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분노표현 양식과 스트레스 노출이 심박변이도에 미치는 영향
김현도,임명호,김현우,이석범,이경규,김현주,노상철,백기청,Kim, Hyun-Do,Lim, Myung-Ho,Kim, Hyun-Woo,Lee, Seok-Bum,Lee, Kyung-Kyu,Kim, Hyun-Joo,Rho, Sang-Cheol,Paik, Ki-Chung 대한불안의학회 2009 대한불안의학회지 Vol.5 No.1
Objective : Using patterns of change in heart rate variability (HRV), we investigated the effects of stress exposure and type of anger expression on cardiovascular diseases. Methods : Eighty-nine medical students were evaluated by STAXI-K, BDI, BAI, and measured HRV. According to the scores of anger expression questions in STAXI-K, objects are comparted to three groups. Each group is compared with others on the levels of depression, anxiety and HRV. Additionally objects are divided into two groups of functional anger expression group and dysfunctional anger expression group, and each group also divided into two groups, depending on the exposure of stressful situation or not. Members who took part in the stress exposure groups, they've got a serial arithmetic process for five minutes. We surveyed patterns of HRV in 4 each groups and estimated interactions between existence of stressful situation or type of anger expression and HRV. Results : Irrespective of stress manipulation, the dysfunctional anger expression group showed a marked increase in the LF/HF ratio in comparison to the functional anger expression group. Also, under conditions of stress manipulation, the stress exposure group exhibited a relatively increased level of TP. It can't be discriminated any correlations between stress manipulation and type of anger expression. Conclusion : Both of them, exposure to the stressful situation and type of anger expression, have influence on cardiovascular diseases. By controlling anger and way of express that, it is possible to diminish the incidence of cardiovascular diseases.
웅담이 CCl<sub>4</sub>로 유발된 mouse의 간 손상에 미치는 영향
김현도,이규재,박승규,권기록,Kim, Hyun-Do,Lee, Kyu-Jae,Park, Seong-Kyu,Kwon, Ki-Rok 대한약침학회 2005 Journal of pharmacopuncture Vol.8 No.3
Objectives : This study was aimed at investigating liver protection mechanism of bear bile juice (Fel Ursi)by inducing liver toxicity through $CCl_4$ in mice and evaluated histological and serological findings. Methods : Experiment groups was categorized into untreated normal group, $CCl_4$ treated control group, and orally administered bear bile juice experiment group. At the termination of experiment, gross examination of the liver as well as histological findings, and Total protein, Albumin, Total bilirubin, Direct bilirubin SGOT, SGPT, and ALP contents in the serum were evaluated. Results : 1. For gross examination and histological findings, $CCI_4$ treated control group showed destroyed lobular structure, increased fibrosis, as well as hepatic cirrhosis. For the group treated with bear bile juice, the lobular structure suffered less damage, and showed lower level of fibrosis and liver cirrhosis compared to the control group. 2. For serum analysis, Total protein and Albumin were significantly increased in the bear bile juice experiment group than the control group. Total bilirubin and Direct bilirubin didn't show significant differences between the two groups. SOOT, SGPT, and ALP were significantly decreased in the normal and bear bile juice experiment groups compared to the control group. Conclusion : Taken together, bear bile juice can be effectively used for recovering the liver functions and further researches must be conducted to verify the efficacies of bear bile juice.
한국한의학 관련학회지의 SCI등재를 위한 준비과정에 관한 고찰
김현도,강태식,권기록,Kim, Hyun-Do,Kang, Tae-Sik,Kwon, Ki-Rok 대한약침학회 2003 Journal of pharmacopuncture Vol.6 No.3
The purpose of this study is to investigate and analyze the selection process of the Science Citation Index(SCI). SCI has been the benchmarking medium of scientific journals for over 40 years by reviewing thousands of journals published each year. The discipline of Traditional Oriental Medicine has been gaining global interest in recent years, yet the number of related journals indexed by SCI has been minimal. Korean Medicine has been producing number of quality journals for decades, but lack of journals in the English language and other problems has hindered consideration for registering with SCI. This paper will focus on the journal selection process at ISI and recommend the criteria needed for a journal to be considered for SCI selection.
단신 : 반응표면분석법을 통한 Enterobacteriaceae sp. PAMC 25617의 protease 생산배지 최적화
김현도 ( Hyun Do Kim ),윤철원 ( Chul Won Yun ),최종일 ( Jong Il Choi ),한세종 ( Se Jong Han ) 한국화학공학회 2015 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.53 No.4
본 논문에서는 저온활성 protease의 생산을 최적화하기 위하여 극지 미생물인 Enterobacteriaceae sp. PAMC 25617의 반응표면분석법을 이용한 배지의 최적화를 수행하였다. One-factor-at-a-time 방법을 이용하여 yeast extract, TritonX-100이 protease의 생산에 영향을 미치는 주요인자인 것을 확인하였다. 물리적인 환경 요인으로 pH를 추가하여 반응표면분석 방법을 이용한 최대 protease 생산 농도를 갖는 각 인자들의 농도를 확인한 결과 5 g/L peptone, 3 g/L malt extract, 10 g/L C6H12O6, 6.690 g/L yeast extract, 0.018 g/L TritonX-100의 농도에 pH 6.777의 조건에서 미생물을 배양하였을 경우, 최대 10.049 U/L의 protease가 생산될 수 있는 것으로 예측되었다. 실제 배양 결과 8.03 U/L의 protease가 얻어졌으며, 최적화 이전의 생산농도와 비교하여 150% 이상의 증가를 이루었다. 결과적으로 배지최적화를 통한 protease 생산량의 증가에 반응표면분석법의 적용이 유용하다는 것을 확인할 수 있는다. 이러한 결과로부터, 배지 최적화를 이용한 극지 미생물 유래 cold-adapted protease 생산량의 증가가 여러 산업 분야에서 유용하게 이용될 수 있을 것으로 생각된다. This study was conducted to optimize the medium composition for cold-adaptive protease production of Enterobacteriaceae sp. by response surface methodology (RSM). Yeast extract, and TritonX-100 were identified as the significant factors affecting protease from one-factor-at-a-time method. RSM studies for optimizing protease production of Enterobacteriaceae sp. have been carried out for three parameters including yeast extract concentration, TritonX-100 concentration, and culture pH. These significant factors were optimized as 6.690 g/L yeast extract, 0.018 g/L Triton™ X-10, and pH 6.677. The experimentally obtained protease activity was 8.03 U /L, and it became 1.5-fold increase before optimization.
단신 : 반응표면분석법을 이용한 Arthrobacter sp. PAMC 25486의 카로티노이드 생산배지 최적화
김현도 ( Hyun Do Kim ),최종일 ( Jong Il Choi ),한세종 ( Se Jong Han ) 한국화학공학회 2014 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.52 No.6
본 논문에서는 반응표면분석법을 이용한 Arthrobacter sp. PAMC 25486의 carotenoids 생산 배지의 최적화를 수행하였다. Placket-Burman 방법을 이용하여 yeast extract, MgSO4, dextrose가 carotenoids의 생산에 영향을 미치는 주요인자인 것을 확인하였다. 반응표면분석 방법을 이용하여 최대 carotenoids 생산 농도를 갖는 yeast extract, MgSO4, dextrose의 농도를 계산한 결과 1 g/L yeast extract, 0.0879 g/L MgSO4 and 1 g/L dextrose의 농도에서 최대 307 mg/L 의 carotenoids 농도가 예측됐으며, 실제 배양 결과 288 mg/L carotenoids가 얻어졌다. 얻어진 농도 값은 최적화 이전의 값에 비하여 200% 이상 증가하였다. 이러한 결과로부터 미생물 배양에 의한 carotenoids 생산을 증가시키기 위한 배지최적화 방법으로서 반응표면분석법의 유용성을 확인할 수 있었다. This study was conducted to optimize the medium composition for carotenoid production in Arthrobacter sp. PAMC 25486 through response surface methodology (RSM). Using a Placket-Burman design, from which yeast extract, MgSO4 and dextrose were identified as the significant factors affecting carotenoids production. RSM studies for carotenoids production by Arthrobacter sp. PAMC 25486 have been carried out for three parameters of yeast extract, MgSO4 and dextrose concentrations. These significant factors were optimized by experiments and RSM, as 1 g/L yeast extract, 0.0879 g/L MgSO4 and 1 g/L dextrose. The experimentally obtained concentration of carotenoid was 288 mg/L, and it became 2-fold increase on concentration before optimization.
센서에 측정에러가 있는 볼-빔 시스템의 출력 궤환 제어기
김현도(Hyun-Do Kim),최호림(Ho-Lim Choi) 제어로봇시스템학회 2011 제어·로봇·시스템학회 논문지 Vol.17 No.10
In this paper, we assume that an output sensor of a ball and beam system is coupled with AC measurement noise. We propose an output feedback controller for a ball and beam system under measurement noise of feedback sensor. Measurement noise makes feedback signals distorted, and results in performance degradation or even system failure. Therefore, we need to design a robust controller to accommodate the possible measurement noise in the feedback information. Our controller is equipped with a gain-scaling factor to minimize the effect of measurement noise in output feedback information. We give an analysis of the controlled system and illustrate the improved control performance via simulation and experiment for a ball and beam system.
적분기 시스템에서 센서의 측정에러를 보상하는 출력 궤환 제어기 설계 및 분석
김현도(Hyun-Do Kim),최호림(Ho-Lim Choi) 제어로봇시스템학회 2011 제어·로봇·시스템학회 논문지 Vol.17 No.4
In this paper, we propose an output feedback controller for a chain of integrators system compensating measurement noise of feedback sensor. Measurement noise makes feedback signals distorted, and results in performance degradation or even system failure. Therefore, we need to design a robust controller to accommodate the possible measurement noise in the feedback information. Our controller is equipped with a gain-scaling factor to reject or minimize the effect of measurement noise in output feedback information. We give a theoretical analysis of the controlled system and illustrate the improved control performance via an example.