췌장암에서 Cyclooxygenase - 2 발현의 역할

김은경,이용욱,이규택,최규완,박동일,백승운,이준행,이종균,고광철,이풍렬,이종철,김재준,김완선,공구 대한소화기학회 2001 대한소화기학회지 Vol.38 No.3

Background/Aims: Accumulating evidence suggests that the use of NSAID may reduce the incidence of colorectal cancer. The likely mechanisms of these effects by NSAID is cyclooxygenase-2 (COX-2)-related inhibition of tumor proliferation and induction of apoptosis. The aim of our study was to examine possible roles and clinical significance of COX-2 expression in pancreatic cancer. Methods: Seventy-two pancreatic adenocarcinoma tissue specimens were obtained from surgical resection. After the immunohistochemical staining of the specimens, we examined proliferation activity (assayed by Ki-67 expression), apoptosis (by TUNEL stain), and microvessel density (by CD34 expression). We also investigated the relationship between the immunohistochemical expression of COX-2 and various clinicopathological characteristics. Results: The COX-2 positive rate in pancreatic epithelial cells was 41.7%. Proliferation index (PI) was significant higher in COX-2 positive specimens comparing to negative specimen (p=0.015) and the increase in intensity of COX-2 expression correlated with increasing PI (p=0.036). Apoptotic index (AI) was significantly higher in positivee COX-2 expression than in negative expression (p=0.044), but there was no significant difference in AI/PI between the COX-2 positive and negative specimens (p=0.44). The expression of COX-2 protein did not correlate with microvessel density, sex, age, differentiation, tumor size, stage, metastasis or patients survival. Conclusions: The expression of COX-2 enzyme in pancreatic cancer contributes to tumor proliferation, but is not related to apoptosis, angiogenesis or clinical characteristics. Further study is needed to examine the clinical usefulness of NSAID and COX-2 selective inhibitors.

허혈성 대장염의 임상 양상과 예후 인자

이미숙,손희정,강태욱,최규완,박동일,백승운,이준행,고광철,이종철,임윤정,이풍렬,김갑철,김재준 대한소화기내시경학회 2001 Clinical Endoscopy Vol.22 No.2

Background/Aims: Colonic ischemia is recognized as the most common vascular disorder of the intestines in the elderly. The severity of the disease may vary considerably with the prevalent benign transient forms, being amenable to conservative treatments and the severe gangrenous forms, requiring surgery. Correct diagnosis is usually made after the ischemic episode is over and colonic ischemia is frequently misdiagnosed. The aim of this study is to identify the clinical patterns and prognostic factors of ischemic colitis. Methods: We found 60 patients with nonoccusive ischemia of the large intestine, We analyzed age, sex, symptoms, signs, associated disease, location, endoscopy, hematologic, histologic, radiologic finding and treatment, retrospectively. Results: The mean age was 60.2±6.3 years. The most common symtoms were abdominal pain or bloody diarrhea. The most common sign was diffuse abdominal tenderness. The most common hematologic findings were anemia and leukocytosis. Associated medical illnesses wer diabetes, rhematoid arthritis and cerebrovascular accident, et al. Both computed tomography (CT) and endoscopy were useful diagnostic tools. The most common involved site was sigmoid colon. 46 patients were treated conservatively and 14 patients were managed surgically. Conclusions: Male gender, those with rebound tenderness, severe anemia, right or total colon involvement as well as rheumatoid arthritis had a poor prognosis. Both CT and endoscopy were useful in predicting prognosis.

위장관 간질종양의 임상 및 병리학적 고찰

김영호,장우영,이순진,손희정,최규완,도재혁,백승운,이준행,이풍렬,이종철,박철근,임윤정,김갑철,김재준,임효근 대한소화기학회 2001 대한소화기학회지 Vol.37 No.3

Background & Aims: Gastrointestinal stromal tumor (GIST) constitutes primary nonepithelial neoplasms of the gastrointestinal tract and includes most tumors previously designated as leiomyomas/leiomyosarcomas. GIST is pathologically divided into benign, borderline and malignanct tumor. This study was carried out to delineate the clinical and pathologic features of GIST and to establish the features predicting malignancy. Methods: Clinicopathologic data of 84 patients who had GIST from 1995 to 1999 were reviewed. Results: The subjects were 42 men and 42 women, and their mean age was 59.3±13.2 years. We located fifty-two tumors in the stomach, 28 tumors in the small intestine and 4 tumors in the colorectum years. Histopathology revealed benign tumors in 23 of the 84 patients, borderline tumors in 22, malignant tumors in 39. The average size of tumors was 6.23 cm in diameter (range, 0.6-26 cm). Metastasis was noted in 15.5% of the patients at diagnosis. On endoscopy, ulceration was more common in malignancy. Endsonographic findings except size were not significant statistically. On contrast enhanced computed tomography, malignancy showed more irregular shape and variable attenuation than benign lesions, which seemed to be valuable factor. Conclusions: The variables predicting malignancy were large tumor size (≥5 cm), location of the colorectum, palpable abdominal mass, ulceration on endoscopy, and less uniformity in shape and variable attenuation on computed tomography.

Glutaraldehyde 와 자동 세척기를 이용한 내시경 소독방법의 임상에서의 유용성

김영호,손희정,윤성원,최규완,이남용,백승운,이준행,고광철,이풍렬,이종철,송재훈,안병훈,김재준,최원혁,홍일철 대한소화기내시경학회 2001 Clinical Endoscopy Vol.22 No.6

Background/Aims: Safety of endoscopic procedures has been a major issue over the last 10 years. Most endoscopy units use 2% glutaraldehyde and automated endoscope reprocessors (AERs) for disinfecting gastrointestinal endoscopes. We attempted an in-use evaluation of the current reprocessing procedures. Methods: Thirty flexible endoscopes were randomly collected just after upper endoscopic examinations and were disinfected using 2% glutaraldehyde in an AER. Cultures were taken from biopsy channels (S-l), tip of the insertion tubes (S-2), umbilical cords (S-3), and angulation knobs (S-4). Results: In 63,3% (19/30) of endoscopes, there was no microbial contamination after disinfection procedures. The culture positive rates of S-l, S-2, S-3, and S-4 samples were 20,0%, 0.0%, 3.3%, and 20.0%, respectively. Microorganisms of 13 species were identified, but there was no pathogen related with reported infectious complications after endoscopic procedures. Conclusions: Current disinfection procedure using 2% glutaraldehyde and an AER appears to be very effective in decontaminating patient-used endoscopes. Low level microbial contamination of endoscopes after conventional reprocessing methods may not impose great risk on patients.

역류성 식도염 환자에서 Helicobacter pylori 치료 1 년 후 증상과 내시경적 변화

김영호,손희정,최규완,박동일,백승운,이준행,고광철,이풍렬,이종철,임윤정,김재준 대한소화기내시경학회 2001 Clinical Endoscopy Vol.24 No.1

이광수의 『사랑의 다각형』 재고(再考)-신문연재본과 단행본의 비교를 중심으로-

이행미 ( Lee Haeng-mi ) 인하대학교 한국학연구소 2019 한국학연구 Vol.0 No.55

이 글은 이광수의 『군상』 3부작 중 2부인 『사랑의 다각형』을 대개 통속성을 중심으로 살펴보았던 기존 연구의 관점과는 다른 각도에서 살펴보고자 하였다. 이와 같은 문제의식의 출발점은 이 소설의 단행본이 작가가 1930년 연재했던 당시의 신문연재본과 상당한 차이가 있다는 사실을 확인하면서 비롯되었다. 신문연재본과 단행본을 비교해 본 결과, 식민지 검열의 영향으로 텍스트의 수정과 변형이 이루어졌음을 확인할 수 있었다. 특히 일제 말기 출간된 단행본은 어휘와 문장 수준의 변형을 넘어 내용이 대폭 누락됨으로써 이 작품을 다른 각도로 해석할 수 있는 가능성을 상당 부분 사라지게 한다. 단행본에 누락되어 있는 신문연재본의 내용에는 안창호와 그의 사상을 상기하거나 그에 공명하는 작자의 모습이 선명하게 나타난다. 이는 1930년 이광수가 가지고 있던 조선 독립운동의 방향을 살펴보게 한다. 이를 바탕으로 『사랑의 다각형』은 이후 창작된 『흙』과 연결하여 그 의미를 들여다볼 수 있다. 신문연재본을 통해 확인된 이러한 부분은 『사랑의 다각형』에 제시된 애정 서사를 다른 방향으로 좀 더 풍부하게 해석할 가능성을 제공한다. 또한 이와 같은 텍스트의 비교 검토를 통해 식민지 시기 텍스트를 적절하게 이해하기 위해서는 어떤 판본을 연구 대상으로 삼아야하느냐는 문제가 중요하다는 사실을 다시금 확인할 수 있었다. This article aims to examine Lee’s Polygon of Love, which is part of the The Group(群像[gun-sang]) of Lee’s novel, from a different angle from the previous researches which mostly examined the popularity. The starting point of this problem consciousness came from affirming that the book of this novel is quite different from the newspaper series of the author’s series in 1930. As a result of comparing newspaper serial and book, it is confirmed that the text is modified and transformed in consideration of the censorship. In particular, the book published in last-stage of Japanese Colonial Era is largely missing the content beyond the vocabulary and sentence level, so the possibility of interpreting the novel from a different angle disappears considerably. The contents of the newspaper series, which are missing from the book, clearly show the author who reminds or supports Ahn Chang-ho and his ideas. This allows us to look into the direction of Lee Kwang-su’s independence movement in 1930, and connects Polygon of Love with The Soil to look into its meaning. This gives the possibility of interpreting the love narrative presented in Polygon of Love in a different direction. In addition, the comparative review of these texts confirmed that the issue of which edition should be targeted for proper understanding of colonial texts was important.

Network Revenue Management with Time and Precedence Constraints

( Lee¸ Haeng-ju ) 한국경영공학회 2020 한국경영공학회지 Vol.25 No.4

This paper explores the network revenue management problem where a firm sells products composed of multiple resources. Unlike the traditional network revenue management problem, the products have time and precedence constraints. This means that some products may be infeasible to deliver. To filter out those infeasible products, this paper proposes a simple linear programming. The firm starts the sales horizon only with the feasible products. The dynamic programming can be formulated to have the optimal policy, but it may suffer from the curse of dimensionality. To overcome this difficulty, this paper proposes the linear programming based heuristic. The numerical study shows that the heuristic can save the computation time greatly while providing a reasonably good solution.

논문 : 북풍회원(北風會員)이 바라본 관동대진재(關東大震災) 정우홍의「진재전후(震災前後)」를 중심으로

이행선 ( Haeng Seon Lee ) 민족문학사학회·민족문학사연구소 2013 민족문학사연구 Vol.52 No.-

이번에 발굴된「진재전후」는 관동대진재를 직접 경험한 사회주의자 정우홍이 8년이 지난 1931년에 쓴 소설이다. 해방 이후에 쓰인 이기영의「두만강」을 제외하고 사실상 진재 관련 소설이 없는 상황에서 전문작가는 아니지만 실제로 경험한 인물이 쓴 식민지기 소설이라 할 수 있다. 사회주의운동을 활발히 한 인물이기 때문에 사회주의운동사의 관점에서도 그 의의를 확보하고 있다. 이 작품은 1923년 1월에서 10월까지 일본 동경과 그 외곽지역을 배경으로 하고 있다. ‘동경 진입 전, 후, 진재기, 유치장기’로 전개된 이 작품은 사회주의운동가의 입장에서 르포르타주 기법으로 쓰여 사실성을 높이고 있다. 이 작품 초반부 (동경 진입 전후)의 빼어난 점은 재일조선인노동자의 열악한 노동현장을 재현하는 핍진성과, 초기 노동조직의 형성과정을 상세하게 형상화하고 있다. 후반부(진재기, 유치장기)는 관동대진재 장면과 흥분하는 일본인의 모습, 그리고 유치장에 수감되는 조선인의 내면성을 구현하고 있다. 그런데 전반부와 달리 후반부는 르포르타주의 사실성이 낮아지고 등장인물의 사적 내면의 기록이 증가한다. 노동투쟁과 관동대진재의 재현에 수반하는 검열을 의식한 서사의 특성을 짐작할 수도 있겠다. 이동성과 활동성의 요소로 해석해보면 점점 사회주의자의 이동성과 활동성이 줄어들고 일본경찰이 출몰하며 종국에는 감옥으로 협소화되면서 작품 말미에는 정치색이 거의 사라지고 있다. 유치장을 직접 경험한 정우홍이 드러낸 서사적 무의식과 식민지 무의식의 연관성을 짐작할 수 있게 한다. Jung woo-hong socialists directly experienced the Great Kanto Earthquake, and eight years later, in 1931, wrote a novel time “before and after the Earthquake” was unearthed. Ki-Young Lee`s “Duman River” written in the meantime, after the liberation, except for Earthquake-related novels was Is not a professional writer, Jeong Woo Hong But actually experience a figure that has significance. Active in the socialist movement figures because, from the point of view of the Socialist Movement has secured its significance. This work January-October 1923, Tokyo, Japan, and its outlying areas are in the background. “Tokyo entry before and after the earthquake period, lockup period” is deployed to work from the perspective of socialist activists written reportage techniques to increase the realism. The beginning of this work (Tokyo before and after) the entry of the superb akin to any reality, and to reproduce the scene of harsh labor workers in Japan, Koreans, shape and detail the process of the formation of the early labor organization. The end of the Great Kanto Earthquake scene and the appearance of excited Japanese, Koreans of being detained in a holding cell, and internality has been implemented. Unlike the first half and the second half of garrulity characters reportage of realism is offset flooding. Involved in the labor struggles of the Great Kanto Earthquake and reproduce the essential constraints that might be to gauge the characteristics of censorship conscious writing. Interpreted as an element of mobility and activity, the increasingly dwindling socialist party mobility and activity, haunted by the Japanese police, and eventually narrowing as he works at the end, political affiliations, almost disappearing into the garrulity of flooding fills the contents. Jung woo-hong prison experience exposed Similarly, the narrative of the colonial unconscious and subconscious association should be able to guess.

1인 가구의 주거선택요인이 원룸 선호도·만족도에 미치는 영향에 관한 연구 : 원룸 거주 대학생을 중심으로

이영행(Lee, Yeong?Haeng),최민섭(Choi, Min?Seub) 한국주거환경학회 2009 주거환경(한국주거환경학회논문집) Vol.7 No.2

As the number of one person householders are increasing, the population is decreasing because one person housing holders have been increased. Approximately 70% of one person housing holders are living in their houses. Most of them live in one-room. So in this study, we tried to recognize the importance of one person households, and established some choice factors of residence. Throughout the research, I made subordinate concepts and abstracted six factors, which are economical efficiency, expediency, cleanness, security, publicity and esthetics. I also investigated how the six factors affect to choosing one person households. Expediency, security, and esthetics affect to satisfaction but economical efficiency, cleanness and publicity are not affected. Preference of their one-room is affected to one-room satisfaction. Economical efficiency is rejected because most of people who live in one-room depend on their parents. So they do not consider the economical efficiency. Thus, through this study, when the government establish residence policy, expediency should be considered. Also the construction industries and the government should consider the choice factors of residence. The result shows that we need to change our thoughts that a single room is only for low-income people but also people who want to live in a convenient one-room.

Can The Markov Switching Model with Time Varying Transition Probabilities Forecast Exchange Rates ?

Kim, Bong Han,Lee, Joon Haeng 한국경제학회 2001 The Korean Economic Review Vol.17 No.2

We use Lee's (1991) Markov switching model with time varying transition probabilities (the TVTP Markov model) to analyze the behavior of the U.S. dollar/ British Pound exchange rate. We employ the magnitude of the deviation of the exchange rate from a monetary equilibrium value as the economic fundamental with which the transition probabilities vary. The empirical results we obtained from this paper are the following: first, the deviation of the exchange rate from a monetary equilibrium value can affect the transition probabilities of the exchange rate from one state to another state. When the exchange rate is overvalued (undervalued) relative to the monetary equilibrium value, the probability of the exchange rate to appreciating (depreciating) will be low (high). Second, the TVTP Markov model can identify both the appreciation state and the depreciation state of the exchange rate better than the Markov model with fixed transition probabilities (the FTP Markav model). Third, the forecasts of the TVTP Markov model are superior at predicting the direction of change of the exchange rate to those of the FTP Markov model.