http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Kim, E-H,Park, A-K,Dong, S M,Ahn, J-H,Park, W-Y Macmillan Publishers Limited 2010 Oncogene Vol.29 No.33
Epigenetic regulation by CpG methylation has an important role in tumorigenesis as well as in the response to cancer therapy. To analyze the mechanism of epigenetic control of radiosensitivity, the CpG methylation profiles of radiosensitive H460 and radioresistant H1299 human non-small cell lung cancer (NSCLC) cell lines were analyzed using microarray profiling. These analyses revealed 1091 differentially methylated genes (DMG) (absolute difference of mean β-values, |Δβ¯|>0.5), including genes involved in cell adhesion, cell communication, signal transduction and transcriptional regulation. Among the 747 genes hypermethylated in radioresistant H1299 cells, CpG methylation of SERPINB5 and S100A6 in radioresistant H1299 cells was confirmed by methylation-specific PCR. Reverse transcriptase–PCR showed higher expression of these two genes in radiosensitive H460 cells compared with radioresistant H1299 cells. Downregulation of SERPINB5 or S100A6 by small interfering RNA in H460 cells increased the resistance of these cells to ionizing radiation. In contrast, promoter CpG sites of 344 genes, including CAT and BNC1, were hypomethylated in radioresistant H1299 cells. Suppression of CAT or BNC1 mRNA expression in H1299 cells also reduced the resistance of these cells to ionizing radiation. Thus, we identified DMGs by genome-wide CpG methylation profiling in two NSCLC cell lines with different responses to ionizing radiation, and our data indicated that these differences may be critical for epigenetic regulation of radiosensitivity in lung cancer cells.
China Spallation Neutron Source: Accelerator Design Iterations and R&D Status
J. Wei,C.-D. Deng,C.-H. Wang,C.-T. Shi,H. Sun,H.-F. Ouyang,H.-M. Qu,H.-Y. Dong,J. Li,J. Zhang,J.-S. Cao,J.-Y. Tang,L. Dong,L.-L. Wang,Q. Qin,Q.-B. Wang,S. Wang,S.-N. Fu,S.-X Fang,T. -G. Xu,W. Kang,Y.- 한국물리학회 2007 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.50 No.I
The China Spallation Neutron Source (CSNS) is a high-power, accelerator-based project currently under preparation. The accelerator complex consists of an H$^-$ ion source, an H$^-$ linac, a rapid-cycling proton synchrotron, and the transport lines. During the past year, the design of most accelerator systems went through major iterations, and initial research and developments was started on the prototyping of several key components.
On Power System Frequency Control in Emergency Conditions
H. Bevrani,G. Ledwich,J. J. Ford,Z. Y. Dong 대한전기학회 2008 Journal of Electrical Engineering & Technology Vol.3 No.4
Frequency regulation in off-normal conditions has been an important problem in electric power system design/operation and is becoming much more significant today due to the increasing size, changing structure and complexity of interconnected power systems. Increasing economic pressures for power system efficiency and reliability have led to a requirement for maintaining power system frequency closer to nominal value. This paper presents a decentralized frequency control framework using a modified low-order frequency response model containing a proportional-integral (PI) controller. The proposed framework is suitable for near-normal and emergency operating conditions. An H∞ control technique is applied to achieve optimal PI parameters, and an analytic approach is used to analyse the system frequency response for wide area operating conditions. Time-domain simulations with a multi-area power system example show that the simulated results agree with those predicted analytically.
Practices and predictors of 2009 H1N1 vaccination in cancer patients: a nationwide survey in Korea.
Shin, Dong W,Kim, Yeol,Park, Jong H,Cho, Juhee,Jho, Hyun J,Yang, Hyung-Kook,Kim, Hyun S,Kim, So Y Blackwell Publishing Ltd 2012 Influenza and other respiratory viruses Vol.6 No.6
<P>Because patients with cancer are considered to be at high-risk for influenza infection and related complications, annual vaccination is recommended. The emergence of the novel H1N1 influenza virus in 2009 complicated the medical care of patients with cancer. The present study examined H1N1 vaccination practices among patients with cancer during the pandemic season and investigated factors related to the vaccination.</P>
Han S. Uhm,Kyung H. Lee,Soon C. Cho,Sung Y. Jo,Chan U. Bang,Dong K. Lee 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.53 No.2
Surface treatments of Y2O3:Eu phosphors for improving the hydrophobic property were carried out using plasmas generated from a O-(Si(CH3)3)2 (HMDSO) in a low-pressure environment. The super-hydrophobic properties of the treated Y2O3:Eu phosphors were investigated. The samples treated by using the HMDSO/toluene glow plasma were analyzed by FTIR and OES and analyzed in terms of their contact angles (CAs). The effects of the HMDSO/toluene plasma treatments on the Y2O3:Eu phosphors were investigated in terms of the total surface free energy by using probe liquids to measure their contact angles (CAs). The total surface free energy of the Y2O3:Eu phosphors before and after a surface treatment with the HMDSO/toluene plasma, as estimated via the Owens-Wendt equation, was found to decrease from 82.2 mJ/m2 to 0.021 mJ/m2. This represents a significant improvement of the hydrophobicity of the Y2O3:Eu phosphors after the plasma treatment.
간호전공과 비 간호전공 여대생의 모유수유 지식과 태도, 실천 지속 의지에 대한 연구
김수정,김희진,동민영,박소민,송예슬,이고은,이승만,장지은,정유진,최예슬 이화여자대학교 간호과학대학 2013 이화간호학회지 Vol.- No.47
Purpose: This study was conducted as benchmark to improve breast-feeding educational programs by comparing knowledge, attitude, and practical volition between female nursing college students and non-nursing college students. Method: The survey was conducted on 236 female students from ‘E’ and ‘Y’ Universities which were located in Seoul. The sample consisted of 114 nursing and 122 non-nursing college students. The data were collected using self-administered questionnaires from October 25 to December 17, 2012. The collected data were analyze dusing SPSS20.0. Result: The nursing college students’ level of knowledge, attitude and practical volition toward breast feeding was higher than non-nursing college students. There was positive correlation between knowledge and practical volition and attitude and practical volition about breast-feeding in nursing college students. But non-nursing college students had positive correlation between knowledge and attitude, and knowledge and practical volition about breast-feeding. Conclusion: Based on the results of the research, there was a correlation between knowledge, attitude, and practical volition toward breast feeding. It was suggested that technical knowledge of breast feeding be offered to female college students, as well as nursing college students. It could help them have the right information on breast feeding. It was also suggested that educational programs to reinforce emotional⋅practical attitude based on the knowledge of breast feeding be developed. Also, this study suggested that female students get their practical education in breast feeding under any circumstances with the practical volition to breast feed. Improving the knowledge, attitude, and the practical volition toward breast feeding, will increase the rate of breast feeding.
Won, Kyoung A.,Lim, Nak H.,Lee, Min K.,Park, Min K.,Yang, Gwi Y.,Park, Yoon-Yub,Ahn, Dong K.,Bae, Yong C. The Korean Academy of Oral Biology 2010 International Journal of Oral Biology Vol.35 No.3
We investigated the role of the central MAPK pathways in extra-territorial (referred) pain resulting from inflammation of the temporomandibular joint (TMJ). Experiments were carried out on male Sprague-Dawley rats weighing 220-280 g. Under anesthesia, these animals were injected with 50 μL of complete Freund's adjuvant (CFA) into the TMJ using a Hamilton syringe. In the control group, saline was injected into the TMJ. To identify the extent of inflammation of the TMJ, Evans blue dye (0.1%, 5 mg/kg) was injected intravenously at 1, 3, 6, 9, 12 and 15 days after CFA injection. The concentration of Evans blue dye in the extracted TMJ tissue was found to be significantly higher in the CFA-treated animals than in the saline-treated group. Air-puff thresholds in the vibrissa pad area were evaluated 3 days before and at 3, 6, 9, 12, 15 and 18 days after CFA injection into the TMJ. Referred mechanical allodynia was established at 3 days, remained until 12 days, and recovered to preoperative levels at 18 days after CFA injection. This referred mechanical allodynia was observed in contralateral side area. To investigate the role of central MAPK pathways, MAPK inhibitors (10 μg) were administrated intracisternally 9 days after CFA injection. SB203580, a p38 MAPK inhibitor, significantly attenuated referred mechanical allodynia, as compared with the vehicle group. PD98059, a MEK inhibitor, also reduced CFA-induced referred mechanical allodynia. These results suggest that TMJ inflammation produces extra-territorial mechanical allodynia, and that this is mediated by central MAPK pathways.
Lee, Min K.,Yoon, Jeong H.,Park, Min K.,Yang, Gwi Y.,Won, Kyung A.,Park, Yoon-Yub,Ahn, Dong K. The Korean Academy of Oral Biology 2010 International Journal of Oral Biology Vol.35 No.3
The present study investigated the role of ERK in the onset of mechanical and cold allodynia in a rat model of compression of the trigeminal ganglion by examining changes in the air-puff thresholds and number of scratches following the intracisternal injection of PD98059, a MEK inhibitor. Male Sprague Dawley rats weighing between 250 and 260 g were used. Under anesthesia, the rats were mounted onto a stereotaxic frame and received 4% agar (10 μl) solution to compress the trigeminal ganglion. In the control group, the animals were given a sham operation without the application of agar. Changes in behavior were examined at 3 days before and at 3, 7, 10, 14, 17, 21, 24, 30, and 40 days after surgery. Compression of the trigeminal ganglion significantly decreased the air-puff thresholds. Mechanical allodynia was established within 3 days and persisted over postoperative day 24. To evaluate cold allodynia, nociceptive scratching behavior was monitored after acetone application on the vibrissa pad of the rats. Compression of the trigeminal ganglion was found to produce significant cold allodynia, which persisted for more than 40 days after surgery. On postoperative day 14, the intracisternal administration of 1 μg or 10 μg of PD98059 in the rat model significantly decreased the air-puff thresholds on both the ipsilateral and contralateral side. The intracisternal administration of 10 μg of PD98059 also significantly alleviated the cold allodynia, compared with the vehicle-treated group. These results suggest that central ERK plays an important role in the development of mechanical and cold allodynia in rats with compression of the trigeminal ganglion and that a targeted blockade of this pathway is a potential future treatment strategy for trigeminal neuralgia-like nociception.
백창현,홍주화,위명용,김기영,이동복 대한금속재료학회 2003 대한금속·재료학회지 Vol.41 No.8
The oxidation behavior of TiN, TiCN and CrN coatings sputtered on a steel substrate was investigated at 850℃ in air. Both TiN and TiCN oxidized to Tio₂ while CrN oxidzed to Cr₂O₃. The oxidation resistance decreased in the order of CrN, TiN and TiCN. During oxidation, the outward diffusion of substrate elements such as Fe, Si occurred to a certain degree. The enrichment of substrate element of Cr at the oxide scale and the depletion of nitrogen at the lower part of the unoxidized CrN coating were observed.