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어성초 전탕액이 흰쥐 장기내 카드뮴 축적에 미치는 영향(I)
이정호,강길웅,정재열,한종민,이기남,정우영,한두석,유일수,김종수,백승화,Lee Jeong-Ho,Kang Kil-Ung,Jeung Jae-Yeal,Han Jong-Min,Lee Ki-Nam,Chung Woo-Young,Han Du-Seok,You Il-Soo,Kim Jong-Soo,Baek Seung-Hwa 대한예방한의학회 1999 대한예방한의학회지 Vol.3 No.2
This study was conducted to investigate the antitoxic component in aqueous extract of Houttuynia cordata $T_{HUNB}$. The results were as follows: Generally, detoxication effects by Houttuynia cordata $T_{HUNB}$ extract increased in proportion to the extract concentrations. When 40mg/kg dosage of Houttuynia cordata $T_{HUNB}$ extract was administered, it showed the highest antitoxic effects in metallothionein induction. After the extract treatment, body weights increased in proportion to the extract concentration. However, after 3 weeks, the body weight decreased insignificantly. From the above results, Houttuynia cordata $T_{HUNB}$ extract increased metallothionein concentration and decreased the toxicity of cadmium in rats. 흰쥐에게 카드뮴 경구투여시, 어성초 전탕액의 경구 투여한 후 카드뮴의 독성에 대한 해독경감효과에 대하여 다음과 같은 결과를 얻었다. 1. 흰쥐에게 어성초 전탕액의 경구 투여 용량이 증가할수록 카드뮴의 독성에 대한 해독경감효과는 증가하였으며, 신장에서보다 간장에서 해독경감효과가 좋았다. 2. 흰쥐 신장 및 간장의 MT의 농도는 간장에서 보다 신장에서 우수한 결과를 보였으며, 신장에서는 어성초 전탕액의 경구 투여 농도가 10mg/kg 이상이 되면 MT 형성은 어성초 전탕액의 투여 농도가 증가하여도 크게 증가하지는 않았다. 3. 흰쥐의 체중변화는 어성초 전탕액의 경구 투여 용량이 증가할수록 흰쥐의 체중변화도 증가하는 경향을 보였으나, 3주 이후에는 체중의 증가가 적게 나타났다. 이상과 같이 어성초 전탕액의 경구투여를 종합해 보면, 어성초 전탕액의 경구 투여 시켰을 경우 카드뮴의 독성에 대한 해독경감효과가 있는 것으로 판단된다.
어성초 메탄올 추출물이 흰쥐 장기내 카드뮴 축적에 미치는 영향 (III)
이정호,유일수,김신기,이기남,정재열,한종민,정명수,이은경,백승화,Lee Jeong-Ho,You Il-Soo,Kim Shin-Kee,Lee Ki-Nam,Jeung Jae-Yeal,Han Jong-Min,Chong Myong-Soo,Lee Eun-Kyoung,Baek Seung-Hwa 대한예방한의학회 2000 대한예방한의학회지 Vol.4 No.1
This study was conducted to investigate the antitoxic component in methanol extract of Houttuynia cordata $T_{HUNB}$. The results were as follows: Generally, detoxication effects by Houttuynia cordata $T_{HUNB}$ methanol extract increased in proportion to the methanol extract concentrations. When 40 mg/kg dosage of Houttuynia cordata $T_{HUNB}$ methanol extract was administrated, it showed the highest antitoxic effects in metallothionein induction. After the methanol extract treatment. Body weights increased in proportion to methanol extract concentrations. However, after 3 weeks, the body weight decreased insignificantly. From the above results, these results suggest that the methanol extract of Houttuynia cordata $T_{HUNB}$ increased metallothionein concentration and decreased the toxicity of cadmium in rats.
이기남,이정호,송용선,정재열,김삼태,임진아,이인아,유형원,장용남,이택준,김홍기,천현자,유일수,김종수,백승화,Lee, Ki-Nam,Lee, Jeong-Ho,Song, Yong-Sun,Jeong, Jae-Yeal,Kim, Sam-Tae,Lim, Jin-A,Lee, In-A,Ryu, Hyeong-Won,Jang, Yong-Nam,Lee, Taek-Jun,Kim, 대한예방한의학회 2003 대한예방한의학회지 Vol.7 No.1
This study was carried out to evaluate cytotoxic effects of Houttuynia cordata $T_{HUNB}$ extracts on A549(lung cancer), B16(mouse melanoma), MDA-MB231(breast cancer) and SNU-C4(colon cancer) cell lines. We have determined by 3-(4, 5-dimethylthiazol-2-Yl)-2, 5-diphenyl-2H-tetrazoliumbromide(MTT) assay. The $150{\mu}g/ml$ concentration of chloroform extract of Houttuynia cordata $T_{HUNB}$ was shown significantly antitoxic activity on MDA-MB231$(65.96{\pm}5.68%)$ and SNU-C4$(55.94{\pm}7.39%)$ cell lines.
박승정,유현주,최희석,서병윤,양선호,김영훈,정재열,이기남,Park Seung-Joung,Yoo Hyun-Ju,Choi Hee-Seok,Seo Byeong-Yun,Yang Seon-Ho,Kim Yeong-Hun,Jeong Jae-Yeal,Lee Ki-Nam 대한예방한의학회 2004 대한예방한의학회지 Vol.8 No.2
1. The cell viability was determined by MTT method. Their cytotoxic activities against three cancer cell lines such as A549, MDA-MB-231 and SNU-C4 cell line were tested. Among them, The methanol extract of Saururus chinensis Baill. showed the strongest cytotoxic effect against SNU-C4 cells. These results suggest that the methanol extract of Saururus Chinensis Baill. possessed a potential antitumorous agent. 2. In vitro the antitoxic activity of ethanol extract of Saururus Chinensis Bail on NIH 3T3 fibroblasts was evaluate by the MTT (3-(4,5-dimethyl- thiazol-2-yl)-2,5-diphenyl-2H-tetra캐lium bromide) and SRB (sulforhodamine B protein) assays. The number of NIH 3T3 fibroblasts were increased and tend to regenerate. These results suggest that Saururus Chinensis Bail extract retains a potential antitoxic activity. 3. Complexation of Cd (II) ion with ligands such as quercetin has been determined by UV-vis spectrophotometric method in tris buffer solution at various pH. It was found that only 1 : 1 Cd-complex is formed by the interaction between catechol moiety in ring B and cadmium [Cd(II)] in aqueous solution. The spectral parameters for Cd-complex were determined by Beer's law at various pH. It has shown that 1 : 1 Cd-complex has a maximum absorbance and red shift by the alkaline pH.