호르몬 불응성 전립선암 환자에서 mitoxantrone과 prednisone의 병합화학요법 후 통증완화 및 삶의 질 측정

이홍우,이지열,김세웅,이충범,강성학,조용현,황태곤,박용현,윤문수 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.3

목적 : 호르몬 불응성 전립선암 환자의 생명을 연장시키는 치료법은 현재로는 없으며, 현 시점에서의 치료목표는 증상의 경감 및 소실에 따른 삶의 질 향상에 두고 있다. 호르몬 불응성 전립선암의 고식적인 치료에 일차적인 치료법으로 간주되는 mitoxantrone과 prednisone의 화학요법이 호르몬 불응성 전립선암 환자의 통증완화 및 삶의 질에 어떠한 영향을 미치는지 알아보았다. 방법 : 1998년 7월부터 1999년 12월까지 증상이 있는 18명의 호르몬 불응성 전립선암 환자를 대상으로 하였으며, 일차적인 치료의 목표는 환자 본인이 기록하는 McGill-Melzack 6단계 통증척도에서 진통제의 증량 없이 2점이 감소(또는 첫 점수가 1점일 경우 통증의 완전소실)하는 것으로 하였다. 이러한 기준은 최소 3주 간격으로 시행한 자가 기록조사에서 연속적으로 2번 이상 유지될 때 유효한 것으로 간주하였다. 건강과 관련된 삶의 질 측정은 전신적 치료의 임상적 응용을 위한 실제적인 측정방법으로 개발되어 환자가 직접 작성하는 전립선암 특이성 삶의 질 측정기구(Prostate Cancer-Specific Quality-of-Life Instrument : PROSQOLI)의 비례연속형의 자가측정 척도(linear analogue self-assessment scale : LASA)를 이용하였으며, ECOG performance status를 사용하여 전신상태의 변화도 측정하였다. 결과 : 통증의 경감으로 나타나는 고식적인 치료의 반응은 66.7%(12/18)에서 나타났으며, 반응의 지속기간은 2개월에서 10개월까지로 평균 4.2±3.6개월이었다. PROSQOLI로 측정한 삶의 질은 통증에 대한 고식적인 치료반응을 보인 12명(66.7%) 모두가 삶의 질이 개선되었으며 특히 통증, 변비, 소변보기, 전반적인 복지상태에서의 유의한(p<0.05) 증가를 보였다. 치료 후 혈장 PSA 수치는 고식적인 반응의 유무에 관계없이 별 다른 변화를 보이지 않았으며, 골주사 또는 전산화 단층촬영으로 측정한 방사선학적 병변은 고식적인 반응을 보인 2명을 제외하고 치료 전과 비교하여 차이를 보이지 않았다. 병합 화학요법과 관련된 특별한 부작용은 관찰되지 않았다. 결론 : 통증을 동반한 호르몬 불응성 전립선암에서 mitoxantrone과 prednisone의 병합화학요법은 66.7%의 환자에서 통증의 감소 및 삶의 질이 향상되었다. 현재는 혈장 PSA 수치, 병소의 크기나 개수등이 치료의 지침이나 치료결과의 판정을 위한 객관적인 기준으로 사용되는 경향이 있지만, 앞으로는 환자를 중심으로 통증을 포함한 삶의 질 측정이 고식적 치료 후 치료결과 판정에 있어 객관적이고 적절한 방법이 될 것이다. Background : There is no evidence that therapeutic modalities prolong the survival of patients with hormone-refractory prostate cancer nowadays. The main goal of treatment is therefore improvement in quality-of-life including palliation of symptoms. We performed this study to investigate the benefit of mitoxantrone and prednisone chemotherapy in patients with symptomatic hormone-refractory prostate cancer using relevant end points of palliation regarding to pain and quality-of-life. Methods : From July 1998 to December 1999, we assessed the 18 patients with symptomatic hormone-refractory prostate cancer receiving mitoxantrone and low dose prednisone. The treatment end point was a palliative response defined as a 2-point decrease in pain assessed by a 6-point pain scale complemented by patients (or complete loss of pain if initially 1+) without an increase in analgesic medication and maintained for two consecutive evaluations at least 3 weeks apart. Health-related quality-of-life was evaluated with a series of linear analogue self-assessment(LASA) scale of the Prostate Cancer-Specific Quality-of-Life Instrument (PROSQOLI) and performance status was also measured. Results : Palliative responses were observed in 12(66.7%) of 18 patients. The duration of palliative responses were 4.2±3.6 months(range: 2 to 10 months). Treatment was well tolerated without specific side effects. There were no differences in prostate-specific antigen (PSA) level following treatment and no significant changes of radiologic findings evaluated by bone scan and/or CT were noted except 2 cases after chemotherapy. All the responding patients had an improvement in quality-of-life scales and performance status, however serum PSA levels were not changed. Conclusions : Chemotherapy with mitoxantrone and prednisone provides palliation and an improvement in quality-of-life for more than half (66.7%) of the patients with symptomatic hormone-refractory prostate cancer.

두경부 편평세포암에서 형질전환 성장인자-알파(TGF-α)의 발현에 관한 연구

도남용,이승학,김완수,김경일,이동용,김용기,최봉남 조선의대 1996 The Medical Journal of Chosun University Vol.21 No.2

추황배(Pyrus pyrifolia Nakai cv. Chuhwangbae) 과피로부터 1종의 Sterol과 3종의 배당체 화합물의 단리·동정

이유건(Yu Geon Lee1),조정용(Jeong-Yong Cho),이현주(Hyun Joo Lee),이용현(Yong Hyun Lee),이상현(Sang-Hyun Lee),한태호(Tae-Ho Han),김월수(Wol-Soo Kim),박근형(Keun-Hyung Park),문제학(Jae-Hak Moon) 한국식품과학회 2013 한국식품과학회지 Vol.45 No.5

본 연구에서는 배의 유용성 증명을 위한 일환으로 배의 화학성분을 분자수준에서 밝히고자 하였다. 이에 배 과피 MeOH 추출물을 용매분획하여 얻은 EtOAc-산성 분획과 EtOAc-중성분획을 대상으로 Sephadex LH-20, silica gel, 그리고 ODS colmn chromatography와 HPLC를 이용하여 정제 및 단리하였다. 그 결과, EtOAc-산성 분획과 EtOAc-중성 분획으로부터 각각 2종씩의 화합물을 단리하였다. 단리된 화합물 1-4는 1H- 및 13C-NMR 분석을 통하여 각각 (S)-(+)-2-cis-abscisic acid O-β-D-glucopyranosyl ester (화합물 1), 1-[4-O-β-D-glucopyranosyl]phenyl ethanone(piceoside, 화합물 2), β-sitosterol (화합물 3), 그리고 β-sitosteryl 3-O-β-D-glucopyranoside (화합물 4)로 동정되었다. 단리된 3종의 배당체 화합물(화합물 1, 2, 4)들은 본 연구에 의해 배로부터 처음 동정되었으며, 화합물 3은 추황배로부터 처음 동정되었다. 본 연구결과가 배 함유 성분연구는 물론 배의 기능성 해명 연구에도 추후 중요한 기초자료로 활용되길 기대한다. We isolated and identified antioxidants from acidic and neutral ethyl acetate fractions of the peel of pear (Pyrus pyrifolia N. cv. Chuhwangbae). We isolated 4 compounds from the methanol extract, by using 3 different types of column chromatography (Sephadex LH-20, silica gel, and octadecylsilane) and preparative HPLC. We identified the isolated compounds as (S)-(+)-2-cis-abscisic acid O-β-D-glucopyranosyl ester (compound 1), 1-[4-O-β-D-glucopyranosyl]phenyl ethanone (picroside, compound 2), β-sitosterol (compound 3), and β-sitosteryl 3-O-β-D-glucopyranoside (compound 4) by nuclear magnetic resonance analysis. We are the first to report the identification of compounds 1, 2, and 4 from pear.

톨루엔 폭로근로자의 요중 마뇨산 농도 및 건강장해

이학성,문광용,안갑환,서정호 한국환경과학회 2004 한국환경과학회지 Vol.13 No.10

The relationships between subjective symptoms of toluene exposed workers and concentration of their urinary excretion of hippuric acid were investigated. The exposed groups of 146 workers exposed to toluene and the control groups of 47 workers have never been exposed to toluene in Ulsan area were selected and studied. Hippuric acid was measured by HPLC, and counts of blood cells and liver function test were also performed. The mean value of urinary hippuric acid concentration of the control group was 0.322(±0.267) g/L, while that of the exposed group was 1.260(±0.395) g/L. As the concentration of hippuric acid had statistical proximity in 0.1% level, WBC, GOT, and GPT didn't have any proximity(P>0.05). The exposed group showed lower level of leucocyte counts 6522.40(1710.3) than the control group 6891.50(1483.7). The exposed group showed higher level of GOT(25.75), GPT(27.09) than GOT(23.75), GPT(25.21) of the control group. Dried skin was the highest complained symptom of toluene exposed workers, the second strained eye, the third poor auditory function, and the fourth was headache.

광고 노출시점의 소비자 기분이 광고효과에 미치는 영향 : 인지적 및 감정적 반응, 광고 및 상표태도, 그리고 기억성과

이학식,전용석 한국방송광고공사 2005 광고연구 Vol.0 No.66

본 연구는 인지심리학 분야에서의 기존 연구 성과를 토대로 소비자의 기분에 따라 광고효과가 어떻게 달라지는지를 인지적 및 감정적 반응, 광고 및 상표태도, 그리고 기억성과 측면에서 조사한 것이다. 피실험자들의 기분을 긍정적 혹은 부정적으로 조작한 다음 실험용광고를 노출시키고 설문지를 이용하여 자료를 수집하였다. 본 연구에서 설정한 모든 가설은 지지되었는데, 이를 요약하면 다음과 같다. 첫째, thought positivity index와 feeling positivity index, 두 가지 모두 소비자의 기분이 긍정적인 경우 부정적인 경우보다 더 높게 나타났다. 둘째, 인지적 반응 → 상표태도의 관계는 소비자의 기분이 부정적인 경우, 그리고 감정적 반응 → 광고태도의 관계는 소비자의 기분이 긍정적인 경우 더 높게 나타났다. 셋째, 기억성과는 소비자의 기분이 부정적인 경우 긍정적인 경우보다 더 높게 나타났다. 추가적으로, 인지적 반응은 소비자의 기분이 부정적인 경우, 그리고 감정적 반응은 소비자의 기분이 긍정적인 경우 더 많이 유발된다는 것이 발견되었다. 본 연구의 결론에는 연구의 요약, 공헌점, 그리고 한계점을 논의하였으며, 끝으로 미래연구에 대한 제언을 하였다. This research is to investigate how advertising effects vary with consumers’ mood based on the findings in cognitive psychology. Advertising effects are examined in the aspects of cognitive and emotional responses, ad and brand attitudes, and memory performance. Subjects were exposed to an experimental ad and answered questionnaires after their mood was manipulated to be either positive or negative. The results indicate that (1) both thought positivity index and feeling positivity index are higher with consumers’ positive mood, (2) the relationship between cognitive responses and brand attitudes is higher with consumers’ negative mood while the relationship between emotional responses and ad attitudes is higher with positive mood, (3) memory performance is higher with consumers’ negative mood. In addition, it was found that more cognitive responses were made with consumers’ negative mood while more emotional responses were made with positive mood. In the conclusions, the authors discuss theoretical contributions and limitations and offer suggestions for future research.

고강도 콘크리트(80MPa이상)를 이용한 콘크리트충전강관구조 적용을 위한 기초물성 연구

이장환,강용학,정근호,김진호,정상진,최문식 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2

One of the most important reasons that CFT is used in many conditions is by using that we can achieve the effect, which reduce the section of the member. This research purpose to find the most ideal composition, which is achieved by the investigation in the concrete's property of matter like ability of Slump, Slump Flow, Air content, Bleeding, and Settlement when the high strength of concrete which is over 80MPa is used m the CFT column.

폴리프로필렌 纖維用 Carbene染料의 開發에 關한 硏究

李學沂,林龍進,민경은 慶北大學校 1982 論文集 Vol.33 No.-

Reactive dyes, which reaction center is carbene, were prepared and the dyeability of polypropylene fiber by those dyestuffs was investigated. Furthermore, a new say of dyeing and an applied technique for pretreating polypropylene with carbenic precursor were studied to improve dyeability. In this experiment, ketones were used as starting materials because these are mostly common functional group in dyes and dyestuff intermediates. Ketones could be changed to tosylhydrazone derivatives by tosylhydrazine in methanol at 0℃ in the presence of aqueous hydrochloric acid. Reactive carbenic dyes were prepared by the reaction of n-butyllithium and these hydrazone derivatives in ethly ether solvent. Dyed polypropylene showed excellent endurance to the light and preserverance to laundry, which were confirmed by means of blue and gray scales. The fact that polypropylene was bonded covalently to dyestuff molecules was confirmed by extraction and reprecipitation. Using the aldehyde as the starting material, carbenic precursor was also prepared analogous route to the dyestuff. After pretreating polypropylene fiber with this precursor, dyeing pattern of fiber in acidic media with butyl orange showed similar adsorption curve which is the typical results of acidic dyeing process. It means that polypropylene could be dyed easily in acidic media if it had pretreated by carbenic precursor.

신경회로망을 이용한 비터비 변환 알고리즘

이용학,전영희 濟州大學校 産業技術硏究所 1995 산업기술연구소논문집 Vol.6 No.-

A great number of papers have been introduced implementation of Viterbi decoding algorithm for convolution codes. But it is problems that long constraint length codes need many storages and hardware implementation is complicated. In this paper, we analized the Viterbi algorithm and represented it with simple matrix operations. We also analized the Hamming neural network which was a parallelism. The procedure computing the Hamming distance between the received codes and codewords was applied to lower subnet in the Hamming neural network and selection of the minimum Hamming distance used MAXNET in the Hamming neural network.

염욕에 의한 강의 Boro-Aluminizing에 관하여

이용학,이민용,양훈영 연세대학교 산업기술연구소 1981 논문집 Vol.13 No.1

본 실험에서는 硼砂熔融鹽중에 Al 또는 Al-B 合金을 첨가하여 浸硼處理할 때 B과 Al의 同時浸透 與否에 대하여 定量的으로 관찰하였고 또한 B과 A1을 차례로 침투시켰을 때 顯微鏡組織, 微小硬度, 耐磨耗性 및 耐高溫酸化性에 대하여 調査하였다. 그 결과 硼砂浴에 40% Al 또는 20% A1-B合金을 첨가하면 FeB와 Fe₂B의 두 層이 生成되었고 50% Al에서 B과 Al이 동시에 침투하였으며 60% Al, 50% Al-B에서 최대의 침붕층을 얻었다. 耐磨耗性 및 耐高溫酸化性은 alumin zing 후 boronizing한 試片에서 가장 좋은 결과를 얻었다. Effects of aluminum or aluminum-boron addition into molten borax on the boro-aluminizing of steel have been studied and effects of simultaneous or successive penetration of boron and aluminum on the microstructure, microhardness, wear resistance and heat resistance have also been studied. Two layers of FeB and Fe₂B were formed at 40% Al and 20% Al-B alloy in molten borax. Boron and aluminum were penetrated simultaneously at 60% Al addition. The thickness of boride layer was maximum at 60% Al and 50% Al-B alloy additions. Wear and heat resistance of boronized specimen after aluminizing showed the best results.

전이성 골종양 환자 1례에 대한 증례보고

이정현,정학수,이은용,김형준 세명대학교 한의학연구소 2001 韓醫學硏究所 論文集 Vol.3 No.-

By process of treatment for a case which diagnosed as metastatic bone tumor and admitted from the 7th March, 2000 to the 7th April, 2000, the results are as follows. Method & Results : This patient was diagnosed as breast cancer metastasizes to bone, was treated with herb medication, acupuncture, moxibustion and kinesio taping. In treatment, cancer pain in lumbar, leg, shoulder, flank and chest portion of the patient was improving. Specially, by moxibustion therapy at pain points, cancer pain was improved remarkably. Conclusion : I consider that cancer pain diseases can be improved remarkably by Acupuncture, Moxibustion therapy.