R&D 투자 영향평가 기반 구축 및 시범분석

황석원(Seog-Won, Hwang),오승환(Seung-Hwan, Oh),우청원(Ceung-Won, Woo),장필성(Pil-Seoung, Jang),홍사균(Sa-Gyun, Hong),강희종(Hee-Jong, Kang),최창택(Chang-Taek, Choi),김기환(Gi-Hwan, Kim),이재진(Jae-Jin, Lee),김지훈(Ji-Hoon, Kim) 과학기술정책연구원 2016 정책연구 Vol.- No.-

This study is a late study of “An Exploratory Study on STI policy impact assessment”. In the research of 2015, in principle, it is necessary to evaluate not only R&D investment but also general policies such as various promotion systems, standards and regulations by putting the term “policy impact assessment” in front of it We emphasized the points. However, it is practically very difficultto collect and analyze detailed data of all STI policies. In addition, it is also restricted to allow policy researchers to access data within a certain range. Therefore, this study focuses on the impact assessment of R&D investment, which accounts for the largest percentage of STI policies. In this research, the impact assessment system of R&D investment is analyzed by classifying it into evaluation of economic impact and social impact assessment. Also, the evaluation of economic impact was analyzed separating into a micro viewpoint and a macro viewpoint. First, The analysis of the economic impact assessment of the micro viewpoint relates to how the government’s R&D investment affects enterprises. Specifically, the main analysis target was the employment and investment of companies, the impact on sales and profits. Second, The Analysis for macroeconomic impact assessment on the economy is related to the influence of government’s R&D investment such as national economic growth, employment etc. We also analyzed the spillover effect by industry according to R&D investment. Third, The social impact assessment is to analyze how R&D investment has impacted technology-based social change. This study is a very difficult attempt. However, we analyzed from the point of view of the consumer considering all social change areas as much as possible. The results of the study are summarized as follows. First, the study of economic impact evaluation shows the effect of R&D investment and it can be used as a basis to improve the efficiency and goal of R&D investment in future sectors such as employment, economic growth and investment. Second, through research on social impact assessment, government R&D investment has focused on specific areas in terms of improving the quality of life and social development of people, and confirmed that most social sectors are neglected. In addition, we proposed policy priorities for specific social change indicators and social sectors and proposed long-term R&D investment strategies. Finally, this study is expected to contribute to the establishment of future strategy of private enterprise through the measurement of social change index, the social influence of private research and development, and the influence of technology shock from abroad.

만경강 상류 수질 및 식생분포와 토양환경에 따른 하천식생의 종 다양성

이경보,김창환,이덕배,김종구,박찬원,나승용 한국환경농학회 2003 한국환경농학회지 Vol.22 No.2

만경강 상류유역 수질 및 하천식생 군락 변화를 조사 분석하여 수질에 따른 하천식생의 종 다양성 및 토양요인에 따른 종 다양성의 변화를 평가하기 위하여 2001년 6월부터 2002년 9월까지 만경강 상류유역 5개 조사지점을 선정한 후 조사를 실시하였다. 수질중 T-N의 농도는 전주천과 삼천에서 높았으며, 겨울철에 전주천에서 7.45 mg/L로 가장 높았다. 무기태 질소 성분벽 함량은 NH₄-N 경우 고산천과 소양천 유역은 0.01~0.06 mg/L 범위로 계절별 커다란 차이가 없는 낮은 농도를 나타냈으나, 생활하수가 유입되는 전주천과 삼천에서는 0.77~3.01 mg/L로 계절별로 큰 차이를 보였다. T-P의 농도는 계절별로 비슷하였으나 전주천에서 겨울천에 0.89 mg/L로 가장 높았다. 계절별 BOD의 농도는 고산천과 소양천 유역에서 0.92~2.14 mg/L를 나타내었으나 생활하수가 유입되는 유역에서는 2.01~7.65 mg/L범위를 보였다. SO₄²^(-)의 농도는 농업용수 수질기준인 50 mg/L를 초과하는 지역은 없었으며 소양천에서 다소 높았다. 만경강 지류인 고산천에서 조사된 식물은 59과 과 129속 165종 20변종으로 총 185종류가 조사되었으며, 소양천에서 조사된 식물은 53과 111속 141종 19변종으로 총 160종이었고, 전주천 하류에서 조사된 식물은 37과 68속 86종 15변종으로 총 103종이었다. 그리고 삼천에서 조사된 식물은 32과 92속 110종 18변종으로 총 128종류 조사되었으며, 만경강 본류인 하리유역에서 조사된 식물은 73과 134속 218종 33변종으로 총 251종류가 조사되었는데 식물의 생활형에 따라 분류하면 침수식물이 13종, 부엽식물이 5종, 부유식물이 2종, 추수식물이 26종, 수생식물이 46종, 습생식물이 47종으로 조사지점중 이 지역의 식생이 가장 다양하였다. 식물사회학적 방법에 따라 분류된 하천식생의 식물군락은 10개의 수생식물 군락과 2개의 습생 및 수변식물 군락으로 대별되어졌다. 이들 군락들에 대한 4종류(종수, 종의 풍부도지수, 종의 이질성지수, 종의 균등도지수)의 종 다양성과 토양요인(pH, EC, 유기물 함량, 전질소, 인삭)과의 관계를 분석한 결과 pH가 높을수록 4종류의 종 다양성 지수는 높아 졌으며, EC는 값이 높을수록 종수(SN), 종의 풍부도지수(SR), 종의 이질성지수(H'), 종의 균등도지수(J')가 낮아 졌다. 또한 유기물 함량(OM)과 전질소(T-N)의 경우도 4종류의 다양성지수와는 부의 상관관계를 나타내었다. 인산(P₂O_(5))은 4종류의 다양성 지수의 변화에 영향을 미치지 않았다. This study was conducted to evaluate influence of chemical properties in the riparian on the species diversity and to get plant information for enhancement of natural purification in Mankyeong River. The concentration of total nitrogen was high in Jeonju and Sam stream, while that of total nitrogen showed the highest peak in Winter. Concentrations of NH₄-N was 0.01-0.06 ㎎/L in Gosan and Soyang stream. The water quality of upstream along with Mankyeong River was suitable for the imgation source. The riparian vegetation was investigated by Zurich-Montpellier school's method from June, 2001 to September, 2002. The number of riparian plants were 59 families, 129 genera, 165 species, 20 varieties in Gosancheon, on the while 53 families, 111 genera, 141 species, 19 varieties in Soyangcheon The number of riparian plants in Hari basin was higher than that of other sites namely, 73 families, 134 genera, 218 species, 33 varieties. Riparian vegetation was consisted of 12 plant communities. The contents of organic matter, total nitrogen and electrical conductivity had negative relationship with species diversity (Species richness index, Heterogeneity index, Species evenness index, Species number). On the while, species diversity had positive relationship with soil pH. Species diversity of the plant communities were affected by topography and disturbance.

Morgagni 탈장 : 1례 보고

오연희,이창욱,김승현,이성우,정병욱,이준희,박동일,권영무,신현종 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

Morgagni 탈장은 횡격막의 전내측 부위의 발달이상으로 열공을 통하여 장관이나 대망과 같은 복강내 구조물이 흉곽내로 빠져나가는 드문 질환으로 알려져 있다. 저자들은 호흡곤란을 주소로 내원하여 방사선학적 검사와 수술로 확진된 1례를 보고한다. Morgagni hernia is improperly located abdominal viscera into the thoracic cavity through the foramen of Morgagni which is a congenital defect at the anterornedial portion of diaphragm. We report a case of Morgagni hernia diagnosed by radiologic examination and operation.

만경강 본류의 자연정화능 향상을 위한 식생학적 진단

이경보,김창환,김종구,이덕배,박찬원,나승용 한국환경농학회 2003 한국환경농학회지 Vol.22 No.2

만경강 본류를 대상으로 수질을 개선하기 위한 일환으로 하천식생의 종구성, 하천형태에 따른 군락의 구조, 단면분석을 통한 현존식생의 분포 등을 종합적으로 분석하여 하천 생태계에 대한 종합적 해석과 식생에 의한 자연정화능 활용방안을 평가하고자 2001년 6월부터 2002년 3월까지 수질 및 식생에 관한 자연정화능을 조사, 평가하였다. 만경강 본류 수질중 T-N의 농도는 갈수기인 겨울철이 17.23 mg/L로 가장 높았으며, 여름철이 8.59 mg/L로 낮았고, 상류보다는 하류에서 그 농도가 높았다. 또한 평균 T-P의 농도는 여름철과 가을철에 각각 0.45, 0.47 mg/L로 비슷하였으나 겨울철에 1.79 mg/L로 농도가 높아졌다. BOD의 농도는 상류유역에서 0.95~2.57 mg/L로 Ⅰ~Ⅱ급수 수질을 나타내었으나 하류유역에서는 6.87~9.72 mg/L로 Ⅴ급수에 가까운 수질이었다. 만경강 상류의 식물상은 73과 134속 218종 33변종으로 총 251종류가 조사되었으며, 중류 일대에서 조사된 식물은 33과 69속 82종 16변종으로 총 98종류가 조사되었다. 그리고 만경강 하류 일대에서 관찰된 식물은 27과 58속 71종 14변종으로 총 85종류가 조사되었다. 만경강 유역에서 자연정화능에 의한 수질개선을 도모하기 위해 식물 생활형별로 하천 정화능이 뛰어난 식물을 조사 분석한 결과 침수식물은 붕어마름, 검정말, 부엽식물은 어리연꽃, 왜개연꽃, 추수식물은 갈대, 줄, 부들, 습생식물은 큰황새 냉이, 고마리 등이 질소, 인 흡수능이 우수한 식물이었다. This study was conducted to get some information on plants abilities to enhance water purification and to find out away to conserve the ecosystem in Mankyeong river. Vegetation were surveyed at 4 sites pointing by 1:5,000 topographical map, from June 2001 through March 2002. T-N content in water were high in all sites of Mankyeong river, the average T-N levels were 8.59 and 17.23 ㎎/L summer and winter, respectively. The average T-P level during summer was 0.47 ㎎/L, but that was 1.79 ㎎/L during winter. The BOD level in Mankyeong upstream ranged from 0.95 to 2.57 ㎎/L which would be in Ⅰ or Ⅱ grade according to water quality criteria by Ministry of Environment, but BOD level in Mankyeong downstream ranged from 6.87 to 9.72 ㎎/L. The plant species of river flora were found 251, 98 and 85, upstream, midstream and down stream, respectively. Among the surveyed plants, Ceratophyllum demersum, submerged plant and Nuphar subinteperrimum took up higher contents of phosphate and nitrogen than other plants. The Phragmites communis and Zizania latifolia having much biomass were thought to be suitable plants for enhancement of the natural water purification.

급성충수돌기염으로 발현된 방선균증 2예

조진원,송진영,김창억,민영훈,최창순,우흥정,현인규,김종현,유기철,채승완,손진희 대한화학요법학회 2001 대한화학요법학회지 Vol.19 No.1

The Actinomyces species are normal flora of oral cavity and upper intestine characterized as gram-positive, non-spore-forming anaerobic or mjcroaerophilic rods. Actinomycosis is a chronic suppurative and granulomatous disease characterized by abscess, sinus, abundant granulation and mass. The appendix is the commonly involved site among abdominal actinomycosis. Abdominal actinomycosis is often difficult to diagnose before operation because of no reliable clinical features and infrequency of the disease. We report two cases of abdominal actinomycosis which were manifested as acute appendicitis. Those were detected Incidentally tv the pathologist after routine appendectomy. Both patients were successfully treated with appendectomy followed by proper antibiotics use.

Pressure-Dependent Structural and Chemical Changes in a Metal–Organic Framework with One-Dimensional Pore Structure

Im, Junhyuck,Seoung, Donghoon,Hwang, Gil Chan,Jun, Jong Won,Jhung, Sung Hwa,Kao, Chi-Chang,Vogt, Thomas,Lee, Yongjae American Chemical Society 2016 Chemistry of materials Vol.28 No.15

<P>Pressure-dependent structural and chemical changes of the metal organic framework (MOF) compound MIL-47(V) have been investigated up to 3 GPa using different pore-penetrating liquids as pressure transmitting media (PTM). We find that at 0.3(1) GPa the terephthalic acid (TPA) template molecules located in the narrow channels of the as synthesized MIL-47(V) are selectively replaced by methanol molecules from a methanol ethanol water mixture and form a methanol inclusion complex. Further pressure increase leads to a gradual narrowing of the channels up to 1.9(1) GPa, where a second irreversible insertion of methanol molecules leads to more methanol molecules being inserted into the pores. After pressure release methanol molecules remain within the pores and can be removed only after heating to 400 degrees C. In contrast, when MIL-47(V) is compressed in water, a reversible replacement of the TPA by H2O molecules takes place near 1 GPa. The observed structural and chemical changes observed in MIL-47(V) demonstrate unique high pressure chemistry depending on the size and type of molecules present in the liquid PTM. This allows postsynthetic nonthermal pressure-induced removal and insertion of organic molecules in MOFs forming novel and stable phases at ambient conditions.</P>

The Effects of Vascular Endothelial Growth Factor in Differentiation of Bone Marrow Stromal Cell into Endothelial Cell

( Seoung Yob Han ),( Jong Wook Kim ),( Sang Yun Jeon ),( Heung Joong Kim ),( Byung Ock Kim ),( Joo Cheol Park ),( Chang Hoon Song ),( Hyun Seon Jang ) 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.1

Tissue engineering is attracting attention because it is new approaches for the repair and replacement of tissues and organs that have lost function due to variable reasons. Clinical application have already begun. One of the fundamental principles that underlies tissue engineering strategies is that a newly formed tissue must acquire sufficient vascularization. In recent studies, differentiation of the endothelial cells from variable cell sources has been reported, and vascular endothelial growth factor(VEGF) is very important factor in differentiation. This study investigated whether differentiation of BMSC, cultured with VEGF in vitro, into endothelial cell is possible. BMSC was obtained from Dog BMSC was loaded onto an equal volume of 75ul VEGF and incubated at 37oC in 5% CO2 and 95% humidity. Media was changed every 2days. Total RNA was extracted by use of Trizol reagent. The gene expression of cultured cells was investigated by RT-PCR using the primers - nestin, VE-Cadherin, vWF and GAPDH as internal control. And the PCR products were electrophoresed on a 1.2% agarose gel. Digital images of electrophoresd gel were taken and quantified by densitometer(Bio-rad(R)). As time goes by, experiment group show spindle shape more clearly than control group and cell number increase. Nestin marker is expressed in all groups, beside expression of VE-Cadherin and vWF are higher in experiment group than control group. Experiment group treated with VEGF show high expression of the EC-specific marker: VE-Cadherin and vWF. The fact that 5 days culture group reveals the highest level of gene expression means that this group reachs the sufficient differentiation into EC and that it has potential to reduce the time of vascular tissue regeneration.

Changes in Blood Manganese Concentration and MRI T1 Relaxation Time During 180 Days of Stainless Steel Welding-Fume Exposure in Cynomolgus Monkeys

Sung, Jae Hyuck,Kim, Choong Yong,Yang, Seoung Oh,Khang, Hyun Soo,Cheong, Hae Kwan,Lee, Jong Seong,Song, Chang-Woo,Park, Jung Duck,Han, Jeong Hee,Chung, Yong Hyun,Choi, Byung Sun,Kwon, Il Hoon,Cho, Myu Informa Healthcare 2007 Inhalation toxicology Vol.19 No.1

<P> Welders are at risk of being exposed to high concentrations of welding fumes and developing pneumoconiosis or other welding-fume exposure-related diseases. Among such diseases, manganism resulting from welding-fume exposure remains a controversial issue, as although the movement of manganese into specific brain regions has been established, the similar movement of manganese presented with other metals, such as welding fumes, has not been clearly demonstrated as being similar to that of manganese alone. Meanwhile, the competition between Mn and iron for iron transporters, such as transferrin and DMT-1, to the brain has also been implicated in the welding-fume exposure. Thus, the increased signal intensities in the basal ganglia, including the globus pallidus and subcortical frontal white matter, based on T1-weighted magnetic resonances in welders, require further examination as regards the correspondence with an increased manganese concentration. Accordingly, to investigate the movement of manganese after welding-fume exposure, 6 cynomolgus monkeys were acclimated for 1 mo and assigned to 3 dose groups: unexposed, low dose of (total suspended particulate [TSP] 31 mg/m3, 0.9 mg/m3 of Mn), and high dose of total suspended particulate (62 mg/m3 TSP, 1.95 mg/m3 of Mn). The primates were exposed to manual metal-arc stainless steel (MMA-SS) welding fumes for 2 h/day in an inhalation chamber system equipped with an automatic fume generator for 6 mo. Magnetic resonance imaging (MRI) studies of the basal ganglia were conducted before the initiation of exposure and thereafter every month. During the exposure, the blood chemistry was monitored every 2 wk and the concentrations of metal components in the blood were measured every 2 wk and compared with ambient manganese concentrations. The manganese concentrations in the blood did not show any significant increase until after 2 mo of exposure, and then reached a plateau after 90 days of exposure, showing that an exposure period of at least 60 days was required to build up the blood Mn concentration. Furthermore, as the blood Mn concentration continued to build, a continued decrease in the MRI T1 relaxation time in the basal ganglia was also detected. These data suggested that prolonged inhalation of welding fumes induces a high MRI T1 signal intensity with an elevation of the blood manganese level. The presence of a certain amount of iron or other metals, such as Cr and Ni, in the inhaled welding fumes via inhalation was not found to have a significant effect on the uptake of Mn into the brain or the induction of a high MRI T1 signal intensity.</P>

Autoimmune Hemolytic Anemia in a Patient with Primary Ovarian Non-Hodgkin's Lymphoma

Park Jong Seung,Lee Eun Ju,Kim Sung Hyun,Kwon Hyuk Chan,Kim Jae Seok,Kim Kyeong Hee,Han Jin Yeong,Kim Hyo Jin,Roh Mee Sook,Jung Chang Kil,Yoon Seoung Kook 대한의학회 2004 Journal of Korean medical science Vol.19 No.2

VDL Mode-2 D8PSK 모뎀 설계 및 개발

김종만(Jong-man Gim),최승덕(Seoung-duk Choi),은창수(Chang-soo Eun) 한국통신학회 2009 韓國通信學會論文誌 Vol.34 No.11