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인간 신경아세포종 세포 배양을 통한 뇌 신경세포 생육 촉진인자의 생산
홍종수,우광회,박경유,이현용 한국산업미생물학회 1997 한국미생물·생명공학회지 Vol.25 No.1
신경세포의 생육과 신경 돌기의 분화 및 성장은 서로 상관관계가 있으나 직선적인 비례 관계는 아닌것으로 입증됐다. 단위 세포당 신경 돌기의 수는 배양 후 약 3∼4일 후에 최대 5.5개로 급속히 증가했으며 이때 신경 돌기의 성장 길이도 2.2 ㎚로 최고도에 도달했다. 또한 신경아세포종 세포 배양시 배양 초기에는 세포 내에서 BDNF가 생산된 후 배양 4일 째부터 세포 외로 분비돼 7×10 exp (5)(viable cells/mL) 의 최대 세포수에 도달 했을 때 전체 BDNF 생산량은 100(ng/mL)있었으며 이때 세포외 BDNF 양은 75(ng/mL)였다. 또한 이때 최대 BDNF 비생산 속도는 2.5×10 exp (-5)(ng/cell/day)로 계산됐다. 특히 신경 돌기 수가 증가함에 따라 단위 신경 돌기의 성장 속도도 동시에 증가하는 흥미로운 현상이 밝혀졌다. 또한 1(㎍/m)의 BDNF를 첨가시 첨가하지 않은 경우보다 배양 말기에 비생산성이 지속적으로 증가했으며, 신경 돌기의 성장은 약 40% 이상 빠르게 증가하는 것으로 입증됐다. 이로서 BDNF가 신경세포의 생육 및 분화에 직접적인 영향을 미치는 것이 확인됐으며 정상 조건에서 100(ng/mL)의 높은 생산성을 갖고 있는 세포주를 선별함으로서 BDNF를 생물 의약품으로 응용하기위한 체외 대량배양 공정의 기초를 제공하게 됐다. In cultivating human neuroblastoma cells maximum number of neurites per cell and length of the neurite were estimated as 5.5 and 2.2 (㎚), respectively. It was found that there was correlation between growth and differentiation of nerve cells. Maximum specific BDNF production rate was also calculated as 2.5×10 exp (-5) (ng/cell/day) at 7×10 exp (5) (viable cells/mL) of maximum cell density, corresponding to 100 (ng/mL) of BDNF. The secretion of BDNF was occurred most in the later peroids of the cultivation, yielding 75 (ng/mL) of BDNF. The production rate of BDNF was elongated in adding 1 (㎍/mL) of BDNF as well as 40% increase of the length of the neurites. It proves that BDNF can be used as one of biopharmaceuticals to treat age-related diseases such as Alzheimer's disease and Prakinson's disease. It can also provide the information of scaling-up mammalian cell cuture system to economically produce BDNF.
제주도 민가의 주거환경에 관한 연구 -오조마을의 공간적 특성을 중심으로-
홍종수,양택훈 한국조경학회 1991 韓國造景學會誌 Vol.19 No.3
The traditional housing of Cheju Island has been steadily researched, but from the point of an environmental view which has been neglectly treated all the while, the formative process of the housing and its relationship to the structure of a village are studied, so the writer summarized the relation to the housing type. To study the peculiarity of the physical space, a type of a way, and element of the spatial structure, by stage and a type of the arrangement of the residential space are researched and analyzed, and to understand the plane peculiarity, the distribution of the plane type has been studied. In consequence, the housing and the structure and the form of the village have an organic relation each other and have been made under a very diverse and mixed background, we can find. Especially, the element of the natural environment acts as an important element which decides the type of life and the residential type. The arrangement of buildings is gradually free from the traditional type, but a traditional type of "Three-Room House" is kept well in spite of a change of the plane type.
벤처기업의 성장 촉진을 위한 벤처부채의 가능성과 도입방안
홍종수,나수미,박재성 한국벤처창업학회 2020 벤처창업연구 Vol.15 No.4
Venture debt is a prominent funding tool to promote scale-up of ventures. In the growth stage, venture firms that need large-scale funding can accelerate their growth by leveraging venture debt without diluting their shares, while venture capitals can quickly recollect their investments by accelerating the growth of the ventures they invest. By supplying venture debt, banks can diversify their asset primarily concentrated on loans, and improve the return on assets. As in the case of Silicon Valley Bank, a leading venture lender, closer cooperation between the two agents is essential to supply venture debt. One is the venture capital, an equity capital supplier, and the other is the bank, a debt capital supplier. To this end, we propose “credit risk sharing venture loans” and “venture loan pooling”. The former encourages banks' participation in the venture debt market where the manager of Korean Fund of Funds, KVIC and policy guarantee schemes such as KODIT and KIBO screen or partially absorbe the risks inherent in venture loans. The latter reduces the burden of banking on individual venture loans through securitization.
홍종수 한국개발연구원 2024 KDI Journal of Economic Policy (KDI JEP) Vol.46 No.1
Since the Global Financial Crisis of 2008-2009, the importance of non-bank financial institutions in macroprudential management has increased significantly. Consequently, major countries and international financial institutions have been actively discussing and implementing macroprudential supervision and regulation for non-bank financial institutions (NBFI). In this context, this paper analyzes the systemic risk of both banks and non-bank sectors (securities firms and insurance companies) in South Korea over different time periods. Using the widely recognized ΔCoVaR methodology for measuring systemic risk, the analysis reveals that systemic risk increased substantially across all three sectors (banks, securities firms, and insurance companies) during the Global Financial Crisis, the European Sovereign Debt Crisis, and the COVID-19 pandemic. Although the banking sector exhibited relatively high systemic risk compared to the securities and insurance sectors, the relative differences in systemic risk varied across the different crisis periods. Notably, during the margin call crisis in March of 2020, the gap in systemic risk between the banking and securities sectors decreased significantly compared to that during both the Global Financial Crisis and the European Sovereign Debt Crisis, indicating that securities firms had a more substantial impact on risk in the overall financial system during this period. Furthermore, I analyze the impact of the issuance of equity-linked securities (ELS) by financial institutions on systemic risk, as measured by ΔCoVaR, finding that an increase in the outstanding balance of ELS issuance by financial institutions had an impact on increasing ΔCoVaR during the three crisis periods. These findings underscore the growing importance of non-bank financial institutions in relation to South Korea’s macroprudential management and supervision. To address this evolving landscape, enhanced monitoring and regulatory measures focusing on non-bank systemic risk are essential components of maintaining financial stability in the country.