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비정맥류, 비궤양성 장관 내 출혈 및 용종 제거술 후 내시경적 밴드 결찰술
이정환,김유선,김은순,배원기,우광훈,문정섭,유권,전영빈,류정임,선휘경,하근우 대한소화기내시경학회 2001 Clinical Endoscopy Vol.23 No.2
Background/Aims: There is no consensus as to the best treatment for non-variceal, non-ulcer gastrointestinal hemorrhage. Endoscopic band ligation is an inexpensive, readily available, and easily learned technique in contrast to conventional thermal methods of endoscopic hemostasis. The purpose of this study is to define the effectiveness of endoscopic band ligation for non-variceal, non-ulcer gastrointestinal hemorrhage and post-polypectomy hemorrhage. Methods: Twenty eight patients were treated by band ligation between July 1996 and October 2000. The lesions treated were; Dieulafoy’s lesion in 13, Mallory-Weiss tear in 7, angiodysplasia in 1, post-polypectomy bleeding in 4, post-endoscopic mucosal resection bleeding in 2, post- endoscopic biopsy bleeding in I. Results: Endoscopic band ligation was successful in 25 of 28 cases. Additional sclerotherapy was necessary in two cases of Dieulafoy’s lesion. The remaining case was early band detachment. Conclusions: Endoscopic band ligation is effective for non-riceal, non-ulcer bleeding. It has the advantage of ease of use and is relatively inexpensive.
자궁 경부암 환자에 있어서 삶의 질에 영향을 미치는 요인
변재광 ( Jae Gwang Byun ),이정필 ( Jung Pil Lee ),박진영 ( Jin Young Park ),김용미 ( Young Mi Kim ),이은희 ( Eun Hui Lee ),장기홍 ( Ki Hong Chang ),유희석 ( Hee Sug Ryu ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.12
목적: 자궁 경부암 환자 치료 후 삶의 질 평가와 이에 영향을 미치는 요소를 평가. 연구 방법: 127명 자궁 경부암 환자와 107명의 일반 부인과 대조군을 대상으로 하였다. 삶의 질과 관련된 여러 항목을 설문지 형식으로 조사하고 환자의 여러 인자와 비교, 분석하였다. 결과: 자궁 경부암 환자의 평균 나이는 54세, 대조군은 43세였다. 추적관찰기간은 환자군은 18.62개월, 대조군은 1개월이었다. 삶의 질을 평가한 여러 항목 중 Physical component score (PCS)는 환자군이 대조군과 비교 시 p=0.049로 통계적 유의성이 있었으나 MCS, CS-QOL, Emotional support, Coping efforts 항목에서는 유의한 차이를 보이지 않았다. 환자들은 경제적 여건이 좋을수록, 병기가 진행될수록 치료에 잘 적응하는 경향을 보였지만 다른 요인들은 환자의 신체적, 정신적 상태에 영향을 주지 않았다. 성생활에 대한 부분은 대부분의 평가항목에서 악화되었으며 특히 젊은 여성에 있어 그 정도가 심했다. Sexual dysfunction 항목은 p=0.004, sexual discomfort 항목은 p=0.070, sexual pleasure 항목은 p=0.011, gynecological symptom 항목은 p=0.001로 통계적 의미가 있었다. 나이 이외에는 병기, 경제적 여건, 배우자 유무, 교육 정도, 종교와 같은 인자들이 성생활의 만족도에 영향을 주지 못하였다. 치료 방법에 있어서는 방사선 치료군에서 성적 불편감이 다른 치료를 받은 군보다 높은 경향을 보였으나, 통계학적 유의성은 없었다 암 환자군은 치료 전 주요 관심사는 건강 (51%), 자녀 (23%), 경제적 문제 (16%)였으나 치료 후에는 자신의 건강 (92%)이 가장 중요한 관심사였다. 암 치료 과정에서 가장 심리적으로 도움을 주는 사람은 가족 (84%), 의료진 (9%) 이라 답했고, 종교 (2%), 친구 (2%)의 역할은 상대적으로 미미하였다. 결론: 자궁 경부암 환자들의 치료와 추적관찰 중에 삶의 질에 대한 고려가 반드시 이루어져야 하며, 이를 위한 상담 등 그룹치료, 약물치료, 교육이 필요하고, 경제적 부담을 줄이기 위한 국가적인 지원이 이루어져야 한다. Objective: To assess the quality of life (QOL) of uterine cervical cancer patients after treatment in Korea and to demonstrate influencing factors. Methods: 127 uterine cancer survivors, 107 controls of benign gynecologic surgery patients were interviewed with study questionnaire by research assistant. Results: Participants were with the mean age of 54 years (cancer patients) and 43 years (controls). Physical component score of General QOL was statistically significant in uterine cervical cancer group compared with control group (p=0.049). Parts of MCS, CS-QOL, Emotional support, Coping efforts didn`t show differences between two groups. In patients` characteristics, high economic status and advanced stage influenced patient`s adaptation to treatment. When evaluating QOL including sexual function, most parts were statistically significantly worsen in uterine cancer patients, ie, sexual dysfunction (p=0.004), sexual discomfort (p=0.070), sexual pleasure (p=0.011), gynecological symptom (p=0.001). Most factors except age didn`t influence sexual function deterioration between cancer group and control group. Common presenting concerns of cancer patients before treatment was health (51%), children (23%), economic problem (16%) but after treatment health (92%). The most helpful people were family members in 84% and physicians in 9%. Conclusion: Uterine cervical cancer survivors in Korea appear to experience greater distress on sexual function especially in young age. Therefore it is important for health care professionals to recognize that aspects of cancer survivorship continue to require education and adequate follow - up program.
Kim, Jae Hee,Kim, Gwang Suk,Kim, Eun Jung,Park, Sungha,Chung, Namsik,Chu, Sang Hui Aspen Publishers 2011 JOURNAL OF CARDIOVASCULAR NURSING Vol.26 No.6
<P>Poor adherence in patients taking warfarin may be one of the most common barriers to obtain favorable anticoagulation outcomes. This study was conducted to identify factors affecting medication adherence and their relationships with anticoagulation control in Korean patients taking warfarin.</P>
박희중,이광수,공광훈,Park, Hui Jung,Lee, Gwang Su,Gong, Gwang Hun Korean Chemical Society 2001 Bulletin of the Korean Chemical Society Vol.22 No.1
To gain further insight into the relationship between structure and function of glutathione S-transferase (GST), the four cysteine mutants, C14S, C47S, C101S and C169S, of human GST P1-1 were expressed in Escherichia coli and purified to electrophoretic homogeneity by affinity chromatography on immobilized glutathione (GSH). The catalytic activities of the four mutant enzymes were characterized with five different substrates as well as by their binding to four different inhibitors. Cys14 seems to participate in the catalytic reaction of GST by stabilizing the conformation of the active-site loop, not in the GSH binding directly. The substitution of Cys47 with serine significantly reduces the affinity of GSH binding, although it does not prevent GSH binding. On the other hand, the substitution of Cys101 with serine appears to change the binding affinity of electrophilic substrate by inducing a conformational change of the $\alpha-helix$ D. Cys169 seems to be important for maintaining the stable conformation of the enzyme. In addition, all four cysteine residues are not needed for the steroid isomerase activity of human glutathione S-transferase P1-1.
경기북부지역 정밀 수치기후도 제작 및 활용 - 2. 콩 생육모형 결합에 의한 재배적지 탐색
김성기 ( Kim Seong Gi ),박중수 ( Park Jung Su ),이영수 ( Lee Yeong Su ),서희철 ( Seo Hui Cheol ),김광수 ( Kim Gwang Su ),윤진일 ( Yun Jin Il ) 한국농림기상학회 2004 한국농림기상학회지 Vol.6 No.1
N/A A long-term growth simulation was performed at 99 land units in Yeoncheon county to test the potential adaptability of each land unit for growing soybean cultivars. The land units for soybean cultivation(CZU), each represented by a geographically referenced land patch, were selected based on land use, soil characteristics, and minimum arable land area. Monthly climatic normals for daily maximum and minimum temperature, precipitation, number of rain days and solar radiation were extracted for each CZU from digital climate models(DCM). The DCM grid cells falling within a same CZU were aggregated to make spatially explicit climatic normals relevant to the CZU. A daily weather dataset for 30 years was randomly generated from the monthly climatic normals of each CZU. Growth and development parameters of CROPGRO-soybean model suitable for 2 domestic soybean cultivars were derived from long-term field observations. Three foreign cultivars with well established parameters were also added to this study, representing maturity groups 3, 4, and 5. Each treatment was simulated with the randomly generated 30 years` daily weather data(from planting to physiological maturity) for 99 land units in Yeoncheon to simulate the growth and yield responses to the inter-annual climate variation. The same model was run with input data from the Crop Experiment Station in Suwon to obtain a 30 year normal performance of each cultivar, which was used as a reference for evaluation. Results were analyzed with respect to spatial and temporal variation in yield and maturity, and used to evaluate the suitability of each land unit for growing a specific cultivar. A computer program(MAPSOY) was written to help utilize the results in a decision-making procedure for agrotechnology transfer.