정신분열병 환자의 사회기능에 대한 올란자핀과 정형적 항정신병약물의 효과비교

김철권,정형모,최병무 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.1

Objectives : The purpose of this study was to compare the social functioning between schizophrenic patients treated with olan-zapine and those with typical antipsychotics. Methods : Fifty-seven schizophrenic patients with acute exacerbation entered consecutively to olanzapine treatment (N=33) or typical antipsychotic treatment (N=24). The assessment of social functioning and symptoms were made at 3 time points : at the time of admission (baseline), 6 months and 12 months after starting medications. Social functioning and symptoms were examined using the Korean version of Social Adjustment Scale II-Revised Version (KSAS n-RV) and the Positive and Nega-tive Syndrome Scale (PANSS). Results : After 6-months and 12-months treatments, olanzapine treatment group showed significantly improved PANSS total scores (p=.02), Positive scores (p=.04), negative scores (p=.01), and KSAS II-RV total score (p=.004), instrumental role (p= .002), social leisure (p= .03), Personal well-being subarea scores (p= .02), compared with the scores of typical antipsy-chotic treatment group. Conclusion : Olanzapine was more effective than typical antipsychotics in reducing the severity of psychopathology and in improving some subareas of social functionings in patients with schizophrenia. The benefits of olanzapine on social functioning, although modest, may be important factor considering their accumulative effects for long-term treatment.

일측 하퇴 의족 착용자의 절단단 길이에 따른 보행특성

조병모,변주남,김기순,김석산,박종 조선대학교 부설 의학연구소 1999 The Medical Journal of Chosun University Vol.24 No.1

This report studied 31 male patients who were in one hospital in Kwangju or came to a prosthesis clinic and are 15 normal control group to analyze the gait characteristics according to the stump length in the prosthesis users with the unilateral below-knee amputations. The patient group was divided into a short stump subgroup of 13 patients and a long stump subgroup of 18 patients according to the stump length, the control group was randomly sampled from 15 males who have similar age, height and weight to the experimental group. The results of analysis are summarized as follows. 1. There were no significant statistical differences of the general characteristics between patient and control groups and there was no difference of characteristics by patient groups except the mean gait distance a day. 2. Of 33 patients with amputation, 18 patients (57.8%) had phantom pain and 25 cases (80.6%) had neuroma. 3. Gait velocity, stride length of the affected side, step length of the sound side and base support among gait characteristics show a significant difference according to the stump length in the state excluding the effects of other factors (p<05) and the group with long stump showed closer gait characteristics to normal persons than those with short stumps. In conclusion, among the patients of unilateral below-knee amputations, the stump length affects the gait characteristics such as gait velocity, stride length, step and base of support and it is found that as the stump length gets longer, it shows the similar characteristics to gait characteristics of normal persons and long unilateral below-knee amputation can secure better gait characteristics.

기능성 소화불량증환자에서 Winstal® 투여에 관한 임상경험

이창형,김영탁,금민수,권중구,안병철,윤영미,권영오,김성국,최용환,정준모 慶北大學校 醫科大學 1994 慶北醫大誌 Vol.35 No.3

목적 : 기능성 소화불량증은 소화, 흡수등 장관의 기능적인 이상과 관련되어 있을 것으로 생각되며 복합소화효소제(Winstal®)를 투여하여 그 임상효과를 평가하고자 본 연구를 실시하였다. 대상 및 방법 : 1994년 3월 부터 6월까지 경북대학교병원 내과를 방문한 기능성 소화불량증을 호소하는 환자 20명을 대상으로 Winstal®을 1회 1정씩, 1일 3회 식후 30분내에 경구로 2주간 투여하였다. 결과 : 소화불량증의 증상은 복부불쾌감, 복부팽만감, 식욕부진 및 오심, 복부동통, 공기연하증, 고창 및 구토순이었으며, 증상의 개선은 복부불쾌감이 76.4%(13/17)로 가장 높았으며, 그 다음으로 복부팽만감 및 공기연하증이 66.5%(10/15, 6/9)이었고, 오심 61.5%(8/13), 식욕부진 53.8%(7/13), 복부동통 41.6%(5/12), 고창 37.5%(3/8)이었다. 각 환자별 종합적인 증상의 개선도는 현저한 개선이 2예(10%), 중등도 개선이 3예(15%), 약간개선이 11예(55%), 불변이 4예(20%)이었으며 종합적인 유효율은 80%(16/20)이었다. 부작용은 한 예에서도 관찰되지 않았다. 결론 : 본 제제는 기능성 소화불량증 환자의 증상개선에 추천할 만한 유효한 약제로 생각된다. Dyspepsia is a common symptom in gastroenterologic practice and trigger for numerous consultations with physician. The treatment of chronic functional dyspesia is unsatisfactory. This study was performed to evaluate the efficacy of the digestive compound (Winstal®) on 20 functional dyspepsia patients. On open trial, all patients were given 6 tablets daily for 2 weeks and we evaluated the efficacy of this preparation according to the degree of the improvement. The improvement of symptoms was 76.4%(13/17) in abdominal discomfort, 66.5%(10/15, 6/9) in abdominal distension and aerophagia, 61.5%(8/13) in nausea, 53.8%(7/13) in abdominal pain, and 37.5% (5/12) in flatulence, respectively. Overall effectiveness of subjective symptoms was 80% (16/20) and there were no untoward effects of the preparations during this study. As a result, We think that this preparation is an effective one to relieve symptoms of functional dyspepsia.

Purge & Trap-GC를 이용한 의약품 필름코팅 정제 중 잔류용제에 관한 연구

장준식,이명자,소유섭,문춘선,이주헌,박희라,김진숙,강경모,이선옥,방성연,유미자,유문균,금오성,이병욱 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

의약품은 약물을 생체에 적풋하기 위하여 유효성분의 효과가 언제나 일정하게 확보되고 사응에 편리하도록 만들어지는 것이므로 유효썽분 이외에 약효에 영향을 주지 않는 성분이 첨가되는 경운가 많다. 이 때 사용되는 용매들은 제피의 광택 및 건쪼시간의 단축 등을 위하여 휘발점이 낮을 용매들이 주로 사용되어진다. 본 연구는 의약품 필름코팅정제 중 잔류용매 4종(chlorofonr benzen, trichloro ethylen, 1,4-dioxane)에 대한 변형된 pirge & trap-GC 장치를 이용한 동시분석방법을 개발하였으며, 각 표준품의 RSD 값은 chloroform 3.03%, benzen 3.17%, trichloroethylen 3.69% and 1,4-dioxane 3.41%였다. 또한 시중 유통중인 의약품 50종에 대하여 잔류웅매 양을 측정하였으며, 검출되는 잔류용매는 한 건도 없었다. This study nras carried out to develope the analytical method for the mixture of chlorefonn, benzen, trichloroethylen and 1,4-dioxane simultaneously and determine the remainingorgauic solvents in coating tablets by Purge & Trap-GC. The results were as follouFs ; 1. Chloroform, benzen, trio:tloroethylen and 1,4-dioxane separated by tenax #5 trap by HP-624GC column by terrlperature programming. The peaks were separated completely at retentiontime of 6.88min for chloroform, 8.21min for benzen, 10.38miu for trichloroethylen and 11.95minfor 1,4-dioxane. 2. Standard RSD were individually chloroform 3.03%, benzen 3.17%, trichloroethylen 3.69%and 1,4-diorane 3.41%. 3. 60 samples were not detrcted chloroform, benzen, trichloroethylen and 1,4-dioxane.

Sequential caspase-2 and caspase-8 activation is essential for saikosaponin a-induced apoptosis of human colon carcinoma cell lines

Kim, Byeong Mo,Hong, Sung Hee Springer-Verlag 2011 Apoptosis Vol.16 No.2

Effect of a Respiratory Training Program Using Wind Instruments on Cardiopulmonary Function, Endurance, and Quality of Life of Elderly Women

Kim, Byeong-Soo,Kim, Ji-Hoe,Park, So-Hyun,Seo, Hyeon-Seon,Lee, Hye-Sun,Lee, Myung-Mo International Scientific Literature, Inc. 2018 Medical science monitor Vol.24 No.-

<P><B>Background</B></P><P>Physical changes due to aging lead to weakening of respiratory muscles and decreased lung functions that result in increasing risk of chronic respiratory disease. A complex respiratory rehabilitation program is needed to prevent respiratory diseases and improve lung functions and quality of life. The purpose of the present study was to examine the effects of respiratory training programs on pulmonary functions, cardiovascular endurance, and quality of life in elderly women.</P><P><B>Material/Methods</B></P><P>The program was structured with respiration exercise and playing wind musical instruments for 10 weeks (n=13) and 5 weeks (n=16), respectively, for elderly women in 2 different community welfare centers. The program consisted of breathing exercises twice a week, 20 min per session, and 40 min of wind instrumentation. Effects were assessed using forced vital capacity (FVC), forced expiratory volume-one second (FEV1), FEV1/FVC ratio (FEV1%), maximum voluntary ventilation (MVV), 6-minute walk test (6MWT), modified Borg scale (MBS), and life satisfaction scale (LSS).</P><P><B>Results</B></P><P>The 10-week program group (10WPG) showed significant differences in FVC, MVV, 6MWT, MBS, and LSS before and after interventions (p<.05), and the 5-week program group (5WPG) showed significant differences in FVC and 6MWT. MVV, MBS, and LSS were not significantly different between the 2 groups (p<.05).</P><P><B>Conclusions</B></P><P>This study confirms that the long-term respiration training program has positive effects on pulmonary functions, cardiopulmonary endurance, and quality of life. Various respiratory training programs and long-term implementations are needed to prevent respiratory illness and to improve lung functions and quality of life of respiratory patients.</P>

A multitude of modifications strategy of ZnFe₂O₄ nanorod photoanodes for enhanced photoelectrochemical water splitting activity

Kim, Ju Hun,Jang, Youn Jeong,Choi, Sun Hee,Lee, Byeong Jun,Kim, Jeong Hun,Park, Yoon Bin,Nam, Chang-Mo,Kim, Hyun Gyu,Lee, Jae Sung The Royal Society of Chemistry 2018 Journal of Materials Chemistry A Vol.6 No.26

<P>Numerous modifications strategies are applied to spinel ZnFe2O4 nanorods with a band gap energy of ∼2.0 eV to enhance their activity as a photoanode for photoelectrochemical (PEC) water splitting. First, hybrid microwave annealing (HMA) imparts high crystallinity to ZnFe2O4 nanorods, while preserving the formed nanostructure and maintaining high electric conductivity of F:SnO2 (FTO) substrate. This is in contrast to conventional thermal annealing (CTA) at 800 °C that causes aggregation of ZnFe2O4 and degradation of FTO. Second, insertion of a TiO2 underlayer blocks charge recombination at the FTO/electrolyte interface and serves as a source of Ti doping. Third, hydrogen treatment yields oxygen vacancies that increase charge carrier density and cause surface passivation. Last, a NiFeOx co-catalyst promotes hole injection into the electrolyte to improve catalytic water oxidation activity. These synergistic modifications lead to enhanced photocurrent density from 0.025 mA cm<SUP>−2</SUP> at 1.23 VRHE for pristine ZnFe2O4 nanorods prepared by CTA to 0.92 mA cm<SUP>−2</SUP> for a fully modified HMA photoanode: a 37-fold increase in photocurrent density. There is also a cathodic shift of the onset potential down to 0.62 VRHE. The multiple modifications enhance bulk charge separation efficiencies from mere 2% to 30% and surface charge separation efficiency from 40% to 80%.</P>

Emodin Sensitizes Hepatocellular Carcinoma Cells to the Anti-Cancer Effect of Sorafenib through Suppression of Cholesterol Metabolism

Kim, Young-Seon,Lee, Yoon-Mi,Oh, Taek-In,Shin, Dong Hoon,Kim, Geon-Hee,Kan, Sang-Yeon,Kang, Hyeji,Kim, Ji Hyung,Kim, Byeong Mo,Yim, Woo Jong,Lim, Ji-Hong MDPI 2018 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.19 No.10

<P>Reduced therapeutic efficacy of sorafenib, a first-generation multikinase inhibitor, is often observed during the treatment of advanced hepatocellular carcinoma (HCC). Emodin is an active component of Chinese herbs, and is effective against leukemia, lung cancer, colon cancer, pancreatic cancer, and HCC; however, the sensitizing effect of emodin on sorafenib-based HCC therapy has not been evaluated. Here, we demonstrate that emodin significantly improved the anti-cancer effect of sorafenib in HCC cells, such as HepG2, Hep3B, Huh7, SK-HEP-1, and PLC/PRF5. Mechanistically, emodin inhibits sterol regulatory element-binding protein-2 (SREBP-2) transcriptional activity, which suppresses cholesterol biosynthesis and oncogenic protein kinase B (AKT) signaling. Additionally, attenuated cholesterol synthesis and oncogenic AKT signaling inactivated signal transducer and activator of transcription 3 (STAT3), an oncogenic transcription factor. Furthermore, emodin synergistically increased cell cycle arrest in the G1 phase and apoptotic cells in the presence of sorafenib. Animal models xenografted with HepG2 or SK-HEP-1 cells also showed that the combination of emodin and sorafenib was sufficient to inhibit tumor growth. Overall, these results suggested that the combination of emodin and sorafenib may offer a potential therapy for patients with advanced HCC.</P>

5-Phenylselenyl- and 5-methylselenyl-methyl-2'-deoxyuridine induce oxidative stress, DNA damage, and caspase-2-dependent apoptosis in cancer cells.

Kim, Byeong Mo,Rode, Ambadas B,Han, Eun Jong,Hong, In Seok,Hong, Sung Hee Rapid Science Publishers ; Kluwer Academic Publish 2012 Apoptosis Vol.17 No.2

<P>In the present study, we investigated the signaling pathways implicated in the induction of apoptosis by two modified nucleosides, 5-phenylselenyl-methyl-2'-deoxyuridine (PhSe-T) and 5-methylselenyl-methyl-2'-deoxyuridine (MeSe-T), using human cancer cell lines. The induction of apoptosis was associated with proteolytic activation of caspase-3 and -9, PARP cleavage, and decreased levels of IAP family members, including c-IAP-1 and c-IAP-2, but had no effect on XIAP and survivin. PhSe-T and MeSe-T also enhanced the activities of caspase-2 and -8, Bid cleavage, and the conformational activation of Bax. Additionally, nucleoside derivative-induced apoptosis was inhibited by the selective inhibitors of caspase-2, -3, -8, and -9 and also by si-RNAs against caspase-2, -3, -8, and -9; however, inhibition of caspase-2 and -3 was more effective at preventing apoptosis than inhibition of caspase-8 and -9. Moreover, the inhibition of caspase-2 activation by the pharmacological inhibitor z-VDVAD-fmk or by the knockdown of protein expression using siRNA suppressed nucleoside derivative-induced caspase-3 activation, but not vice versa. PhSe-T and MeSe-T also induced a δψ(m) loss via a CsA-insensitive mechanism, ROS production, and DNA damage, including strand breaks. Moreover, ROS scavengers such as NAC, tiron, and quercetin inhibited nucleoside derivative-induced ROS generation and apoptosis by blocking the sequential activation of caspase-2 and -3, indicating the role of ROS in caspase-2-mediated apoptosis. Taken together, these results indicate that caspase-2 acts upstream of caspase-3 and that caspase-2 functions in response to DNA damage in both PhSe-T- and MeSe-T-induced apoptosis. Our results also suggest that ROS are critical regulators of the sequential activation of caspase-2 and -3 in nucleoside derivative-treated cancer cells.</P>

An Efficient Feature Point Extraction and Comparison Method through Distorted Region Correction in 360-degree Realistic Contents

Byeong-Chan Park(박병찬),Jin-Sung Kim(김진성),Yu-Hyeon Won(원유현),Young-Mo Kim(김영모),Seok-Yoon Kim(김석윤) 한국컴퓨터정보학회 2019 韓國컴퓨터情報學會論文誌 Vol.24 No.1

One of critical issues in dealing with 360-degree realistic contents is the performance degradation in searching and recognition process since they support up to 4K UHD quality and have all image angles including the front, back, left, right, top, and bottom parts of a screen. To solve this problem, in this paper, we propose an efficient search and comparison method for 360-degree realistic contents. The proposed method first corrects the distortion at the less distorted regions such as front, left and right parts of the image excluding severely distorted regions such as upper and lower parts, and then it extracts feature points at the corrected region and selects the representative images through sequence classification. When the query image is inputted, the search results are provided through feature points comparison. The experimental results of the proposed method shows that it can solve the problem of performance deterioration when 360-degree realistic contents are recognized comparing with traditional 2D contents.