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Rosiglitazone-mediated dendritic cells ameliorate collagen-induced arthritis in mice
Byun, S.H.,Lee, J.H.,Jung, N.C.,Choi, H.J.,Song, J.Y.,Seo, H.G.,Choi, J.,Jung, S.Y.,Kang, S.,Choi, Y.S.,Chung, J.H.,Lim, D.S. Pergamon Press 2016 Biochemical pharmacology Vol.115 No.-
<P>Rosiglitazone is a selective ligand for peroxisome proliferator-activated receptor-gamma (PPAR-gamma), which serves diverse biological functions. A number of autoimmune disease models have been used to examine the anti-inflammatory and immunosuppressive effects of tolerogenic dendritic cells (tDCs). The aim of the present study was to investigate whether rosiglitazone-mediated DC (Rosi-DC) therapy suppressed arthritis in a collagen-induced arthritis (CIA) mouse model. Rosi-DCs were generated by treating immature DCs with TNF-alpha, type II collagen, and rosiglitazone. CIA mice then received subcutaneously (s.c.) two injections of Rosi-DCs. The severity of arthritis was then assessed histopathologically. The phenotypes of the DC and regulatory T (Treg) cell populations in CIA mice were determined by flow cytometry and the effect of Rosi-DCs on the secretion of autoimmunity-inducing cytokines was examined by ELISA. Rosi-DCs expressed lower levels of DC-related surface markers than mature DCs. Histopathological examination revealed that the degree of inflammation in the paws of Rosi-DC-treated mice was much lower than that in the paws of PBS-treated CIA mice. Taken together, these results clearly show that rosiglitazone-mediated DCs ameliorate CIA, most likely via the induction of antigen-specific Treg cells. (C) 2016 Elsevier Inc. All rights reserved.</P>
鄭元采,盧載榮,安長憲,卞珠燮 충북대학교 엽연초연구소 1974 煙草硏究 Vol.2 No.-
This works has been carried out in order to study the influence of different condition of soil moisture on the growth and yield of tobacco leaves. It was investigated the soil moisture on the cultivating farm of tobacco for the study on the variation in soil moisture. The results are summarized as follow; 1.In the deficient supply of soil moisture, S1 treatment at the setting stage caused the delay of growth, and S3 treatment at the period vigrous growth influenced eriousely on the yield. Dry leaf weight decreased gradually in order S1>S6>S2>S3>S5>S4. 2.The dry leaf weight was decreased according to the increase of treatment duration, the results showed as T1=T2=T3<C 3.In the excessive supply of soil moisture, 90% (maximum water holding capacity) treatment during 10~20 days was damaged at early stage more than latter stage treatment in the growth. 4.In the deficient or excessive supply of soil moisture, excessive supply treated plots in long period and the replication plots in the deficient supply treated influenced on the yields.
원발성 간암에서 PIVKA-II 및 Lens Culinaris Agglutinin-A 반응성 Alpha-fetoprotein(AFP-L3)의 임상적 유용성
배시현,박두호,양진모,박영민,차상복,최종영,성광용,조세현,정규원,선희식,김부성,최상욱,변병훈,한남익 대한간학회 2000 Clinical and Molecular Hepatology(대한간학회지) Vol.6 No.2
Background/Aims: Des-γ-carboxy prothrombin(DCP), a protein induced by vitamin K absence or antagonist-II(PIVKA-II), and Lens culinaris agglutinin-A reactive AFP-L3 have been reported to be useful markers for the diagnosis of hepatocellular carcinoma (HCC). In the present study, both the PIVKA-II and AFP-L3 were analyzed and compared with a conventional AFP to determine its usefulness, specificity and sensitivity in the diagnosis of HCC. Methods: Sera were collected from 108 patients consisting of 17 patients with chronic hepatitis, 22 patients with liver cirrhosis and 69 patients with HCC. The AFP-L3 was determined by an lectin affinity electrophoresis coupled with an antibody-affinity blotting. Level of DCP was measured by an enzyme immunoassay with an anti-DCP monoclonal antibody. Results: The sensitivity and specificity of PIVKA-II and AFP L3 were 49.3% and 89.5%, and 32.5% and 85.7%, respectively. No significant correlation was found between the PIVKA-II or AFP L3 and serum AFP. No correlation was found etween the PIVKA-II or AFP L3 and the characteristics of HCC. Conclusion: The determination of plasma DCP and AFP L3 levels combined with AFP levels may be useful especially for the differential diagnosis between HCC and chronic liver diseases without HCC.(Korean J HepatoBackground/Aims: Des-γ-carboxy prothrombin(DCP), a protein induced by vitamin K absence or antagonist-II(PIVKA-II), and Lens culinaris agglutinin-A reactive AFP-L3 have been reported to be useful markers for the diagnosis of hepatocellular carcinoma (HCC). In the present study, both the PIVKA-II and AFP-L3 were analyzed and compared with a conventional AFP to determine its usefulness, specificity and sensitivity in the diagnosis of HCC. Methods: Sera were collected from 108 patients consisting of 17 patients with chronic hepatitis, 22 patients with liver cirrhosis and 69 patients with HCC. The AFP-L3 was determined by an lectin affinity electrophoresis coupled with an antibody-affinity blotting. Level of DCP was measured by an enzyme immunoassay with an anti-DCP monoclonal antibody. Results: The sensitivity and specificity of PIVKA-II and AFP-L3 were 49.3% and 89.5%, and 32.5% and 85.7%, respectively. No significant correlation was found between the PIVKA-II or AFP-L3 and serum AFP. No correlation was found etween the PIVKA-II or AFP L3 and the characteristics of HCC. Conclusion: The determination of plasma DCP and AFP-L3 levels combined with AFP levels may be useful especially for the differential diagnosis between HCC and chronic liver diseases without HCC.(Korean J Hepatol 2000;6:205-214)l 2000;6:205-214)
趙成鎭,卞珠燮,陸昌洙 충북대학교 엽연초연구소 1974 煙草硏究 Vol.2 No.-
With the aim of surveying soil characteristics of main Y.S.A-producing fields, the results obtained from the soils in the Cheungju-Cheungwon-gun producers' cooperative area are summarized as follows : 1.The results obtained from the present survey of soils were not consistent with the originalgrades designated as A, B and C by the producers' cooperative. 2.Particularly in terms of the relationship between cultivation periods(yrs) and yields, the yields in normal-productive soils decreased gradually with time, whereas no such tendency was observed in the low-productive soils. Pest damages were noticeable in the case of the low-productive fields. 3.Physical properties showed that the depths of surface soils were, on average, over 20cm in both normal and low-productive fields, the former being a little deeper. In soil texture, in general most of them were coarse sandy soils, low-productive fields abounding in clayey soils. 4.Chemical properties indicated that both normal and low-productive soils were strongly acidic, Mostly the latter having lower pH's than the former to be pH 4.6~5.0. Proportionally, exchangeable base and degree of base saturation of low-productive soils were lower than those of normal soils. This seems to be the cause of low-productivity in terms of soil itself. Contents of total nitrogen, available phosphorus, and humus were very low and far below the average contents of field soils of this country. No difference was recognized between normal and low-productive soils.
이정일,이무하,민중석,김일석,이상옥,신대근,변준석,강석남 한국축산학회 1998 한국축산학회지 Vol.40 No.4
Microorganisms were taken at the surfaces of pork and beef. Microbial sampling of pork was carried out at 4 steps, i.e. immediately after slaughtering(PA), at 24hrs after slaughtering(PB), before deboning(PC) and after deboning(PD). And the sampling of beef was carried out at 5 steps, i.e. immediately after slaughtering(BA), at 6hrs after slaughtering(BB), at 24hrs after slaughtermg(BC), before deboning(BD) and after deboning(BE). Total plate count was significantly higher in the step before deboning(PC) than in the other steps of pork processing(P$lt;0.05). The numbers of coliforms and E. coli increased in proportion to the total plate counts. Microbial contamination was significantly higher in the step before deboning than any other step of beef processing(P$lt;0.05). The step immediately after slaughtering(BA) was the next highest level in microbial contamination. The results of multiple regression analysis among total plate counts, coliforms and E. coli showed that determination coefficients(R²) were as high as 0.8307-0.9971. This meant that E. coli increased as total plate counts and coliforms increased. The results of PMP(pathogen model program) analysis showed that pathogenic microorganisms grew similarly in low ambient temperature(5℃), while they grew faster as ther initial numbers were high. In the same initial number, growth rate was 10 times faster in 15℃ than in low ambient temperature(5℃) and 4 times faster in 25℃ than in 15℃.