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급성기 중풍환자에서 비만 및 혈액지표의 기허 및 화열 변증의 차이에 대한 고찰
차민호,김소연,임지혜,강병갑,고미미,김노수,이정섭,방옥선,Cha, Min-Ho,Kim, So-Yeon,Lim, Ji-Hye,Kang, Byung-Kab,Koo, Mi-Mi,Kim, No-Soo,Lee, Jeong-Sub,Bang, Ok-Sun 대한한방내과학회 2009 大韓韓方內科學會誌 Vol.30 No.4
Object : In the present study, we investigated the obesity and blood parameters between Qi-deficiency and Fire/Heat pattern identification/syndrome differentiation (PI/SD) in acute stroke patients. Materials and Methods : A total of 391 stroke patients within 7 days after onset were consecutively recruited from 12 hospitals across South Korea from Nov. 1st, 2006 to Jun. 31st, 2009. They were diagnosed as Fire/Heat or Qi-deficiency among five PI/SD subtypes by two independent stroke experts. We investigated the differences of obesity and blood characteristics between Fire/Heat and Qi-deficiency by statistical analyses. Results : In male subjects, obesity was significantly associated with Fire/Heat PI/SD. The averaged mean BMI ($24.13kg/m^2$) and waist circumference(89.34cm) of the Fire/Heat group were higher than those of the Qi-deficiency group ($22.60kg/m^2$ and 83.43 cm, respectively). The number of obese patients was larger in the Fire/Heat group than in the Qi-deficiency group (p = 0.001). Hyperlipidemia was also related with Fire/Heat. However, obesity was not associated with PI/SD in female subjects where the number of hyperlipidemic patients was higher in the Qi-deficiency group. Among blood parameters, the levels of triglycerides and fasting blood sugar were higher in the Fire/Heat group compared with the Qi-deficiency group in male subjects. However, total cholesterol of the Qi-deficiency group was higher than in the Fire/Heat group among female subjects. Conclusion : This study shows that obesity and hyperlipidemia are significantly difference between Qi-deficiency and Fire/Heat. We suggests that PI/SD may be associated with clinical characteristics and large population study between PI/SD and clinical characteristics including blood parameters are needed.
Association of UCP1 Genetic Polymorphisms with Blood Pressure among Korean Female Subjects
차민호,강병갑,서동철,김길수,양영,윤유식 대한의학회 2008 Journal of Korean medical science Vol.23 No.5
Recent studies have provided some clues with regard to the relationship existing between uncoupling protein 1 (UCP1) and blood pressure in animal experiments. In an attempt to determine the genetic polymorphisms that are associated with blood pressure in humans, we have analyzed genetic polymorphisms in UCP1 gene. In this study, we assessed the association between UCP1 genotypes and systolic blood pressure (SBP) and diastolic blood pressure (DBP), in a population comprised of 832 Korean female subjects, using a general linear model, which was adjusted for age and body mass index (BMI). Among 4 genetic polymorphisms and the haplotypes constructed from them, haplotype3 of UCP1, UCP1-ht3[GAGA], evidenced significant associations with SBP (p=0.005) and DBP (p=0.013). However, this haplotype was not significantly associated with obesity phenotypes, including BMI or fat mass (p>0.05), thereby suggesting that its association with blood pressure was independent of obesity phenotypes.
자궁 내 피임기구와 연관되어 발생한 원발성 방광 방선균증
차민호,강지훈,서경식,원용연,조대성,주희재,김세중 대한비뇨의학회 2005 Investigative and Clinical Urology Vol.46 No.1
Actinomycosis is a chronic suppurative infectious disease usually caused by the anaerobic bacterium Actinomyces israelii. Pelvic actinomycosis is rare, and usually associated with the use of intrauterine contraceptive devices. Primary vesical actinomycosis is extremely rare. Herein, a case of a 42-year-old woman, who presented with bladder irritative symptoms and had a 13 year history of intrauterine device insertion, is reported. With the presumptive diagnosis of bladder tumor or abscess, partial cystectomy was performed. Pathological examination revealed a primary vesical actinomycosis.
고지방식이를 섭취한 mouse의 hypothalamus에서의 유전자군의 발현양상 변화
차민호,김경선,강봉주,심웅섭,윤유식,Cha, Min-Ho,Kim, Kyung-Seon,Kang, Bong-Joo,Sim, Woong-Seop,Yoon, Yoo-Sik 한국한의학연구원 2003 한국한의학연구원논문집 Vol.9 No.1
Obesity is caused by imbalance of energy intake and expense. If energy intake is more than its expenditure, body does fat accumulation and affects body weight. It can be fetal disease although obesity is not disease in itself. Central regulatary system is affected by many neurotransmitters regulating .food intake in brain. Hypothalamus was known as one of food intake regulation in CNS. In order to investigate gene expression difference in hypothalamus by different nutrient, we used C57/BL6 control mouse and db-/db- mouse. They divided each of two group with mouse, and fed control diet and high-fat diet for 4 weeks. Each of control and high-fat diet contained 11.7% and 59.7% fat, respectively. Then we performed microarray assay with them. We compared among changed genes in hypothalamus region. In the results, we observed that increased genes were more than decreased genes. Although hypothalamus size of db-/db- mouse is smaller than that of C57/BL6, more genes were affected in db-/db- mouse. In this study, many genes are affected by nutrient in hypothalamus region.