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채기병,장기성,소대화 明知大學校 産業技術硏究所 1990 産業技術硏究所論文集 Vol.9 No.-
In this study, a new sintered specimens of Y₁-xSmxBa₂Cu₃Oy is composed by substituting Sm for a part of Y in the YBa₂Cu₃Oy high Te superconductor. in order to study of making (Y-Sm)-Ba-Cu-O system sintered specimens and their characteristics. And their change affected on superconductivity and their characteristics are studied by changing the x range of the composition rate. The resistances of electrical characteristics under the conditions of the composition and the temperature are measured by using Ac four probe method in the procedure of this. experiments. And it is confirmed that the Meissner effect from the superconductivity of compose S m system exists in the range of 0 < x 0.5. As for the type of the grain structure, by the SEM photographs, it is observed that the grain structures of the superconductors are formed into the stick type.
Lim, Byung Chan,Kim, Gi Beom,Bae, Eun Jung,Noh, Chung Il,Hwang, Hee,Kim, Ki Joong,Hwang, Yong Seung,Ko, Tae Sung,Chae, Jong-Hee SAGE Publications 2010 Journal of child neurology Vol.25 No.4
<P>Andersen cardiodysrhythmic periodic paralysis or Andersen-Tawil syndrome includes the distinct clinical features of periodic paralysis, cardiac arrhythmia, and facial and skeletal dysmorphisms and exhibits autosomal dominant inheritance. Mutations in the KCNJ2 gene, which encodes the human inward rectifier potassium channel Kir2.1, have been identified in the majority of cases. Despite well-established clinical and molecular characteristics, treatment is still case oriented, and timely diagnosis could be delayed because of the low incidence and phenotypic heterogeneity of this disease. This article describes the clinical and molecular features of 3 cases of Andersen-Tawil syndrome in 2 families. One of the mutations (G144D) was located in the pore selectivity filter residue (which is mutated recurrently) and was considered novel. Intermittent muscle weakness in childhood warrants careful evaluation of cardiac dysrhythmia and skeletal anomalies.</P>
Soon Gi Hong,Chae-Kyu Park,Byung-Goo Cho,Jae-Joon Wee,Sun Hee Hyun,정신교 한국응용생명화학회 2009 Applied Biological Chemistry (Appl Biol Chem) Vol.52 No.5
In the present study, we synthesized a diglyceride (CLA-DG) from glycerol and conjugated linoleic acid (CLA). CLA-DG contained about 66% CLA as fatty acids. The safety of CLA-DG was assessed in acute and subchronic studies and in genotoxicity assays. In a single-dose acute study of CLA-DG, male and female rats were administered 5000 mg/kg body weight. CLA-DG caused no adverse effects and body weight gain and food consumption were within the normal range, thus the LD50 of CLA-DG was determined to be greater than 5000 mg/kg. In a 90-day subchronic study (500, 1000, and 2000 mg/kg b.w./day, oral via gavage) in male and female rats, no significant adverse effects in food consumption, body weight, mortality, clinical chemistry, hematology, gross pathology, and histopathology were observed. CLA-DG did not show any potential to induce gene mutations in reverse mutation tests using Salmonella typhimurium TA98, TA100, TA1535, TA1537, and Escherichia coli WP2uvrA strains. CLA-DG did not induce chromosomal aberrations in cultured Chinese hamster lung cells. The results from these studies support the safety of CLA-DG.
A study on the traceability and uncertainty of skin hydration measurement on the sole of the foot
Yang, Gi-Young,Choi, Ji-Won,Chae, Han,Lee, Byung-Ryul The Society of Korean Medicine 2017 대한한의학회지 Vol.38 No.4
Objectives: In order to accurately measure skin moisture and accumulate normal skin moisture data, analyzing the uncertainty of the skin moisture measurement and establishing standard reference data is essential. It helps to evaluate the skin's condition and has great significance in diagnosis and treatment. In this study, the traceability of the equipment and the uncertainty of the results were analyzed for their potential use in the field of Korean medicine. The data was collected measuring skin moisture on the sole of the foot. Methods: One professional measured the moisture of the adult male's foot 10 times following a determined protocol. The standard uncertainty of repeated measurements was calculated from the mean value of 10 repeated measurements. Ten trainee participants also measured the adult male's foot following a determined protocol. The standard uncertainty by tester was calculated from the value of repeated measurements. Results: As a result of analyzing the difference between the mean and standard uncertainties in both the expert and trainees, it was confirmed that the variance in this study did not satisfy the normal distribution. In addition, the Mann-Whitney U-test was carried out, and it was found that there was no significant difference in the measured values of the two groups. The authorized uncertainty of measurements and traceability of all the equipment was not confirmed. Conclusions: This paper establishes the basis for later measurement-equipment research to provide the objective indicators to approach the dryness of plantar skin from dehydration, the Korean medicine perspective.
강병채(Byung Chae Kang),김사진(Sa Jin Kim),이귀세라(Gui Se Ra Lee),허수영(Soo Young Hur),이초희(Cho Hee Lee),진기홍(Gi Hong Jin),박정희(Jung Hui Park),정대영(Dae Young Chung),이영(Young Lee),신종철(Jong Chul Shin),김수평(Soo Pyung Ki 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.2
본 연구의 목적은 태반 조기 박리의 임상 양상을 기존의 다른 연구와 비교, 분석하여 신속한 진단 및 처치를 통해 산모와 태아의 건강을 유지하는데 있다. 1990년부터 1997년까지의 가톨릭대학교 중앙 의료원의 3개 병원에 입원하여 태반 조기 박리로 진단된 369예의 임상 기록지를 관찰, 분석하였다. 그 결과 태반 조기 박리의 빈도는 0.51% 이였으며, 연령별 분포는 25세에서 35세 사이의 산모가 79.6%를 차지했으나 그 발생률에 있어서는 40세 이상에서 가장 높았고, 35세에서 39세 사이와 20세에서 24세가 그 다음이고, 30세에서 34세에서 가장 적은 발생 빈도를 보였다. 98.4%가 37주 이전에 진단되었고 28주미만에 태어난 아이의 84%는 생후 1달 이내 사망하였다. 알려진 원인으로는 임신성 고혈압이 가장 많았고, 그밖에 조기 양막 파수, 자궁 근종, 다태 임신, 외상 등이다. 임상 증상으로는 질 출혈과 자궁 압통 및 복부 압통이 대부분이였고, 조기 양막 파수, 유도 분만 중 태아 긴박증이 있거나 기 제왕절개로 제왕절개 시 우연히 발견된 경우도 있었다. 합병증으로는 Couvelaire uterus, 범발성 혈액응고증, 급성 신부전등이 발견되었으며, 기타 자궁파열과 뇌색전증 및 폐의 색전증이 동반된 경우가 1예가 있었다. 산모의 사망은 없었고 태아 사망은 73예에서 발견되었고, 이중 41예가 태내 사망이었다. 신생아 유리질막증은 24예에서 관찰되어 이중 18예가 사망하였다. 태반 조기 박리는 대부분이 37주 이전에 심한 질출혈과 자궁 압통을 일으키는 질환으로 조기 진단 및 처치로 태아 사망과 부작용이 줄어들기는 했으나 여전히 산모와 태아에 중대한 합병증을 일으킨다. Objective: To evaluate for the clinical analysis on abruptio placenta, we examined its incidence, diagnostic methods, symptom and sign, perinatal mortality, and recurrence rate. Methods: We reviewed the medical records of the 396 cases of abruptio placenta among 72.580 deliveries, from Jan. 1, 1990 to Dec. 31, 1997, at St. Mary, Kang Nam St. Mary, and Holy Family Hospital of Catholic University. Results: The total incidence of abruptio placenta was 0.51%, the incidence plotted by age from 1993 to 1997 has shown that the age incidence was higher in 20-24years old(0.7%), and over 35years old (0.8%). 42.5% of the case occurred between 32 to 37weeks of gestational age, 39.6% was over 37weeks. 38% of the patient was diagnosed before delivery with ultrasonography and the most common complaint was vaginal bleeding. The complication of abruptio placenta is as follows, Couvelaire uterus occurred in 26cases(7.0 %), DIC in 10cases(2.7 %), ARF in 4cases (1.1 %), and uterine rupture in 1case(0.3 %). Perinatal mortality including 41cases of stillbirth was 19.9 %(73cases) but no maternal death was noted. A history of abruptio placenta increased risk of a similar incident in a subsequent pregnancy by 19 cases(4.6 %: 9.0 fold)complicated with 13 cases of pregnancy induced hypertension(76.5 %). Conclusion: The incidence of abruptio placenta plotted by age have shown higher in 20-25years old and over 35 years old, hypertensive women experienced abruptio placenta are more likely to have higher graded recurrent rate in subsequent pregnancy, and abruptio placenta is major obstetric bleeding disease causing serious maternal and fetal complication.
천병렬,김권배,김기식,김영조,김윤년,김창윤,박의현,신동구,심봉섭,이종주,이충원,장성국,전재은,조용근,채성철,최지용,하영애,이영숙 경북대학교 의학연구소 1999 경북대학교병원의학연구소논문집 Vol.3 No.1
To estimate the incidence rate of coronary heart disease in Korea, of all residents in Taegu city aged 25 or above, those who had an acute MI or a fatal coronary event between 1 July 1996 and 30 June 1997 were registered. Seven hundreds and eight patients were registered during the study period(685 were identified at hospital and 23 were autopsy cases). Age-standardized annual incidence rate of men in city area was 93 per 100,000(95% CI; 61-142) and 33(95% CI; 16-67) in women(100 in men and 20 in women aged 35-64). The incidence was rapidly increased after age 40 in men, however, in women after age 60. Twenty-eight-days case fatality rate was 45% in men and 47% in women. However, in the age group of 45-59 case fatality rate in women was two times higher than that in men. In conclusion, crude annual incidence rate of CHD in city area was 73 per 100,000 in men and 33 in women. The age-standardized annual incidence of CHD in men(93 per 100,000) was 2 times higher than that in women (33 per 100,000) in Korea.
간세포암 환자에 있어서 AST / ALT 비의 진단적 의의
박병채(Byung Chae Park),안수열(Su Yul Ahn),김영곤(Young Gon Kim),조기범(Gi Beum Cho),김미선(Mi Sun Kim),고용호(Yong Ho Ko),박무인(Mu In Park),우인기(In Ki Woo) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.5
N/A To assess the possibility that the measurement in peripheral venous blood of AST/ALT ratios might be helpful in detection of hepatocellular carcinoma (HCC), the AST/ALT ratios were evaluated in 282 cases of chronic active hepatitis (CAH), 59 cases of CAH with early cirrhotic change (CAH with LC), 213 cases of liver cirrhosis (LC), and 220 cases of hepatocellular carcinoma (HCC). The ratio of male to female was 72.9% to 27.1% in HBsAg seropositive groups and 68.8% to 3I.2% in HBsAg seronegative groups, respectively. The mean age was 43.7 years old in HBsAg seropositivity and 49.9 years old in HBsAg seonegativity, respectively. In HBsAg seropositive groups, the AST/ALT ratio was 0.68+-0.30 in CAH group, 0.78+-0.19 in CAH with LC, 1.68+-0 83 in LC, 2.17+- l.60 in HCC. In HBsAg seronegative groups, AST/ALT ratio was 0.71+-0.58 in CAH group. 0.82+-0.31 in CAH with LC, 1.72+-0.87 in LC, 1.95+-1.38 in HCC. AST/ALT ratio was gradually increased according to the progress of the chronic liver disease in both HBsAg seropositive groups as well as negative groups. AST/ALT ratio was significantly (p<0.005) elevated in patients with HCC, being above 2.0, as compared to other groups. AST/ALT ratio in the patients with serum AST>200 units was higher than in those with AST<200 units, and the mean AST/ALT ratio in the HCC patients with AST.> 200 units was significantly higher than in other chronic liver disease. AST/ALT ratio above 3.3, without evidence of circulatory disturbance, was almost entirely restricted to the patients with HCC. In conclusion, since elevated AST/ALT ratio reflects the progress of chronic liver disease from CAH to HCC, a gradual increase in AST/ALT ratio might be a useful marker assessing for detection of HCC.