Direct effectiveness of pneumococcal polysaccharide vaccine against invasive pneumococcal disease and non-bacteremic pneumococcal pneumonia in elderly population in the era of pneumococcal conjugate vaccine: A case-control study

Kim, Jong Hun,Chun, Byung Chul,Song, Joon Young,Kim, Hyo Youl,Bae, In-Gyu,Kim, Dong-Min,Choi, Young Hwa,Jun, Yoon Hee,Choi, Won Suk,Kang, Seong Hee,Kwon, Hyun Hee,Jeong, Hye Won,Kee, Sae Yoon,Hur, Jia Elsevier Ltd. 2019 Vaccine Vol. No.

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>While herd effects and serotype replacement by childhood pneumococcal protein conjugated vaccines (PCVs) continues to accumulate worldwide, direct effectiveness of 23-valent pneumococcal polysaccharide vaccine (PPV23) against pneumococcal diseases in the elderly has been challenged. We estimated the direct effectiveness of PPV23 in the elderly population.</P> <P><B>Methods</B></P> <P>For a hospital-based case-control study, cases of invasive pneumococcal disease (IPD) and non-bacteremic pneumococcal pneumonia (NBPP) (adults ≥ 65 years) were identified in 14 hospitals participated in the pneumococcal surveillance program from March 2013 to October 2015, following implementation of PPV23 national immunization program (NIP) for the elderly in the Republic of Korea. Controls matched by age, sex, and hospital were selected at ratios of 1:2 (IPD) or 1:1 (NBPP). Clinical data and vaccination records were collected. Vaccine effectiveness was calculated as (1-adjusted odds ratio) × 100.</P> <P><B>Results</B></P> <P>We enrolled 148 IPD and 557 NBPP cases, and 295 IPD and 557 NBPP controls for analyses. Overall effectiveness of PPV23 against IPD was 28.5% [95% confidence interval (CI) −5.8%–51.6%] and against NBPP was 10.2% (-15.1-30.6) in all patients ≥ 65 years. However, in subgroup analysis of patients aged 65–74 years, PPV23 was protective against IPD [effectiveness 57.4% (19.4–77.5)] and against NBPP [effectiveness 35.0% (2.3–56.7)]. Furthermore, serotype-specific effectiveness of PPV23 against IPD was 90.6% (27.6–98.8) for PPV23-unique serotypes and 81.3% (38.6–94.3) for PPV23 serotypes excluding serotype 3.</P> <P><B>Conclusions</B></P> <P>This study indicates that PPV23 with broad serotype coverage might be beneficial in preventing IPD and NBPP due to non-PCV13 serotypes in the young-elderly, with potentially increasing effectiveness in the setting of childhood PCV NIP.</P> <P><B>Highlights</B></P> <P> <UL> <LI> National immunization program for PPV23 for the elderly was implemented in Korea. </LI> <LI> PPV23 was effective against IPD and NBPP for young elderly patients aged 65–74. </LI> <LI> Effectiveness of PPV23 against IPD was higher for PPV23 unique serotypes. </LI> <LI> PPV23 was non-protective against IPD caused by PCV13 serotypes. </LI> </UL> </P>

지식관리시스템의 설계 및 구축

배재학,김영권,남철기,신필순 울산대학교 2000 공학연구논문집 Vol.31 No.1

기업의 지적자산을 직접적인 경영 대상으로 보는 새로운 인식이, 최근 지식경영이라는 이름으로 확산되고 있다. 이에 본 논문에서는, 실제 중소기업에서 지식관리와 재사용에 활용할 정보시스템의 설계 및 구축을 시도하였다. 구체적으로는, 지식관리 시스템 개발시 고려해야 할 사항, 개발방향 설정, 그리고 개발 방법론 등을 검토하였다. 이를 토대로 지식관리 시스템의 원형을 구현하였다. There is growing recognition by the name of knowlege management that tintellectual assets are the management objects that should be directly managed. In this paper, we try to design and implement an information system for knowledge management and reuse in small-to-medium-sized enterprises. In doing this, we study initial considerations, development directions ans methodology for knowledge management systems. Based on the study, a prototype of the knowledge management system is constructed and described here.

치수유래 구심성 신경섬유의 삼차신경 감각핵군에서의 연접특성

배용철,이은희,최민기,홍수형,김현정,남순현,김영진 대한소아치과학회 2001 大韓小兒齒科學會誌 Vol.28 No.2

일차연접부위에서 악안면 영역에서 유래하는 유해자극의 전달 및 처리기전을 이해하고자 horseradish pe개xidase를 치수지배 구심성 신경섬유를 표식한 후 연수후각에서 미세구조 및 연절 양상을 분석하여 다음과 같은 결과를 얻었다. 표식종말은 소수의 큰 치밀소포가 관찰되는 종말 (S형) 및 다수의 치밀소포를 함유하는 종말 (LDCV형)등 2종류로 분류할 수 있었다. S형 및 LDCV형 표식종말의 연접양식은 유사하였으며, 다수의 표식종말이 1개 혹은 2개의 neurofile과 연접을 이루어 대단히 단순한 연접양상을 보였다. 표식종말은 가지돌기체 보다는 다수의 가지돌기가시와 연접을 이루는 빈도가 높았다. 표식종말이 세포체 및 이에 인접한 근심부 가지돌기와 연접하는 경우는 드물었으며, 소수의 표식종말에서 p-ending과 연접하는 경우를 보였다. 표식종말의 체적, 표면적, 사립체의 체적, neurofile과 접하는 면적, 활성부위의 면적, 단위표식종말당 연접소포의 수 및 연접소포의 밀도등은 넓은 범위의 계측치를 나타내었으며, 이는 5명 및 LDCV형 표식종말 사이에 유의한 차이가 없었다. 이상의 결과로 미루어보아 연수후각에서 치수유래 구심성 신경섬유 종말의 연접양식은 고유의 특징을 보이며 이는 신경회로의 기능과 밀접한 상관관계를 가지는 것으로 판단되었다. Little is known about processing mechanism of pain sensation of the oral cavity at the 1st synapse of trigeminal sensory nuclei. Serial ultrathin sections of tooth pulp afferent terminals, identified by the transganglionic transport of 1% wheatgerm agglutinin conjugated horseradish peroxidase, were investigated wih electron microscope. Quantitative ultrastructural analysis was performed on digitizing tablet connected to Macintoshi personal computer (software: NIH Image 1.60, NIH, Bethesda, MD). Labeled boutons could be classified into two types by the shapes of containing vesicles : S bouton which contained mainly spherical vesicles (Dia. 45-55 nm) and few large dense cored vesicles (Dia. 80-120nm), and LDCV bouton, which contained spherical vesicles as well as large number of large dense coredd vesicles. Most of the parameters on the ultrastruotural characteristic and synaptic organization of labeled boutons were similar between S and LDCV boutons, except shapes of containing vesicles. Majority of the labeled boutons showed simple synaptic arrangement. The labeled bouton were frequency presynaptic to dendritic spine, and to a lesser extent, dendritic shaft. They rarely synapsed with soma and adjacent proximal dendrite. A small proportion of labeled boutons made synaptic contacts with presynaptic pleomorphic vesicless containing endings and synaptic triad. Morphometric parameters of labeled boutons including volume and surface area, total apposed area, mitochondrial volume, active zone area, vesicle number and density showed wide variation and theme were not significantly different between S and LDCV boutons. The present study revealed characteristic features on ultrastructure and synaptic connection of pulpal afferents which may involved in transmission of oral pain sensation.

Human Rotavirus 위장관염에 대한 임상적 고찰

배현,이홍준,서우철,양은석,문경래,박영봉 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.2

We observed clinical features of 161 patients of acute gastroenteritis who were adimitted to the Department of Pediatrics in the Chosun University Hospital from January 1. 1989 to December 31. 1993. The stool specimen on admission was tested for rotavirus Ag by ELISA(Rotazyme Ⅱ^R)method. The results are as follows : 1) HRV antigen was detected in 97 patients (58.4%) among 161 patients with gastroenteritis. 2) In monthly distribution. 77.7% of cases developed between October and December 3) The majority if patients were under 24month of age with the peak incidnce being between 6-12 month of age. 4) Mean frequency of diarrhea per day were 5.3±2.6 days in HRV antigen rhinorrhea(48.5%), cough(44.7%). Dehydration was noted 87.2% of cases and 93.9% Was isotonic dehydration. 6) The mean duration of hospitalization was 5.3±2.6 days. 7) AST and AIT elevation in HRV group were 91.5%, 42.6% respectively. AST and ALT elevation in Non-HRV group were 73.1%, 26.9% respectively. AST elevation between two group was not correlated statistically. but ALT concentration was significantly increased in HRV group above normal than Non-HRV group (p<0.05%).

혼돈 해석에 기초한 고저항 고장전류의 특징 추출에 관한 연구

배영철 麗水大學校 産業基術硏究所 1999 産業基術硏究所 論文集 Vol.8 No.-

Previous studies on high impedance faults assumed that the erratic behavior of fault current would be random. In this paper, we prove that the nature of the high impedance faults is indeed a deterministic chaos, not a random motion. Algorithms for estimating Lyapunov spectrum and the largest Lyapunov exponent are applied to various fault currents in order to evaluate the orbital instability peculiar to deterministic chaos dynamically, and fractal dimensions of fault currents, which represent geometrical self-similarity are calculated. In addition, qualitative analysis such as phase planes, Poincare maps Obtained from fault currents indicate that the irregular behavior is described by strange attractor.

Green函數를 利用한 熱擴散係數의 解析

裵信徹,金榮殷 단국대학교 1984 論文集 Vol.18 No.-

To determine the thermal diffusivity coefficient Green function was applied. With its derived results experiment was performed to find its coefficient with flash method technique. Copper alloy was used as an experimental material and rolling process was applied to produce different anisotropy. Anisotropic effect, increased with increase of percent reduction in thickness, prevented thermal conductivity and its characters were investigated with measured thermal diffusivity in experiment.

물체의 표면 반사특성을 고려한 이치화 및 물체 복원

배철민,문영식 漢陽大學校 工學技術硏究所 1996 工學技術論文集 Vol.5 No.1

In many vision tasks one of the major obstacles is the specular highlight of smooth objects, which causes a misinterpretation of objects. The paper presents an efficient algorithm for highlight detection and object reconstruction, based on the theory of photometric stereo in which the location of highlight changes as the position of illumination source changes. Two images, referred to as base image and reference image, are sequentially taken with two different positions of the illumination source but from the same viewing direction. The reference image is normalized by the average of the two images. The difference image is thresholded to detect the specular spike of the highlight. Then the specular lobe around the specular spike is detected to reconstruct the object. The proposed algorithm can be applied to metals and dielectrics, regardless of the surface characteristics. This method can also be applied to the case when the background is brighter than the object.

적응 뉴로 퍼지 시스템(ANFIS)을 이용한 고저항 고장 검출에 관한 연구

배영철 麗水大學校 産業基術硏究所 1999 産業基術硏究所 論文集 Vol.8 No.-

The analysis of distribution line faults is essential to the proper protections of the power system. A high impedance fault does not make enough current to cause the appropriate action of conventional protective devices. From a Staged high impedance fault test, which was carried in Korean electric power systems, it was found that a arcing phenomenon occurred during the high level portion of conductor voltage in each cycle. In this paper, we propose a new method for detection of high impedance faults, which uses the arcing fault current difference during high voltage and low voltage and low voltage portion of conductor voltage waveform. To extract this difference, we divided one cycle fault current into equal spanned four data windows according to the magnitude of voltage waveform and applied fast fourier transform(FFT) to each data window. The frequency spectrum of current waveform in each portion are used as the inputs of ANFIS(Adaptive Neuro-Fuzzy Inference System) and is trained to detect high impedance faults. The proposed method shows improved accuracy when applied to staged fault data.

Bimodal SiC 입자강화 AZ91D 마그네슘 복합재료의 유동성 및 기계적 특성 평가

裵徹洪,金世光,金永稷 대한금속재료학회 2002 대한금속·재료학회지 Vol.40 No.7

The objective of this study was to investigate the influence of bimodal reinforcement on the fluidity and mechanical properties of SiC particle reinforced AZ91D Mg composites. The fraction of bimodal SiC particles was fixed at 20 wt% and the mixing ratios of 5 ㎛ to 50 ㎛ SiC particles were 0:1, 1:2, 1:1, 2:1 and 1:0. The results clearly showed that the fluidity and mechanical properties of the composites with bimodal reinforcement were dependent on mixing ratio. In terms of molten state fabrication and tailored mechanical properties, it was obtained that the proper mixing ratio seems to be 1:2.

남자대학생들의 피부관리실태와 관련요인 조사연구

배향선,남철현,김성우,최연희,강영숙,김선혜,구재희 慶山大學校 保健福祉硏究所 2003 保健福祉硏究 Vol.8 No.-

This study was conducted to examine aspects of skin care of male students at colleges and universities of male students at colleges and universities and its related factors in order to provide informations on skin care for men. The subjects of this study was 600 men who were students at colleges and universities in Daegu City and Kyungbuk Province. Data were collected from May 1, 2002 to June 30, 2002. The results of this study can be summarized as follows. 1. According to the respondents' socio-demographic characteristics, 55.9% of them was 20 to 24 years old and 29.6% was more than 25 years old. 84.9% of them was university students, while 15.1% was college students. 25.3% belonged to the lower class, while 22.4% belonged to the upper class. 52.7% did not have a girl friend, while 47.3% has a girl friend. 41.8% lived in big cities and 48.1% lived in small and medium cities. 2. 63.0% of the respondents replied that they were in good health, while 8.8% of them were in bad health. 41.9% of them was concerned about face and body skin care, while 14.1% was not concerned about it. Among most serious skin problems, the proportion of acne was highest (44.5%). 3. Among the persons who advised the respondents when they selected cosmetics, the proportion of selecting cosmetics as their own will was highest (44.7%). 25.3% of them selected it by recommendation of female family members and 18.3% selected it by recommendation of the girl friend. In the case of selecting it as their own will, the older they were, the higher the proportion was. In the case of having the girl friend, the proportion of selecting cosmetics by recommendation of the girl friend was higher than that of selecting it by recommendation of female family members. 4. 90.4% of the respondents replied that they never visited skin care rooms, while only 9.6% of them replied that they ever visited them. In the case of visiting skin care rooms, the proportion of the upper class was higher than that of the lower class. 5. According to the frequency of visiting skin care rooms, the proportion of once a week was highest (51.0%). 29.4% of them visited them once per 6 months and 19.6% visited them once a month. 6. In the case of the reasons they did not visit the skin care rooms, the proportion of 'no interest' was highest (36.6%). 23.2% did not visit them because they thought the fee for skin care was expensive and 19.5% did not visit them because they thought the skin care room were only for women. 7. In the variables of giving advice concerning skin care, the proportion of 'their own' was highest (29.8%). The proportion of female family members was 28.2% and the proportion of the girl friend was 27.7%. In the case of the age related to having the girl friend's advice, the proportion of 'over 25 years old' was 31.9% and the proportion of '20 years old to 24 years old' was 26.4%. The proportion of 'less than 19 years old' was 23.5%. The older they were, the more they had the girl friend's advice. 8. According to the sources of getting information on skin care, the proportion of mass media (TV, Radio etc.) was highest (36.7%). 26.0% of them obtained them through the girl friend and 13.9% obtained them through female family members. Only 8.4% got them through magazines. 9. The factors influencing the experience of visiting skin care rooms were experience of side effect of foundation cosmetics, concern about skin care, expiration date of cosmetics or checking of directions of using cosmetics, donsideration of skin character when using soap, and regular exercise for health. From above results, it can be concluded that skin care and beauty specialists working in beauty academies or the department of cosmotology at colleges or universities must make efforts to change the negative recognition of male skin care through deep and comprehensive research. It is also necessary to develop systematic education course and institutionalize the qualification management system.