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Zinc와 Arachidonic Acid가 고 Fructose 식이로 유도된 인슐린 저항성에 미치는 영향
최철수(Chul-Soo Choi),김영욱(Young-Wook Kim),이효선(Hyo-Sun Lee),윤태호(Tae-Ho Yoon),조병만(Byung-Mann Cho),이수일(Soo-Il Lee),김성수(Sung-Soo Kim),황인경(In-Kyung Hwang) 한국식품영양과학회 2009 한국식품영양과학회지 Vol.38 No.4
고 fructose 식이를 섭취시켜 제 2형 당뇨를 유발한 쥐에서 ZA의 섭취가 혈당 조절에 미치는 기전을 밝히고자 하였다. 4주 동안의 실험기간 중 Control군(normal chow diet), Fructose군(high-fructose diet)과 Fructose+ZA군(highfructose diet+ZA treatment) 간의 체중, 먹이 및 물의 섭취량에는 유의한 차이를 나타내지 않았다(p<0.05). 기저상태(basal state)에서 혈장 포도당, 인슐린 농도 및 간의 포도당 생성률을 측정한 결과 Control군과 Fructose군 및 Fructose +ZA군 간의 차이를 나타내지 않았다. 인슐린 감수성을 알아보기 위한 hyperinsulinemic euglycemic clamp 실험에서 인슐린 농도와 포도당 농도는 군 간의 차이를 나타내지 않았다. 또한 인슐린 감수성 지표인 포도당 흡수(glucose uptake)에서도 역시 군 간의 차이를 발견하지 못하였다. 그러나 간의 인슐린 감수성 지표인 간의 포도당 생성률(HGO)에서는 Fructose군이 Control군에 비하여 유의적으로 증가되었고(p<0.05), Fructose+ZA군이 대조군의 수준으로 감소되었다. 이것으로 미루어 볼 때 fructose 식이는 간에서 인슐린 감수성을 감소시켰으나 당뇨는 유발되지 않았으며, ZA 섭취가 간의 포도당 생성률을 억제하는 것으로 보아 인슐린 감수성을 증가시키지만, 말초조직의 포도당 이용에는 영향을 미치지 않는 것으로 사료된다. We previously demonstrated that zinc plus arachidonic acid (ZA) treatment lowered blood glucose levels in streptozotocin-induced diabetic rats, genetically diabetic obese (ob/ob) mice, and genetically diabetic, non-obese Goto-Kakizaki rats. However, plasma insulin levels did not increase with ZA treatment, suggesting that ZA lowers blood glucose levels not by stimulating pancreatic insulin secretion. However, it is unclear whether these agents lower blood glucose levels by decreasing hepatic glucose output (HGO) or by increasing glucose utilization in peripheral tissues, or both. In order to determine ZA target organ of insulin action, we divided 18 Sprague-Dawley rats weighing ~130 g into 3 groups (6 rats per group) and treated them for four weeks with: (1) Control diet (regular rat chow), (2) High fructose (60.0%) diet only, and (3) the same fructose diet plus zinc (10 ㎎/ℓ) and arachidonic acid (50 ㎎/ℓ) containing drinking water. After 4 weeks, insulin action was assessed using the hyperinsulinemic euglycemic clamp technique. Food intake and body weights were comparable in all three groups of rats throughout the study period. Plasma glucose and insulin concentrations, glucose uptake, and HGO in the basal state were all the same in these three rat groups. During the clamp study, fructose-treated and fructose+ZA treated rat groups did not exhibit any detectable change on insulin-mediated glucose uptake compared to controls. High fructose feeding impaired insulin mediated suppression of HGO, compared to controls during clamp (4.39 vs. 2.35 ㎎/㎏/min; p<0.05). However, ZA treatment in high fructose-fed rats showed a remarkable increase in hepatic insulin sensitivity compared to high fructose-fed rats, reflected by a complete recovery in suppression of HGO during the clamp (4.39 vs. 2.18 ㎎/㎏/min; p<0.05). This data suggests that ZA increases insulin sensitivity in liver but not glucose utilization of peripheral tissues in high fructose-fed rats.
이영주(Lee, Young Ju),최철수(Choi, Chul Soo),박동진(Park, Dong Jin) 한국자동차공학회 2012 한국자동차공학회 학술대회 및 전시회 Vol.2012 No.11
Perceive quality of interior trim was improved by the development of Cup Holder with Automatic Mechanism.
양용석(Yong Seok Yang),김영수(Young Su Kim),최성호(Seong Ho Choi),최철수(Chul Su Choi),백태현(Tae Hyun Baek),이경인(Kyung In Lee),곽임수(Ihm Soo Kwak),나하연(Ha Youn Rha) 대한내과학회 1995 대한내과학회지 Vol.49 No.3
Tuberous sclerosis is inherited as an autosomal dominant trait which is characteristics of epilepsy mental retardation and adnoma sebaceum. It may be associated with hamartomas including rena angiomyolipoma. Renal angiomyolipoma are uncomman benign neoplasms composed of mature adipose tissue, thick-walled blood vessels and smotth muscle in varying proportions, which are found in more than 50% o the patients with tuberous sclerosis. When associated with tuberous sclerosis, they are usually small, bilateral and multifocal. We present a case of bilatera renal angiomyolipoma with tuberous sclerosis in a 31-year old female.
간세포암환자에 있어서 이상프로트롬빈 ( PIVKA - 2 ) 의 진단적 의의
신영민(Young Min Shin),이선희(Sun Hee Lee),이동필(Dong Pil Lee),최성호(Seong Ho Choi),백태현(Tae Hyun Paik),최철수(Chul Soo Choi),송근암(Geun Am Song),조몽(Mong Cho),양웅석(Ung Suk Yang),문한규(Han Kyu Moon) 대한내과학회 1995 대한내과학회지 Vol.48 No.1
Results: 1) The positivity of PIVKA-2 in hepatocellular carcinoma was 82.9% (34/41) and the mean value of plasma PIVKA-2 was 19.90±16.48 AU/ml, and there were statistically significant differences between the patients with hepatocellular carcinoma and control groups. 2) The positivity of AFP in hepatocellular carcinoma was 61% (25/41) and the mean value of serum AFP was 218.5±180.2ng/ml, and there was no statistically significant difference between the patients with hepatocellular carcinoma and those with liver cirrhosis. 3) The sensitivity and specificity of PIVKA-2 as a marker of hepatocellular carcinoma with cut-off value of 0.1 AU/ml were 82.9% and 87.2%, and those of AFP with cut-off value of 20ng/ml were 61.0% and 71.8% respectively. 4) By the combined assay with the cut-off values of AFP above 20ng/ml and PIVKA-2 above 0.1 AU/ml, the diagnostic sensitivity for HCC can be elevated to 92.7%. 5) There was no significant correlation between the plasma PIVKA-2 and serum AFP in patients with hepatocellular carcinoma. Conclusions: PIVKA-2 has higher sensitivity and specificity than AFP in patients with hepatocellular carcinoma which is larger than 2㎝ in diameter by imaging diagnosis and especially it is valuable tumor marker which can improve sensitivity and specificity to diagnose hepatocellular carcinoma by combination assay with AFP.
김용기,이재복,김인주,최철수,이일두 대한내분비학회 1993 Endocrinology and metabolism Vol.8 No.1
The multiple endocrine neoplasia (MEN) syndromes were classified into two broad categories, MEN type I (MEN I) and MEN type II(MEN II). The MEN II syndrome has been further subcategorized into two variants called MEN Iia and MEN Iib (formerly MEN III). There are a number of rare hereditary MEN syndromes which do not fit the MEN I or MEN II categories, which is called as mixed type. This mixed thpe MEN occurs very rarely. In 1978, Tateishi et al. Reported a case of bilateral pheochromocytoma associated with pancreatic islet cell tumor for the first time. Thereafter, only several cases of such mixed type MEN have been reported all over the world. However there was no case report of a mixed type MEN in Korea. Recently, we experienced qa case of familial pheochromocytoma associated with parcreatic islet cell tumor. A pancreatic islet cell tumor occurred in a 25-year old woman who received a bilateral adrenalectomy for pheochromocytoma 6 hears ago. She had family history of mother and younger sister diagnosed as having pancreaic head tumor, and younger brother who had been ooperated for pheochromocytoma and conifirmed hestologically. (J Kor Soc Endocrinol 8:100~105, 1993)