황련해독탕 약침액의 iNOS 생성 억제를 통한 항염증효과가 알레르기성 비염 유발 생쥐의 치료에 미치는 영향

조재용,김유종,김은정,이승덕,김갑성 대한침구의학회 2012 대한침구의학회지 Vol.29 No.1

Objectives : The purpose of this study was find out the therapeutic effects of its exclusive use on the rat with allergic rhinitis. Materials and Methods : Thirty Sprague-Dawley rats were divided into three group : normal group, control group and sample group. To induce the allergic rhinitis in control group and sample group, rats were sensitized intraperitoneally with 0.1% ovalumin solution 3 times at intervals of 1 week. Then intranasal sensitization was performed by diffusing 0.1% ovalumin solution 3 times at intervals of 2 days. After that time, rats in the sample group were administered by Yonghyang(LI20) subcutaneously to treat the inflammation. Results : 1. The anti-oxidant effects of Hwangryunhaedok-tang extract was dose-dependantly increased. 2. The RAW 264.7 cells were treated with LPS for 1 hours prior to the addition of indicated concentrations (0.4, - 1.0 ㎎/㎖) of HHT, and the cells were further incubated for 24 hours. The LPS-induced iNOS mRNA expression and NO production were dose-dependantly decreased in HHT treated RAW 264.7 cells. 3. The number of eosinophil in HP noticeably decreased than CON and this decrease had probability. The infiltration of eosinophil in HP noticeably decreased than CON. 4. The damaged mucosa as disruption of cilia in respiratory cell and vacant mucose secreting cell were increased CON, but HP same as normal configuration. Decrease of PAS positive cell were shown in CON, but goblet cell occupied with neutral mucous were shown in HP. Decrease of mucosal stress(HSP70). Decrease of perennial sign(PPAR-γ). Decrease of icthing and sneezing intricate neurotransmitter(substance P). 5. The anti-inflammation of HHT pharmacopuncture for AR caused mucosa comes to result as belows. Decrease of pre-inflammation cytokine(TNF-α). Decrease of transcription factor (NF-κB p65). Decrease of transcription factor inhibitor(p-IκB). Decrease of inflammation cytokine(iNOS). Conclusions : The results may suggest that administration treatment using Hwangryunhaedok-tang pharmacopucnture decreases the inflammatory response on an animal model with allergic rhinitis.

Molecular Diagnosis for Personalized Target Therapy in Gastric Cancer

조재용 대한위암학회 2013 Journal of gastric cancer Vol.13 No.3

Gastric cancer is the second leading cause of cancer-related deaths worldwide. In advanced and metastatic gastric cancer, the conventional chemotherapy with limited efficacy shows an overall survival period of about 10 months. Patient specific and effective treatments known as personalized cancer therapy is of significant importance. Advances in high-throughput technologies such as microarray and next generation sequencing for genes, protein expression profiles and oncogenic signaling pathways have reinforced the discovery of treatment targets and personalized treatments. However, there are numerous challenges from cancer target discoveries to practical clinical benefits. Although there is a flood of biomarkers and target agents, only a minority of patients are tested and treated accordingly. Numerous molecular target agents have been under investigation for gastric cancer. Currently, targets for gastric cancer include the epidermal growth factor receptor family, mesenchymal-epithelial transition factor axis, and the phosphatidylinositol 3-kinase–AKT–mammalian target of rapamycin pathways. Deeper insights of molecular characteristics for gastric cancer has enabled the molecular classification of gastric cancer, the diagnosis of gastric cancer, the prediction of prognosis, the recognition of gastric cancer driver genes, and the discovery of potential therapeutic targets. Not only have we deeper insights for the molecular diversity of gastric cancer, but we have also prospected both affirmative potentials and hurdles to molecular diagnostics. New paradigm of transdisciplinary team science, which is composed of innovative explorations and clinical investigations of oncologists, geneticists, pathologists, biologists, and bio-informaticians,is mandatory to recognize personalized target therapy.

A Phase II Study of Capecitabine Combined with Gemcitabine in Patients with Advanced Gallbladder Carcinoma

조재용,남지선,박미숙,유정식,백용한,이세준,이동기,윤동섭 연세대학교의과대학 2005 Yonsei medical journal Vol.46 No.4

Capecitabine and gemcitabine are used in the treatment of a variety of solid tumors including pancreatic and biliary tract carcinomas. The authors evaluated survival, response, and toxicity associated with using a combination of capecitabine and gemcitabine to treat patients with unresectable or metastatic gallbladder adenocarcinoma (GBC). Eligible patients had histologically- or cytologically-confirmed GBC, no prior systemic therapy with capecitabine or gemcitabine, Karnofsky Performance Status 70%, serum total bilirubin up to three times normal, and measurable disease. Treatment consisted of gemcitabine 1000mg/m2 IV on Days 1 and 8 concurrent with administration of capecitabine 1000mg/m2 PO BID on Days 1 through 14, on a 3-week cycle. Tumor response was assessed by the response evaluation criteria in solid tumors (RECIST criteria) and survival was calculated from initiation of CapGem therapy. A total of 24 patients were enrolled. Median age at the time of diagnosis was 62 years (range, 41-78 years). Fourteen patients had undergone prior surgery. Results showed that eight patients achieved partial response (33%) with an additional 10 patients achieving stable disease (42%). The overall median time to disease progression was 6.0 months (95% CI, 3.8-8.1 months) and overall survival was 16 months (95% CI, 13.8-18.3 months). The one-year survival rate was 58%. No Grade 4 toxicity was seen. Transient Grade 3 neutropenia/ thrombocytopenia and manageable nausea, hand-foot syndrome and anorexia were the most common toxicities. Our study shows that CapGem is an active and well-tolerated chemotherapy regimen in patients with advanced GBC.

Hybrid Stenting at proximal entry and DCB at distal part in long ilio-femoro-popliteal Lesion

조재용,박상호 대한내과학회 2020 대한내과학회 추계학술대회 Vol.2020 No.1

중소기업을 위한 통합경영시스템 구축

조재용,박수용,이동형 한국산업경영시스템학회 2023 한국산업경영시스템학회 학술대회 Vol.2023 No.춘계

불균등 국부부식이 강말뚝의 극한강도에 미치는 영향

조재용,신수봉 동아대학교 건설기술연구소 2000 硏究報告 Vol.24 No.2

The effects of non-uniform local corrosion on the ultimate strength of steel piles in harbor structures have been investigated through nonlinear finite element analysis. Geometric and material nonlinearities have been considered in the analysis using 2-D plastic beam elements. For the current study, a both-end-hinged column is analyzed with axial force. Non-uniform local corrosion along the column is modeled as the reduction in the sectional area. It is assumed that corrosion is uniform within a section. Parametric studies have been carried out to evaluate the effects of each parameter on the ultimate strength of locally corroded column. Parameters considered in the current study include reduction in thickness, location of corroded areas, column length, diameter, and thickness of a pile.

RFID를 이용한 Production Traceability System 구축 및 활용

조재용,신철민,홍종수,이천희 한국정보통신설비학회 2007 한국정보통신설비학회 학술대회 Vol.2007 No.1

시술자와 방습법에 따른 치면열구전색제의 유지에 관한 연구

조재용,김정욱,장기택,김종철,한세현,이상훈,Cho, Jae-Yong,Kim, Jung-Wook,Jang, Ki-Taeg,Kim, Chong-Chul,Hahn, Se-Hyun,Lee, Sang-Hoon 대한소아치과학회 2003 大韓小兒齒科學會誌 Vol.30 No.3

치면열구전색제의 예방효과는 전색제의 유지와 매우 밀접한 상관관계가 있으며 시술시의 환경과 시술 방법, 개개 환자의 구강 위생이 유지에 영향을 미치는 것으로 알려져 있다. 현재 우리나라에서는 대규모로 '치아홈메우기 사업'이 진행 중에 있지만 시술 여건이나 시술자에 따라 여러 가지 방법의 방습법과 치면 세마가 행해지고 있는 실정이다. 본 연구의 목적은 치면열구전색제의 시술 시 소아치과의사, 일반치과의사, 치과위생사 등 시술자에 따른 유지율 차이와 러버댐과 코튼롤(cotton roll) 방습법 등 격리 방법에 따른 유지율의 차이를 알아보고 실패가 일어나는 치아의 특정 부위를 알아보기 위한 것이다. 6세-11세인 119명의 아동(남자 64명, 여자 55명)에서 상하악 제1대구치에 시술된 279개의 치면열구전색제를 대상으로 1년 후의 유지율을 조사하였다. 이 아동들은 평균 연령이 $8.59{\pm}0.772$세였으며 각각 러버댐을 사용한 소아치과의사가 시술한 1군, 러버댐을 사용한 일반치과의사가 시술한 2군, 코튼롤(cotton roll)을 사용한 치과위생사가 시술한 3군으로 나누었다. 1년 후의 치면열구전색제의 유지율을 조사하여 다음과 같은 결론을 얻었다. 1. 1년 후의 치면열구전색제 유지율은 러버댐을 사용한 소아치과의사가 시술한 1군이 90.8%, 러버댐을 사용한 일반치과 의사가 시술한 2군은 85.0%, 코튼롤을 사용한 치과위생사가 시술한 3군은 64.7%였으며 1군과 2군간에는 통계적인 유의차가 없었으나(P>0.05) 1,2군과 3군 간에는 통계적인 유의차가 있었다(P<0.05). 2. 상악과 하악의 유지율 비교에서 1군과 2군은 차이가 없었으나(P>0.05) 3군은 차이가 있었다(P<0.05). 3. 실패부위 분석에서 교합면의 실패는 58.3%, 협/설면구는 41.7%를 차지하였다. Currently, 'National program of dental sealant' has begun in Korea, but various isolation techniques and preparation is performing. The aim of the present study was to compare pit and fissure sealant retention rates between different operators using two different isolation techniques. Additionally, the failed surface was examined. One examiner performed the examination after one year of the initial operation. The population consisted of 119 children(mean age $8.59{\pm}0.772$) of which the total sealed number was 279 permanent first molars. Pediatric dentists sealed 131 molars using the rubber dam isolation technique (Group 1), general practitioners sealed 80 molars using the rubber dam isolation technique (Group 2), and dental hygienists sealed 69 molars using the cotton roll isolation (Group 3). The results were as follows ; 1. The complete retention rate between Group 1 (90.8%) and 2 (85.0%) showed no significant statistical difference (P>0.05). However, there were significant statistical different retention rates between Group 1 and Group 3(64.7%) and between Group 2 and Group 3 (p<0.05). 2. In comparing retention rates between maxilla and mandible, Only Group 3 showed a significantly lower complete retention rate in mandible than maxilla (p<0.05). 3. In failed surface analysis, occlusal failed surface was 58.3%, buccal/palatal failed surface was 41.7%.

휴윈 (Huwin)

조재용 한국전자파학회 2016 전자파기술 Vol.27 No.2

비공진 압전 에너지 하베스팅 기술을 활용한 산업용 사물인터넷 기반 자가발전 센서 모니터링 시스템

조재용,Jo, Jae-Yong 전력전자학회 2020 전력전자학회지 Vol.25 No.4