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HMG-CoA 환원효소 억제제에 의한 ICAM-1 유전자의 발현조절
김현진,정효균,홍우정,김군순,조영석,김도희,채수흥,구본정,송민호,노흥규,김영건 충남대학교 의과대학 지역사회의학연구소 2001 충남의대잡지 Vol.28 No.1
Background : ICAM-1 act as one of major adhesion molecules in the atherosclerotic lesion. ICAM-1 expression is mainly regulated at the level of transcription and depend on IFN-γ signal transduction pathway in which the STAT1 transcrption factor is a critical intermediate. IFN-γreceptor not only initiates tyrosine 701 phosphorylation of STAT1 by Jak1 and Jak2, but also phosphorylates serine 727 through the activation of Raf-1/MAP kinases. HMG-CoA reductase inhibitors have anti-atherosclertic effects, beyond normalization of hypercholesterolemia, by directly acting on endothelial cells, macrophages and vascular smooth muscle cells. HMG-CoA reductase inhibitors suppress the synthesis of isoprenoid intermediates such as geranylgeranyl-pyrophosphate or farnesylpyrophosphate. These effects results inhibitors suppress the synthesis of isoprenoid intermediates such as geranylgeranyl-pyrophosphate or farnesylpyrophosphate. These effects results inhibition posttranslational farnesylation and geranyl-geranylation processing of small GTP-binding preoteins and inhibition of normal signaling activities. Method : We made several 5'-deletion constructs of rat ICAM-1 promoter and analyzed the promoter activities by measuring the luciferase activity after transfection into ECV304 cells and smooth muscle cells. We checked the level of total and phosphorylated STAT1 protein by immunoblot analysis using specific antibodies. Results : Lovastatin inhibits IFN-γ-induced ICAM-1 gene expression in the ECV304cell. The cells pretreated with PD98059, MEKK inhibitor showed significantly low ICAM-1 RNA induction with IFN-γ stimulatio. IFN-γ induced phosphorylation of tyrosine 701 was not significantly changed by the pretreatment of lovastatin. But lovastatin suppresses IFN-γ-induced phosphorylation of ERK1/ERK2 which are responsible for the seine 727 phosphorylation in STAT1. Conclusion : We showed that HMG-CoA reductase inhibitors, lovastatin, suppresses IFN-γ mediated ICAM-1 gene expression through the inhibition of transcription. HMG-CoA reductase inhibitor suppresses IFN-γ-induced phosphorylation of serine 727 in STAT1 through the modulation of MAP kinases.
GPS 측위법을 이용한 차량추종자료 측위방법간 정확성 비교
김도균,이종달,김성훈,정광수,박관 嶺南大學校 工業技術硏究所 2003 工業技術硏究所論文集 Vol.31 No.2
The purpose of this study is to examine GPS data accuracy on traffic behavior analysis and to investigate GPS measurement in the real road condition. This measurement uses GPS hardware and software for collecting speed and position of two model cars at the same time. Data of Disto meter and GPS data which are bases of GPS data value are compared for judging through t-testing and correlation analysis. GPS data is used for calculating car moving distance and speed change. It is useful to traffic control in a city by analyzing basic traffic behavior appeared on leading car and following car.
김대중,양승하,정도영,강상균,김의한 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.1
To observe the expression of p53 protein and PCNA in lung carcinomas and to evaluate the correlationship between the two results, the author has been carried out immunohistochemical staining with mononuclear antibodies against p53 and PCNA. 64 cases of lung carcinomas used consist of 32 cases of squamous cell carcinomas, 18 cases of adenocarcinomas and 14 cases of small cell carcinomas, respectively. 1. p53 protein expression was seen in 16 cases out of 32 (50%) in squamous cell carcinoma, 7 cases out of 18 (39%) in adenocarcinoma and 10 cases out of 14 (71%) in small cell carcinoma. The positive rate of p53 is highest in small cell carcinoma. 2. p53 staining degrees showed that 3+ in 75% of squamous cell carcinoma, 1+ in 58% of adenocarcinoma and 1+ in 50% in small cell carcinma. were observed. The tumor cell composing of squamous cell carcinoma showed most strong staining to p53 protien. 3. PCNA labelling index showed higher index in p53(+) cases than p53(-) cases. The PCNA index of squamous cell carcinoma was highest and adenocarcinoma and small cell carcinoma in order. Above findings suggested that the PCNA index was related to p53 protein in tumor cells, but the PCNA index appeared to be influenced by the p53 protein content in tumor cells than whether the p53 protien was or not. So the growth rate of squamous cell carcinoma appeared to be most rapid than adenocarcinoma and small cell carcinoma.
김도균,이준호,유승엽,장정수,권영수 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1
The electrical properties of Maleate copolymer (C_(18)MA-VE_(2)) and Itaconate copolymer (C_(18)ITA-VE_(2)) Langmuir-Blodgett (LB) films for in-plane were investigated to develop the gas sensor. The C_(18)MA-VE_(2) and C_(18)ITA-VE_(2) were used as sensitive materials and deposition on the slide-glass substrate using LB method which could control the thickness in the molecular order (Å). The current-voltage (I-V) characteristics were measured to investigated the response characteristics in chloroform, acetone, ethanol and methanol gases. The conductivity of sensitive films were 10^(-)7[S/cm] for an in-plane. The change of conductivity was occurred by behavior of organic gases, which mean that the behavior of organic gases could be analyzed using conductivity change and application to gas sensor. In the experimental results, the relation between sensitive films and organic gases could be divided by three-type. Thus, we could analyze the modeling of the response characteristics of organic gases using the conductivity change of sensitive films.
RAPD(Random Amplified Polymorphic DNA)법을 이용한 한약재의 판별 연구
김대원,김도균,안선경,조동욱 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1
Conventionally, identification and classification methods of natural products include the morphological survey and assay of chemical disposition. Using these methods, however, is not satisfying for the precise identification of natural products because they are often variable in the compositions, genomic DNA analysis such as RAPD, RFLP and Amp-FLP can be adopted for this purpose. In this study, various ginsengs and bear gall bladder were tested for the development of genetic identification and classification method. Varieties of ginsengs such as, P. ginseng, P. quinquefolium, P. japonicus and P. notohinseng, were genetically analyzed by RAPD. Also, DNA isolated form Bear blood and gall bladder, Ursus thibetanus, Ursus americanus and Ursus arctors, were analyzed by the same method. The results demonstrated that the identification and classification of bear gall bladder and various ginsengs were possible by RAPD analysis. Therefore, this method was thought to be used as a additional method for the identification of other natural products.
기계적 합금화에 의한 Al-Fe 및 Al-Fe-Ce 합금의 고온 변형거동
김선진,이도인,안인섭,허보영,조권구 국립경상대학교 공과대학 부설 첨단소재연구소 1992 尖端素材 Vol.2 No.-
The deformation behavior of a mechanical alloyed Al-Fe and Al-Fe-Ce alloy was studied in the temperature range of 300℃ to 500℃. The steady state for Al-8wt.%Fe powder was obtained after 1000 minutes of mechanical alloying at the process condition of 2wt.% stearic acid, 46:1 of grinding media/powder weight ratio, and 300 rpm of impeller revolving velocity. The relative densities of Al-8wt.%Fe alloy powders reached almost 100% after 1 hour sintering at 470℃ under vacuum state. With increasing the amount of PCA, hardness of the sintered alloys increased but the relative densities were not affected. It was also found that decrease in hardness and tensile strength after high temperature aging treatment was reduced with increasing the amount of Ce addition.
김도균,이종달 嶺南大學校 工業技術硏究所 2004 工業技術硏究所論文集 Vol.32 No.2
This study which is for ITS construction interprets GPS driving data and car following model by the Fuzzy theory. GPS driving data is useful to get high precision of moving model. First, this study analyze the basic traffic characters such as speed, acceleration, distance between two cars and so on, by using actual driving data. Then calculate the speed of following car for Fuzzy design by using speed, acceleration of leading car and distance between two cars. This study gets determination coefficient 0.998, RMSE value 1.197 by comparing Fuzzy presumpted speed with actual driving data. This shows that the fitness of two data is excellent. So, this study suppose that we can analyze more microscopic traffic forms by using Fuzzy theory.