식,나용길,설종구 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

This study was designed to clarify histologic changes in the experimental rabbit kidney and ureter after unilateral partial or complete ureteral obstruction. A total of 20 adult white rabbits were divided into 4 subgroups in the partial obstruction followed by 2 weeks, the partial obstruction followed by 4 weeks, the complete obstruction followed by 2 weeks, and the complete obstruction followed by 4 weeks. The normal control group was consisted of 5 adult white rabbits. The kidneys and ureters for light microscopy were fixed in 10% neutral formalin, embedded in paraffin and stained with hematoxylin and eosin. Abnormal histologic fingings showed in ipsilateral kidney and ureter of all subgroups(such as dilatation of uriniferous tubule, focal necrosis and desquamation of epithelium, interstitial fibrosis, glomerular congestion, widening of Bowman's space, dilatation of ureter, epithelial cell atrophy or loss, interstitial fibrosis and interstitial inflammation). These findings were most severe in the group of the complete-obstructed ureter for 4 weeks. No significant changes showed in contralateral ureter of all subgroups. The degree of obstruction was severe and period of obstruction was long, the histological changes in ipsilateral side were severe. Despite of changes in ipsilateral side no abnormal findings showed in contralateral side. We suggest that long term experimental investigation of histologic changes in ipsilateral side and compensatory changes in contralateral side have to be studied.

파골세포 활성에 있어 gp130과 PTH의 연관성

김영준,류현모,김신윤,신홍인 경북대학교 병원 2002 경북대학교병원의학연구소논문집 Vol.6 No.1

gp130,a subunit for serveral cytokine signal transducing receptors, mediates diverse activities including osteoclastogenesis. In vitro obaervations suggest that PTH also triggers the gp130-mediated signal for bone resorption by stimulating secretion of IL-6,IL-11 and LIF from osteoblast/stromal cells. Though this gp130 signaling is required for full activation of bone resporption by PTH in vitro, the relationship between PTH and gp130 signaling pathway in vitro is not yet clanified. To address the importance of gp130 as a mediator of PTH action in osteoclast activation, the blood ionized calium and blood serum PTH level was investigated in gp130-/- and wild type mice at E18.5 using a CIBA/Coming 634 Ca^+2/pH analyzer and rat intact PTH Kit, respectively.In addition, calium transport efficiency was assessed from gp130 mice at E17.5. The resorptive activity of osteoclasts from intact calvariae by a ^45Ca release assay and the osteoclastic developmental condition in tibiae were also analyzed, respectively.The gp130-/- micerevealed significantly lower ionized calcium level(1.44±0.03 vs1.77±0.03 mmol/ℓ, p<0.001)and significantly higher blood serum PTH(251.8±5.3 VS 20.5±5.3 pg/㎖,p<0.001) compared to wild type littermates.There was no remarkable pathologic change of placenta in gp130-/- and the ^45Ca transport though placenta was accelerated in gp130-/- compared to wild type littermates(%to Het 83%in -/- vs 148% in +/+).The gp130-/- embryos had small skeletons with bones containing little primary spongiosa, and large multinucleated TRAP+ cells along the lower border of the growth plate. Release of ^45Ca from prelableled calvarial bone(E18.5)in response to either 10^-7 M hpTH(1-34)or 20 ng/㎖ sRANKL was lower in gp130-/-calvarial bone compared to gp130+/+ calvarial bone (PTH 1.83±0.6 fold over basal in-/- vs 2.79±0.6 in +/+and sRANKL1.3±0.4 in -/- vs 2.79±0.6 in +/+ and sRANKL1.3±0.4 in -/- vs 2.0±0.4 in +/+,p<0.5). These result strongly support the hypothesis that PTH activates bone resortion,in part, by stimulating ostedtrophic cytokine secretiom from osteoblast/stromal cells, which tirggers gp130-mediated signaling for osteoclastic activation.

승모판 대치술후에 발생한 좌심실유출로 폐색 1예

김도연,조홍근,정익모,박시훈,박성훈,신길자,정병철 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.1

여자 창던지기 도움닫기 최종 1보 착지와 릴리즈 국면의 운동학적 분석

홍순모,이영선,김태삼 한국운동역학회 2004 한국운동역학회지 Vol.14 No.1

S. M. HONG, Y. S. LEE, T. S. Kim. The Kinematic Analysis of the Last Stride Landing and Release Phase in the Woman Javelin. Korean Journal of Sport Biomechanics, Vol. 14, No. 1, pp. 51-63, 2004. The purpose of this study was to investigate a three dimensional kinematic variables about the last stride and the release phase of the throwing technique for female javelin throwers. For the motion analysis, Six female javelin throwers were used as subjects. Three-dimensional coordinates were collected using the Kwon3D Motion Analysis Package Version 2.1 Program. Two S-VHS Video Cameras were used to record the locations and orientations of control object and the performances of the subjects at a frequency of 6.0 HZ. After the kinematic variables such as the time, the distance, the velocity, and the angle were analyzed about the last stride and release phase, the followings were achieved; 1. For the effectively javelin throwing, the subjects appeared to do long the approach time in the phasel of landing phase, and short the delivery time in release phase 2. In the release event, the other subjects except for subject A appeared to throwing in the lower condition than the height of themselves. This result showed to slow the projecion velocity. 3. For increase the projection vcelocity of the upper extremity joint in the release event, it appeared to do extend rather the shoulder angle than increase the extension of elbow joint. 4. The body of COG angle showed to gradually increase nearly at the vertical axis in the release event. But the front lean angle of trunk showed a small angle compare to increase of the body of COG angle. Therefore for the effectively momentum transmission of the whole body in the javelin, the front and back lean angle of trunk appeared to do fastly transfer the angle displacement in the arch posture or the crescent condition during the deliverly motion of the release phase.

차세대 고속철도 특수교량의 설계 및 기술사양 조사

박만호(Park Man-Ho),문제우(Mun Je-U),김성일(Kim Sung-Il),홍성모(Hong Seong-Mo),김종태(Kim Jong-Tae) 한국철도학회 2008 한국철도학회 학술발표대회논문집 Vol.- No.-

Mo-Am arch bridge is only the long-span bridge (with 125m span) in the Kyong-Bu high-speed line in service, while other bridges are PSC box girder bridges and steel composite bridges with span lengths of 25~50m. However, in foreign high-speed lines, special cable-supported bridges like cable-stayed bridges and extradosed bridges are being adopted in earnest with technical specifications. The cable supported bridge is recognized as one of the indices of technology in civil engineering field, and thus it is being adpoted with a sense of rivalry in countries with advanced technology in railway engineering. In this paper, to apply the top-level cable-supported bridge technology to the domestic high-speed line up to 400㎞/h by establishing the technical specifications on cable-supported bridges including span length, the requirements for securing the dynamic stability and running safety of high speed train are analyzed through case studies for domestic and foreign cases.

Rieger syndrome : 증례보고 A CASE REPORT

이홍모,김정욱,장기택,이상훈,한세현,김종철 大韓小兒齒科學會 2003 大韓小兒齒科學會誌 Vol.30 No.4

Rieger syndrome은 눈의 전안방 기형과 치아결손을 특징으로 하는 희귀한 유전질환으로 두 개안면 이상과 체성기형을 동반하기도 한다. Rieger syndrome은 상염색체 우선유전(autosomal dominant inheritance)되며, 발생빈도는 약 200,000분의 1이고, Paired-like homeodomain transcription factor2(PITX2)의 변이가 이 질환과 연관이 있는 것으로 보고되고 있다. 본 증례는 Rieger syndrome으로 진단 받은 4세 7개월 된 여아에 대한 것으로, 양안에 다동공증과 후태생환을 보이고, 측모두부계측에서 상악골 열성장이 나타났으며, 상악유측절치와 더불어 다수의 영구치 결손이 방사선 상에서 관찰되었다. 이 증례를 통하여 Rieger syndrome 환아의 구강 및 두 개안면의 소견을 관찰하고, 관련 문헌을 고찰하여 다소의 지견을 얻었기에 보고하는 바이다. Rieger syndrome is a rare, autosomal dominant gentic disorder characterized by malformation of the anterior chamber of the eye(goniodysgenesis) coincident with hypodontia. It may also be accompanied by a spectrum of dental, craniofacial and somatic anomalies. Mutations in paired-like homeodomain transcription factor2(PITX2) are associated with the syndrome, and its frequency in the general population has been estimated to be 1 : 200.000. In the present case, the patient, 4 year 7 month-old female, had posterior embryotoxon and polycoria. The maxilla was retrusive in cephalometric radiography. She had congenital missing on #52, #62 and some tooth germs of permanent tooth were not detected in panoramic radiography. The purpose of this paper is to report the dental and craniofacial findings and review the pertinent literature through this case.

가토에 있어서 편측 요관 폐색시 환측, 반대측 요관에 대한 변화 : 조직학적 소견을 중심으로

설종구,김용웅,육승모,노안식,김홍식,김상현,이충식 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

This study was designed to clarify histological changes in the experimental rabbit ureter after unilateral prartial or complete ureteral obstruction. A total of 20 adult white rabbits were divided into 4 subgroups in the partial obstruction followed by 2 weeks, partial obstruction followed by 4 weeks, complete obstruction followed by 2 weeks, complete obstruction followed by 4 weeks. The normal control group consisted of 5 adult white rabbits. The H & E stain. light microscopy were used. Abnormal histological fingings were showed in ipsilateral ureter of all subgroups; dilatation of ureter, epithelial cell atrophy or loss, interstitial fibrosis, interstitial inflammation. These findings were most severe in the complete-obstructed ureter for 4 weeks. There were no significant changes in contralateral ureter of all subgroups. Despite of progressive histological changes in ipsilateral ureter no abnormal findings were showed in contralateral ureter. We suggest that long term experimental investigation for histological changes in ipsilateral ureter and compensatory changes in contralateral ureter should be done.

Squalene Adjuvant를 이용한 단백질 항원의 세포성 면역반응 유도

도현주,김성열,안종성,하영주,이승찬,오재택,장명호,정홍석,문홍모,박해준 大韓免疫學會 1996 大韓免疫學會誌 Vol.18 No.3

To investigate the role of adjuvant for cytotoxic T lymphocytes (CTL) induction, squalene-based adjuvant was studied its capability eliciting to the induction of cellular immunity as well as humoral immunity to exogeneous proteins. Ovalbumin (OVA) was used as model proteins. It was demonstrated that antigen formulation consisted of metabolizable oil squalene mixed with Tween 80 and pluronic L121 (S/TJ121) could induced the antigen specific CTL responses and antibodies irrespective of immunization routes in mice. We also demonstrated that this antigen formulation was a inducer of CD8+, major histocompatibility complex(MHC) class I-restricted, and antigen-specific C;1'Ls. These data suggest that the squalene-based emulsion system is a potent adjuvant inducing cellular immunity as well as humoral immunity.

압박 고 나사로 치료한 대퇴골 전자부 골절 : 고정 실패의 인자에 대한 분석 Analysis of Factors associated with Failure of Fixation

유찬훈,김홍태,변영수,남준모,조영호,문성건 대한골절학회 2002 대한골절학회지 Vol.15 No.4

목 적 : 압박 고 나사로 치료한 대퇴골 전자부 골절의 고정 실패에 영향을 미치는 요소에 대하여 분석하고자 하였다. 대상 및 방법 : 1995년 5월부터 2000년 7월까지 대퇴골 전자부 골절을 압박 고 나사를 이용하여 치료하고 1년 이상 추시가 가능했던 97예를 대상으로 하였다. 골절의 분류는 Jensen 분류법을, 골다공증의 정도는 Singh 지수를 이용하였다. 술후 방사선 검사에서 경체각, 정복 상태, 지연 나사의 대퇴골 두 내 위치, tip-apex distance(TAD) 및 지연 나사의 활강 거리를 측정하였고 고정 실패에 미치는 영향을 통계학적으로 분석하였다. 결 과 : 97예 중 17예(17%)에서 고정 실패가 발생하였고 그 중 지연 나사의 과도한 활강으로인한 경우가 15례(15.4%), 골두 천공 1얘, 10도 이상의 외반 변형 1예였다. 고정 실패의 발생과 80세 이상의 고령, 불안정성 골절, telescoping 정복, 원위 골편의 내측 혹은 전방 전위, 대퇴골 두 내 지연 나사의 위치와 밀접한 관계가 있었다. 결 론 : 압박 고 나사를 이용한 대퇴골 전자부 골절의 치료에서 고정 실패를 방지하기 위해서는 정확한 정복이 필요하고 대퇴골 두 내에서 지연 나사의 전방 위치를 피하는 것이 좋을 것으로 사료된다. Purpose : This study was performed to analyze the significant factors that may affect failure of fixation in trochanteric fractures of the femur treated with the compression hip screw. Materials and Methods : From May 1995 to July 2000, the authors analyzed 97 cases of trochanteric fracture of the femur treated with the compression hip screw and followed more than one year. We classified the fracture type by Jensen's method. We used Singh index for the degree of osteroporosis. In the post-operative radiograph, we checked neck-shaft angle, state of reduction, position of the lag screw within the femoral head, tip-apex distance, and sliding distance of the lag screw. The relationship between these factors and failure of fixation was statistically analyzed. Results : There were 17 cases(17.5%) of failure of fixation ; 15 cases(15.4%) of excessive sliding of the lag screw, 1 case (1%) of cutting out of the lag screw, and 1 case (1%) of valgus malunion. There were significant relationship between failure of fixation and old age over 80 , unstable fracture, telescoping reduction, anterior or medial displacement of the distal fragment, and anterior placement of the lag screw within the femoral head. Conclusion : Accurate reduction and avoidance of the placement of the lag screw in the anterior part of the femoral head were important factors to prevent failure of fixation in trochanteric fractures of the femur treated with the compression hip screw.