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전승주,김석영,조누리,민들레,황유진,Mizuko Mamura 연세대학교의과대학 2013 Yonsei medical journal Vol.54 No.2
Purpose: Patients with gestational diabetes mellitus (GDM) have been reported to exhibit the same genetic susceptibility as that observed in those with type 2 diabetes mellitus (T2DM). Recent polymorphism studies have shown that several genes are related to T2DM and GDM. The aim of this study was to examine whether certain candidate genes, previously shown to be associated with T2DM, also offer a specific genetic predisposition to GDM. Materials and Methods: The current study was conducted in 136 Korean pregnant women, who gave birth at Gil Hospital,from October 2008 to May 2011. These study subjects included 95 subjects with GDM and 41 non-diabetic controls. We selected the specific genes of PPARγ2, IGF2BP2, and KCNQ1 for study and amplified them using the polymerase chain reaction. This was followed by genotyping for single nucleotide polymorphisms. We then compared the genotype frequencies between patients with GDM and non-diabetic controls using the χ2 test. We obtained and analyzed clinical information using Student’s t-test, and statistical analyses were conducted using logistic regression with SPSS Statistics software, version 19.0. Results: Significant differences were observed in maternal age, body mass index, weight gain and weight at time of delivery between the groups compared. Among pregnant women, polymorphisms in PPARγ2 and IGF2BP2 were shown to be highly correlated with GDM occurrence, whereas no correlation was found for KCNQ1 polymorphisms. Conclusion:Our results indicated that genetic polymorphisms could also be of value in predicting the occurrence and diagnosis of GDM.
Synthesis of Indole and Phthalimide Based π-Conjugated Organic Cations for 2D perovskites
전승주,노유진,고지영,노용영,황도훈,임보규 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.2
Two-dimensional (2D) layered standard ABX3 cubic halide perovskite is being actively studied because it has many advantages, such as solution processability, extensive structural and property tunability, and excellent optoelectronic properties. By tuning the ‘A’ cations in the perovskite, it is possible to achieve high-performance in electronic devices. Indole and phthalimide have high thermal stability and excellent charge carrier mobility. In addition, it is possible to introduce various substituents to nitrogen, which allows tuning of solubility and molecular packing. In this study, we designed and synthesized novel organic cations for 2D layered halide perovskites based on thiophene-incorporated indoles and phthalimides. The properties of the perovskite film made of synthesized cations were observed under various conditions. Crystalline properties were observed through UV-vis and XRD analysis, and electrical properties were confirmed by fabricating FETs.
전승주,전호승,조계남,윤형구,정강우 대한골절학회 2001 대한골절학회지 Vol.14 No.1
Purpose: The results of treatment of tibial plateau fractures by extensive soft tissue exposure were less satisfactory even if anatomical reduction was achieved. The purpose of this study is to assess the functional and radiological results of the treatment of tibial plateau fractures by cannulated screw fixation to decrease soft tissue injury and operation time. Materials and Methods: From January 1996 to February 2000, 19 patients were treated by limited open reduction and internal fixation by cannulated screw. According to scoring of Rasmussen, the functional results were rated. Results: In all cases, Bony union was obtained and according to scoring of Rasmussen, excellent in 1 case, good in 14, fair in 4 cases. There were 2 cases of limitation of joint motion and 2 cases of persistant pain as sequale. Conclusion: We considered that if accurate preoperative evaluation was done, Cannulated screw fixaction was easier and faster method than other methods for treatment of tibial plateau fractures.
전승주,허진영,윤보현,정연수,서석교 대한폐경학회 2016 대한폐경학회지 Vol.22 No.3
Objectives: Menopause is a natural aging process causing estrogen deficiency, accelerating atherogenic processes including dyslipidemia. Prevalence of thyroid dysfunction is also high in postmenopausal women, and it is known to elevate the risk of cardiovascular disease (CVD). Therefore, we are to study on the associations in between serum thyroid stimulating hormone (TSH) and prevalence of CVD in postmenopausal women who have normal thyroid function.Methods: We performed a retrospective review of 247 Korean postmenopausal women who visited the health promotion center from January, 2007 to December, 2009. Postmenopausal women with normal serum TSH were included in the study. Coronary atherosclerosis was assessed by 64-row multidetector computed tomography. Results: In multiple linear regression analysis, serum TSH was associated with serum triglyceride (TG) (β = 0.146, P = 0.023). In multiple logistic regression analysis, increasing age and serum TSH were associated with an increased risk of coronary atherosclerosis in euthyroid postmenopausal women (odds ratio [OR] = 1.107 [1.024-1.197], P = 0.011 and OR = 1.303 [1.024-1.658], P = 0.031, respectively).Conclusions: It revealed that significant predictor of serum TSH was serum TG, and increasing age and TSH were found to have associations with an increased risk of coronary atherosclerosis in euthyroid postmenopausal women. Screening and assessing risks for CVD in healthy postmenopausal women would be helpful before atherosclerosis develops. (J Menopausal Med 2016;22:146-153)