DROWSY BEHAVIOR DETECTION BASED ON DRIVING INFORMATION

M. S. WANG,N. T. JEONG,K. S. KIM,S. B. CHOI,S. M. YANG,S. H. YOU,J. H. LEE,서명원 한국자동차공학회 2016 International journal of automotive technology Vol.17 No.1

Drowsy behavior is more likely to occur in sleep-deprived drivers. Individuals’ drowsy behavior detection technology should be developed to prevent drowsiness related crashes. Driving information such as acceleration, steering angle and velocity, and physiological signals of drivers such as electroencephalogram (EEG), and eye tracking are adopted in present drowsy behavior detection technologies. However, it is difficult to measure physiological signal, and eye tracking requires complex experiment equipment. As a result, driving information is adopted for drowsy driving detection. In order to achieve this purpose, driving experiment is performed for obtaining driving information through driving simulator. Moreover, this paper investigates effects of using different input parameter combinations, which is consisted of lateral acceleration, longitudinal acceleration, and steering angles with different time window sizes (i.e. 4 s, 10 s, 20 s, 30 s, 60 s), on drowsy driving detection using random forest algorithm. 20 s-size datasets using parameter combination of accelerations in lateral and longitudinal directions, compared to the other combination cases of driving information such as steering angles combined with lateral and longitudinal acceleration, steering angles only, longitudinal acceleration only, and lateral acceleration only, is considered the most effective information for drivers’ drowsy behavior detection. Moreover, comparing to ANN algorithm, RF algorithm performs better on processing complex input data for drowsy behavior detection. The results, which reveal high accuracy 84.8 % on drowsy driving behavior detection, can be applied on condition of operating real vehicles.

Proteomic Analysis Reveals PGAM1 Altering cis-9, trans-11 Conjugated Linoleic Acid Synthesis in Bovine Mammary Gland.

Wang, T,Lee, S B,Hwang, J H,Lim, J N,Jung, U S,Kim, M J,Kang, H S,Choi, S H,Lee, J S,Roh, S G,Lee, H G American Oil Chemists' Society 2015 Lipids Vol.50 No.5

<P>cis-9, trans-11 Conjugated linoleic acid (CLA) is one of the most extensively studied CLA isomers due to its multiple isomer-specific effects. However, the molecular mechanisms of cis-9,trans-11 CLA synthesis in ruminant mammary gland are still not clearly understood. This process may be mediated, to a certain extent, by trans-11 C18:1 regulated by stearoyl-CoA desaturase-1 (SCD1) and/or its syntrophic proteins. This study aimed to investigate the effects of TVA on SCD1-mediated cis-9,trans-11 CLA synthesis in MAC-T cells and its potential molecular mechanism. Results showed that trans-11 C18:1 was continually taken up and converted into cis-9,trans-11 CLA in MAC-T cells during the 4-h incubation of 50?μM trans-11 C18:1. SCD1 protein expression increased more than twofold at 2?h (P?<?0.01) and 2.5?h (P?<?0.05) before decreasing to less than half of the normal level at 4?h (P?<?0.05). One up-regulated (RAS guanyl releasing protein 4 isoform 1 [RASGRP4]) and six down-regulated proteins (glucosamine-6-phosphate deaminase 1 [GNPDA1], triosephosphate isomerase [TPI1], phosphoglycerate mutase 1 [PGAM1], heat shock protein beta-1 [HSPB1], annexin A3 [ANXA3], thiopurine S-methyltransferase [TPMT]) were found in MAC-T cells treated with trans-11 C18:1. Of these seven identified proteins, the presence of GNPDA1 and PGAM1 was verified in several models. More trans-11 C18:1 was taken up after PGAM1 knockdown by small interfering RNA (siRNA). In conclusion, our data suggested that PGAM1 may have a negative relationship with SCD1 and seemed to be involved in cis-9, trans-11 CLA synthesis by facilitating the absorption of trans-11 C18:1 in the bovine mammary gland.</P>

Structural Changes in the Oxygen-Evolving Complex of Photosystem II Induced by the S ₁ to S ₂ Transition: A Combined XRD and QM/MM Study

Askerka, Mikhail,Wang, Jimin,Brudvig, Gary W.,Batista, Victor S. American Chemical Society 2014 Biochemistry Vol.53 No.44

<P/><P>The S<SUB>1</SUB> → S<SUB>2</SUB> transition of the oxygen-evolving complex (OEC) of photosystem II does not involve the transfer of a proton to the lumen and occurs at cryogenic temperatures. Therefore, it is commonly thought to involve only Mn oxidation without any significant change in the structure of the OEC. Here, we analyze structural changes upon the S<SUB>1</SUB> → S<SUB>2</SUB> transition, as revealed by quantum mechanics/molecular mechanics methods and the isomorphous difference Fourier method applied to serial femtosecond X-ray diffraction data. We find that the main structural change in the OEC is in the position of the dangling Mn and its coordination environment.</P>

Evaluation of Sulfur and Multi-Walled Carbon Nanotube Composite Synthesized by Dissolution and Precipitation for Li/S Batteries

Park, J. S.,Kim, D. J.,Park, J. W.,Ryu, H. S.,Kim, K. W.,Wang, G. X.,Ahn, H. J. American Scientific Publishers 2012 Journal of Nanoscience and Nanotechnology Vol.12 No.7

<P>An elemental sulfur and multi-walled carbon nanotube (S-MWNT) composite was synthesized by dissolving sulfur in ammonium sulfides and then precipitating on MWNT. Morphology observation by scanning electron microscopy (SEM) confirmed that S-MWNT product was successfully prepared by incorporating sulfur into MWNT network. Without additional conducting material, the S-MWNT composite cathodes were prepared for electrochemical tests. The properties measured in discharge-charge cycling test showed that the composite had the initial discharge capacity of 1024 mAh g(-1), which is about 61% sulfur utilization. However, in the subsequent cycling, the capacities faded. To determine the reason of rapid capacity drop, S-MWNT composite cathodes were compared in the cycling tests with varying three kinds of electrolytes and the cathode was subjected to physical force by rolling. The changes in the cycle performances proved that the deterioration of S-MWNT composite cathodes was not related to the electrolytes but to physical bonding that may not maintain the conducting path between sulfur and MWNT.</P>

Bendable and flexible supercapacitor based on polypyrrole-coated bacterial cellulose core-shell composite network

Wang, F.,Kim, H.J.,Park, S.,Kee, C.D.,Kim, S.J.,Oh, I.K. Elsevier Applied Science Publishers 2016 Composites science and technology Vol.128 No.-

We report a bendable and flexible supercapacitor based on polypyrrole-coated core-shell bacterial cellulose composite networks. As an initial step, gel-type bacterial cellulose was transformed into individually ultrathin bacterial cellulose nanofibers (TOBC) with diameters of 3-5 nm, by using 2,2,6,6-tetramethylpylperidine-l-oxyl radical (TEMPO)-mediated oxidation and successive mild disintegration in water. And, PPy-TOBC core-shell nanofiber network electrodes were synthesized in situ by oxidative polymerization of pyrrole with iron (III) chloride on the TOBC nanofibers in aqueous medium. The PPy-TOBC core-shell nanofiber network electrode exhibited a high porosity (101 m<SUP>2</SUP>/g) and high conductivity (~6.63 S/cm) due to the homogenous coating of PPy nanoparticles on the TOBC nanofiber network. The as-prepared PPy-TOBC supercapacitor cell, fabricated with PVDF-EMIMBF<SUB>4</SUB> (1-Ethyl-3-methylimidazolium tetrafluoroborate) polymer electrolyte, showed a specific capacitance of 153 F/g and energy density of 21.22 Wh/kg at the current density of 0.2 A/g. Moreover, the PPy-TOBC supercapacitor exhibited an exceptionally good cyclic stability with ~93% capacitance retention after 100 cycles; it also showed good bending stability due to the mechanical failure tolerance of the nanofiber-networked electrodes. The present approach is a versatile, inexpensive, and promising way to develop the cellulose-based nanofiber network electrodes for practical energy storage applications.

Semisupervised Tripled Dictionary Learning for Standard-Dose PET Image Prediction Using Low-Dose PET and Multimodal MRI

Wang, Yan,Shen, Dinggang,Ma, Guangkai,An, Le,Shi, Feng,Zhang, Pei,Lalush, David S.,Wu, Xi,Pu, Yifei,Zhou, Jiliu IEEE 2017 IEEE Transactions on Biomedical Engineering Vol.64 No.3

<P>Objective: To obtain high-quality positron emission tomography (PET) image with low-dose tracer injection, this study attempts to predict the standard-dose PET (S-PET) image from both its low-dose PET (L-PET) counterpart and corresponding magnetic resonance imaging (MRI). Methods: It was achieved by patch-based sparse representation (SR), using the training samples with a complete set of MRI, L-PET and S-PET modalities for dictionary construction. However, the number of training samples with complete modalities is often limited. In practice, many samples generally have incomplete modalities (i.e., with one or two missing modalities) that thus cannot be used in the prediction process. In light of this, we develop a semisupervised tripled dictionary learning (SSTDL) method for S-PET image prediction, which can utilize not only the samples with complete modalities (called complete samples) but also the samples with incomplete modalities (called incomplete samples), to take advantage of the large number of available training samples and thus further improve the prediction performance. Results: Validation was done on a real human brain dataset consisting of 18 subjects, and the results show that our method is superior to the SR and other baseline methods. Conclusion: This paper proposed a new S-PET prediction method, which can significantly improve the PET image quality with low-dose injection. Significance: The proposed method is favorable in clinical application since it can decrease the potential radiation risk for patients.</P>

The Expression of Porcine Adiponectin and Stearoyl Coenzyme a Desaturase Genes in Differentiating Adipocytes

Wang, P.H.,Ko, Y.H.,Liu, B.H.,Peng, H.M.,Lee, M.Y.,Chen, C.Y.,Li, Y.C.,Ding, S.T. Asian Australasian Association of Animal Productio 2004 Animal Bioscience Vol.17 No.5

The gene expression of porcine adiponectin and stearoyl coenzyme A desaturase (SCD) was investigated in this study. The partial gene sequences for adiponectin and SCD were amplified by RT-PCR from subcutaneous adipose tissue and cloned by TA cloning techniques. Sequences of these genes were determined and found to be highly homologous to that of other species, suggesting similar function of these genes as in other species. The transcripts of these adipocyte-related genes in pig tissues were measured by Northern analysis. The transcripts for adiponectin and SCD were highly expressed in porcine subcutaneous adipose tissue; the transcripts for SCD were also barely detected in the liver, but the greatest concentrations were in the adipose tissue. In porcine stromalvascular cells (S/V cells) cultured in vitro, transcripts for adiponectin and SCD increased gradually during adipocyte differentiation. The level of adipocyte adiponectin mRNA was associated with late adipocyte differentiation, indicating the gene may not be involved in adipocyte differentiation but has great importance in porcine adipocyte functions. The SCD transcripts were not detectable until 2 d after induction of adipocyte differentiation. It was highly expressed in differentiating porcine adipocytes (2 to 10 d after the induction of adipocyte differentiation), indicating a significant role of SCD in adipocytes.

Cloning of Chicken Microsomal Glutathione S-transferase 1 Gene (MGST1) and Identification of Its Different Splice Variants

Wang, X.-T.,Zhang, H.,Zhao, C.-J.,Li, J.-Y.,Xu, G.-Y.,Lian, L.-S.,Wu, C.-X.,Deng, Xuemei Asian Australasian Association of Animal Productio 2009 Animal Bioscience Vol.22 No.2

Mammal microsomal glutathione transferase 1 (MGST1) can conjugate many toxic or carcinogenic substances and depress oxidative stress. In this study, Chicken MGST1 and its variants were cloned for the first time and were composed of 956 or 944 nucleotides. The 12 nt deletion in the exon 2 did not alter the GT-AG rule and the ORFs for the two MGST1 variants were the same, which both comprised 465 nucletides and encoded a peptide with 155 amino acids. It was found that the two different splice variants identified using RT-PCR expressed in all three organs investigated of Dwarf Brown Chicken, namely liver, spleen and shell gland. Moreover, the expression level of MGST1 mRNA in the liver of Dwarf Brown chickens was the highest (p<0.01), and there were no significant differences between the spleen and the shell gland. These results provide a base for studying the biological function of Chicken MGST1.

Unconventional superconductivity of NdFeAsO_0.82F_0.18 indicated by the low temperature dependence of the lower critical field <i>H</i>_c1

Wang, X L,Dou, S X,Ren, Zhi-An,Yi, Wei,Li, Zheng-Cai,Zhao, Zhong-Xian,Lee, Sung-IK IOP Pub 2009 Journal of physics, an Institute of Physics journa Vol.21 No.20

<P>We measured the initial <I>M</I>–<I>H</I> curves for a sample of the newly discovered superconductor NdFeAsO<SUB>0.82</SUB>Fe<SUB>0.18</SUB>, which had a critical temperature, <I>T</I><SUB>c</SUB>, of 51 K and was fabricated at the high pressure of 6 GPa. The lower critical field, <I>H</I><SUB>c1</SUB>, was extracted from the deviation point of the Meissner linearity in the <I>M</I>–<I>H</I> curves, which show linear temperature dependence in the low temperature region down to 5 K. The <I>H</I><SUB>c1</SUB>(<I>T</I>) indicates no s-wave superconductivity, but rather an unconventional superconductivity with a nodal gap structure. Furthermore, the linearity of <I>H</I><SUB>c1</SUB> at low temperature does not hold at high temperature, but shows other characteristics, indicating that this superconductor might have multi-gap features. Based on the low temperature nodal gap structure, we estimate that the maximum gap magnitude Δ<SUB>0</SUB> = (1.6 ± 0.2)  <I>k</I><SUB>B</SUB><I>T</I><SUB>c</SUB>.</P>

고환종양 : 21례에 대한 임상 및 병리조직학적 고찰 Analysis of 21 Cases and Review of Literatures

조정실,노재윤,김지환,이유복,김동식,최승강,이진무,왕종순 中央醫學社 1973 中央醫學 Vol.24 No.3

Clinicopathological study was made on 21 testis tumors that were obtained during a period of 12 years, from 1960 to 1971, at the Department of Pathology and Urology, Yonsei University. The 21 cases of testis tumor are consisted of 18 malignant and 3 benign tumors and are classified histologically into 7 seminomas, 8 embryonal carcinomas, 3 teratomas, 1 reticulum cell sarcoma, 1 rhabdomyosarcoma, and I gonadoblastoma. The mean age is 24.7 years, and 36.4 years in seminoma, 15 years in embryonal carcinoma, 17.7 years in teratoma, and 33 years in miscellaneous. The tumors occurred more frequently in the right than the left. There's no bilateral occurrence. The most frequent clinical complaint was painful palpable mass which were present in 6 cases out of 10 cases. One case of seminoma is arisen from intraabdominal testis which seems frequently to precipitate tumor occurrence. The other notable case is gonadoblastoma arisen in dysgenetic testis of true hermaphroditism.