Cisplatin 병용화학요법시 발생한 오심, 구토에 대한 Ondansetron과 Metoclopramide의 효과에 대한 비교

김미자,국기용,김태원,박유환,김완중,허경,정춘해,홍순표 朝鮮大學校 附設 醫學硏究所 1993 The Medical Journal of Chosun University Vol.18 No.1

Inspite of possible effects for emesis following chemotherapy including cisplatin, nausea and vomiting are the most unpleasant side effects of cancer chemotherapy. None of the currently available antiemetic agents is entirely effective preventing emesis. Ondansetron, a 5-HT(5-hydroxytryptamine)_(3) receptor antagonist, has been shown to be effective antiemetic agent in the control of cisplatin induced emesis. Twenty solid tumor patients who are scheduled to receive cisplatin containing combination chemotherapy participated in a prospectively randomized study to compare the antiemetic efficacy and safety of ondansetron and metoclopramide. Ondansetron was given in dose of 8mg intravenous 30min before cisplatin and then 4hours and 8hours after cisplatin on day 1, and Ⅰ.Ⅴ. every 8hours from day 2 to 5. In the metoclopramide group, metoclopramide was given in dose of 2 ㎎/㎏ intravenous every 8hours from day 1 to 5. The control of emesis was graded in the following way : complete response, no vomiting : major response, 1-2 emetic episodes : minor response, 3-5 emetic episodes : failure, above 5 emetic episodes. Complete or major response of emesis was achieved 10 of 12(83.2%) patients receiving ondansetron and in 5 of 8(62.5%) patients receiving metoclopramide, but effectiveness was not significantly different. Ondansetron was at least as effective as metoclopramide therapy in controlling cisplatin induced emesis. Side effects in ondansetron was less than in Metoclopramide.

척수압박으로 발현된 급성 골수성 백혈병에 동반된 과립구성 육종 1 례

윤상준,김영곤,김희종,박유환,정춘해,김양수,김태균,박영진,전호종 조선대학교 부설 의학연구소 2000 The Medical Journal of Chosun University Vol.25 No.1

저자들은 척수압박으로 하지마비를 보인 환자에서 수술 후에 급성 백혈병에 동반된 과립구성 육종으로 진단된 환자 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Granulocytic sarcoma(GS) is an uncommon tumor composed of immature cells of the granulocytic series. Most case of GS occur in the course of acute leukemia and the blast crisis of chronic leukemia, Rarely, however, it may present before leukemia becomes clinically apparent. It may also occur in patients with myeloproliferative disoders. GS has been reported that it occurs in 3% to 9% of patients with acute myelogenous leukemia(AML) and the incidence of GS is reported to be higher in patients with t(8;21). GS occurs relatively commonly in africa and has been reported to affect 10-25% of black children presenting with AML. This is very rare case of granulocytic sarcoma with AML(FAB M5) presented with spinal cord compression which was supported by decompression laminectomy.

쪽거리 차원을 통한 다공질규소의 미세구조 분석

김영유,홍사용,이춘우,류지욱,이기환,최봉수 대전산업대학교 반도체기술연구소 1999 半導體技術硏究所報 Vol.1 No.-

p형 단결정 규소 웨이퍼를 불화수소 용액속에서 전류밀도와 양극반응 시간을 변화시켜 다공질규소를 제작하고, 그 질량을 측정한 후 이 값으로부터 다공도와 쪽거리(fractal)차원을 계산하였다. 그 결과 양극반응 시간이 일정한 경우 다공도는 전류밀도에 비례하였다. 그리고 전류밀도가 일정한 경우 여러 양극반응 시간의 데이터로부터 얻은 쪽거리 차원은 일정하였다. 또한 쪽거리 차원은 불화수소의 농도 증가에 따라 감소하였다. 이같은 실험 결과를 퍼짐한계침전(diffusion limited deposition) 모형으로 계산된 2차원 컴퓨터 시늉내기(simulation) 결과와 비교 분석하였다. 시늉내기 결과 다공도는 퍼짐거리에 비례하였으며, 쪽거리 차원은 퍼짐거리와 반비례하였다. 이때 퍼짐거리는 전류밀도에 비례하고 불화수소의 농도에 반비례하는 물리량이므로 정성적으로 실험 결과와 일치하였다. 그러나 쪽거리 차원이 증가함에 따라 다공도가 감소되는 결과는 실험결과와 상반되었다. Porous silicon layers were fabricated with various conditions of HF concentration and current density. And their masses were measured. From these data, the porosity and fractal dimension were estimated and analyzed. We found that the porosity was proportional to the current density when the anodic reaction time was fixed and the constant values of fractal dimension could be estimated from a series of data with fixed HF concentration. The values of fractal dimension were decreased with increasing HF concentration. The obtained porosity and fractal dimension were compared with the 2-dimensional computer simulation based on diffusion limited deposition model. According to the simulation, the porosity was proportional to the diffusion length and the fractal dimension was inversely proportional to the diffusion length. Since, the diffusion length is proportional to current density and inversely proportional to base concentration, our experimental data qualitatively agreed with the results from the simulation. The porosity obtained by experiments, however, was not consistent with the results by simulation.

cis-platin에 의한 급성구토예방의 Dexamethasone의 4가지 정주량의 비교

김원,강지은,서영선,이동민,서정균,신병철,정기영,박유환,정춘해 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.1

B5-hydroxytryptamine _3수용체(5-HT_3) 길항제와 dexamethasone의 동시투여가 cis-platin에 의한 급성 구토를 막는데 가장 효과적이다. 그러나 현재까지 가장 적절한 정주dexamethasone의 용량이 알려져 있지 않았다. 이에 dexamethasone의 4가지 다른 용량을 투여하여 그 효과를 비교하였다. 환자는 임의 추출되어 cis-platin 투여 45분전에 15분 동안 정주로 각각 dexamethasone 5, 10, 15, 20 mg을 투여 받았다. cis-platin 투여 30분전에는 ondansetron 8 mg이 부가하여 정주 되었다. 1999년 3월부터 2000년 2월까지 54명의 환자가 연구에 등록되어졌고 53명의 환자가 연구 대상으로 실험에 4군 (dexamethasone 5 mg 13명, 10 mg 14명, 15 mg 13명, 20 mg 13명)으로 나뉘어 평가 되어졌다. 급성구토와 구역질의 완전한 예방은 dexamethasone 5 mg을 투여 받은 환자에서 각각 69.2%, 60.9%, dexamethasone 10 mg을 투여 환자에서 69.1%, 61%, dexamethasone 15 mg 투여 환자에서 78.5%, 66.9%, dexamethasone 20 mg을 투여 환자에서 83.2%, 71.0%로 나타났다. 구토로부터 완전한 예방은 dexamethasone 20 mg을 투여 환자에서 5, 10 mg을 투여 환자와 비교하여 높았고, dexamethasone 15 mg을 투여 군에 비교하여서는 약간 우수한 효과만 있었다. 구역질으로부터의 완전한 예방도 월등한 것은 아닐지라도 20 mg을 받은 환자에서 높았다. 항 구토 치료는 특별한 불편 없이 조절되었고, 부작용의 발생에서 4가지그룹간에는 커다란 차이가 발견되지 않았다. Dexamethasone의 20 mg 정주양이 cis-platin으로 인한 급성구토를 예방하는데 가장 효과적인 예방량으로 사료되어진다. Background and objective: A 5-hydroxytryptamine _3(5-HT_3) receptor antagonist plus dexamethasone is the most efficacious antiemetic prophylactic treatment for the prevention of cis-platin induced acute emesis, but the optimal intraveous (Ⅳ) dose of dexamethasone is unknown. This prompted us to perform a randomized, double-blind, dose-finding study that compared four different doses of dexamethasone. Materials and Methods: Patients were randomized to receive dexamethasone, either 5, 10, 15, 20 mg, administered by 15-minute Ⅳ infusion 45 minutes before cis-platin. Ondansetron 8 mg was added to dexamethasone and was administered Ⅳ 30 minutes before cis-platin. From March 1999 to February 2000, 54 patients were enrolled onto the study and 53 were assessable according to the intention-to-treat principle (13 patients received 5 mg; 14 patients, 10 mg; 13 patients, 15 mg and 13 patients, 20 mg of dexamethasone). Results: Complete protection from acute vomiting and nausea was achieved by 69.2% and 60.9% of patients, respectively, who received 5 mg of dexamethasone, by 69.1% and 61.0% of those who received 10 mg, by 78.5% and 66.9% of those who received 15 mg, and by 83.2% and 71.0% of those who received 20 mg of dexamethasone. Complete protection from vomiting was significantly superior in patients who received 20 mg compared with those who received 5 and 10 mg of dexamethasone (P<05) and was superior, but not significantly, compared with those who received 15mg. Complete protection from nausea was superior, but not significantly, in patients who received 20 mg of dekamethasone. Multifactorial analysis confirmed these results. Antiemetic treatment was well tolerated, and no significant difference was found among the four groups in the incidence of adverse events. Conclusion: A 20mg single Ⅳ dose of dexamethasone should be considered the most efficacious prophylactic dose for the prevention of ois-platin induced acute amesis in treatment of cancer.

行政行爲의 瑕疵承繼의 判斷基準

金春換 조선대학교 환경연구소 2000 環境硏究 Vol.16 No.1

競業者訴訟

김춘환 朝鮮大學校 社會科學硏究所 1999 社會科學硏究 Vol.20 No.3

行政行爲의 瑕疵承繼의 判斷基準

金春換 조선대학교 환경공해연구소 2000 環境公害硏究 Vol.16 No.1

環境法上의 市民訴訟에 관한 硏究

金春換 조선대학교 환경공해연구소 2001 環境公害硏究 Vol.17 No.2

行政上 紛爭處理基準으로서의 取消訴訟

金春煥 한국공법학회 2002 公法硏究 Vol.31 No.1

This paper is concerned with how to choose between the standard types of suits in administrative litigation. It is very difficult to decide whether some cases are subject to a civil suit or administrative litigation because their boundary is not clear. There are four types of administrative litigation; complaint litigation, party litigation, instrument litigation and popular litigation. Generally speaking, administrative litigation has a lot of peculiarities compared to civil suits. A plaintiff brings the case to court to cancel a case if an executive agency violates the law by using their public power which result in damages. In these cases, a defendant is the agency which violates the law and is accused of causing some damages to the plaintiff. It is called an action for nullity. As well, other cases are subject to parties litigation in public law or civil suit in private law. This paper constitutes 5 chapters (introduction, conception, structure, objection of the action for nullity etc ...) and aims to solve these problems.

法規命令形式의 行政規則의 法的 性質의 判斷基準

金春煥 朝鮮大學校 社會科學硏究所 1999 社會科學硏究 Vol.20 No.2