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Kim, Suhee,Kim, Hyunwoo,Lee, Soo-Hyeon,Cho, Ilhan,Kang, Seongwoo,Bae, Junwoo,Kim, Woosun,Ahn, Soomin,Choi, Jihye,Kim, Sang-Ki,Do, Yoonjung,Yoo, Jae Gyu,Park, Jinho,Yu, DoHyeon 한국조명·전기설비학회 2017 한국조명·전기설비학회 학술대회논문집 Vol. No.
<P>Acute lymphocytic leukemia (ALL) is uncommon lymphoid malignancy in dogs, and its diagnosis is challenging. A 14-year-old spayed female mixed breed dog was transferred to a veterinary medical teaching hospital for an immediate blood transfusion. The dog showed lethargy, pale mucous membranes, and a weak femoral pulse. Complete blood count revealed non-regenerative anemia and severe leukopenia with thrombocytopenia. ALL was tentatively diagnosed based on the predominance of immature lymphoblasts on blood film examination. For confirmation of lymphoid malignancy, PCR for antigen receptor rearrangement (PARR) on a peripheral blood sample and flow cytometry analysis were performed after blood transfusion. Flow cytometry analysis revealed that lymphocyte subsets were of normal composition, but PARR detected a T-cell malignancy. The dog was diagnosed with ALL and survived 1 wk after diagnosis. In conclusion, after blood transfusion, flow cytometry was not a reliable diagnostic method for an ALL dog, whereas PARR could detect lymphoid malignancy. Our results suggest that PARR should be the first-line diagnostic tool to detect canine lymphoid malignancy after a blood transfusion.</P>
Kim, Ki Woong,Kim, Soo Min,Choi, Suhee,Kim, Jongwon,Lee, In Su American Chemical Society 2012 ACS NANO Vol.6 No.6
<P>A novel electroless Pt deposition method was exploited by employing the galvanic replacement process occurring between the Mn<SUB>3</SUB>O<SUB>4</SUB> surface and PtCl<SUB>4</SUB><SUP>2–</SUP> complexes. The newly discovered process provides a simple protocol to produce the catalytic nanocomposite, in which a high density of ultrafine Pt nanocrystals is stably immobilized in a homogeneously dispersive state on the surface of Mn<SUB>3</SUB>O<SUB>4</SUB> nanoparticles. When the eletrocatalytic activity was tested for the oxygen reduction reaction, which limits the rate of the overall process in proton-exchange membrane fuel cells, the resulting Pt/Mn<SUB>3</SUB>O<SUB>4</SUB> nanocomposite showed highly enhanced specific activity and durability, compared with those of the commercial Pt/C catalyst.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2012/ancac3.2012.6.issue-6/nn300782m/production/images/medium/nn-2012-00782m_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn300782m'>ACS Electronic Supporting Info</A></P>
Kim, Suhee,Lee, Hye Jin American Chemical Society 2015 ANALYTICAL CHEMISTRY - Vol.87 No.14
<P>The challenges associated with performing surface plasmon resonance (SPR) based measurements in serum and other biofluids have continued to limit the applicability of this valuable sensing technology for sensitive bioaffinity measurements of proteins in clinically relevant samples. In thiS paper, a new sandwich assay is introduced for the quantitative SPR analysis of alpha-I antitrypsin (AAT), which is a recognized biomarker for Alzheimer's disease. Detection was performed via the specific adsorption of AAT onto a gold chip surface modified with a DNA aptamer. The measurement dynamic range and also sensitivity in serum were improved with the subsequent surface binding of antiAAT. A methodology was established to measure the target protein in serum, albumin and immunoglobulin G (IgG) solutions with the results correlated with measurements in buffer only. A comparison between SPR and enzyme-linked immunosorbent assay (ELISA) measurements was also made. The detection of AAT in serum at clinically relevant concentrations was demonstrated with target concentrations as low as 10 fM readily achievable.</P>
Kim, Min Je,Jung, A-Ra,Lee, Myeongjae,Kim, Dongjin,Ro, Suhee,Jin, Seon-Mi,Nguyen, Hieu Dinh,Yang, Jeehye,Lee, Kyung-Koo,Lee, Eunji,Kang, Moon Sung,Kim, Hyunjung,Choi, Jong-Ho,Kim, BongSoo,Cho, Jeong H American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.46
<P>We report high-performance top-gate bottom-contact flexible polymer field-effect transistors (FETs) fabricated by flow-coating diketopyrrolopyrrole (DPP)-based and naphthalene diimide (NDI)-based polymers (P(DPP2DT-T2), P(DPP2DT-TT), P(DPP2DT-DTT), P(NDI2OD-T2), P(NDI2OD-F2T2), and P(NDI2OD-Se2)) as semiconducting channel materials. All of the polymers displayed good FET characteristics with on/off current ratios exceeding 10(7). The highest hole mobility of 1.51 cm(2) V-1 s(-1) and the highest electron mobility of 0.85 cm(2) V-1 s(-1) were obtained from the P(DPP2DT-T2) and P(NDI2OD-Se2) polymer FETs, respectively. The impacts of the polymer structures on the FET performance are well-explained by the interplay between the crystallinity, the tendency of the polymer backbone to adopt an edge-on orientation, and the interconnectivity of polymer fibrils in the film state. Additionally, we demonstrated that all of the flexible polymer-based FETs were highly resistant to tensile stress, with negligible changes in their carrier mobilities and on/off ratios after a bending test. Conclusively, these high-performance, flexible, and durable FETs demonstrate the potential of semiconducting conjugated polymers for use in flexible electronic applications.</P>
Kim, Suhee,Ahn, Sun Hee,Yang, Hee-Young,Lee, Jin-Sil,Choi, Hyang-Gi,Park, Young-Kyu,Lee, Tae-Hoon Informa UK (TaylorFrancis) 2017 Redox report Vol.22 No.6
<P>Discussion: Pg appears to be redox-sensitive in cancer, and the C457 modification may impair cell migration and proliferation by affecting its interaction with the E-cadherin/catenin axis. Our findings suggest that redox-sensitive cysteines of Pg may be the targets for CRC therapy.</P>
KIM, Young-Ok,HONG, Suhee,NAM, Bo-Hye,LEE, Jeong-Ho,KIM, Kyung-Kil,LEE, Sang-Jun Japan Society for Bioscience, Biotechnology, and A 2005 Bioscience, Biotechnology, and Biochemistry Vol.69 No.7
<P>Hepcidin is a cysteine-rich cationic antimicrobial peptide central to iron metabolism. We report a comparative analysis of the sequences, gene organization and expression of two hepcidin genes from olive flounder <I>Paralichthys olivaceus</I>. Both consist of two introns and three exons that encode a prepropeptide (81 amino acids for hepcidin I and 89 amino acids for hepcidin II). A TATA box and several consensus-binding motifs for transcription factors were found upstream of the transcriptional starting site. Hepcidin II was predominantly expressed in the liver and highly inducible under the effect of lipopolysaccharide (LPS), while a large amount of hepcidin I transcripts was detected in various tissues but did not appear to have a significant effect during LPS-stimulation.</P>