Clinicopathological role of kidney injury molecule-1 in immunoglobulin A nephropathy

( Yu Ho Lee ),( Yang-gyun Kim ),( Sang-ho Lee ),( Ju-young Moon ),( Kyung-hwan Jeong ),( Tae-won Lee ),( Chun-gyoo Ihm ) 대한신장학회 2014 Kidney Research and Clinical Practice Vol.33 No.3

Background: Urinary kidney injury molecule-1 (KIM-1) is an early and sensitivebiomarker of acute kidney injury, but it is unclear if it is a biomarker of chronicglomerulonephritis. We evaluated whether urinary KIM-1 levels in patients withimmunoglobulin A (IgA) nephropathy can be a marker to reflect clinicopathologicalseverity and predict the prognosis. Methods: We measured urinary KIM-1 levels in 40 patients (15 males; mean age36.6712.9 years) with IgA nephropathy and 10 healthy people (5 males; mean age37.379.6 years) as controls. The correlation of urinary KIM-1 levels with patients’clinical parameters, histological grades, and follow-up data were analyzed using themodified H. S. Lee grading system and tubulointerstitial change scores. Results: Urinary KIM-1 levels were higher in patients with IgA nephropathy thanhealthy controls (P¼0.001). Univariate and multivariate regression analyses showedthat urinary KIM-1 levels had a direct correlation with H. S. Lee grade andtubulointerstitial inflammation (P¼0.004 and P¼0.011, respectively). Conclusion: In patients with IgA nephropathy, urinary KIM-1 has a significantcorrelation with histopathologic severity.

성전환증 치험례

김태연,정전은,구상환 大韓成形外科學會 1989 Archives of Plastic Surgery Vol.16 No.5

The transsexualism is defined as "a distribution of gender identity in which the person manifests, with constant and persistent conviction, the desire to live as a member of the opposite sex and progressively takes steps to live in the opposite sex role full-time." Although its etiologty is unknown, the majority of modern psychiatrists and behavioral scientists agree that the transsexualism is a disease entity belonged to gender identity disorder, but not to be confused with the transvestite, homosexualism, or psychopaths. We experienced five cases of male-to-female transsexualism. The basic requirements for this type of operation were that the patient be more than 21 years old, a transsexual for at least 3 years, cross dressing for more than 1 year and taking female hormones for at least 9 months. The patient who approved himself a transsexualism by psychiatrists with psychological tests including MMPI, Rosarch test had recieved several preoperative studies including EEG to rule out temporal lobe epilepsy, excrtory urogram to rule out genitourinary abnormalities, sex chromation study with peripheral blood smear for diagnosis of genetically normal male person, and hormonal study(17-KS in urine) to rule out endocrine abnormalities. Once the patient was admitted to the hospital , he was placed on a 2-day mechanical bowel preparation with a clear liquid diet. The three male transsexuals underwent the vaginal reconstruction using one-stage penile skin flap inversion surgery after vaginal pocket dissection, and the other two transsexuals who had recieved penile amputation underwent modified McIndoe operation for vaginal reconstruction using full-thickness skin graft from inguinal area. The ancillary procedures for male transsexuals including double fold operation, augmentation rhinoplasty, augmentation mammoplasty, facial bone contouring surgery, laryngeal chondroplasty, and electrolysis were also done, before of simultaneously. Herein we describe the technique, mainly about vagnal reconstrution and briefly report the results

직렬 리액터를 이용한 계통연계형 태양광 발전 시스템

金大均,鄭春炳,全基英,李丞煥,吳鳳煥,李勳九,金容珠,韓慶熙 명지대학교 산업기술연구소 2005 産業技術硏究所論文集 Vol.24 No.-

Since the residential load is an AC load and the output of solar cell is a DC power, the photovoltaic system needs the DC/AC converter to utilize solar cell. In case of driving to interact with utility line, in order to operate at unity power factor, converter must provide the sinusoidal wave current and voltage with same phase of utility line. Since output of solar cell is greatly fluctuated by insolation, it is necessary that the operation of solar cell output in the range of the vicinity of maximum power point. In this paper, DC/AC converter is three phase PWM converter with smoothing reactor. And then, feedforward control used to obtain a superior characteristic for current control and digital PLL circuit used to detect the phase of utility line.

行政計劃의 法的 諸問題

金春煥 朝鮮大學校 社會科學硏究所 1990 社會科學硏究 Vol.13 No.-

닥터소음의 피드포워드제어에 관한 연구

김천덕,차경환 釜山水産大學校 1989 釜山水産大學 硏究報告 Vol.29 No.1-2

This paper has described the efficiency for the new method of the active control of the duct noise which is adaptive filtering application by experiment which set the additional sound source. Firstly the active noise control system becomes stable since the acoustic feed back quantity can be set under -30 dB by setting the additional sound source at an excite of duct and for the signal which is supplied to additional sound source by the setting the microphone at the upstream of duct. Secondly, since the noise of duct output and additional sound source constructs dipole source, radiating power will be decreasing over all the direction in comparison with the case without the additional sound source in the range of frequency which the distance between the duct and the additional sound source is shorter than wave length that is a center frequency of the duct noise. The result of noise cancelling amount for simulation and fan noise experiment by the active control system has been attenuated about 5∼6 dB by only using the proposed active control system and about 9∼10 dB can be attenuated by using adaptive filtering algorithm with the proposed active control system on the desired frequency band.

원통형 연소실에서 단발 분출화염의 온도분포에 관한 연구

김춘중,최태환 영남이공대학 산업기술연구소 2003 産業技術硏究 Vol.15 No.-

Many researches about the combustion process gas temperature and velocity in a constant volume combustion chamber have been conducted. The temperature and the distribution of velocity in the combustion chamber have a large influence in the combustion process. Temperature distribution and their histories of jet flame in a constant combustion chamber were measured by a laser rayleigh pyrometer , as a fundamental study of the combustion process in a spark ignition engine. It makes this study get the important data of temperature histories and flame state of jet flame.

급성골수성백혈병 환자에서 DAV 병용화학요법 후의 장기생존율

김삼용,최지영,윤환중,전의건,길준영,조덕연 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

Background : Despite substantial progress, the treatment of acute myeloid leukemia(AML) has produced complete remission in 60-80% of patients receiving induction chemotherapy, and median remission duration is about 12 months and only 20% to 35% of patients undergoing consolidation chemotherapy achieve long-term disease-free survival(DFS). We evaluated the long-term outcome of AML patients treated with doxorubicin/Ara-C/VP-16(DAV) induction chemotherapy and consolidation/intensification therapy. Method : Induction therapy : From January 1986 to December 1991, twenty three patients with previously untreated acute myelogenous leukemia received a course of 45mg/㎡ doxorubicin daily intravenously for three consecutive days with Ara-C at 100mg/㎡ by continuous intravenous infusion for eight consecutive days and VP-16 at 100mg/㎡ daily intravenously for three consecutive days. A second course of treatment was started if leukemia persisted on 22 days after treatment. Post-remission therapy : Three to six cycles were given at three or four months interval with Ara-C/doxorubicin/VP-16 regimen or other therapy. Results : Twenty two pateints were evaluable and complete remission was achieved in 16 of 22(73%). Median duration of complete remission was 8 months. The relapse rate was 81% and 63% relapsed in first year. 4-year survival rate of patients entering complete remission(n=16) was 19% and median survival duration was 14.5 months. The postremission chemotherapy was the only significant prognostic factor influencing long term disease free survival. No significant correlation was observed between the probability of survival and age (40< or >40), sex, FAR subgroup, and leukocyte count at diagnosis. The median survival duration were 21 months and 12.5 months for patients who received, or not received postremission chemotherapy respectively(P=0.035). Conclusion : Our results show that DAV combination chemotherapy is a useful therapeutic regimen in remission induction and postremission chemotherapy offering survival advantage in patients with AML entering complete remission.

비호지킨 림프종의 임상적 고찰

김태원,조은택,조기섭,정재용,허재봉,장영,박유환,정춘해 조선대학교 1995 The Medical Journal of Chosun University Vol.20 No.1

A retrospective clinical and histologic study of 30 non-Hodgkin's lymphomas diagnosed at the Department of Hemato-oncology of the Chosun University from January 1989 to December 1993 is presented. Among total 30 cases whose sexes were mentioned, male were 18 and female were 12 and the ratio is 1.5:1. The peak incidence of non-Hodgkin's lymphoma was found in the third decade. The case distributions by Working formulation were summarized in table 3. The most common histopathologic type of non-Hodgkin's lymphoma was the diffuse large cell type of intermediate grade. The presenting symptoms at the time of first visit to the hospital were summarized in table 4. The most common symptoms were palpable mass. Lymph node enlargements were found in 87 %, and most frequently on cervical area(35%). The incidence of primary nodal lymphoma is more frequent than extranodal lymphoma, 1.2:1. The most common primary site of extranodal lymphoma is the gastrointestinal tract. In the laboratory findings, the data of hemoglobin and hematocrit were summarized in table 8, 9, Values of hemoglobin and hematocrit of female patients greater than those of male patients. The results of the immunophenotypings of nodal and extranodal lymphoma indicates that the B-cell lymphoma are predominant(B:T=1.4:1). The clinical stage was Ⅱ in 9 cases(30%) Ⅲ in 9 cases(30%), Ⅳ in 8 cases(26.7%), Ⅰin 4 cases(13.3%), 28 cases were treated with CHOP regimen. Among them, 17 cases(60.8%) achieved a complete remission. 5 cases had a partial response. The most frequent toxicities were toxic hepatitis.

물리치료사들의 대체의료에 관한 인식도 조사

김영희,김기열,배주환,김상수,남철현 경산대학교 보건복지연구소 2000 保健福祉硏究 Vol.5 No.-

This study was conducted to examine physical therapists' awareness of alternative medicine and their treatment. 250 physical therapists who were working in Daegu were selected as subjects of this study. Data were collected from February 21, 2000 to March 31, 2000. The results of this study are summarized as follows. 1. Among 218 respondents, 72.7% of them directly experienced alternative medicine. According to general characteristics of the respondents, 79.0% of them who were in thirties had experiences in alternative medicine. 83.3% of the respondents who had worked for above twenty years experienced alternative medicine and 90.0% of the respondents who were working in Oriental medical clinics had experiences in it. 79.8% of the respondents who had been married experienced alternative medicine and 88.4% of them who were Buddhists had experience in it. 2. The sources of information on alternative medicine were newspapers and broadcast (22.9%), seminars of related associations (22.5%), and Books (20.0%). 3. The respondents experienced alternative medicine for the purpose of treating their chronic diseases (67.0%), improving their energy and quality of life (20.5%), and improving their weak physical constitution (13.4%). 4. According to the respondents' trust in alternative medicine, 40.8% of them trusted chiropractic, while 25.2% of them trusted massage and finger-pressure therapy. 19.7% of them trusted taping therapy and 15.1% of them trusted sports massage. 5. 67.0% of the respondents treated patients by alter native medicine in the hospitals and clinics. In the case of treatment methods by alternative medicine, 35.3% of them gave patients the massage and finger-pressure. 33.0% of them adopted taping therapy and 24.3% of them tried to treat patients by chiropractic. 17.0% of them applied moxacautery, while 15.1% of them gave patients the sports massage. 6. The respondents adopted alternative medicine to treat following diseases: lumbago (57.5%), shoulder pain (51.8%), sciatica (39.9%), arthritis (36.2%), headache (31.1%), hypertension (24.3%), diseases of the peripheral nervous system (22.4%), diseases of digestive organ (14.6%), insomnia (12.3%), obesity (8.7%), stroke (5.5%), allergy and skin diseases (4.1%), cystitis (3.6%). 7. According to their motives of concern about alternative medicine, 59.1% of them were interested in it because they expected additional effect which could be obtained from it in parallel with Western medicine. 16.7% of them were concerned about alternative medicine because they lacked ability to solve patients' clinical problems, while 15.3% of them were interested in it because they acknowledged the effect of it. 8.9% of them had interest in alternative medicine because they were dissatisfied with medical and scientific approach of Western medicine. 8. 73.4% of the respondents thought that alternative medicine needed to be introduced in the college/university curriculum

실리콘 겔에 활성화된 복강 대식세포의 interleukin-6 및 tumor necrosis factor-α에 의한 섬유모세포 중식 자극

김환묵,한상배,이백권,이종원,한기택,천지훈 大韓成形外科學會 1998 Archives of Plastic Surgery Vol.25 No.5

Silicone gel breast implants may induce local(fibrous capsular contracture) or systemic(rheumatoid arthritis, systemic sclerosis, etc) complications. The exact mechanism of fibrous capsular contracture has not been fully understood. In the present study, we tried to find out the effect of silicone gel on the fibroblast proliferation which has been known as a major contributing factor in fibrous capsular contracture formation. In vitro, activated macrophages are known to secrete monokines which affect fibroblast proliferation and collagen synthesis. And tumour necrosis factor-α(TNF-α) and interleukin-6(IL-6), which were released by macrophages, were reported as potent stimulator of fibroblast proliferation. The goal of this study is to investigate the role of macrophages and tumour necrosis factor-αor interleukin-6 in the interaction of fibroblasts and silicone gel. We designed four groups, two experimental and two control, using Institute for Cancer Research(ICR) mouse peritioneal macrophage and silicone gel. For the preparation of the conditioned medium of macrophages, peritoneal macrophages were prepared and cultured for 24 hours on the silicone gel-coated and naked (not coated) surface [silicone gel-macrophage conditioned medium(SCM; experimental group) and normal polystyrene-macrophage conditioned medium(NCM; control group) respectively]. To correct the effect of 10% fetal bovine serum which was included in Rapid Prototyping and Manufacturing Institute (RPMI) 1640 medium and draw the effect only by macrophages, the RPMI 1640 medium with 10% fetal bovine serum was cultured by the same method on the silicone gel-coated and naked surface (silicone gel-macrophage free conditioned medium; SFM and normal polystyrene-macrophage free conditioned medium; NFM respectively). Each conditioned medium was added onto NIH 3T3 fibroblasts culture at a final 25% concentration of total culture medium and followed by the cultivation for 24 hours. For antibody neutralizing experiments, each conditioned medium was preincubated with polyclonal rabbit anti-mouse TNF-α antibody or polyclonal rat anti-mouse IL-6 antibody for 1 hour and then, conditioned medium with antibody was added to the culture medium of NIH 3T3 fibroblasts by the same method. After 24 hours cultivation, total number of viable fibroblast(cell growth), DNA synthesis and collagen synthesis of fibroblasts with each medium were measured by sulforhodamine B(SRB) assay, 3H-thymidine and 3H-proline incorporation respectively. The results were as follows: 1. In the experiment about the effect of the conditioned medium on the fibroblast activity, the experimental group(SCM), compared with the control group(NCM), showed a significant increase of the cell growth (p<0.01), a significant decrease of DNA synthesis(p<0.001), but no significant difference in the collagen synthesis. 2. In the experiment about the effect of polyclonal rabbit anti-mouse TNF-α antibody on the fibroblast activity, after the addition of antibody the experimental group, compared with the control group, showed a significant decrease of the cell growth(p<0.001), a significant increase of DNA synthesis(p<0.01), but no significant difference in the collagen syn thesis. 3. In the experiment about the effect of polyclonal rat anti-mouse IL-6 antibody on the fibroblast activity, after the addition of antibody the experimental group, compared with the control group, showed a significant decrease of the cell growth(p<0.001), a significant increase of DNA synthesis(p<0.0001), but no significant difference in the collagen synthesis. In conclusion, culture supernatants (conditioned medium) of peritoneal macrophages, activated by silicone gel, stimulate the NIH 3T3 fibroblast proliferation. TNF-α and IL-6, products of macrophage, are involved in the stimulation of NIH 3T3 fibroblast proliferation in an in vitro condition.