프로스타글란딘 E₁에칠에스테르의 외용 리오겔 제제 설계

양성운,이진교,이지은,김희규,박혜숙,김종석,최한곤,용철순,최영욱 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.2

External lyogels containing prostaglandin E₁ethyl ester(PGE₁-EE), a produrg of prostaglandin E₁(PGE₁) as a therapeutic agent for erectile dysfunction, were formulated to overcome the aqueous instability and enhance the percutaneous absorption. Lyogels of PGE₁-EE were prepared with ethanol (EtOH)/proplyene glycol (PG) cosolvent system as a vehicle, cineol as an enhancer, and hydroxypropylcellusose as a gelling agent. In vitro percutaneous absorption studies were performed to determine the rate of PGE₁ absorption through rat or hairless mouse skin. The permeability of PGE₁-EE lyogel with enhancer was 16-fold greater than that of lyogel without enhancer. Cosolvent produced 9-fold increase in percutaneous absorption. Pharmacodynamic effects of lyogels were evaluated in mature male cats in terms of intracavernosal pressure (ICP). Lyogles containing 0.01% of PGE₁-EE showed higher ICP compared to intraurethral preparation of PGE₁(1%) and enhancer-free control lyogel. The shelf-life (t_(10%) of lyogel at refrigerated condition (4℃) was calculated as 928 days, which is 4.2 times longer than that of control hydrogel. As a result, PGE₁-EE was formulated successfully to a lyogel system with a selective enhancer and cosolvent system for the topical delivery of PGE₁.

고추 탄저병 저항성 중간모본 ‘원예 100005호 ’,‘원예 100006호’ 육성

양은영,김수,채영,채수영,조명철,문지혜,박태성,이우문,곽정호 忠北大學校 農業科學硏究所 2015 農業科學硏究 Vol.31 No.2

Owing to frequent heavy rain due to abnormal weather, the occurrence of pepper anthracnose has recently increased, which affects the supply and demand of pepper. As a result, the price of red pepper powder in 2011, for example, increased three times compared to the average year. Although anthracnose of pepper plants has been controlled by fungicides until now, it is important to develop new resistant cultivars because of the reduction of the labor force in rural area and occurrence of new anthracnose strains resistant to fungicides. National Institute of Horticultural and Herbal Science developed two pepper lines, ‘Wonye 100005’ and ‘Wonye 100006’ that are resistant to pepper anthracnose. These lines were developed by continuous selection of progenies from a cross between ‘Wonye AR1’, which were developed from interspecific hybridization and ‘TF68’. The anthracnose resistance level of the two lines was higher than that of commercial cultivars and similar to check varieties showing highest level of anthracnose resistance.

역류식 충진탑에서 수력학적인 분석과 이산화탄소의 탈착에 관한 연구

楊善惠,崔東勳,지혜미,金恩貞,金彰昊 동아대학교 환경문제연구소 1996 硏究報告 Vol.19 No.1

This study was carried out to interpret hydraulic behavior and CO₂gas desorption in countercurrent packing tower which packed 50 mm plastic Hiflow-ring. The results are as follows: 1. To compare with conventional packing, 50mm Hiflow-ring could save energy because of low pressure drop under high load. 2. As relative error between calculated value and investigated value was less than 6% in the loading point and flooding point we found that we can predict results mathematically which occurres in the packing tower. 3. The unique magnituteds of packing which was used are as follows. C_(L) = 2.1×10^(-4), n = 0.787 so we can predict efficency which occurres.

간호사의 투약안전 역량 강화를 위한 교육요구 분석

양혜영, 이광희, 홍선영, 이정은 신한대학교 2021 신한대학교 논문집 Vol.44 No.-

The purpose of this study is to present basic data necessary for the development of educational programs to improve nurses' medication safety competency by analyzing educational needs. A survey was conducted on 37 clinical nurses at secondary hospitals or higher in Seoul and Gyeonggi-do. As a result of analyzing the nurse's medication experience, there were no cases of administering expired drugs, but various medication errors occurred. In addition, nurses had many organizational problems in performing oral prescriptions rather than receiving regular instructions for medication. There were six items that showed the largest statistical difference between the group of important and implementation levels of nurse's medication safety competency. In addition, as a result of the Borich’s demand analysis, the highest priority items were "Measures can be established to prevent recurrence in the event of drug side effects" and "Cases can be analyzed to find the root cause of medication errors." Based on the results of this study, follow-up studies on the development of educational programs that can strengthen nurses' medication competency should be conducted.

중환자실 병원감염에 대한 다기관 공동 조사연구

박은숙,박미라,진혜영,김정은,최정실,송영구,최영화,이위교,홍성관,허애정,양동규,김준명 대한병원감염관리학회 2003 의료관련감염관리 Vol.8 No.1

유치원 원감의 역할지각과 역할수행에 대한 연구

박양인,박은혜 이화여자대학교 교육과학연구소 2000 교육과학연구 Vol.31 No.1

본 연구는 유치원 원감들이 자신의 역할에 대하여 어떻게 인식하고 실제로는 어떻게 수행하고 있는지를 알아보는 것을 목적으로 하였다. 본 연구의 목적을 위하여 서울과 경기지역에 소재 유치원에 재직하고 있는 원감 75명을 대상으로 설문지 조사를 하였다. 연구결과 첫째,유치원 원감이 자신의 직무로 가장 중요하게 생각하는 것은 인화적 역할이었으며 이러한 인식은 개인의 특성이나 조직의 특성에 영향을 받지 않는 것으로 나타났다. 둘째, 유치원 원감의 직무영역에 대한 역할수행은 역할지각보다 유의하게 낮았으며 관리적 역할을 가장 많이 수행하고 있는 것으로 나타났고 개인적 특성에 따른 차이가 있었다. 셋째, 유치원 원감의 직무에 대한 역할지각과 현재 수행간의 차이를 알아본 결과 지각과 수행간의 차이가 가장 큰 것은 인화적 역할이었으며 개인 및 조직적 특성에 따른 차이가 나타났다. 연구결과에 따른 논의와 시사점이 제시되었다. The Kindergarten Vice-principal's Role Perception and Role Performance The purpose of this study was to investigate kindergarten vice-principals' perceptions and performances of their role. In order to achieve the purpose, the following questions were addressed. 1.What is the kindergarten vice-principal's perception of their role? 2.What is the kindergarten vice-principal's performance of their role like? 3.What is the discrepancy between role perception and role performance of kindergarten vice-principals? 75 kindergarten vice-principals working at kindergartens located in Seoul and Kyeonggi Province were participated in this study. In order to answer the research questions, questionnaires devised by the researchers were used. The result of this study can be summarized as follows: First, kindergarten vice-principals considered the role of harmony with others as the most importance task. The role perceptions of the kindergarten vice-principal were not affected by personal and organizational characteristics. Second, role performances of the kindergarten vice-principal were much lower than the role perceptions. Administrative role was the most frequently performed. The kindergarten vice-principal's age and job career affect to the leadership role performance. Third, The study revealed that 'role of harmony with other' had the biggest gap between perception and performance.

Bacillus subtilis 接種이 土壤微生物相에 미치는 影響(Ⅰ) : 볏짚 및 크로버 添加區에서의 微生物相의 變動 Changes in Microflora by Application of Straw and Clover

孔惠淑,柳恩珠,梁昌述 建國大學校 附設 農業資源開發硏究所 1993 農資源開發論集 Vol.18 No.-

토양으로부터 분리한 B. subtilis를 有機物이 施用된 토양에 還元 接種하여 有機物 種類에 따른 B. subtilis의 토양중에서 適應·定着性 및 B.subtilis가 다른 土壤微生物相에 미치는 영향을 經時的으로 조사하였다. 또한 有機物이 시용된 토양중에서 B,subtilis와 植物 病原菌인 F. oxysporum을 동시에 接種하여 상호간의 拮抗的 關係를 검토한 결과는 다음과 같다. 1) B. subtilis菌數는 對照區에서보다 B. subtilis 接種區에서 增加를 보였고 단지 볏짚 및 크로버만을 사용한 區에서보다 볏짚 및 크로버 施用區에 B. subtilis를 접종한 區가 약 2배 정도 B. subtilis菌數의 증가를 보였다. 특히 B.subtilis를 有機物 施用區에 접종했을 때 볏짚 시용구가 크로버 시용구에서보다 B. subtilis菌數가 약 3배 정도 현저하게 증가하였다. 2) 細菌과 絲狀菌數는 대조구보다 B.subtilis 接種區에서 각각 23% 및 20%씩 감소하였으므로 또한 크로버 시용구에서보다 크로버+B. subtilis 접종구에서도 각각 33% 및 16%씩 감소하였고, 볏짚 시용구에서는 볏짚+B. subtilis 접종구에서 각각 29% 및 32%씩 감소경향을 나타내었다. 3) 胞子形成菌數는 대조구보다 B. subtilis 접종구에서 약 10배 정도 증가하였으며 단지 有機物만을 시용한 區보다도 크로버+B. subtilis 접종구와 +B. subtilis 접종구에서 각각 2배, 4배 정도의 증가경향을 보였다. 또한 gram(-)細菌도 胞子形成菌數와 비슷한 경향을 나타내었고, B. subtilis接種이 그람 음성 세균수의 변동에는 영향을 미치지 않았다. 4) F. oxysporum의 菌數는 크로버 시용구에서보다 크로버+F. oxysporum 접종구에서 25배 정도 증가하였으나 크로버+B. subtilis 접종구에서는 크로버+F. oxysporum 접종구보다 약 5배 정도의 감소경향을 나타내었다. 또한 F. oxysporum菌數는 볏짚+F. oxysporum區에서 볏짚 單獨施用區보다 3배 정도 증가하였으나 볏짚+B. subtilis+F. oxysporum접종구는 볏짚+F. oxysporum접종구보다 F. oxysporum의 數가 약 17배 정도 감소경향을 나타내었다. 더욱이 F. oxysporum菌數는 크로버+B. subtilis+F. oxysporum접종구보다 볏짚+B. subtilis+F. oxysporum접종구에서 약 40배 정도의 감소경향을 나타내었다. 5) 크로버 시용구의 토양 pH는 약 ph 9에 이르러 토양 ph가 alkali화되었으며 볏짚시용구의 토양 ph는 큰 변화 없이 약산성을 유지하였다. This study has been conducted to investigate the adaptation of Bacillus subtilis to the soil and the antagonistic interaction between B. subtilis and pathogen Fusarium oxysporum as well as the periodic change of soil microflora when B. subtilis was inoculated to the soil treated with organic matters. Some results obtained from this study are as follows : 1) The number of B. subtilis was more increased about 6 times in the plot inoculated with B.subtilis than in control plot. It was relatively double in the organic matter+ B. subtilis plot than in the only organic matter plot. B. subtilis was particuraly increased about 3 times in the straw +B. subtilis plot, compared with the clover +B. subtilis plot. 2) The number of total bacteria and fungi was decreased by 23% and 20% in the plot inoculated with B.subtilis respectively than in control plot. It was not only decreased by 33% and 16% in the clover+B. subtilis plot respectively than in the only clover plot but it was also decreased by 29% and 32% in the straw+B. subtilis plot respectively than in the only straw plot. 3) The number of spore-forming bacteria was increased about 10 times in the plot inoculated with B.subtilis than in the control plot. It was also increased 2 times and 4 times in the clover+B.subtilis plot and in the straw+B. subtilis plot respectively than in each organic matter plot. The number of gram-negative bacteria and the spore-forming bacteria were slightly increased in all the plot inoculated with B. subtilis. 4) The number of F. oxysporum was increased about 25 times in the clover+ F. oxysporum plot than in the only clover plot. But it was decreased about 5 times in the clover+B.subtilis+ F. oxysporum plot than in the clover +F. oxysporum plot. Furthermore, F. oxysporum was remarkably decreased about 40times in the straw+B. subtilis+ F. oxysporum plot than in the clover+b. subtilis+ F. oxysporum plot. It occured that B. subtilis had inhibited the growth of pathogen F. oxysporum when B. subtilis was inoculation to the soil treated with straw. 5) Soil pH was changed to pH 9 in the plot treated with clover to become the alkalification of experimental soil. Meanwhile it was not changed in the plot treated with straw.

Isoniazid 복용후 나타난 정신증상

전양환,김은혜,김광수 한국의학사 1992 診斷과治療 Vol.12 No.6

정서유발단어에 대한 주의이동시 뇌신경망의 활성 양상

김연희,장은혜,고명환,신승훈,양경혜,손진훈 한국뇌학회 2002 한국뇌학회지 Vol.2 No.2

본 연구는 fMRI를 사용하여 정서유발단어에 의한 주의이동과 관련한 뇌신경망을 규명하기 위하여 12명의 오른손잡이 여대생을 대상으로 수행하였다. fMRI 실험을 위한 뇌활성화 과제는 예비실험을 통하여 선정된 행복, 슬픔, 위협에 해당하는 각각 36개씩의 단어와 각 단어의 짝을 이루기 위한 중성단어를 이용하여 변형된 Posner 패러다임을 블록디자인으로 고안하였다. fMRI 영상은 1.5T Simens Vision scanner를 사용하여 실시하였으며, single-shot EPI 기법으로(TR/TE:3840/40ms, flip angle: 90, FOV: 220, 64x64 matrix, Slice thickness: 6mm) 이미지를 얻었고 피험자의 반응시간을 기록하였다. 자료분석은 SPM-99 소프트웨어를 사용하였다. 정서유발단어는 중성단어에 비하여 반응시간이 의미있게 빨라 효과적인 주의이동이 일어났음을 알 수 있었다. 정서유발단어와 중성단어에 의한 뇌활성화 상태를 감산분석한 결과, 좌측 상두정엽, 양측 후두엽 및 소뇌에서 뇌활성화를 보였고, 이들 영역은 정서유발단어에 의한 주의이동시 특징적으로 활성이 일어나는 뇌영역임을 보여주었다. 또한 여러 가지 정서가를 가진 단어에 의해 유발되는 주의의 정도가 특징적인 신경망의 활성과 관련되어 있음을 알 수 있었다. The purpose of this study is to delineate the neural network related to the shift of attention and its modulation by emotion-provoking words using functional MRI (fMRI). Twelve right-handed normal female volunteers participated in fMRI study. Their mean age was 24 years and the mean modified Edinburgh score was +90. Emotion-provoking words representing happy, sad, threatened, and neutral emotional valences respectively were chosen by the assessment of 60 normal volunteers using semantic differentiation and Mannequin scales. The activation tasks were designed using modified Posner's paradigm to have 4 blocks of each emotional and control periods, Imaging was conducted on a 1.5T Siemens Vision scanner. Single-shot echoplanar images (TR/TE = 3840/40 ms, flip angle = 90, FOV = 220, matrix = 62 ? 64, slice thickness = 6㎜) were acquired in 20 contiguous slices parallel to the AC_PC line as well as conventional T1-weighted images. Response times were obtained during the scanning, Imaging data were realigned, coregistered, normalized, smoothed, and statistically analyzed in group using SPM-99 software. The results showed that emotional valence of word stimuli produced the effect of attentional engagement. The left superior parietal, inferior frontal, bilateral occipital lobes and cerebellum were main area of modulation of attentional network by emotional words stimuli. The different extent of brain activation induced by different emotion-provoking words were determined.

ICNP를 적용한 학교간호현상 및 특성과 초·중·고등학교의 학교간호현상 비교

김영임,왕명자,양순옥,현혜진,박은옥 韓國學校保健學會 2004 韓國學校保健學會誌 Vol.17 No.1

Purpose : this study purposed to investigate school nursing phenomena in Korea by applying ICNP, the international standard nursing classification system developed by ICN, and to compare school nursing phenomena at elementary, middle and high schools. Method : The subjects of this study are 110 nursing teachers from 82 elementary schools, 16 middle schools, and 12 high schools. In the survey, subjects were asked to score the degree to which phenomena and characteristics of Koran school nursing, identified in previous research, on a 5 point scale. Questionnaires were distributed and recovered by mad and email. The period of data collection was 6 months from July to December 2003. The general characteristics of schools and nursing teachers were represented with frequencies and percentages, the phenomena and characteristics of school nursing with the score of the questions, and the phenomena school nursing by school grade with ANOVA and Duncan's posterior analysis. Results : 1) As for the characteristics of schools according to school nursing phenomena related to human behavior, the mean score of questions on inadequate stress management was highest at 3.24 points followed by the score on inadequate weight control (3.23), inadequate eating habits (3.22), the risk of spine disorders (2.68), inadequate emergency management (2.62), inadequate response to sex -related problems (2.19), and smoking and drug use (1.85). 2) As for the characteristics of schools according to school nursing phenomena related to human function, the mean score of questions on oral health management was highest at 3.11 points followed by the score on the risk of digestive system disorder (2.87), improper eyesight management (2.81), the risk of respiratory system disorders (2.75), lack of sexual identity (2.52), and inadequate contagious disease control (2.12). 3) As for the mean score according to school nursing phenomena related to environment, the score of the risk of accidents in classroom was highest as 2.68 points followed by the score of the risk of accidents around the school (2.66), maladjustment to school (2.62), the risk of accidents outside the classroom (2.43), inadequate learning environment (1.83), the risk of exposure to socially and physically harmful environment factors (La), and inadequate waste disposal (1.77). 4) This study tested the m n scores of questions corresponding to each school nursing phenomenon in order to see if there is a difference in the school nursing phenomenon among elementary, middle and high schools, and performed Duncan's posterior comparison for school nursing phenomena. A significant difference was found at p<.l. According to the results, school nursing phenomena found to be significantly different among elementary, middle and high schools was smoking and drug use (p<.05), which appeared more problematic in high school than in elementary school. phenomena such as inadequate eating habits, inadequate weight control, inadequate response to sex-related problems and inadequate waste disposal were also found to be statistically different at p<.l; however, according to the result of Duncan s posterior comparison, no difference was found among groups in improper eating habits and improper response to sex-related problems, and a significant difference was found between middle and high schools in inadequate weight control and inadequate waste disposal. Conclusion: Based on the results of this study, it is necessary to plan school health projects focused on the characteristic school nursing phenomena that had high scores and to develop and execute school healthe projects in accordance with the characteristics of elementary, middle and high schools. Considering that the scores of school nursing phenomena related to human behavior are high, it is necessary to introduce school health promotion projects in a systematic way.