대시호탕(大柴胡湯)이 3T3-L1 지방전구세포와 고지방식이 유도 비만쥐에 미치는 영향

민들레,박은정,Min, Deul Le,Park, Eun Jung 대한한방소아과학회 2015 대한한방소아과학회지 Vol.29 No.1

Objectives This experimental study was designed to investigate the effects of Dai-saiko-to (DSH) on differentiation of 3T3-L1 preadipocytes and body weight, serum lipid levels in high-fat diet-induced obese mice. Materials and Methods Cells were incubated with DSH at an indicated concentration (0.01-1 mg/ml) for 24h, then the growth rate was assessed by MTS assay. 3T3-L1 preadipocytes were incubated in DMEM for 2 days with the indicated concentrations of DSH. On Day 6, the cells were fixed and the cellular lipid contents were assessed by Oil-Red-O staining. The expression of peroxisome proliferator-activated receptor ${\gamma}$ ($PPAR{\gamma}$) and cytidine-cytidine-adenosine-adenosine-thymine (CCAAT)/enhancer-binding proteins ${\alpha}$ ($C/EBP{\alpha}$) as adipocyte-specific proteins were determined by real time RT-PCR and western blotting. Four-weeks old mice (wild-type C57BL/6) were used for all experiments. Body weight gain and serum lipid levels were measured in the obesity-induced mice. Results DSH did not show toxicity even at the concentration of 1 mg/ml and DSH significantly inhibited the differentiation of 3T3-L1 preadipocytes in a dose-dependent manner. Also, DSH significantly reduced the expressions of $PPAR{\gamma}$ and $C/EBP{\alpha}$ in a dose-dependent manner. Furthermore, DSH significantly reduced body weight gain, serum glucose, total cholesterol and LDL-cholesterol contents in obesity-induced mice. Conclusions These results demonstrated that DSH inhibited 3T3-L1 preadipocyte differentiations and high-fat diet-induced obesity in mice.

간호대학생의 환자안전 역량에 영향을 미치는 요인

민들레,곽은주,박승미 한국간호교육학회 2022 한국간호교육학회지 Vol.28 No.3

Purpose: The purpose of this study is to identify nursing students' level of critical thinking disposition, communication skills, and self-leadership and to identify factors that affect the patient safety competency of nursing students. Methods: This study employs a descriptive research, method and was conducted from April 20 to May 19, 2022, with students from three nursing colleges in Korea. The collected data were analyzed by frequency and percentage, independent t-test, Pearson's correlation coefficients, and multiple regression. All analyzes were conducted using IBM SPSS 22.0. Results: The results of the multiple regression analysis showed that the regression model was significant (F=17.30, p<.001) and that communication skills (β=.22, p=.001), self-leadership (β=.31, p<.001), patient safety education experience (β=.15, p=.009), and subjects for credit (β=.15, p=.006) explained 28.0% of nursing students' patient safety competency. Conclusion: It is necessary to develop a self-leadership and communication skills improvement program and to organize rgular courses safety education subjects to improve the patient safety competency of nursing students.

A Study on the Variation of Hazardous Pollutant Emissions in Korea: Focused on Substances for Emissions Reduction Plan

민들레,김보경,이청수,임지영,윤준헌 환경독성보건학회 2022 한국독성학회 심포지움 및 학술발표회 Vol.2022 No.5

Underrepresentation of Asian Americans in U.S. Sports: A Self-efficacy View

민들레,권웅,김석규 한국체육학회 2019 International journal of human movement science Vol.13 No.2

Data from a series of the Racial and Gender Report Cards conducted by the University of Central Florida indicate that Asian Americans have long been underrepresented in various levels of sports in the United States at both the amateur and professional levels. A review of literature suggests that most published work related to diversity in sport has predominantly focused on females and African Americans and calls for more studies of Asian Americans. For this reason, this study aims to raise academic awareness of Asian Americans’ underrepresentation in U.S. sports. A conceptual model based on self-efficacy developed to stimulate future research about Asian Americans in U.S. sports is presented.

Application and Effectiveness of a Program to Promote Adolescent Musculoskeletal Health: A Pilot Study

민들레,한창숙,김효경,김수희 한국보건간호학회 2022 韓國保健看護學會誌 Vol.36 No.2

Purpose: Adolescence is a developmental period characterized by the rapid growth of the musculoskeletal system, which is important for maintaining correct posture. Incorrect posture, lack of exercise, and reduced physical activity can cause spine deformities and affect lifelong health. This study was designed to evaluate the application and effect of a program for improving adolescents’ musculoskeletal health. Methods: A quasi-experimental pilot study was conducted with 13 male and 20 female middle and high school students, with an average age of 15.39 years. Their general characteristics and physical measurements were obtained. The program consisted of group exercises (60 minutes, once per week), gait pattern monitoring, and online communication. A paired t-test and Wilcoxon signed-rank test were used to examine the program’s effect. Results: Overall posture habits improved, and the total musculoskeletal index decreased; however, these results were not statistically significant. Conclusions: The devised program was effective in improving musculoskeletal imbalance. Therefore, effective programs and health devices should be developed to help adolescents maintain correct posture and encourage and support continuous participation in such programs.

한국 사회에서 좋은 죽음에 대한 개념분석

민들레,조은희 한국노인간호학회 2017 노인간호학회지 Vol.19 No.1

Purpose: The purpose of this study was to define the meaning of a good death mentioned in Korean culture. Methods: This study was carried out using Rodgers' evolutionary concept analysis strategy. A review of the literature was done with key words related to good death and other relevant words in literature published in English or Korean. The literature search was conducted from 1995 to 2016 for overseas and from 2000 to 2016 for domestic. The final selection target was 44 pieces. Each document was divided into 7 disciplines, including 25 domestic documents. Results: Three dimensions and seven attributes were identified; 1) The preparation stage for death: living well, preparation for dying, 2) The final stage of death: avoiding meaningless extension of life, dignity, comfort and interaction with healthcare providers, 3) The post death stage: positive feeling of families. Antecedent to good death were dying persons, families and healthcare providers' wishes for good death, The consequences were their experience during the period of dying and feeling after dying. Conclusion: There was a change in the concept of good death according to the times. It is important for nurses to understand the concept of good death in order to provide care with good quality to patients who are faced with death, their families and healthcare providers.

Gestational diabetes and breastfeeding-related pain as major contributors to early breastfeeding cessation

민들레,곽은주,박승미 한국지역사회간호학회 2023 지역사회간호학회지 Vol.34 No.1

Purpose: This study aimed to determine the effects of gestational diabetes mellitus, breastfeeding-related pain, and infant growth on the cessation of breastfeeding. Methods: This is secondary data analysis. This study included 60 pregnant women from 3 prenatal breastfeeding clinics. Pregnant women aged 20–49 years, with or without a diagnosis of gestational diabetes mellitus were enrolled. The participants were administered four self-reported questionnaires, one at 5 days, 14 days, 3 months, and 6 months postpartum. A linear mixed model and Cox regression analysis were used. Data were collected between May 25, 2020 and June 14, 2021. Results: The rate of breastfeeding cessation was 55.0% (n=33). The average maternal ages were 32.30 (±4.61) and 31.33 (±7.05) years in the cessation and maintenance groups, respectively. The average duration of breastfeeding in the cessation group was 56.27 (±37.48) days. After adjusting for all covariates, the risk of breastfeeding cessation was 2.5 times greater among participants diagnosed with gestational diabetes mellitus (p=.042). Additionally, the risk of breastfeeding cessation was 1.3 times greater among those with severe breastfeeding-related pain (p=.015). Conclusion: The first two months postpartum is the most essential time for healthcare workers to provide support and address difficulties associated with breastfeeding for mothers with gestational diabetes mellitus.

교부와 여성

민들레 한영신학대학교 출판부 2009 한영연구논문 Vol.1 No.

당귀음자가감방(當歸飮子加減方)과 외치법(外治法)을 병용한 소아(小兒) 건선(乾癬) 치험 1례

민들레,장성진,박은정,Min, Deul-Le,Chang, Sung-Jin,Park, Eun-Jung 대한한방소아과학회 2012 대한한방소아과학회지 Vol.26 No.3

Objectives The purpose of this case study is to report the effect of concurrent administration of Danguieumja-gagambang and external treatments on childhood psoriasis. Methods The subject is a child with psoriasis. This patient was treated with oriental herbal medicine (Danguieumjagagambang) and external treatments. The improvement of the skin condition is observed by Psoriasis Area and Severity Index (PASI) score. Results After the treatment, the symptoms of psoriasis were relieved. PASI score of this child went down from 4.7 to 0. Conclusions This study showed that concurrent administration of Danguieumja-gagambang and external treatments can be an effective choice for psoriasis.

영유아 아토피피부염 환자 69명의 한의학적 치료효과에 대한 후향적 연구

민들레,한명화,박건,서산,한수련,Min, Deul Le,Han, Myeong Hwa,Park, Gun,Seo, San,Han, Su Ryun 대한한방소아과학회 2014 대한한방소아과학회지 Vol.28 No.3

Objectives The purpose of this study is to report the effectiveness of Korean medicine treatment on 69 infant and young child atopic dermatitis patients. Methods 69 infants and young child atopic dermatitis patients who had visited oriental medical clinics from 2011.1.9 to 2012.1.31 were studied. All of them were continually treated for 3 to 9 months, and were analyzed by Objective SCORAD Index (OSI). A detailed analysis of OSI was done according to gender, age, using of topical steroid ointment, family history of atopic disease, treatment period, and intensity. Results 1. Male and female percentage of the study group was 56.5%: 43.5%. The average period of treatment was 6.09 months. 71.0% used topical steroid ointment, and 65.2% had family history of atopic disease. 2. The average period of treatment was significantly longer in patients who used topical steroid ointment, or who had family history of atopic disease. 3. 95.7% of total patients reported decrease in OSI score at the final visit. OSI was significantly lowered after 3, 6, and 9 months of treatment. The longer period of treatment, the lower average post-treatment OSI. 4. 85.5% of the study group had severe dermatitis, and 14.5% was moderate case based on the OSI intensity assessment at initial visit. These percentages got changed at the final visit as 34.8% of severe, 58.0% of moderate, and 7.2% of mild cases. The average treatment period of patients who were diagnosed as severe at the initial visit was 6.18 months, and their final OSI improvement rate was 39.58%. 58% of them were improved to be mild or moderate at the final visit. Conclusion The Korean medicine treatment is effective in treating infant and young child atopic dermatitis patients. There was significant decrease in OSI score after 3, 6, and 9 months of treatment. The difference increase with the treatment period.