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홍영훈 ( Young Hoon Hong ),이은영 ( Eun Young Lee ),이충기 ( Choong Ki Lee ) 대한류마티스학회 2001 대한류마티스학회지 Vol.8 No.2
Objective: To investigate the frequency of autonomic nervous dysfunction and assess the factors associated with autonomic nervous dysfunction in patients with rheumatoid arthritis (RA). Methods: Three battery of cardiovascular autonomic nervous function tests (CAN test); heart rate response to Valsalva maneuver, deep breathing and standing up, were performed in 68 patients who met the 1987 American Rheumatism Association revised criteria for RA and 58 healthy controls. Autonomic nervous dysfunction was defined as 2 of 3 CAN tests were abnormal. Clinical and radiographic variables such as age, sex, disease duration, erythrocyte sedimentation rate (ESR) and bone destruction, were analyzed in patients with or without autonomic nervous dysfunction. Results: In patients with RA, the frequency of autonomic nervous dysfunction was higher than healthy controls (50.8% in RA vs 15.5% in healthy controls, p<0.05). Age, sex, disease duration, ESR and bone destruction were not associated with autonomic nervous dysfunction in patients with RA. Conclusions: This results suggest that autonomic nervous dysfunction may be a significant feature in patients with RA.
오정현,정재윤,홍영훈,박상규,김삼용,Oh, Jung-Hyun,Jung, Jae-Yoon,Hong, Young-Hoon,Park, Sang-Gue,Kim, S. 한국통계학회 2010 응용통계연구 Vol.23 No.5
대학 입학전형은 각 대학의 교육목적에 맞고 그 교육목표를 이룰 수 있는 적합한 인재상에 부합하는 학생들을 선발하는 것에 있다. 그리고 최근 입학사정관제의 도입으로 학생의 잠재력을 발굴하여 선발하는 전형을 정착시키려는 노력을 하고 있다. 이 점에서 과연 다양한 평가방식이 학생들의 질적 특성까지 반영하여 그들의 잠재력이 잘 평가되는지, 또 전형요소에 따라 계열, 모집단위 등의 특성에 맞는 학생들이 제대로 평가되고 있는지에 대하여 통계적 타당성을 검증할 필요성이 있다. 대학학업성취도를 바탕으로 하여 여러 요인들의 영향력을 통계적 방법으로 분석한다. The goal of the entrance examination models is to promote promising and potential students who are suitable for post-secondary education purposes. Recently, a promotion system based on the admissions supervisors has been the major role for the promotion of students. Various statistical models and methods should be applied for the better and reasonable promotion of promising Korean and international students. In this study, we applied the proper methods in statistical methodologies and show the meaningful results on the performance evaluation of the several entrance examination models for a university in Seoul, Korea.
아급성 골수종과 급성 재활성 만성 B형 간염에서 발생한 I형 저온글로불린혈증 1예
김현제 ( Hyun Je Kim ),홍영훈 ( Young Hoon Hong ),이한솔 ( Han Sol Lee ),김민정 ( Min Jung Kim ) 대한류마티스학회 2011 대한류마티스학회지 Vol.18 No.4
저자들은 급성 재활성 만성 B형 간염과 아급성 골수종에 병발한 저온글로불린혈증을 경험하여 이를 보고하는 바이다. A 58-year-old male patient with chronic hepatitis B infection and hypertension was referred for the evaluation of a skin rash. The skin biopsy showed multiple hyaline thrombi in small blood vessels, red blood cell extravasation, and epidermal atrophy. The CBC, chemistry, UA, and radiological studies were unremarkable except for elevated AST/ALT on liver function tests. The hepatitis B virus markers were compatible with the diagnosis of acute replicative phase chronic hepatitis B; HBeAg 86,646 cpm (count per minute), anti-HBeAb (-), HBV PCR (Quantitative) >1.10×108 IU/mL, and >640,200,000 copies/mL. Rouleaux formation was seen on the peripheral blood smears. Serum PEP/IEP demonstrated an M-spike (27.53%) in the gamma region and abnormal bowed arcsin IgG, kappa light chain with Cryoglobulin (+), ANCA (+), FANA (-), and rheumatoid factor (-) on the serological test. The percent of plasma cells on the bone marrow biopsy was approximately 15%. Type I cryoglobulinemia is a rare disease that can be associated with hematologic disorders, but smoldering myeloma or/and hepatitis B has not been reported in association with Type I cryoglobulinemia. Here, we report a case of Type I cryoglobulinemia that showed multiple skin ulcers due to vascular occlusion related to the monoclonal cryoglobulin with smoldering myeloma and acutely reactivated chronic hepatitis B.
김성동 ( Seong Dong Kim ),류동환 ( Dong Hwan Ryu ),이정훈 ( Jeong Hoon Lee ),권창모 ( Chang Mo Kwon ),홍영훈 ( Young Hoon Hong ),이충기 ( Choong Ki Lee ) 대한류마티스학회 2002 대한류마티스학회지 Vol.9 No.3
Objective: To investigate the prevalence of autonomic dysfunction and to evaluate the relationship between autonomic dysfunction and clinical parameters in patients with systemic lupus erythematosus (SLE). Methods: Fifty-eight patients with SLE who met the American College of Rheumatology criteria for SLE and forty-five healthy controls were selected at our hospital. Cardiovascular autonomic nervous function (CAN) test, including heart rate variation in deep breathing, Valsalva maneuver and orthostatic change and blood pressure response to standing, handgrip, was done in patient group and controls. Erythrocyte sedimentation rate (ESR), antinuclear antibody, anti-dsDNA antibody, complete blood count, complement and disease duration of patients were retrospectively reviewed and disease activity was assessed by Mexican SLE disease activity index (MEX-SLEDAI). Results: The frequency of parasympathetic damage was 51.7% in patients with SLE and 15.6% in controls. There was significant difference between 2 groups in heart rate variation in deep breathing. No significant correlations were observed between autonomic dysfunction and ESR, antinuclear antibody, anti-dsDNA antibody, thrombocytopenia, complement, disease duration of patients, but there was slightly positive correlation between number of abnormal parasympathetic function test and MEX-SLEDAI (r=0.32, p<0.05). Conclusion: The prevalence of autonomic dysfunction was high in SLE patients and there was high frequency in patients with high disease activity. Prospective studies are needed to determine the clinical significance of autonomic dysfunction in the morbidity and mortality of SLE.
정용욱 ( Yong Wook Jung ),오명진 ( Myung Jin Oh ),윤대영 ( Dae Young Yun ),홍영훈 ( Young Hoon Hong ),이충기 ( Choong Ki Lee ) 영남대학교 기초/임상의학연구소 2007 Yeungnam University Journal of Medicine Vol.24 No.2S
Pigmented villonodular synovitis (PVNS) is a benign proliferative disorder of uncertain etiology that affect synovial lined joints. This disesse is an uncommon that usually afflicts the knee joint. Two types of villi are present in this disease, localized form is called ``nodular PVNS`` and non localized form is ``diffuse PVNS``. On microscopy, PVNS is characterized by the presence of hemosiderin-laden, multinucleated, giant cells. But plain radiograph in PVNS shows normal finding exclude effusion, so cannot help diagnosis of PVNS. We experienced a case of a 59-years-old male patient who complained multiple arthralgia, swelling, limit of motion of Lt knee. We gave diagonsis of gout with PVNS by MRI and arthroscopic procedure. So we report this case with review of literature.
전신성 홍반성 루푸스에서 고용량 경정맥 당질코르티코이드로 치료된 단백질 소실성 장질환 1예
이규형 ( Kyu Hyung Lee ),권창모 ( Chang Mo Kwon ),김현도 ( Hyun Do Kim ),윤대영 ( Dae Young Yun ),이재웅 ( Jae Yoong Lee ),홍영훈 ( Yeong Hoon Hong ),이충기 ( Choong Ki Lee ) 영남대학교 기초/임상의학연구소 2005 Yeungnam University Journal of Medicine Vol.22 No.2
Generalized edema and hypoalbuminemia are relatively common presenting manifestations in many clinical situations. The differential diagnosis of hypoalbuminemia include: Kwashiorkor, synthetic dysfunction of the liver, and excessive protein loss as in nephrotic syndrome. In systemic lupus erythematosus (SLE), hypoalbuminemia and generalized edema are most commonly due to protein loss associated with lupus nephritis; gastrointestinal involvement is uncommon, and therefore protein loss through the gastrointestinal tract is quite rare. We report a case of a protein losing enteropathy (PLE) associated with SLE. The patient was referred to our hospital for generalized edema, arthralgia and facial rash. After clinical evaluation, the patient met the criteria for the SLE diagnosis; hypoalbuminemia with general edema was consistent with a protein losing enteropathy. After two weeks of therapy with parenteral high dose glucocorticoid, the patients was improved in laboratory findings as well as clinical symptoms.
정다은 ( Da Eun Jeong ),김민경 ( Min Kyoung Kim ),고성애 ( Sung Ae Koh ),이경희 ( Kyoung Hee Lee ),최준혁 ( Joon Hyuk Choi ),홍영훈 ( Young Hoon Hong ),조재호 ( Jae Ho Cho ),구은주 ( Eun Ju Goo ),현명수 ( Myung Soo Hyun ) 영남대학교 의과대학 2015 Yeungnam University Journal of Medicine Vol.32 No.1
Sarcoidosis is a systemic disease of unknown cause involving multiple organs and is characterized by noncaseating granuloma. Immune thrombocytopenia (ITP) is an autoimmune disease characterized by increased peripheral platelet destruction due to the presence of an antibody to the platelet and abnormal platelet production. There is no known pathogenesis that occurs concurrently with ITP and sarcoidosis. However, considering together of 2 known pathogenesis, abnormal immune response triggers either ITP or sarcoidosis. The disease that develops first stimulates secondary disease. After development of secondary disease, they stimulate each other. A few cases of ITP associated with sarcoidosis are well documented in English; however, the disease has rarely been reported in Korea. Here, we report on a case of ITP with sarcoidosis in a 29-year-old man. He suffered from easy bruising. The chest X-ray and the contrast-enhanced computed tomography scan showed bihilar lymphadenopathy and reticulonodular infiltrates. Bone marrow study and fluoroscopy-guided percutaneous needle biopsy were performed and the patient was diagnosed with sarcoidosis and ITP. He was put on 400 mg/kg of intravenous immunoglobulin for 5 days and administered oral steroids and further follow-up will be carried out. He has shown a good response without significant bleeding event. However, administration of more oral steroid and additional follow-up is required than for single disease, whether sarcoidosis or ITP.
Plasmodium vivax에 의한 지연형 말라리아 8예
송영두,김봉준,홍영훈,이충기,문진영,이재춘,이은영 영남대학교 의과대학 1997 Yeungnam University Journal of Medicine Vol.14 No.2
저자들은 1994년에서 1995년 사이에 경기도 북부 휴전선 부근에서 말라리아가 유행 할 때 그 지역에서 근무하고 제대한 후에 외국 여행이나 수혈의 경력이 없는 젊은 남자에서 오한과 동반된 발작적 발열 등의 임상 증상과 말초 혈액 도말 검사에 의해 삼일열 말라리아로 확진되어 치료한 8예를 경험하였다. 삼일열 말라리아의 재정착이 확인되었으므로 오한을 동반한 발열 환자의 원인으로서 말라리아가 반드시 고려 대상이 되어야 하며 말라리아 재유행에 대한 조사와 함께 감시 대책이 필요하리라 생각된다. South Korea has been free from endemic malaria by P. vivax since the mid-1980s, but malaria infections, including military outbreak in 1995, have been increasing steadily in the soldiers serving near the western part of Demilitarized Zone(DMZ) since its frist resurgence in 1993. We experinced 8 cases of delayed onset P. vivax malaria in young men who had never been abroad and had no history of blood transfusion or parenteral use of drug. All the patients had served near the western part of DMZ during their military life. They were admitted to Yeungnam University hospital due to cyclic fever with chills and the clinical symptoms were developed 2 months to 11months after discharge from military service, Peripheral blood smears showed typical ring forms and trophozoites of P. vivax in red blood cell. Patients were treated with hydroxychloroquine and primaquin showing rapid clinical and hematologic responses in all cases, but 2 cases were relapsed later. We presumed that theses cases were delayed onset of P. vivax infection resulted from the recent outbreak in the western part of DMZ, in 1995. Therefore, we reported theses cases to emphasize the need of active surveillance and prevention.