Second-Level Agenda Setting Effects: The Internet Portal Sites’ Visual Framing of the 2012 Korean Presidential Candidates

박경국,한세희,Hanna Park,Eunju Kang 한국학술연구원 2015 Korea Observer Vol.46 No.4

This study explored the effects of second-level agenda setting through visual framing on portal sites during the 2012 Korean presidential campaign. To examine how the political bias of digital news affected visual images of candidates, two major portal sites, most online newspapers, and diverse visual attributes were adopted. The data sample (n = 625) focused on the photographs of Park Geun- Hye as a conservative candidate and Moon Jae-In as a progressive. The results demonstrated that Park’s photographs were most positively covered in conservative online newspapers in the conservative portal, while Moon’s photographs were most favorably covered in progressive online newspapers in the progressive portal. These results show that portal sites serve as not only news aggregators and providers, but also as online gatekeepers.

참오동나무 목질부 추출물의 생리활성

박한나 ( Hanna Park ),박경찬 ( Kyoung-chan Park ),김병호 ( Byeongho Kim ),박세영 ( Se-yeong Park ) 한국목재공학회 2021 한국목재공학회 학술발표논문집 Vol.2021 No.2

속성 조림수인 참오동나무(Paulownia tomentosa (Thunb.) Steud.)는 오동나무과(Paulowniaceae) 오동나무속(Paulownia)이며 낙엽활엽 교목이다. 한국, 중국, 일본에 분포하고 있으며 국내에서는 중부이남에서 자생하고 있다. 참오동나무는 예부터 장롱이나 거문고와 같은 전통 악기를 제작하기 위해 목재 이용 목적으로 생육되어져 왔다. 한편, 참오동나무에는 내후성이 좋은 것으로 알려진 lignan류 중 (+)- paulownin과 (+)- sesamin 등이 있다고 알려져 있다. 따라서 국산 참오동나무로부터 추출된 천연 내후성 물질을 탐색하고자 하였으며, 참오동나무 목질부로부터 분리된 추출성분 분석을 통해 효율적 이용을 위한 기초적인 자료를 얻고자 하였다. 사용된 공시재료는 강원대학교 학술림에서 채취한 참오동나무를 이용하였으며, 목질부를 분쇄하여 60% 에탄올로 상온 침지한 후 조추출물(crude)로 회수하였다. 농축된 조추출물은 n-hexane, chloroform, ethyl acetate 순으로 분획을 실시하였다. 본 연구에서는 추출물의 분획물에 대한 박층 크로마토그래피, 항산화 활성 및 항진균 시험을 수행하였다. 항산화 활성 평가에는 DPPH radical 소거법을, 항진균에 대한 활성 시험에서는 한국 목재 내후성 평가용 공시 부후균인 백색부후균(Trametes versicolor ), 갈색부 후균(Fomitopsis palustris) 대한 paper disc 확산법을 수행하였고, 이에 대한 결과를 보고하고자 한다.

굴참나무(Quercus variabilis) 코르크 내 수베린의 항미생물 활성 평가

박한나 ( Hanna Park ),김병호 ( Byeongho Kim ),박경찬 ( Kyoung-chan Park ),김예선 ( Yesun Kim ),장재혁 ( Jae-hyuk Jang ),김남훈 ( Nam-hun Kim ),박세영 ( Se-yeong Park ) 한국목재공학회 2022 한국목재공학회 학술발표논문집 Vol.2022 No.1

굴참나무(Quercus variabilis)는 참나무과에 속한 낙엽교목이며, 일본, 중국 및 우리나라에 주로 분포하는 참나무 수종이다. 국내 참나무류 중 굴참나무는 수피에 코르크층이 두껍게 발달 되어있는 것이 특징이다. 이러한 코르크는 수베린(suberin)이 주성분으로 함유되어 있으며, 전체 조성에서 약 50%를 차지한다. 한편, 선행된 연구인 갈색부후균(Fomitopsis palustris)과 백색부후균(Trametes versicolor )에 대한 내후성 평가를 통해 내후성 등급이 매우 큰 것을 확인하였으며, 이를 토대로 본 연구에서는 굴참나무 코르크 내 수베린 성분에 대한 항미생물 활성 평가를 수행하고자 하였다. 코르크 내 수베린 추출을 위해 먼저 디클로로메탄, 에탄올, 물로 추출물을 추출한 후 메탄올분해 반응을 수행하였으며, 그 결과 굴참나무 내 수베린 함량은 약 52%로 나타났다. 추출된 수베린에 대한 항미생물 활성 평가를 위해 Agar well diffusion과 Paper disc법을 수행하였으며, 균주는 Fomitopsis palustris, Trametes versicolor와 표면오염균인 Penicillium glabrum, Trichoderma harzianum 및 Aspergillus niger를 사용하였다. 또한, 성분에 대한 항산화 활성 평가를 위해 DPPH 활성 및 ABTS 라디칼 소거법을 수행하였다.

Phytochemical constituents from the leaves of Sageretia theezans Brongn

Hanna Cha,Yeon Woo Jung,Wonsik Jeong,Ji Eun Lee,Dong Woo Han,Gwang Hun Park,Youngki Park,Sang-Hyun Koh,Chun Whan Choi,Seong Su Hong 한국분석과학회 2021 학술대회논문집 Vol.2021 No.11

Sageretia theezans, commonly known as Chinese bird plum, is an evergreen tender shrub of the Rhamnaceae family. In Korea, it grows along the southern seashore areas, and traditionally the leaves have been used as tea materials. Although S. theezans is widely used to create bonsais, it has been used in traditional herbal medicine for the treatment of hepatitis and fevers in Korea and China. S. theezans has been reported to show various pharmacological activities for neuroprotective, hepatoprotective and anti-oxidant. However, there have been only a few chemical composition studies of S. theezans so far. In this study, phytochemicals (1-11) were isolated from the ethanol extract of S. theezans leaves using different chromatographic techniques, and the chemical structures of isolates were elucidated as anthraquinone glycoside (1), five myricetin glycosides (2-6), three quercetin glycosides (7-9), a flavanol (10), and a simple phenolic compound (11) by NMR and mass analysis, and comparison to the literature. To the best our knowledge, compounds 1, 5, and 10 were obtained from the genus Sageretia for the first time.

Sunflower

HanNa PARK 한국색채학회 2019 International Invitation Exhibition of Color Works Vol.- No.-

Promising Therapeutic Effects of Embryonic Stem Cells-Origin Mesenchymal Stem Cells in Experimental Pulmonary Fibrosis Models: Immunomodulatory and Anti-Apoptotic Mechanisms

Hanna Lee,Ok-Yi Jeong,Hee Jin Park,Sung-Lim Lee,Eun-yeong Bok,Mingyo Kim,Young Sun Suh,Yun-Hong Cheon,Hyun-Ok Kim,Suhee Kim,Sung Hak Chun,Jung Min Park,Young Jin Lee,Sang-Il Lee 대한면역학회 2023 Immune Network Vol.23 No.6

Interstitial lung disease (ILD) involves persistent inflammation and fibrosis, leading to respiratory failure and even death. Adult tissue-derived mesenchymal stem cells (MSCs) show potential in ILD therapeutics but obtaining an adequate quantity of cells for drug application is difficult. Daewoong Pharmaceutical’s MSCs (DW-MSCs) derived from embryonic stem cells sustain a high proliferative capacity following long-term culture and expansion. The aim of this study was to investigate the therapeutic potential of DW-MSCs in experimental mouse models of ILD. DW-MSCs were expanded up to 12 passages for in vivo application in bleomycin-induced pulmonary fibrosis and collagen-induced connective tissue disease- ILD mouse models. We assessed lung inflammation and fibrosis, lung tissue immune cells, fibrosis-related gene/protein expression, apoptosis and mitochondrial function of alveolar epithelial cells, and mitochondrial transfer ability. Intravenous administration of DWMSCs consistently improved lung fibrosis and reduced inflammatory and fibrotic markers expression in both models across various disease stages. The therapeutic effect of DW-MSCs was comparable to that following daily oral administration of nintedanib or pirfenidone. Mechanistically, DW-MSCs exhibited immunomodulatory effects by reducing the number of B cells during the early phase and increasing the ratio of Tregs to Th17 cells during the late phase of bleomycin-induced pulmonary fibrosis. Furthermore, DW-MSCs exhibited antiapoptotic effects, increased cell viability, and improved mitochondrial respiration in alveolar epithelial cells by transferring their mitochondria to alveolar epithelial cells. Our findings indicate the strong potential of DW-MSCs in the treatment of ILD owing to their high efficacy and immunomodulatory and anti-apoptotic effects.

Characteristics of patients with psoriatic arthritis in Korea: focusing on axial involvement

Hanna Park,Ji Hyun Lee,Seung-Ki Kwok,Ji Hyeon Ju,Wan-Uk Kim,Sung-Hwan Park,Jennifer Jooha Lee 대한내과학회 2024 The Korean Journal of Internal Medicine Vol.39 No.1

Background/Aims: We aimed to clarify the clinical characteristics of psoriatic arthritis (PsA) in Korean patients focusing on PsA with axial involvement. Methods: A retrospective medical chart review was performed to identify PsA patients at a single tertiary center. Cases of AS patients with psoriasis were recruited from a prospective AS registry of the same center. Demographics, laboratory findings, and radiologic characteristics were assessed. Results: A total of 69 PsA patients were identified. In PsA patients, spondylitis (46.4%) was the most common form. Compared to AS patients with psoriasis, PsA patients with radiographic axial involvement were older (50.9 vs. 32.4 years; p < 0.001) and showed greater peripheral disease activity (peripheral arthritis 78.1 vs. 12.5%, p < 0.001; enthesitis 50.0 vs. 6.3%, p = 0.003). AS patients with psoriasis presented a higher rate of HLA-B*27 positivity (81.3 vs. 17.2%; p < 0.001) and a more frequent history of inflammatory back pain (100.0 vs. 75.0%; p = 0.039) than PsA patients with radiographic axial involvement. Significant proportions of PsA patients with radiographic axial involvement had cervical spine involvement (10/18, 55.6%) reacand spondylitis without sacroiliitis (10/23, 43.5%). Conclusions: We demonstrate that axial involvement is common in Korean PsA patients, and its characteristics can be distinct from those of AS.

Campo Marizo

Hanna Park(박한나) 한국디자인학회 2019 한국디자인학회 국제초대전도록 Vol.2019 No.6

In situ synthesis of silver nanoparticles in methylcellulose hydrogel

Hanna PARK,Hee Chul KIM,Won Ho PARK 한국고분자학회 2016 한국고분자학회 학술대회 연구논문 초록집 Vol.41 No.2

The PPARδ ligand L‐165041 inhibits vegf‐induced angiogenesis, but the antiangiogenic effect is not related to PPARδ

Park, Jin‐,Hee,Lee, Kuy‐,Sook,Lim, Hyun‐,Joung,Kim, Hanna,Kwak, Hyun‐,Jeong,Park, Hyun‐,Young Wiley Subscription Services, Inc., A Wiley Company 2012 Journal of cellular biochemistry Vol.113 No.6

<P><B>Abstract</B></P><P>Peroxisome proliferator‐activated receptor (PPAR)δ is known to be expressed ubiquitously and involved in lipid and glucose metabolism. Recent studies have demonstrated that PPARδ is expressed in endothelial cells (ECs) and plays a potential role in endothelial survival and proliferation. Although PPARα and PPARγ are well recognized to play anti‐inflammatory, antiproliferative, and antiangiogenic roles in ECs, the general effect of PPARδ on angiogenesis in ECs remains unclear. Thus, we investigated the effect of the PPARδ ligand L‐165041 on vascular EC proliferation and angiogenesis in vitro as well as in vivo. Our data show that L‐165041 inhibited VEGF‐induced cell proliferation and migration in human umbilical vein ECs (HUVECs). L‐165041 also inhibited angiogenesis in the Matrigel plug assay and aortic ring assay. Flow cytometric analysis indicated that L‐165041 reduced the number of ECs in the S phase and the expression levels of cell cycle regulatory proteins such as cyclin A, cyclin E, CDK2, and CDK4; phosphorylation of the retinoblastoma protein was suppressed by pretreatment with L‐165041. We confirmed whether these antiangiogenic effects of L‐165041 were PPARδ‐dependent using GW501516 and PPARδ siRNA. GW501516 treatment did not inhibit VEGF‐induced angiogenesis, and transfection of PPARδ siRNA did not reverse this antiangiogenic effect of L‐165041, suggesting that the antiangiogenic effect of L‐165041 on ECs is PPARδ‐independent. Together, these data indicate that the PPARδ ligand L‐165041 inhibits VEGF‐stimulated angiogenesis by suppressing the cell cycle progression independently of PPARδ. This study highlights the therapeutic potential of L‐165041 in the treatment of many disorders related to pathological angiogenesis. J. Cell. Biochem. 113: 1947–1954, 2012. © 2012 Wiley Periodicals, Inc.</P>