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        • KCI등재

          Anti-proliferative effect of Guichulpajing-Tang extract on MCF-7 cells

          조성희,박경미,반혜란,Cho, Seong-Hee,Pak, Keung-Mi,Ban, Hye-Ran The Society of Korean Medicine Obstetrics and Gyne 2006 大韓韓方婦人科學會誌 Vol.19 No.1

          이 연구는 MCF-7 인간 유방암 세포주에 대한 귀출파징탕(歸朮破?湯) 추출물의 증식억제효과 세포독성효과 세포사 유발효과를 확인하기 위하여 이루어졌다. MCF-7 인간 유방암 세포주는 Dulbecco's modified Eagle's medium/F12 (DMEM/F12)에 10% fetal bovine serum(FBS;Gibco) 와 항생제를 가하여 만든 배지를 이용하여 배양하였고, MCPF-7 세포를 96- well plate에 접종한 후 다양한 농도(0~2000g/ml)의 귀출파징탕(歸朮破?湯)이 든 배지로 처리하고 다양한 시간(48, 96, 192)동안 배양하여 현미경으로 관찰하고 각각 MTS assay kit를 이용하여 세포생존율을 측정하였다. 세포독성은 Sulforhodamine B assay 방법을 이용해 측정하였고 세포사 과정에서 MCF-7세포에서의 caspase 활성화를 측정하기 위해 Western blotting을 수행하여 poly ADP ribose polymerase(PARP)의 절단을 확인하였다. 실험결과 귀출파징탕(歸朮破?湯) 추출물에 의한 세포성장 및 독성효과는 시간 및 농도에 비례하는 것으로 나타났고 세포고사과정에서 작용하는 caspase의 전 기질인 PARP 절단량이 귀출파징탕(歸朮破?湯) 처리 농도와 시간에 비례하여 증가하였다. 이것은 caspase-3가 MCF-7 세포의 성장을 억제하는데 중요한 역할을 수행함을 의미한다. 따라서 귀출파징탕(歸朮破?湯)은 다양한 기전에 의해서 유방암 세포에 대한 억제효과를 가진다는 것을 인식할 수 있다.

        • KCI등재

          임신오조 2례에 대한 임상적 고찰

          조성희,반혜란,Cho Seong-Hee,Ban Hye-Ran 대한한의학방제학회 2004 大韓韓醫學方劑學會誌 Vol.12 No.2

          Background: We had treatment for two cases of Hyperemesis Gravidarum . they had difficulty in taking herbal medcine(Gamibosengtang), because of bitter taste and increased nausea and vomiting. So We used acupuncture treatment for increasing of taking herbal medicine and reduction of nausea and vomiting. Methods: The patients estimated their dgree of chief complain on a visual analogue scale and change of oral intake and change of frequency of vomiting. Result: Herbal treatment andacupuncture treatment was efficacious for Hyperemesis Gravidarum. Conclusion: More study fo herbal medicine is needed because of bitter taste.

        • SCOPUSKCI등재

          레니텍<sup>®</sup> 정(말레인산 에날라프릴, 10 mg)에 대한 에나레이스 정의 생물학적 동등성

          조성희,하용화,홍성제,서성훈,류재환,김동현,이경태,Cho, Sung-Hee,Ha, Yong-Hwa,Hong, Sung-Je,Seo, Seong-Hoon,Rew, Jae-Hwan,Kim, Dong-Hyun,Lee, Kyung-Tae 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.3

          The purpose of the present study was to evaluate the bioequivalence of two enalapril maleate tablets, $Renitec^{TM}$ (MSD Korea Ltd.) and $Enalace^{TM}$ (Welfide Korea Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty-four normal male volunteers, $22.33{\pm}2.55$ year in age and $66.54{\pm}8.30$ kg in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After two tablets containing 10 mg of enalapril maleate per tablet were orally administered, blood was taken at predetermined time intervals and concentrations of enalapril in plasma were determined using LC-MS-MS. Pharmacokinetic parameters such as $AUC_t,\;C_{max}\;and\;T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t,\;and\;C_{max}$ untransformed $T_{max}$. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals for the log transformed data were acceptance range of log0.8 to log1.25$(e.g.,\;log1.02{\sim}log1.14\;and\;log1.03{\sim}log1.19\;for\;AUC_t\;and\;C_{max},\;respectively)$. The major parameters, $AUC_t,\;and\;C_{max}$, met the criteria of KDFA for bioequivalence indicating that $Enalace^{TM}$ tablet is bioequivalent to $Renitec^{TM}$ tablet.

        • KCI등재

          가미귀비환 투여로 호전된 갱년기장애 환자 21례에 대한 증례보고

          조성희 ( Seong Hee Cho ) 대한한방부인과학회 2014 大韓韓方婦人科學會誌 Vol.27 No.4

          Objectives: The purpose of this study is to evaluate the effects of Kamikubi-hwan on menopausal disorder patients. Methods: We surveyed 21 menopausal disorder patients was administered Kamikubi-hwan. The patients of menopausal disorder was estimated twice with Kupperman``s index (KI) and Stress response inventory (SRI). Results: After treatment, the mean of KI and SRI score were decreased. Symptoms of menopausal disorder were decreased. Conclusions: This study shows that Kamikubi-hwan is significantly effective on menopausal disorder patients.

        • 사회복지사 보수교육 교육만족도 평가 -충청남도사회복지사협회 주관 보수교육 교육생의 평가를 중심으로-

          조성희 ( Seong Hee Cho ) 순천향대학교 사회과학연구소 2010 사회과학연구 Vol.16 No.1

          사회복지사 배출경로가 다양해지면서 자격취득자가 급증하여 곧 40만명이 될 것으로 예상하고 있다. 이처럼 양적으로 팽창하고 있는 사회복지사의 질적인 향상을 유도할 수 있는 제도적 기반을 확충하자는 필요성이 확산되면서 사회복지사 보수교육이 법제화되었다. 사회복지사의 전문성을 강화하기 위한 방안의 하나로 2009년부터 시행되기 시작한 보수교육의 운영실태를 파악하기 위하여 교육실시기관중의 하나인 충청남도사회복지사협회에서 개설 운영한 교육과정에 참여한 교육생 522명을 대상으로 실시한 교육만족도 평가결과에 기초하여 분석하였다. 분석결과 교육생들은 자기 계발 및 업무능력 향상이라는 자발적이기 보다 평점 취득, 직무명령 등 비자발적으로 보수교육에 참여하고 있지만, 강사 전문성, 교육내용, 교육효과 등에 대해 높은 만족정도를 보이는 등 대체적으로 긍정적으로 평가하고 있는 것으로 나타났다. The purpose of this study is to analyze a satisfaction of education for social workers as a human service profession. The degree of training satisfaction is important for several reasons, particularly professionalism. This thesis is to seek an opportunity for search strategies for enhancing the stability of the education system for social workers by reviewing run in 2009, the Chungnam area. The education for the social workers contribute to the development of professionalism. To accomplish the purpose, the bill was passed and the law could compel social workers to attend 8 hours` a year.

        • KCI등재

          방광암 후유증 환자 치험 1례

          조성희 ( Seong Hee Cho ),송유림 ( Yu Rim Song ) 대한한방부인과학회 2015 大韓韓方婦人科學會誌 Vol.28 No.2

          Objectives: This study aims to report the effect of Korean medicine treatment on Sequela of Bladder Cancer. Methods: The patient was treated with korean medicine of Paljeongsan-gamibang, acupuncture at Qihai (CV6), Guanyuan (CV4), Qugu (CV2), Hyeolhae (SP10), Sameumgyo (SP6) and we evaluated treatment effects by visual analogue scale (VAS) and urine analysis (UA) finding. Results: After treatments, the symptoms such as perineal pain, painful urination, dysuria, anorexia were improved and taking number of narcotic analgesic was reduced. Conclusions: This clinical study suggests that korean medicine treatment shows possibility to care for sequela of bladder cancer patient.

        • KCI등재

          여성 난임환자 20례의 임상결과보고

          조성희 ( Seong Hee Cho ) 대한한방부인과학회 2015 大韓韓方婦人科學會誌 Vol.28 No.2

          Objectives: This study is to report the effect of herbal medicine and acupuncture on a clinical pregnancy. Methods: From february 2014 to july 2014, a prospective analysis study was performed in 20 patients after taking her medicine and acupuncture treatment. Results: After treatment, two patients naturally became pregnance and one patient became pregnance after in vitro fertilization-embryo transfer (IVF-ET). Conclusions: This study suggests that herbal medicine and acupuncture treatment are useful and shows possibility to increasing pregnancy rates.

        • KCI등재

          괴테의 『친화력』에서 오틸리에의 체념 문제

          조성희 ( Seong Hee Cho ) 서울대학교 독일어문화권연구소 2015 독일어문화권연구 Vol.24 No.-

          Goethes Roman Die Wahlverwandtschaften, durch dessen seltsame Liebesgeschichte das Zeitbild schimmert, ruft seit der Veroffentlichung im Jahr 1809 heftige Diskussionen und mannigfaltige Interpretationen hervor. Die Frage, wie Ottilies Entsagung und Suhne nach dem Ertrinken Ottos verstanden werden sollen, wurde sowohl in der zeitgenossischen Rezeption als auch in unzahligen Forschungsarbeiten wiederholt diskutiert. Wenn man berucksichtigt, dass dieser Roman ursprunglich als eine Novelle fur die Wanderjahre entworfen war und deren Untertitel Die Entsagenden ist, kann man die entscheidende Rolle des Themas ‘Entsagung‘ fur das Verstandnis der Wahlverwandtschaften nicht verneinen. Das gilt auch aus der biografischen Perspektive: Goethe schuf die Figur Ottilie aus seiner eigenen Erfahrung, namlich aus seiner Altersliebe zu dem achtzehnjahrigen Madchen Minna Herzlieb. In Ottilies Entsagung und Tod spiegelt sich seine eigene personliche Erfahrung der Entsagung wider. Im vorliegenden Beitrag wird versucht werkimmanent zu erhellen, aus welchen Beweggrunden und unter welchen Umstanden Ottilie entsagt und inwieweit ihre Entsagung dem entspricht, was der alte Goethe unter dem Begriff der Entsagung verstand. Ottilie, die als arme Waise sich selbst ubermaßig unterdruckte, wird aus den sehr druckenden Verhaltnissen im Madchenpensionat gerettet, indem sie als ?ein Viertes“ ins Feld der Wahlverwandtschaften eintritt. Sie scheint dadurch geheilt zu werden, dass sie den vaterlichen Eduard liebt und von ihm geliebt wird. Ihre zarte Seele wird jedoch durch seine kindische Ungeduld und seine Willkur wiederholt verletzt: In dem hochsten Hoffnungsmoment muss sie die plotzliche Trennung von ihrem Geliebten, die entsetzliche Wahrheit von Charlottes Schwangerschaft und die erschreckende Nachricht von Eduards Teilnahme an dem Krieg erleiden. Der zuruckgekehrte Geliebte versetzt sie wiederum in volle Erwartung auf die Heirat mit ihm, was jedoch gleich in eine Katastrophe mundet. Ottilie entschließt sich danach, durch die Tatigkeit als Erzieherin im Madchenpensionat ihre Schuld zu suhnen und gleichzeitig sich selbst zu huten. Ihr Entschluss scheitert jedoch wiederum durch die unerwartete Begegnung mit Eduard im Wirtshaus. Sie sieht von nun an keinen Ausweg mehr aus dem Widerstreit zwischen ihrer sittlichen Natur und ihrer sinnlichen Natur, namlich zwischen den selbst geschaffenen Gesetzen oder verinnerlichten Normen und der Leidenschaft fur Eduard. Vor der Aporie, dass sie nicht Eduards Frau werden kann, obwohl sie ihn liebt, greift sie zum letzten Mittel: Sie beginnt zu schweigen und sich der Nahrung zu enthalten. Dieser Weg zur Selbstvernichtung lasst sich nicht als wahre Entsagung verstehen, die der alte Goethe sich uberlegte. Fur ihn bedeutete Entsagung die Einsicht in die notwendige Bedingtheit des Menschseins, deren tatige Realisierung, bisweilen schmerzlichen Selbstzwang, aber auf der hochsten Stufe heitere Gelostheit und eine Freiheit als freiwillige Abhangigkeit. Selbst Ottilies Verweigerung zu sprechen und zu essen ist aber nicht auf ihre eigenen tiefsinnigen Uberlegungen und ihren selbststandigen Entschluss, sondern auf Charlottes Rat zuruckzufuhren, den sie verinnerlicht hat. Und es ist auch ironisch, dass das Suizidmittel, das sie gewahlt hat, das Fasten ist. Wenn man die Tatsache, dass die ?große Maßigkeit im Essen und Trinken“ fur Ottilie eine Gewohnheit war, und Eduards Worte, ?Was ihr Seligkeit gewesen, wird mir Pein“, berucksichtigt, lebt sie bis zu ihrem Hungertod als Liebende fort. Freilich stellt sich die Frage, ob man sich ohne Selbstuberwindung bis zum Tode der Nahrung enthalten kann. Auch wenn sie darunter gelitten hatte, kann man ihren Versuch der Selbstvernichtung nicht als Entsagung zur Freiheit ansehen. Wenn sie gemaß ihrem eigentlichen Plan zum Madchenpensionat gegangen ware, dort die Qual des Abschieds erduldet und durch die Tatigkeit eine neue Hoffnung des Lebens gefunden hatte, hatte sie sich dem Ideal der Entsagung im Sinne der Wanderjahre angenahert.

        • KCI등재

          노인돌봄 환경 변화와 불교계의 과제

          조성희 ( Cho Seong-hee ),김정귀 ( Kim Jeung-kwi ) 동아시아불교문화학회 2016 동아시아불교문화 Vol.0 No.28

          인구 고령화현상은 우리나라 정책은 물론이고 불교계에도 고민거리가 되고 있다. 유래없이 빠른 속도로 진행되는 우리나라의 고령화 속도는 대비할수 있는 시간적인 여유를 허락하지 않아 높은 빈곤율, 열악한 건강상태, 증가추세의 노인학대, 높은 자살율 등 다양한 위험에 노인들은 노출되어 있다. 이는 오랫동안 전통으로 이어져 온 가족 중심의 비공식적 노인 돌봄서비스가 그 역할을 다하지 못하게 된 것에 원인이 있으며 공식적 노인돌봄서비스가 등장하였다. 그러나 독거노인이나 저소득층으로 대상자를 제한하고 있어 대다수 일반노인들은 배제되는 결과로 이어지고 있는 변화된 노인돌봄 환경을 보완하고, 다른 종교와 비교하여 불교 신도층의 고령화현상이 두드러지게 나타나고 있는 불교계의 위기상황을 극복하기 위한 방안의 하나로 사찰이 출가자의 수행 및 생활공간에서 교육·여가·문화 등 다양한 복합공간으로서의 역할을 담보할 것을 기대한다. The aging phenomenon of the population is a problem of not only Korean policy but also Buddhist. Korea`s aging pace, which is rapidly progressing at a rapid pace, does not allow time to prepare, and the elderly are exposed to various risks such as high poverty rate, poor health status, increasing elder abuse, and high suicide rate. This is due to the fact that the family-centered informal elderly caring service, which has long been a tradition, has failed to fulfill its role and official elderly care services have emerged. However, since the elderly living alone or the low-income group limit the number of elderly people, as one of the ways to overcome many older elderly people are compensated for the changed elderly care services and the Buddhist crisis in which the aging phenomenon of the Buddhist are prominent compared with other religions, the Buddhist temple insists on the role of the Buddhist temple as a diverse space including education, leisure, culture, etc.

        • KCI등재

          여성불임환자 6례의 임상보고

          조성희 ( Seong Hee Cho ),양승정 ( Seung Jeong Yang ) 대한한방부인과학회 2014 大韓韓方婦人科學會誌 Vol.27 No.2

          This study was performed to assess whether herbal medicine andacupuncture is effective on clinical pregnancy. Methods: From february 2013 to july 2013, a prospective analysis study wasperformed in 6 patients after taking her medicine and acupuncture treatment. Results: After treatment, one patients naturally became pregnance and onepatients became pregnance after in vitro fertilization-embryo transfer (IVF-ET). Conclusions: This study suggests that herbal medicine and acupuncture treatmentshows possibility to increasing pregnancy rates.

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