모유 수유아와 조제 분유 영양아에서 수유 방법에 따른 아미노산 농도 비교 및 혈청 트립토판 농도와 수면 유도와의 관계

정다운,김은영,양은석,박상기,박영봉,문경래 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2

Objective: Sleep behavior is modulated by serotonergic neurons within the brain, and the synthesis and release of serotonin by such neurons is thought to be influenced by the availability of tryptophan, the amino acid precursor of serotonin. Formula-feeding infants have depressed plasma tryptophan concentration relative to breast milk-feeding infants. Because tryptophan alters sleep waking patterns in adults, a study was designed to determine the difference of sleep latency relative to differences in plasma tryptophan and tryptophan : large neutral amino acid (LNAA) ratio between formula-feeding infants and breast milk-feeding infants. Method: 45 newborns who were born in Chosun University Hospital from December 2002 to December 2003 were selected. The newborns were divided to three group, 15 newborns were fed breast milk and 15 newborns were fed formula A, and last 15 newborns were fed formula B. At 6 weeks and 12 weeks, infants were sampled for measuring of serum amino acid level and tryptophan, tryptophan : LNAA ratio. And we taught infants' parents to measure sleep latency that means the time after a feeding to the first episode of active REM sleep that persist ≥ 1 min. Result: 1) At 6weeks, Serum α-amino-n-butyric acid, citrulline, tryptophan level was higher in formula A group than breastmilk group (P<0.05) and proline level was lower than breast milk group (P<0.05). In formula B group, serum n-amino-n-buryric acid, citrulline, cystine, hydroxylysine, hydroxyproline, isoleucine, leucine, lysine, methionine, phenylalanine, taurine, threonine, valine levels were higher than breastmilk group (P<0.05). And Serum isoleucine, methionine, proline, valine level were higher in formula B group than formula A group (P<0.05). 2) At 12 weeks, serum glutamic acid, methionine, ornithine levels were higher in formula group A than breast milk group (P<0.05). Serum β-alanine, aspartic acid, α-amino-n-butyric acid, ethanolamine, glutamic acid, threonine level were higher in formula B group than breast milk group (P<0.05). Serum β-alanine, ethanolamine levels were higher and arginine level was lower in formula B group than formula A (P<0.05). 3) At 6 weeks, serum tryptophan concentration and tryptophan: LNAA ratio were higher in formula A group (P<0.05). Sleep latency was 21 minutes in formula group A, 24 minutes in breast milk group, 25 minutes in formula B group but there was no statistically significance (P>0.05). 4) At 12 weeks, serum tryptophan concentration and tryptophan: LNAA ratio, time after feeding to the first episode of active REM sleep were no difference with each other group. Conclusion: There is significant difference of serum amino acids between breast-feeding infants and formula-feeding infants. And serum tryptophan and tryptophan: LNAA ratio differ between brest-feeding infants and formula-feeding infants. But there is no association between serum tryptophan, tryptophan: LNM ratio and sleep latency.

근피로 후 세 가지 회복 방법

이예영,김지은,서예은,정다연,강현주 순천향대학교 기초과학연구소 2022 순천향자연과학연구 논문집 Vol.28 No.1,2

Muscle fatigue is a symptom that decreases your muscles’ ability to perform over time. It can be associated with a state of exhaustion, often following excessive sports activity or exercise. While exercise is a common cause of muscle fatigue, this symptom can be the result of other health conditions. Muscle fatigue caused by excessive activity limits activities of daily living and difficult to maintain a stable posture. Therefore, the purpose of this study was to investigate the effect of stretching, icing, and sports massage on muscle fatigue recovery.

노인과 대학생의 낙상 위험 분석

정다현,김예희,김지은,이예영,강현주 순천향대학교 기초과학연구소 2021 순천향자연과학연구 논문집 Vol.27 No.1.2

The purpose of this study was to analyze risk of falls between elderly people and college students. The subjects of this study were 25 people aged 70 years or older and 17 college students located in Asan. We measured sensory, integrated balance, nervous, musculoskeletal system and HQR by FRA system (Inbody, Korea). The results of measurement showed significant differences in sensory system (p<.01), integrated balance (p<.001), nervous system (p<.001), and musculoskeletal system (p<.001) between groups. These results suggest that aging makes difference of function of these systems. In our view, counterplans need to be implemented, including exercise intervention to prevent decreases of fall risk,

사무직 근로자의 수면의 질 및 직무스트레스와 우울과의 관련성

강미나,강수영,권수정,김현주,배재원,이보연,이예진,임의롬,정다영,조한솔 이화여자대학교 간호과학대학 2013 이화간호학회지 Vol.- No.47

Purpose: The purpose of this study was to understand the degree of depression, sleep quality, job stress and their association among office workers. Method: A self-administered questionnaire was distributed to 147 workers employed in 5 big enterprises, and 5 small and medium enterprises from October 21 to November 21, 2012. The questionnaires included socio-demographic and health-related characteristics, job-related characteristics, sleep quality, job stress (KOSS) and depression (CES-D). Result: Among all subjects, 23.1% was in the depression group (21 points and over in the CES-D score). Depressive level was positively correlated with job stress and quality of sleep. The adjusted odd ratio for the effects of sleep quality and job stress on depression significantly increased in the depression group compared to that of the normal group. Multiple regression analysis revealed that the following factors of influence had combined explanatory powers on depression: BMI, life satisfaction, quality of sleep, and job stress. Conclusion: The study revealed that complicated influences were exerted on the level of depression by variable factors, as well as socio-demographic characteristics, health-related characteristics, quality of sleep, and job stress. Specifically, the level of depression was influenced by the quality of sleep and job stress.

Phytochemical Changes of Fermented White Peony and Potential Effect as a Nutraceutical for Alleviating Psychiatric Disorders

Da Yeong KIM,Hyo Jeong SONG,So Young PARK,Jui CHAKMA,Eun Ji LEE,Na Yeong BEEN,Dong Nyoung OH,Sunjay YOON,Ga Yeong KIM,Ji Eun LIM,Dong Pil KIM,Yun-Jy HEO,Nan Kyung KIM,Jong Min LEE 한국생물공학회 2023 한국생물공학회 학술대회 Vol.2023 No.4

Anti-inflammatory Activity of the Sargassum sagamianum Ethanol Extracts in LPS-induced RAW 264.7 cells

Da-hyun Jeong,Min-ji Kim,Koth-bong-woo-ri Kim,Seul-a Jung,Hyun-jee Kim,Hee-ye Jeong,Ga-yeong Lee,Bo-kyeong Kang,Si-woo Bark,Dong-hyun Ahn 한국식품영양과학회 2012 한국식품영양과학회 학술대회발표집 Vol.2012 No.10

농촌주택 부속사의 적정규모 기준 설정방안

정다영 ( Da-yeong Jeong ),리신호 ( Shinho Rhee ) 한국농공학회 2015 한국농공학회 학술대회초록집 Vol.2015 No.-

건립연도가 50년 이상 된 재래식 농촌주택은 정부와 개인의 요구에 의해 여러 차례 개량과 보수가 거듭되면서도 노후불량주택이라는 문제를 지속적으로 이어오고 있다. 농업의 생산방식의 축소 또는 편기됨에 따라 1960년대에 지어진 부속사들은 여전히 존재하면서 현 실정에 맞도록 증·개축 및 점증부가 되면서 무질서하게 방치되고 있다. 농촌주택의 부속사는 살림채와 별도로 다른 재료와 간이 구조로 필요에 따라 축조되므로 주택의 주변에 산재되어 농촌경관에 이질감을 불러일으키고 있다. 자연환경과 지역의 정체성 및 생활양식을 담아내는 농촌주택을 계획함에 있어 부속사에 대한 적합한 공간구성과 규모산정이 요구된다. 공간구성의 요인을 분석하고 적정규모 최적화를 위해 규모 설정기준을 마련해한다. 농촌주택 부속사의 공간은 기능, 계절, 동선과 기계 점유면적 등에 따라 구성된다. 세부적으로 농기구, 농자재, 농기계, 농약품, 농산물 보관 및 저장 등으로 부속사의 면적을 소요한다. 농사규모와 공간구성요인에 따라 농사소모품창고, 농산물(저온, 실온, 건조)보관창고, 농기계보관창고 등으로 부속사 공간을 크게 분리해 볼 수 있다. 부속사의 공간을 최적으로 계획하기위해 농자재와 기계의 용도와 이용특성, 계절별 사용빈도와 크기에 따라 공간을 분리·통합하고 농산물과 농기계 보관, 살림채와의 접근 생활방식에 따른 기능적 동선체계 등을 조사·분석함으로써 적정규모 기준 설정방안을 제시한다.

RAW 264.7 대식세포에서 지질 다당류에 의한 미세먼지(PM<SUB>2.5</SUB>) 유발 염증 반응 증진에 미치는 ROS-NF-κB 신호 전달 경로의 역할

권다혜(Da Hye Kwon),김다혜(Da Hye Kim),김민영(Min Yeong Kim),황보현(Hyun Hwangbo),지선영(Seon Yeong Ji),박세광(Seh-Kwang Park),정지원(Ji-Won Jeong),김미영(Mi-Young Kim),이혜숙(Hyesook Lee),정재훈(JaeHun Cheong),남수완(Soo-Wan Nam),황혜 한국생명과학회 2021 생명과학회지 Vol.31 No.12

본 연구의 목적은 LPS가 처리된 RAW 264.7 대식세포에서의 염증 반응이 미세먼지(PM2.5)에 의해 더욱 증가될 수 있는지를 조사하는 것이다. 이를 위하여 LPS와 미세먼지(PM2.5)가 단독으로 처리되거나 LPS가 존재하는 조건에서 미세먼지(PM2.5)가 처리된 RAW 264.7 세포에서 염증 매개변수와 ROS의 생성 정도 및 염증 조절 유전자들의 발현 수준을 조사하였다. 본 연구의 결과에 의하면 세포 독성이 없는 범위에서 LPS가 처리된 세포에서 미세먼지(PM2.5)는 염증성 매개 인자(NO 및 PGE₂) 및 cytokine (IL-6 및 IL-1β)의 생성 수준이 각각의 단독 처리군에 비하여 매우 증가되었으며. 이는 이들의 생성에 관여하는 유전자들의 전사 및 번역 수준에서의 발현 증가와 연관성이 있었다. 또한, LPS가 처리된 RAW 264.7 세포에 미세먼지(PM2.5)가 노출되었을 때, 핵에서 NF-κB의 발현이 더욱 증가하였고, 세포질에서는 NF-κB 뿐만 아니라 IκB-α의 발현이 감소되었다. 이러한 결과는 LPS와 미세먼지(PM2.5)의 단독 처리에 비하여 동시 처리된 경우 NF-κB 신호계의 활성이 더욱 증가하여 염증성 유전자들의 전사 활성 촉진에 기여하였음을 의미한다. 나아가 LPS가 처리된 RAW 264.7 세포에서 미세먼지(PM2.5)에 의해 ROS 생성이 크게 증가되었지만 NF-κB 억제제는 ROS의 생성을 감소시키지 못하였다. 그러나, ROS 생성을 인위적으로 억제하였을 경우, 미세먼지(PM2.5)에 의해 증가된 염증 매개 인자의 발현 및 생성과 NF-κB의 활성화가 모두 감소되었다. 따라서, 본 연구의 결과는 LPS가 처리된 RAW 264.7 세포에서 미세먼지(PM2.5)에 의해 유도된 NF-κB 매개 염증 반응의 증가는 ROS 생성 의존적 현상임을 시사한다. The purpose of this study was to investigate whether the inflammatory response in lipopolysaccharide (LPS)-treated RAW 264.7 macrophages could be promoted by particulate matter 2.5 (PM2.5) stimulation. To this end, the levels of inflammatory parameters, reactive oxygen species (ROS) and inflammation-regulating genes were investigated in RAW 264.7 cells treated with PM2.5 in the presence or absence of LPS. Our results showed that the production levels of pro-inflammatory mediators (nitric oxide and prostaglandin E₂) and cytokines (interleukin-6 and -1β) were significantly increased by PM2.5 stimulation in LPS-treated RAW 264.7 cells, which was correlated with increased expression genes involved in their production. In addition, when LPS-treated RAW 264.7 cells were exposed to PM2.5, nuclear factor-kappaB (NF-κB) expression was further increased in the nucleus, and the expression of inhibitor of NF-κB as well as NF-κB in the cytoplasm was decreased. These results suggest that the co-treatment of PM2.5 and LPS further increases the activation of the NF-κB signaling pathway compared to each treatment alone, thereby contributing to the promotion of transcriptional activity of inflammatory genes. Furthermore, although the generation of ROS was greatly increased by PM2.5 in LPS-treated RAW 264.7 cells, the NF-κB inhibitor did not reduce the generation of ROS. In addition, when the generation of ROS was artificially suppressed, the production of inflammatory mediators and the activation of NF-κB were both abolished. Therefore, our results suggest that the increase in the NF-κB-mediated inflammatory response induced by PM2.5 in LPS-treated RAW 264.7 macrophages was a ROS generation-dependent phenomenon.

농촌마을 공간구성에 관한 특성 분석 -고드미녹색마을, 명심체험마을, 오박사마을을 중심으로-

정다영 ( Da Yeong Jeong ),리신호 ( Shin Ho Rhee ) 한국농촌계획학회 2013 농촌계획 Vol.19 No.4

The purpose of this study is that suggest space composition in rural village so that it can had foundations for Activation of regional community by analysis and re-organization of rural community places based on regionality and historicity. First, this study have been investigated about changes of overall space configuration and community places that has been lost or were ongoing in rural village. Factors of changes were changes in lifestyle, rural policy, social and political system, economic principles and ect. Therefore, This study focused on understanding basic principles of rural village space configuration and inherited it. Second, basic principle of the space configuration of rural village were entryway and center that improve community cohesion in the community space. This study figured out improving of "Ma-Dang" and functional mix-use community hall was important for more efficient management. Third, This study set direction according to characteristic of space configuration of each village and suggested detail plans.

서울시 당뇨예방사업의 제2형 당뇨 환자에서 당뇨망막병증과 프래밍험 위험도 점수와의 관계

김다영(Da Yeong Kim),송수정(Su Jeong Song),배정훈(Jeong Hun Bae),박철영(Cheol Young Park),이은정(Eun Jung Rhee) 대한안과학회 2016 대한안과학회지 Vol.57 No.5

목적: 제2형 당뇨병 환자에서 당뇨망막병증과 프래밍험 위험도 점수(Framingham Risk Score) 간의 관계를 통해 당뇨망막병증에서 심혈관계 합병증의 위험성을 알아보고자 하였다. 대상과 방법: 2008년 9월부터 2009년 9월까지 서울시 당뇨병예방사업에 참여한 40세 이상을 대상으로 하였다. 당뇨망막병증의 단계는 1단계는 당뇨망막병증 없음, 2단계는 경도 비증식당뇨망막병증, 3단계는 중등도 비증식당뇨망막병증, 4단계는 중증 비증식당뇨망막병증, 5단계는 증식당뇨망막병증으로 하였다. 1단계는 제1군으로, 2단계는 제2군으로, 3단계와 4단계, 5단계를 합쳐서 제3군으로 하였으며 집단 간의 프래밍험 위험도 점수가 어떻게 변화하는지 일원배치 분산분석 방법을 이용하여 확인하였다. 결과: 총 529명 중 제1군은 403명, 제2군은 22명, 제3군은 104명으로 분포됐다. 당뇨망막병증의 중증도가 증가함에 따라 나타난 평균 프래밍험 위험도 점수는 제1군에서 10.89 ± 7.98, 제2군에서 12.25 ± 10.84, 제3군에서 13.25 ± 10.66으로 나타났으며, 제1군과 제3군 간의 차이는 통계적으로 유의하였다(p=0.014). 결론: 우리의 연구에서 당뇨망막병증이 심할수록, 프래밍험 점수는 유의하게 증가하였다. 심혈관계 질환이 세계적으로 사망의 가장 큰 원인 중 하나이며, 당뇨망막병증의 확인이 인체에서 쉽게 접근 가능하다는 점을 고려할 때 그 유용성은 적지 않을 것으로 사료된다. 하지만 본 연구는 단면연구로 진행되었기 때문에 정확한 인과관계를 알기는 어려우며, 향후 추가적 연구가 필요할 것이다. Purpose: In this study, we compared the risk of cardiovascular complications between diabetic retinopathy (DR) groups based on the Framingham Risk Score. Methods: Subjects 40 years of age or older were enrolled in the present study from September 2008 to September 2009. Five scales were used to evaluate the severity of DR for the most severely affected eye in each patient: no DR, mild nonproliferative DR (NPDR), moderate NPDR, severe NPDR and proliferative DR (PDR). The first group included no DR patients and the second group included mild NPDR patients. The third group included moderate NPDR, severe NPDR and PDR patients. The Framingham Risk Score was analyzed among the groups to determine whether a difference in score existed. Results: DR was found in 126 subjects. The first group included 403 subjects, the second group 22 subjects and the third group 104 subjects. The average Framingham Risk Score that appeared with increasing severity of DR was 10.89 ± 7.98 in the first group, 12.25 ± 10.84 in the second group and 13.25 ± 10.66 in the third group. The average difference between the first and third groups was statistically significant (p = 0.014). Conclusions: In our study, the Framingham Risk Score increased significantly with more severe DR (p = 0.042). Our results are useful when considering the easily accessible identification of DR and that cardiovascular disease is one of the main causes of death worldwide. However, confirming the exact causal relationship based on our results is difficult because the study design was cross-sectional and additional studies are necessary.