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최명권 대한영상의학회 1983 대한영상의학회지 Vol.19 No.4
The radiographic measurement of the renal size position provide important information of diseases of the kidney and the adjacent organs. The author analyzed the 213 cases of intravenous pyelography of normal Korean children from 0 to 18 years of age (135 males and 78 females) and measured the following points ; the length of the kidney, the width of the kidney, the level of both hila, and the ratio of the kidney length to the total height of upper 4 lumbar vertebral bodies plus intervertebral discs. The results were obtained as follows ; 1. Above 4 years of age, the annual increase rate of the kidney length was 0.31cm, and that of the height of lumbar vertebrae was 0.44cm in male and 0.55cm in female ; the height of lumbar verterbrae grew more rapidly than the kidney length. 2. The age group of the most rapid growth in the length and the width of the kidney was 16 to 18 years of age in male, and 13 to 15 years of age in female, and that of the most delayed growth was 4 to 6 years of age in both sexes. 3. The size of the left kidney was usually larger than that of the right. But, the right kidndy was larger than the left in 20% of the cases. 4. The right hilum was usually lower than that of the Left. In the 12% of the cases, however, the right hilum was higher in position than the left. 5. The width of the kidney in most children corresponded to the 45 to 60% of the kidney length. 6. The kidney size in age group between 16 and 18 years was within the range of that of normal adults. 7. The ratio of the kidney length to the height of upper 4 lumbar vertebral bodies plus intervertebral discs were as follws : > 1.1 below 3 years of age. 1$\pm$0.1 between 4 and 12 years of age. < 0.9 above 13 years of age.
Localization of Translation Initiation Factors to the Postsynaptic Sites
최명권(Myoung-Kwon Choi),박성동(Sung Dong Park),박인식(In Sick Park),문일수(Il Soo Moon) 한국생명과학회 2011 생명과학회지 Vol.21 No.11
신경세포의 연접후 위치에서 단백질합성은 국소적 연접가소성의 조절에 중요한 역할을 한다. 본 연구에서는 연접후 위치에 eIF들이 존재하는지를 배양한 흰쥐해마신경세포의 면역세포화학적 염색과 immunoblot, 그리고 세제세척실험으로 알아보았다. 단백질해석 시작단계의 초기에 중요한 역할을 하는 eIF4E와 eIF4G, 개시코돈을 찾는 단계에서 중요한 eIF5, 외부자극에 의하여 합성을 시작하게 하는 eIF6, 그리고 불리한 환경에서 해석의 효율을 높여주는 eIF5A 들은 모두 해마신경세포의 연접후에 위치함을 배양한 해마신경세포를 다중초점형광현미경으로 관찰할 수 있었다. 또한 Immunoblot 실험에서도 이들은 연접후치밀질(PSD) 분획에서 검출되었으며, 여러 가지 세제에 의하여 PSD로부터 잘 떨어지지 않는 것으로 보아 PSD와 강하게 결합하고 있음을 알 수 있었다. 본 연구결과는 여러 가지 eIF들이 연접후에 위치하여 다양한 상황에서 단백질합성을 시작하게 할 수 있음을 시사한다. Local protein synthesis in neuronal dendrites is important for site-specific regulation of synaptic plasticity. In this study, we investigated whether translation initiation factors (eIFs) are present at the postsynaptic sites. High resolution confocal microscopy showed that the eIF4E and eIF4G (which bind the 5’-terminal mRNA cap), eIF5 (which is important during the 3’ direction scanning to find an initiation codon), eIF6 (which mediates upregulation of translation by external stimuli), and eIF5A (which mediate translation upregulation under adverse conditions) were localized to the postsynaptic sites. Immunoblot and detergent extraction experiments also indicated that these eIFs were present in the synapse in association with the postsynaptic density (PSD). Our data provide evidence for the strategic positioning of eIFs at the postsynaptic site for initiation of translation in diverse situations.
Myoung Kwon Choi(최명권) 한국실험동물학회 2010 한국실험동물학회 학술발표대회 논문집 Vol.2010 No.2
Although it has been known that the cytosolic DNA derived from virus infection or tissue damage can cause innate immune responses, the cytosolic DNA-sensing mechanism is currently unknown. In this study, we report DAI (DNA?dependent Activator of Interferon-regulatory factors) as a candidate of the DNA sensor, which was previously named DLM-1 (also called Z-DNA binding protein1 (ZBP1)) and demonstrate its novel function in innate immunity. The artificial overexpression of DAI (DLM-1/ZBP1) in murine fibroblast L929 cells selectively enhances the DNA-mediated induction of type I IFN (Interferon) and other genes involved in innate immune responses. And RNA interference of DAI (DLM-1/ZBP1) in L929 cells inhibits the induction of these genes when stimulated by DNA from a variety of sources. Additionally, DAI (DLM-1/ZBP1) binds to double-stranded DNA and associates with the IRF3 (Interferon-regulatory factor3) transcription factor and the TBK1 serine/threonine kinase, which activates DNA-mediated innate immune responses. These results suggest that DAI (DLM-1/ZBP1) is a critical sensor for DNA-mediated activation of innate immune responses, and may provide new insight into the signaling mechanisms underlying DNA-associated antiviral immunity and autoimmune diseases.
이진탁,천현우,Thu-Huyen Pham,윤재환,이지연,최명권,류형원,오세량,오재욱,윤도영 한국미생물·생명공학회 2020 Journal of microbiology and biotechnology Vol.30 No.2
A novel compound named ‘kanakugiol’ was recently isolated from Lindera erythrocarpa and showed free radical-scavenging and antifungal activities. However, the details of the anticancer effect of kanakugiol on breast cancer cells remain unclear. We investigated the effect of kanakugiol on the growth of MCF-7 human breast cancer cells. Kanakugiol affected cell cycle progression, and decreased cell viability in MCF-7 cells in a dose-dependent manner. It also enhanced PARP cleavage (50 kDa), whereas DNA laddering was not induced. FACS analysis with annexin V-FITC/PI staining showed necrosis induction in kanakugiol-treated cells. Caspase-9 cleavage was also induced. Expression of death receptors was not altered. However, Bcl-2 expression was suppressed, and mitochondrial membrane potential collapsed, indicating limited apoptosis induction by kanakugiol. Immunofluorescence analysis using α- tubulin staining revealed mitotic exit without cytokinesis (4N cells with two nuclei) due to kanakugiol treatment, suggesting that mitotic catastrophe may have been induced via microtubule destabilization. Furthermore, cell cycle analysis results also indicated mitotic catastrophe after cell cycle arrest in MCF-7 cells due to kanakugiol treatment. These findings suggest that kanakugiol inhibits cell proliferation and promotes cell death by inducing mitotic catastrophe after cell cycle arrest. Thus, kanakugiol shows potential for use as a drug in the treatment of human breast cancer.