뚜렛 장애 남아에서 틱 억제시 대뇌 피질 정보 전달

홍현주,차민호,최강,황선희,소유경,주민경,남궁기,정재승 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.1

Objectives : Tourette's Disorder (TD) is a chronic neuropsychiathc disorder characterized by multiple motor and vocal tics with onset in childhood. The aim of this study was to ascertain the increased cortical information transmission in frontal area during tic suppression in drug naive boys with TD using new nonlinear analysis of EEGs, be called Transfer Entropy (TE) which can detect the directed exchange of information between two systems. Methods : Subjects were 11 drug naive boys with DSM-IV diagnosis of TD and 10 control boys. Clinical assessments were performed, and EEGs were recorded from 19 scalp loci of the international 10-20 systems. TE was estimated by EEG time-series data after noise reduction. TE difference between TD and control during resting state and between tic suppression and resting state in TD were investigated. Rcsults : Elevated TE was found in extensive channels, including frontal, central and temporal channels (F7, Fz, F8,Cz, C3, P3, T3, and T4) in resting state ofTourette's disorder compared to normal controls. Duhng tic suppression elevated TE was found in more extensive and asymmetrical channels especially prefrontal area (Fpl, Fp2, F3, Fz, F7, F8, Cz, C4, C5, T3, and T4). Conclusion : These findings suggest that pathogenesis of Tourette's disorder involve impaired cortical neuronal modulation in subcortical neural circuits. EEG analysis of TE may be a useful tool to investigation of cortical mechanism of psychiatric illness.

주의력결핍 과잉행동 장애 아동에서 Methylphenidate 치료반응 예측인자로서의 기저신경절 Dopamine Transporter Density-[123I]IPT SPECT 연구

홍현주,유영훈,낭궁기,김찬형,천근아,이홍식 대한정신약물학회 2003 대한정신약물학회지 Vol.14 No.4

Objective : Dopamine transporter is a key regulator of dopamine neurotransmission and is also the primary target of methylphenidate. This study tested the hypothesis that dopamine transporter(DAT) density in basal ganglia is a predictor of favorable methylphenidate(MP) treatment response. Method : 15 drug-naive boys with ADHD were included in this study. (8 children :treatment responder, 7 children : treatment non responder) They were assessed with psychiatric interview, KEDI-WISC, K-ARS, ADS and CBCL. After then, they were performed [123I]IPT SPECT. They were evaluated about treatment response after treatment with methylphenidate during 8 weeks. SPECT data reconstructed for the assessment of specific/nonspecific DAT binding ratio of the basal ganglia were compared between treatment responders and nonresponders. Result : There were not significant differences in dopamine transporter density in basal ganglia between the two groups. Conclusion :This finding suggests that dopamine transporter density does not mediate the MP treatment response in a direct way. 목 적:methylphenidate(MP)는 ADHD에서 효과적인 치료제이며 70%의 환자가 MP에 좋은 치료반응을 보인다. 본 연구는 ADHD 아동에서 약물의 주 작용부위이자 도파민 체계에서 중요한 조절자인 기저신경절 Dopamine Transporter(DAT) 밀도가 MP 치료반응을 예측할 수 있는지에 대해 알아보고자 한다. 방 법:연세대학교 의과대학 정신과 영동 세브란스 병원 소아 청소년 정신과를 내원한 6~12세 ADHD 남아 15명을 대상으로 한다. 이중 MP에 대한 반응군은 8명이며 비반응군은 7명이었다. 이들에게 약물치료 전 임상평가와 함께 [123I]IPT SPECT를 시행하였다. MP 투홍현주 등 385 여 8주 후 다시 치료반응을 평가하며 MP 반응군과 비반응군 사이의 기저핵 DAT 밀도의 차이를 알아보았다. 또한 DAT 밀도에 영향을 미치는 다른 인자와 치료반응을 예측하는 다른 인자들도 알아보았다. 결 과:MP반응군과 비반응군 사이에는 기저신경절 DAT 농도차이를 보이지 않았다.

兒童福祉機關의 結緣事業의 實態와 問題點

홍현주 이화여자대학교 사회사업학과 1985 사회사업 Vol.- No.10

흰쥐에서 안와하신경을 절단한후 삼차신경절에서의 Neuropeptide Y 면역반응세포의 분포에 관한 연구

홍현주,백기석,김명국 대한구강해부학회 1996 대한구강해부학회지 Vol.20 No.2

졸-겔법으로 제작된 저온 TiO₂ 박막의 촉매농도에 따른 광분해 특성 분석

홍현주,허민찬,한성홍,김의정,이충우,주종현,Hong, Hyun-Joo,Heo, Min-Chan,Hahn, Sung-Hong,Kim, Eui-Jung,Lee, Chung-Woo,Joo, Jong-Hyun 한국광학회 2006 한국광학회지 Vol.17 No.3

졸-겔법으로 촉매농도에 따라 저온 $TiO_2$ 졸을 제조한 후, 침지코팅법을 이용하여 $TiO_2$ 박막을 제작하였다. 제작된 저온 $TiO_2$ 박막의 광학적, 구조적, 광활성 특성을 조사하였다. 0.10 mol, 0.25 mol, 0.50 mol과 0.75 mol의 촉매농도로 제작된 저온 $TiO_2$ 박막은 가시광 영역에서 높은 투과율 특성을 나타내었다. XRD 스펙트럼 결과에 의하면 촉매농도가 증가함에 따라 아나타제 결정구조에서 루타일 결정구조로의 상전이가 촉진되고 결정크기는 촉매농도가 증가함에 따라 아나타제 결정크기가 감소하였다. SEM 결과로부터 $TiO_2$ 박막의 표면입자크기가 0.25 mol의 측매농도에서 가장 작았다. 아나타제 결정구조를 가지는 0.10 mol, 0.25 mol과 0.50 mol의 $TiO_2$ 박막 존재 하에서 메틸렌블루가 완전히 광분해 되는 것을 확인하였다. ILow-temperature $TiO_2$ sol was synthesized with various catalyst contents by using a sol-gel method. $TiO_2$ thin films were produced by a dip-coating method and their optical, structural and photocatalytic properties were examined. Transmittance of $TiO_2$ thin films with 0.10 mol, 0.25 mol, 0.50 mol and 0.75 mol catalyst content showed high transmittance in the visible range. XRD results showed the anatase-to-rutile phase transition was accelerated with increasing catalyst content and the crystallinity size of the $TiO_2$ thin films increased with increasing catalyst content. SEM results indicated that the particle size of the $TiO_2$ thin films was the smallest with catalyst content of 0.25 mol. Photocatalytic results showed that methylene blue was completely decomposed in the presence of anatase film prepared with 0.10 mol, 0.25 mol and 0.50 mol catalyst content.

비소세포폐암에서 Tissue array를 이용한 Survivin, HSP, Bcl-2등의 아포프토시스 억제 단백질 발현에 관한 면역조직화학적 분석

홍현주,유철규,이춘택,한성구,심영수,김영환,홍석균,이계영,김우호 대한결핵 및 호흡기학회 2001 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.93 No.0

사교육: 얻는 것과 잃는 것

홍현주 대한소아청소년정신의학회 2011 대한소아청소년정신의학회 학술대회논문집 Vol.2011 No.4

Differences in the Clinical Characteristics of Remission and Non-Remission Groups with Once-Daily OROS-Methylphenidate Treatment of Attention-Deficit/Hyperactivity Disorder

홍현주,홍나래,윤형준,최태규,이상혁,육기환 대한정신약물학회 2008 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.6 No.1

Objective:Attention-deficit/hyperactivity disorder (ADHD) is a common, life-long condition associated with major functional impairment, and remission is the primary goal of treatment. The purpose of this study was to identify differences in the clinical characteristics of remission and non-remission groups composed of Korean children and adolescents with ADHD. Methods:Fifty-nine children and adolescents, 6-15 years old, diagnosed with ADHD according to the Diagnostic and Statistical Manual-IV (DSM-IV) criteria were included in the study. The study design was an 8-week, open-label trial of OROSmethylphenidate (OROS-MPH) monotherapy. The subjects were assessed using the Korean ADHD Rating Scale (K-ARS), Clinical Global Impression of Severity (CGI-S), Clinical Global Impression of Improvement (CGI-I), and Barkley Side Effect Rating Scale at baseline and 1, 2, 4, and 8 weeks after starting OROS-MPH treatment. Remission was defined as both a score of ≤2 on the CGI-S and a score of ≤18 on the K-ARS at the eighth week of the trial, when we examined the differences in the clinical characteristics between the remission and non-remission groups. Results:The remission rate at the eighth week was 47.5% (n=28). No differences were observed in the age, sex, weight, severity of symptoms reported by the parent, comorbidities at baseline, or doses of OROS-MPH at each evaluation point between the remission and non-remission groups. However, the non-remission group had higher scores in the CGI-S at baseline than the remission group. A difference in symptom improvement between the two groups began at the first week of the trial, and the remission group was less likely to have side effects at the eighth week. Conclusion:The results suggest that individual biological diversity may mediate different treatment responses to OROS-MPH. Interventions other than medication are needed to achieve remission and to restore proper functioning of patients with ADHD in the nonremission group.

여성 강박장애의 임상적 특성과 치료 전략

홍현주,김찬형 대한신경정신의학회 2006 신경정신의학 Vol.45 No.2

This article reviews clinical characteristics, neurobiological aspects and treatment strategies in female patient with obsessivecompulsive disorder (OCD) compared to male. Female with OCD had a later age of onset and different patterns of OCD symptomatology and comorbidity. Female with OCD showed more favorable course and also reported more frequently stressful event in preceding OCD onset. The onset or worsening of OCD was related to female reproductive cycle events, especially at menarche and postpartum. There is a paucity of investigation regarding gender difference in treatment response in OCD. It has been suggested that gender may contribute to the clinical and biological heterogeneity of OCD and also sexually dimorphic pattern of genetic susceptibility to OCD may be present. (J Korean Neuropsychiatr Assoc 2006;45(2):93-99) 강박장애는 강박 사고와 강박행동을 특징으로 하며 예 전에는 매우 드문 질환으로 여겨져 왔으나 최근에는 평생 유병율이 3.3%까지 보고되는 비교적 흔한 질환으로 알려 져 있다.1) 최근 강박장애의 신경생물학적 기전 및 증상의 특징들에 대해서 많은 연구 결과들2-4)이 발표되면서 강박 장애는 동질적인(homogenous) 질환이라기 보다는 비동 질적인(heterogenous) 질환군이라는 견해가 분명해지고 있다.5,6) 성별에 따른 강박장애의 차이에 대한 이해를 통해 강박 장애를 보다 깊게 이해할 수 있을 것이다. 여성과 남성은 신체의 크기 및 모양뿐 아니라 뇌의 크기나 발달과정에 이 르기까지 다양한 차이가 존재한다. 이러한 성별에 따른 신 체생리학적인 차이로 인해 성별에 따라 서로 다른 특이적 인 질환이 발현될 수도 있으며, 각각의 임상 양상, 치료반 응, 예후 또한 다를 수 있다.7) 이 주제는 매우 흥미로운 부 분이긴 하나, 강박장애의 경우 최근에서야 남녀 성별에 따 른 질환의 특성을 규명하려는 시도들이 이루어지고 있다. 이에 본 논문에서는 성에 따른 강박장애의 임상양상 및 여러 생물학적인 특성, 특히 여성 강박장애의 임상적인 특 성과 치료적인 측면을 중심으로 고찰하고자 한다.

정신과 약물의 대사 : 성과 관련된 주제

홍현주,김찬형 대한정신약물학회 2003 대한정신약물학회지 Vol.14 No.4